Xi Lin

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Perception of sound and gravity by TMC1 and TMC2
    Xi Lin
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Clin Invest 121:4633-6. 2011
  2. pmc Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities
    Xi Lin
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Hear Res 288:67-76. 2012
  3. pmc Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea
    Yu Sun
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    J Comp Neurol 516:569-79. 2009
  4. pmc Analysis of connexin subunits required for the survival of vestibular hair cells
    Yan Qu
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Comp Neurol 504:499-507. 2007
  5. pmc Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice
    Qing Chang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 3:e4088. 2008
  6. doi request reprint Functional studies reveal new mechanisms for deafness caused by connexin mutations
    Qing Chang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Otol Neurotol 30:237-40. 2009
  7. pmc A low-cost exon capture method suitable for large-scale screening of genetic deafness by the massively-parallel sequencing approach
    Wenxue Tang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Test Mol Biomarkers 16:536-42. 2012
  8. pmc Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models
    Emilie Hoang Dinh
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Brain Res 1277:52-69. 2009
  9. pmc Targeted connexin26 ablation arrests postnatal development of the organ of Corti
    Yunfeng Wang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Biochem Biophys Res Commun 385:33-7. 2009
  10. doi request reprint Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstem response thresholds
    Yunfeng Wang
    Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China
    J Gene Med 15:123-33. 2013

Collaborators

Detail Information

Publications18

  1. pmc Perception of sound and gravity by TMC1 and TMC2
    Xi Lin
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Clin Invest 121:4633-6. 2011
    ....
  2. pmc Applications of targeted gene capture and next-generation sequencing technologies in studies of human deafness and other genetic disabilities
    Xi Lin
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Hear Res 288:67-76. 2012
    ....
  3. pmc Connexin30 null and conditional connexin26 null mice display distinct pattern and time course of cellular degeneration in the cochlea
    Yu Sun
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA 30322 3030, USA
    J Comp Neurol 516:569-79. 2009
    ..The radically different pathogenesis processes displayed by cCx26 and Cx30 null mice suggest heterogeneous underlying deafness mechanisms, despite co-assembly of Cx26 and Cx30 in forming gap junctions in the cochlea...
  4. pmc Analysis of connexin subunits required for the survival of vestibular hair cells
    Yan Qu
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322 3030, USA
    J Comp Neurol 504:499-507. 2007
    ..Hybrid GJs co-assembled from Cx26 and Cx30 were not essential for the survival of saccular hair cells...
  5. pmc Gap junction mediated intercellular metabolite transfer in the cochlea is compromised in connexin30 null mice
    Qing Chang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, GA, USA
    PLoS ONE 3:e4088. 2008
    ....
  6. doi request reprint Functional studies reveal new mechanisms for deafness caused by connexin mutations
    Qing Chang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Otol Neurotol 30:237-40. 2009
    ..Our hypothesis is that specific loss of GJ-mediated biochemical coupling in the cochlea is sufficient to cause deafness...
  7. pmc A low-cost exon capture method suitable for large-scale screening of genetic deafness by the massively-parallel sequencing approach
    Wenxue Tang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Test Mol Biomarkers 16:536-42. 2012
    ..The high coverage depth and cost benefits of the cDNA-probe-based exon capture approach may also facilitate widespread applications in clinical practices beyond screening mutations in deafness genes...
  8. pmc Diverse deafness mechanisms of connexin mutations revealed by studies using in vitro approaches and mouse models
    Emilie Hoang Dinh
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Brain Res 1277:52-69. 2009
    ....
  9. pmc Targeted connexin26 ablation arrests postnatal development of the organ of Corti
    Yunfeng Wang
    Department of Otolaryngology, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Biochem Biophys Res Commun 385:33-7. 2009
    ..These results demonstrated that Cx26 plays essential roles in postnatal maturation and homoeostasis of the organ of Corti before the onset of hearing...
  10. doi request reprint Early postnatal virus inoculation into the scala media achieved extensive expression of exogenous green fluorescent protein in the inner ear and preserved auditory brainstem response thresholds
    Yunfeng Wang
    Department of Otolaryngology, Eye and ENT Hospital, Fudan University, Shanghai, PR China
    J Gene Med 15:123-33. 2013
    ..The present study aimed to define a suitable strategy for preserving hearing after viral inoculation directly into the scala media performed at various postnatal developmental stages...
  11. pmc Atoh1 directs the formation of sensory mosaics and induces cell proliferation in the postnatal mammalian cochlea in vivo
    Michael C Kelly
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci 32:6699-710. 2012
    ..Furthermore, Atoh1 also activates proliferation within the normally postmitotic cochlear epithelium. These results provide insight into the potential and limitations of Atoh1-mediated hair cell regeneration...
  12. pmc Restoration of connexin26 protein level in the cochlea completely rescues hearing in a mouse model of human connexin30-linked deafness
    Shoeb Ahmad
    Department of Otolaryngology, Yerkes Microarray Core, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322 3030, USA
    Proc Natl Acad Sci U S A 104:1337-41. 2007
    ....
  13. pmc Protection of spiral ganglion neurons from degeneration using small-molecule TrkB receptor agonists
    Qing Yu
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China 100730
    J Neurosci 33:13042-52. 2013
    ..Our findings suggest that these novel small-molecule TrkB agonists are promising in vivo therapeutic agents for preventing degeneration of SGNs. ..
  14. pmc Pannexins are new molecular candidates for assembling gap junctions in the cochlea
    Wenxue Tang
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia, USA
    Neuroreport 19:1253-7. 2008
    ..These data for the first time showed expressions of Panxs in the cochlea, therefore adding a new family of gap junction proteins to those used to form intercellular transport pathways in the cochlea...
  15. pmc 7,8,3'-Trihydroxyflavone, a potent small molecule TrkB receptor agonist, protects spiral ganglion neurons from degeneration both in vitro and in vivo
    Qing Yu
    Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital Capital Medical University, 1 Dong Jiao Min Xiang Street, Beijing 100730, China
    Biochem Biophys Res Commun 422:387-92. 2012
    ..Our findings suggest that 7,8,3'-THF is a promising therapeutic agent protecting the SGNs from degeneration both in vitro and in vivo...
  16. doi request reprint Genetics of hearing and deafness
    Simon Angeli
    Department of Otolaryngology, University of Miami, Miami, Florida 33136, USA
    Anat Rec (Hoboken) 295:1812-29. 2012
    ..org). Thus, today's clinician must understand the science of medical genetics as this knowledge can lead to more effective disease diagnosis, counseling, treatment, and prevention...
  17. pmc Deoxygedunin, a natural product with potent neurotrophic activity in mice
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 5:e11528. 2010
    ..Hence, deoxygedunin imitates BDNF's biological activities through activating TrkB, providing a powerful therapeutic tool for treatment of various neurological diseases...
  18. ncbi request reprint A novel mechanism for connexin 26 mutation linked deafness: cell death caused by leaky gap junction hemichannels
    Benjamin C Stong
    Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Laryngoscope 116:2205-10. 2006
    ..Mutations in connexin (Cx) 26 are the most common cause of nonsyndromic hereditary hearing impairments. Our goal is to investigate molecular mechanisms responsible for hearing impairment caused by various types of Cx26 mutations...

Research Grants16

  1. MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONS
    Xi Lin; Fiscal Year: 2001
    ..Our overall Hypothesis is that the cholinergic and GABAergic neurotransmission in the LOC ..
  2. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
    ..By finishing these specific aims, we will be able to collect crucial preclinical data required for filing an investigational new drug (IND) application with the food and drug administration (FDA) at the end of the funding period. ..
  3. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2009
    ..abstract_text> ..
  4. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2010
    ..abstract_text> ..
  5. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Xi Lin; Fiscal Year: 2009
    ..By finishing these specific aims, we will be able to collect crucial preclinical data required for filing an investigational new drug (IND) application with the food and drug administration (FDA) at the end of the funding period. ..
  6. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2009
    ..abstract_text> ..
  7. Mouse models for human deafness caused by diverse types of connexin26 mutations
    Xi Lin; Fiscal Year: 2007
    ..The knowledge gained should help us design better treatment strategies for a large portion of hereditary deafness patients. ..
  8. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2007
    ....
  9. Role of connexins in cochlear functions
    Xi Lin; Fiscal Year: 2006
    ....
  10. MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONS
    Xi Lin; Fiscal Year: 2005
    ..Our overall Hypothesis is that the cholinergic and GABAergic neurotransmission in the LOC ..
  11. MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONS
    Xi Lin; Fiscal Year: 2004
    ..Our overall Hypothesis is that the cholinergic and GABAergic neurotransmission in the LOC ..
  12. MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONS
    Xi Lin; Fiscal Year: 2003
    ..Our overall Hypothesis is that the cholinergic and GABAergic neurotransmission in the LOC ..
  13. MOLECULAR MECHANISMS OF THE COCHLEAR EFFERENT FUNCTIONS
    Xi Lin; Fiscal Year: 2002
    ..Our overall Hypothesis is that the cholinergic and GABAergic neurotransmission in the LOC ..
  14. Auditory Neuroprotection by Small Molecule Agonists of the TrkB Receptor
    Keqiang Ye; Fiscal Year: 2010
    ..By finishing these specific aims, we will be able to collect crucial preclinical data required for filing an investigational new drug (IND) application with the food and drug administration (FDA) at the end of the funding period. ..