Yuying Liang

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA
    Yuying Liang
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, 94143 0414, USA
    J Virol 78:6818-26. 2004
  2. pmc Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers
    Yuying Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E65-74. 2009
  3. pmc Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments
    Yuhong Liang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:229-36. 2008
  4. pmc Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
    Yuying Liang
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, CA 94143 0414, USA
    Proc Natl Acad Sci U S A 100:8490-5. 2003
  5. pmc Identification of virulence determinants within the L genomic segment of the pichinde arenavirus
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    J Virol 87:6635-43. 2013
  6. pmc NF-kappaB signaling differentially regulates influenza virus RNA synthesis
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:9880-9. 2008
  7. pmc Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 55:5553-9. 2011
  8. pmc Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 83:6357-62. 2009
  9. pmc Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity
    Yuhong Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e29485. 2012
  10. pmc Genome comparison of virulent and avirulent strains of the Pichinde arenavirus
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, 105P Whitehead Bldg, Atlanta, GA 30322, USA
    Arch Virol 153:1241-50. 2008

Research Grants

Collaborators

  • Jill Bechtel
  • Hinh Ly
  • DON E GANEM
  • Aftab Ansari
  • Neal S Young
  • Rodrigo T Calado
  • Eric Hunter
  • Naveen Kumar
  • Lisa McLay
  • Shuiyun Lan
  • Tristram G Parslow
  • Zhong Tao Xin
  • Sushma Bhosle
  • John F Regan
  • Xiaojie Wang
  • Nishi R Sharma
  • Suganthi Suppiah
  • Dennis Liotta
  • Natalia Makarova
  • John Petros
  • Jerry Blackwell
  • William Diehl
  • Rebecca Arnold
  • Ross Molinaro
  • Lisa McLay Schelde
  • Jialong Wang
  • Judy Aronson
  • Jennifer W Bradford
  • Aarthi Shenoy
  • Peter M Lansdorp
  • Adam D Beauchamp
  • Joshua A Regal
  • Shirley Gillam

Detail Information

Publications19

  1. pmc RBP-J (CSL) is essential for activation of the K14/vGPCR promoter of Kaposi's sarcoma-associated herpesvirus by the lytic switch protein RTA
    Yuying Liang
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, 94143 0414, USA
    J Virol 78:6818-26. 2004
    ..The regulation of K14/vGPCR transcripts by RBP-J raises the possibility that other modulators of Notch signaling might be able to induce expression of this RNA outside the context of lytic KSHV replication...
  2. pmc Molecular determinants of Pichinde virus infection of guinea pigs--a small animal model system for arenaviral hemorrhagic fevers
    Yuying Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E65-74. 2009
    ..We have recently developed molecular clones for both the virulent and avirulent strains of PICV. Using the available reverse genetics tools, we are characterizing the molecular determinants of virulent arenavirus infections in vivo...
  3. pmc Mutational analyses of packaging signals in influenza virus PA, PB1, and PB2 genomic RNA segments
    Yuhong Liang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:229-36. 2008
    ..Interestingly, certain mutations showed strong tendencies to revert to wild-type sequences, which implies that these putative packaging signals are critical for the influenza life cycle...
  4. pmc Lytic but not latent infection by Kaposi's sarcoma-associated herpesvirus requires host CSL protein, the mediator of Notch signaling
    Yuying Liang
    Howard Hughes Medical Institute and Department of Microbiology, University of California Medical Center, San Francisco, CA 94143 0414, USA
    Proc Natl Acad Sci U S A 100:8490-5. 2003
    ..RBP-J kappa-mediated repression is therefore not essential for establishment of latent infection, but the RTA-mediated redirection of RBP-J kappa activity from repression to activation is critical for lytic viral replication...
  5. pmc Identification of virulence determinants within the L genomic segment of the pichinde arenavirus
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    J Virol 87:6635-43. 2013
    ..Our laboratory findings serve to reinforce field observations that a high level of viremia often correlates with severe disease outcomes in LASV-infected patients...
  6. pmc NF-kappaB signaling differentially regulates influenza virus RNA synthesis
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael St, Room 105P, Atlanta, GA 30322, USA
    J Virol 82:9880-9. 2008
    ....
  7. pmc Receptor tyrosine kinase inhibitors that block replication of influenza a and other viruses
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 55:5553-9. 2011
    ....
  8. pmc Development of infectious clones for virulent and avirulent pichinde viruses: a model virus to study arenavirus-induced hemorrhagic fevers
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 83:6357-62. 2009
    ..These novel infectious clones for the PICV provide essential tools to identify the virulence factors that are responsible for the severe VHF-like disease in infected animals...
  9. pmc Mutational analyses of the influenza A virus polymerase subunit PA reveal distinct functions related and unrelated to RNA polymerase activity
    Yuhong Liang
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 7:e29485. 2012
    ....
  10. pmc Genome comparison of virulent and avirulent strains of the Pichinde arenavirus
    Shuiyun Lan
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, 105P Whitehead Bldg, Atlanta, GA 30322, USA
    Arch Virol 153:1241-50. 2008
    ..Four out of the five amino acid changes in the L protein occur in a small region of the protein that may contribute to viral virulence by enhancing its function in viral genomic RNA synthesis...
  11. pmc The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the Notch signaling pathway
    Yuying Liang
    Howard Hughes Medical Institute and Departments of Microbiology and Medicine, University of California, San Francisco, California 94143 0414, USA
    Genes Dev 16:1977-89. 2002
    ..These results indicate that KSHV has evolved a ligand-independent mechanism for constitutive activation of the Notch pathway as a part of its strategy for reactivation from latency...
  12. pmc Defective assembly of influenza A virus due to a mutation in the polymerase subunit PA
    John F Regan
    Biomedical Sciences Graduate Program, University of California, San Francisco, California 94143, USA
    J Virol 80:252-61. 2006
    ....
  13. pmc Receptor tyrosine kinase inhibitors block multiple steps of influenza a virus replication
    Naveen Kumar
    Department of Pathology and Laboratory Medicine, 615 Michael St, Ste 177, Rm 175, Whitehead Biomedical Research Bldg, Emory University, Atlanta, GA 30322, USA
    J Virol 85:2818-27. 2011
    ....
  14. pmc cis-Acting packaging signals in the influenza virus PB1, PB2, and PA genomic RNA segments
    Yuying Liang
    Department of Pathology and Laboratory Medicine, Emory University, 1364 Clifton Road, N E, Room H 184, Atlanta, GA 30322, USA
    J Virol 79:10348-55. 2005
    ..e., whose 5' and 3' ends are derived from different vRNA segments) were poorly packaged, implying that the two ends of any given vRNA may collaborate in forming specific structures to be recognized by the viral packaging machinery...
  15. pmc Host range of Kaposi's sarcoma-associated herpesvirus in cultured cells
    Jill T Bechtel
    Howard Hughes Medical Institute and Department of Microbiology and Medicine, University of California Medical Center, San Francisco 94143, USA
    J Virol 77:6474-81. 2003
    ....
  16. pmc Targeting virulence mechanisms for the prevention and therapy of arenaviral hemorrhagic fever
    Lisa McLay
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, United States
    Antiviral Res 97:81-92. 2013
    ..This review summarizes current knowledge of the role of each viral protein and host factor in the pathogenesis of arenaviral HF. Insights from recent studies are being exploited for the development of novel therapies...
  17. pmc Evaluation of cellular determinants required for in vitro xenotropic murine leukemia virus-related virus entry into human prostate cancer and noncancerous cells
    Sushma Bhosle
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Virol 84:6288-96. 2010
    ....
  18. ncbi Functional characterization of natural telomerase mutations found in patients with hematologic disorders
    Zhong Tao Xin
    Department of Pathology and Laboratory Medicine, Emory University, 105L Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Blood 109:524-32. 2007
    ..Inherited telomerase gene mutations, therefore, operate by various mechanisms to shorten telomere lengths, leading to limited marrow stem cell reserve and renewal capacity in patients with hematologic disorders...
  19. ncbi Rescue of rubella virus replication-defective mutants using vaccinia virus recombinant expressing rubella virus nonstructural proteins
    Xiaojie Wang
    Department of Pathology and Laboratory Medicine, University of British Columbia, BC Research Institute for Children s and Women s Health, 950 West 28th Avenue, Vancouver, BC, Canada
    Virus Res 86:111-22. 2002
    ..Rescue of cleavage-defective mutant by either p200 alone, or p150 plus p90 but not by p150 or p90 alone suggests that p150 and p90 function together as a replication complex in positive-strand RNA synthesis...

Research Grants1

  1. Molecular determinants of virulent arenavirus infection in hosts
    Yuying Liang; Fiscal Year: 2010
    ..We propose here to study the molecular mechanisms by which some arenaviruses can cause virulent infections in the hosts. These studies may lead to the development of effective treatments against the deadly arenavirus HF in humans. ..