Lian Li

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc SIMPLE: A new regulator of endosomal trafficking and signaling in health and disease
    Lih Shen Chin
    Department of Pharmacology Emory University School of Medicine Atlanta, GA USA
    Commun Integr Biol 6:e24214. 2013
  2. ncbi request reprint The molecular machinery of synaptic vesicle exocytosis
    L Li
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322 3090, USA
    Cell Mol Life Sci 60:942-60. 2003
  3. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
  4. pmc Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking
    Elizabeth Webber
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 4218, USA
    J Mol Biol 382:638-51. 2008
  5. pmc Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    Di Sha
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 19:352-63. 2010
  6. pmc Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 124:3319-31. 2011
  7. pmc Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:21765-75. 2009
  8. pmc Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    FEBS J 276:118-31. 2009
  9. pmc Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
    Bong Yoon Kim
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 18:1129-42. 2007
  10. pmc PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Biol 5:e172. 2007

Collaborators

Detail Information

Publications37

  1. pmc SIMPLE: A new regulator of endosomal trafficking and signaling in health and disease
    Lih Shen Chin
    Department of Pharmacology Emory University School of Medicine Atlanta, GA USA
    Commun Integr Biol 6:e24214. 2013
    ..We propose that endosomal trafficking and signaling dysregulation is a key pathogenic mechanism in CMT and other diseases that involve SIMPLE dysfunction...
  2. ncbi request reprint The molecular machinery of synaptic vesicle exocytosis
    L Li
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322 3090, USA
    Cell Mol Life Sci 60:942-60. 2003
    ..This review summarizes present knowledge about the molecular mechanisms by which these components mediate and/or regulate synaptic vesicle exocytosis...
  3. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
    ..Our study provides new insights into the oxidative modifications of DJ-1 and indicates association of oxidative damage to DJ-1 with sporadic PD and AD...
  4. pmc Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking
    Elizabeth Webber
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 4218, USA
    J Mol Biol 382:638-51. 2008
    ..Our findings support a role for Trak1 in the regulation of Hrs-mediated endosomal sorting and have important implications for understanding hypertonia associated with neurological disorders...
  5. pmc Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    Di Sha
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 19:352-63. 2010
    ..Our findings support a direct link between PINK1-mediated phosphorylation and parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kappaB neuroprotective signaling pathway in the pathogenesis of PD...
  6. pmc Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 124:3319-31. 2011
    ....
  7. pmc Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:21765-75. 2009
    ..Our findings suggest that printor is a new component of the DYT1 pathogenic pathway and provide a potential molecular target for therapeutic intervention in dystonia...
  8. pmc Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    FEBS J 276:118-31. 2009
    ....
  9. pmc Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
    Bong Yoon Kim
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 18:1129-42. 2007
    ..Our findings support a role for Mahogunin in a proteasome-independent ubiquitylation pathway and suggest a link between dysregulation of endosomal trafficking and spongiform neurodegeneration...
  10. pmc PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Biol 5:e172. 2007
    ..Our findings suggest a novel pathway by which PINK1 phosphorylates downstream effector TRAP1 to prevent oxidative-stress-induced apoptosis and implicate the dysregulation of this mitochondrial pathway in PD pathogenesis...
  11. ncbi request reprint GRIF1 binds Hrs and is a new regulator of endosomal trafficking
    Elizabeth Kirk
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 119:4689-701. 2006
    ..Our findings suggest that GRIF1 may also participate in microtubule-based transport of early endosomes by acting as an adaptor linking Hrs-containing endosomes to kinesin...
  12. pmc Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage
    Jue Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 19:2395-408. 2010
    ..Our findings support a role for DJ-1 protease in cellular defense against oxidative stress and have important implications for understanding and treating PD...
  13. pmc Neuroprotection by selective allosteric potentiators of the EP2 prostaglandin receptor
    Jianxiong Jiang
    Department of Pharmacology, Emory Chemical Biology Discovery Center, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:2307-12. 2010
    ..Our results strongly reinforce the notion that activation of EP2 receptors by endogenous PGE(2) released in a cell-injury setting is neuroprotective...
  14. ncbi request reprint Cancer and virus leads by HTS, chemical design and SEA data mining
    Pahk Thepchatri
    Chemical Biology Discovery Center, 1510 Clifton Road, Emory University, Atlanta, GA 30322, USA
    Curr Top Med Chem 9:1159-71. 2009
    ..In parallel with HTS, a unique component of the Emory virtual screening (VS) effort, namely, substructure enrichment analysis (SEA) program has been utilized in several cases...
  15. pmc Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 178:1025-38. 2007
    ....
  16. pmc Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease
    James A Olzmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:585-99. 2007
    ..Together, these findings indicate neuronal and synaptic expression of DJ-1 in primate subcortical brain regions and suggest a physiological role for DJ-1 in the survival and/or function of nigral-striatal neurons...
  17. pmc Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking
    Samuel M Lee
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 199:799-816. 2012
    ..Our findings indicate a function of SIMPLE as a regulator of endosomal trafficking and provide evidence linking dysregulated endosomal trafficking to CMT pathogenesis...
  18. ncbi request reprint Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 280:11648-55. 2005
    ..This work suggests that AD, PD, and ALS may share a common or overlapping pathogenic mechanism(s) that could potentially be targeted by similar therapeutic strategies...
  19. pmc Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
    Lih Shen Chin
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Soc Trans 38:144-9. 2010
    ..The present review summarizes the current knowledge of the aggresome-autophagy pathway, its regulation by parkin-mediated Lys(63)-linked polyubiquitination, and its dysfunction in neurodegenerative diseases...
  20. ncbi request reprint Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death
    James T Lee
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 17:906-17. 2008
    ..Our findings suggest that Siah-1-mediated alpha-synuclein ubiquitination may play a critical role in Lewy body formation and PD pathogenesis...
  21. pmc TorsinA protein degradation and autophagy in DYT1 dystonia
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Autophagy 5:82-4. 2009
    ....
  22. pmc Synthesis and SAR study of N-(4-hydroxy-3-(2-hydroxynaphthalene-1-yl)phenyl)-arylsulfonamides: heat shock protein 90 (Hsp90) inhibitors with submicromolar activity in an in vitro assay
    Thota Ganesh
    Chemical Biology Discovery Center, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 18:4982-7. 2008
    ..In this report, we present a new and general method for the synthesis of a variety of analogs around this scaffold, and discuss their structure-activity relationships...
  23. pmc Distinct growth factor-induced dynamic mass redistribution (DMR) profiles for monitoring oncogenic signaling pathways in various cancer cells
    Yuhong Du
    Departments of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Recept Signal Transduct Res 29:182-94. 2009
    ..5). This technology is applicable to other oncogenic pathways for the discovery of novel therapeutic agents for the treatment of various cancers...
  24. pmc Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 22:1755-70. 2013
    ..The results from this study suggest that myelin infolding and paranodal damage may represent pathogenic precursors preceding demyelination and axonal degeneration in CMT1C patients...
  25. pmc A dual-readout F2 assay that combines fluorescence resonance energy transfer and fluorescence polarization for monitoring bimolecular interactions
    Yuhong Du
    Department of Pharmacology and Emory Chemical Biology Discovery Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Assay Drug Dev Technol 9:382-93. 2011
    ..This strategy can be generally extended to other FP-based assays and is expected to enrich primary HTS information and enhance the hit quality of HTS campaigns...
  26. pmc The ubiquitin-proteasome system in spongiform degenerative disorders
    BRANDI R WHATLEY
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1782:700-12. 2008
    ....
  27. ncbi request reprint Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 279:13256-64. 2004
    ..Together, these results provide evidence supporting a direct link between oxidative damage to the neuronal ubiquitination/de-ubiquitination machinery and the pathogenesis of sporadic AD and PD...
  28. pmc Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 17:2712-22. 2008
    ....
  29. ncbi request reprint Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    Yankun Li
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:28212-21. 2002
    ..These findings implicate, for the first time, the involvement of HAP1 in the regulation of vesicular trafficking from early endosomes to the late endocytic compartments...
  30. ncbi request reprint Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation
    Lih Shen Chin
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:35071-9. 2002
    ..These findings suggest that Staring is a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation by the ubiquitin-proteasome pathway...
  31. ncbi request reprint Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
    ..Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease...
  32. pmc Protein misfolding and clearance in demyelinating peripheral neuropathies: Therapeutic implications
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA USA
    Commun Integr Biol 5:107-10. 2012
    ..These studies suggest that targeting protein quality control systems involved in cytoprotection against CMT-associated misfolded proteins could have therapeutic benefits for treating demyelinating CMT...
  33. pmc Discovery of aminoquinolines as a new class of potent inhibitors of heat shock protein 90 (Hsp90): Synthesis, biology, and molecular modeling
    Thota Ganesh
    Chemical Biology Discovery Center, 1510 Clifton Road, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem 16:6903-10. 2008
    ..These compounds represent a new class of Hsp90 inhibitors with simple chemical structures...
  34. pmc Nitric oxide-dependent proteasomal degradation of cytochrome P450 2B proteins
    Choon Myung Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:889-98. 2008
    ..These data are consistent with the hypothesis that NO-dependent CYP2B ubiquitination and proteasomal degradation are dependent on protein modification by reactive nitrogen species...
  35. ncbi request reprint Hrs interacts with SNAP-25 and regulates Ca(2+)-dependent exocytosis
    J Kwong
    Department of Pharmacology, Bowles Center for Alcohol Studies, School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA
    J Cell Sci 113:2273-84. 2000
    ..Moreover, overexpression of Hrs in PC12 cells inhibits Ca(2+)-dependent exocytosis. These results suggest that Hrs is involved in regulation of neurosecretion through interaction with SNAP-25...
  36. pmc Ubiquitin C-terminal hydrolase l1 in tumorigenesis
    Jennifer Hurst-Kennedy
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Res Int 2012:123706. 2012
    ..In this paper, we provide an overview of the evidence supporting the involvement of UCH-L1 in tumor development and discuss the potential mechanisms of action of UCH-L1 in oncogenesis...
  37. ncbi request reprint Regulation of synaptophysin degradation by mammalian homologues of seven in absentia
    Tiffany C Wheeler
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:10273-82. 2002
    ..Our findings indicate that Siah proteins function as E3 ubiquitin-protein ligases to regulate the ubiquitination and degradation of synaptophysin...

Research Grants24

  1. Mechanisms of Endosome-to-Lysosome Trafficking in Brain
    Lian Li; Fiscal Year: 2007
    ..abstract_text> ..
  2. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2007
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  3. Mechanisms of Endosome-to-Lysosome Trafficking in Brain
    Lian Li; Fiscal Year: 2006
    ..abstract_text> ..
  4. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2005
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  5. Pathogenic Mechanisms of Environmental Toxicants in Parkinson's Disease
    Lian Li; Fiscal Year: 2009
    ..The results of the proposed studies will promote the discovery of new therapies for preventing and treating this devastating illness. ..
  6. Mechanisms of Endosome-to-Lysosome Trafficking in Brain
    Lian Li; Fiscal Year: 2004
    ..abstract_text> ..
  7. Characterization of a neuronal ubiquitination machinery
    Lian Li; Fiscal Year: 2004
    ..abstract_text> ..
  8. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2004
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  9. Pathogenic Mechanisms of Environmental Toxicants in Parkinson's Disease
    Lian Li; Fiscal Year: 2010
    ..The results of the proposed studies will promote the discovery of new therapies for preventing and treating this devastating illness. ..
  10. The PINK1 Mitochondrial Signaling Pathway
    Lian Li; Fiscal Year: 2009
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to treat numerous mitochondrial diseases in human. ..
  11. The PINK1 Mitochondrial Signaling Pathway
    Lian Li; Fiscal Year: 2010
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to treat numerous mitochondrial diseases in human. ..
  12. MOLECULAR GENETIC ANALYSIS OF SYNAPTIC TRANSMISSION
    Lian Li; Fiscal Year: 2001
    ....
  13. Characterization of a neuronal ubiquitination machinery
    Lian Li; Fiscal Year: 2007
    ..abstract_text> ..
  14. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2006
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  15. Characterization of a neuronal ubiquitination machinery
    Lian Li; Fiscal Year: 2006
    ..abstract_text> ..
  16. Characterization of a neuronal ubiquitination machinery
    Lian Li; Fiscal Year: 2005
    ..abstract_text> ..
  17. Mechanisms of Endosome-to-Lysosome Trafficking in Brain
    Lian Li; Fiscal Year: 2005
    ..abstract_text> ..
  18. MOLECULAR GENETIC ANALYSIS OF SYNAPTIC TRANSMISSION
    Lian Li; Fiscal Year: 2002
    ....
  19. Ubiquitin-mediated proteolysis at synaptic terminals
    Lian Li; Fiscal Year: 2003
    ..These studies should advance our understanding of protein degradation at synaptic terminals, and provide a basis for the development of therapeutic strategies for treating malfunctions of the nervous system. ..
  20. NOVEL PROTEINS IN NEUROTRANSMITTER RELEASE
    Lian Li; Fiscal Year: 2001
    ....
  21. The PINK1 Mitochondrial Signaling Pathway
    Lian Li; Fiscal Year: 2009
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to treat numerous mitochondrial diseases in human. ..