W Lewis

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 93:151-8. 2013
  2. pmc Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma
    William Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lab Invest 87:326-35. 2007
  3. pmc Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis
    William Lewis
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    AIDS 20:675-84. 2006
  4. ncbi request reprint Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy
    William Lewis
    Department of Pathology, Emory University, Atlanta, GA, USA
    Antivir Ther 10:M13-27. 2005
  5. ncbi request reprint Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS
    William Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Lab Invest 85:972-81. 2005
  6. ncbi request reprint Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine
    W Lewis
    Department of Pathology, University of Cincinnati College of Medicine, Ohio, USA
    Lab Invest 80:187-97. 2000
  7. ncbi request reprint Use of the transgenic mouse in models of AIDS cardiomyopathy
    William Lewis
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    AIDS 17:S36-45. 2003
  8. ncbi request reprint Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions
    William Lewis
    Department of Pathology, Emory University, Room 7117, 1639 Pierce Drive, Atlanta, GA 30030, USA
    Antiviral Res 58:189-97. 2003
  9. ncbi request reprint Mitochondrial DNA replication, nucleoside reverse-transcriptase inhibitors, and AIDS cardiomyopathy
    William Lewis
    Department of Pathology, Emory University Atlanta, GA 30322, USA
    Prog Cardiovasc Dis 45:305-18. 2003
  10. ncbi request reprint Cardiomyopathy in AIDS: a pathophysiological perspective
    W Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Prog Cardiovasc Dis 43:151-70. 2000

Research Grants

  1. CARDIAC DYSFUNCTION, AIDS AND COCAINE
    William Lewis; Fiscal Year: 1999
  2. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2005
  3. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2005
  4. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2005
  5. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2005
  6. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2006
  7. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2006
  8. Cardiomyocyte Cell Cycle, Antiretrovirals and AIDS
    William Lewis; Fiscal Year: 2006
  9. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2007
  10. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2006

Collaborators

Detail Information

Publications37

  1. pmc Transgenic mouse model with deficient mitochondrial polymerase exhibits reduced state IV respiration and enhanced cardiac fibrosis
    Christopher A Koczor
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 93:151-8. 2013
    ..Together, these results demonstrate that defective pol-γ function promotes cardiomyopathy, cardiac fibrosis, mtDNA depletion, and reduced mitochondrial energy production...
  2. pmc Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma
    William Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lab Invest 87:326-35. 2007
    ..The transgenic model pathophysiologically links human mutant Pol gamma, mtDNA depletion, and mitochondrial oxidative stress to the mtDNA replication apparatus and to CM...
  3. pmc Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis
    William Lewis
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    AIDS 20:675-84. 2006
    ..Transgenic mice (TG) expressing human DNC targeted to murine myocardium served to define mitochondrial events from NRTIs in vivo and findings were corroborated by biochemical events in vitro...
  4. ncbi request reprint Nucleoside reverse transcriptase inhibitors, mitochondrial DNA and AIDS therapy
    William Lewis
    Department of Pathology, Emory University, Atlanta, GA, USA
    Antivir Ther 10:M13-27. 2005
    ..Further studies will help us unravel mechanisms of NRTI MT and the natural history of mitochondrial biogenesis in humans and other mammalian systems...
  5. ncbi request reprint Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS
    William Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Lab Invest 85:972-81. 2005
    ..Data suggest the DNC is integral to mitochondrial homeostasis in vivo and may relate mechanistically to mitochondrial dysfunction in patients treated with HAART regimens that contain NRTIs...
  6. ncbi request reprint Cardiac dysfunction occurs in the HIV-1 transgenic mouse treated with zidovudine
    W Lewis
    Department of Pathology, University of Cincinnati College of Medicine, Ohio, USA
    Lab Invest 80:187-97. 2000
    ..In transgenic mice, AZT treatment worsens molecular and ultrastructural features of cardiomyopathy. HIV-1 constructs and AZT each contribute to cardiac dysfunction in this murine model of AIDS cardiomyopathy...
  7. ncbi request reprint Use of the transgenic mouse in models of AIDS cardiomyopathy
    William Lewis
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    AIDS 17:S36-45. 2003
    ..These TG target the selected HIV-1 genes expressed in cardiac ventricular myocytes. Tissue-specific targeting of this type enables us to define structural and functional effects of specific HIV-1 gene products on the cardiac myocyte...
  8. ncbi request reprint Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: experimental clarifications and persistent clinical questions
    William Lewis
    Department of Pathology, Emory University, Room 7117, 1639 Pierce Drive, Atlanta, GA 30030, USA
    Antiviral Res 58:189-97. 2003
    ..With increased use of NRTIs, mtDNA mutations may become increasingly important pathophysiologically. One important future goal is to prevent or attenuate the side effects so that improved efficacy is achieved...
  9. ncbi request reprint Mitochondrial DNA replication, nucleoside reverse-transcriptase inhibitors, and AIDS cardiomyopathy
    William Lewis
    Department of Pathology, Emory University Atlanta, GA 30322, USA
    Prog Cardiovasc Dis 45:305-18. 2003
    ..Subsequent to those findings, other observations suggested that mitochondrial energy deprivation is concomitant with or the result of mitochondrial oxidative stress in AIDS (from HIV, for example) or from NRTI therapy itself...
  10. ncbi request reprint Cardiomyopathy in AIDS: a pathophysiological perspective
    W Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Prog Cardiovasc Dis 43:151-70. 2000
    ..Because it is possible that more than 1 of these factors is present in a given patient inflicted with AIDS, a multifactorial pathogenesis in AIDS cardiomyopathy must be considered...
  11. ncbi request reprint Combined antiretroviral therapy causes cardiomyopathy and elevates plasma lactate in transgenic AIDS mice
    W Lewis
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Lab Invest 81:1527-36. 2001
    ..No changes were found in other cohorts. After 10 days, only ANF was elevated, and only in the TG + HAART cohort. Results show that cumulative HAART caused mitochondrial CM with elevated LA in AIDS transgenic mice...
  12. ncbi request reprint AIDS cardiomyopathy: physiological, molecular, and biochemical studies in the transgenic mouse
    W Lewis
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 946:46-56. 2001
    ..Each transgenic approach is a model system that affords a distinct opportunity to explore the pathogenesis and pathophysiology of AIDS CM...
  13. pmc Targeted transgenic overexpression of mitochondrial thymidine kinase (TK2) alters mitochondrial DNA (mtDNA) and mitochondrial polypeptide abundance: transgenic TK2, mtDNA, and antiretrovirals
    Seyed H Hosseini
    Department of Pathology, Emory University School of Medicine, 7117 Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Am J Pathol 170:865-74. 2007
    ..NRTIs abrogated functional effects of transgenically increased TK2 activity but had no effect on TK2 mtDNA abundance. Thus, NRTI mitochondrial phosphorylation by TK2 is integral to clinical NRTI mitochondrial toxicity...
  14. ncbi request reprint Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy
    James J Kohler
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 89:782-90. 2009
    ..As dysfunctional changes are ameliorated by decreasing and worsened by increasing H(2)O(2) abundance, oxidative stress from H(2)O(2) is crucial pathogenetically in AZT-induced mitochondrial CM...
  15. ncbi request reprint A brief overview of mechanisms of mitochondrial toxicity from NRTIs
    James J Kohler
    Department of Pathology, Emory University, Atlanta, Georgia
    Environ Mol Mutagen 48:166-72. 2007
    ..Mechanisms of mitochondrial toxicity are reviewed with respect to key cell biological, pathological, and pharmacological events...
  16. ncbi request reprint Targeted myocardial transgenic expression of HIV Tat causes cardiomyopathy and mitochondrial damage
    Scott M Raidel
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 282:H1672-8. 2002
    ..Tat caused cardiac dysfunction in this TG and may impact on cardiomyopathy in acquired immunodeficiency syndrome...
  17. ncbi request reprint Cocaine increases mortality and cardiac mass in a murine transgenic model of acquired immune deficiency syndrome
    Roy L Sutliff
    Department of Experimental Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Lab Invest 83:983-9. 2003
    ..Histopathologically, perivascular fibrosis and interstitial fibrosis were evident in cocaine-treated TG. Data suggest that additive cardiac insults (from AIDS and cocaine) result in combined deleterious effects...
  18. doi request reprint Transgenic mouse models of mitochondrial toxicity associated with HIV/AIDS and antiretrovirals
    Christopher Koczor
    Department of Pathology, Emory University, Atlanta, GA, USA
    Methods 51:399-404. 2010
    ..This chapter summarizes data from TG models that help unravel the individual and combined effects of HIV-1 infection and NRTI therapy on mouse physiology. Emphasis is placed on cardiac mitochondrial toxicity of NRTIs used in HIV/AIDS...
  19. ncbi request reprint Cardiac peroxisome proliferator-activated receptor gamma is essential in protecting cardiomyocytes from oxidative damage
    Guoliang Ding
    Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, USA
    Cardiovasc Res 76:269-79. 2007
    ..However, little is known about the roles of PPARgamma in the heart. The present study is to investigate in vivo role(s) of PPARgamma in the heart...
  20. pmc Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation
    James J Kohler
    Department of Pathology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Lab Invest 89:122-30. 2009
    ..EM features were consistent with cardiac dysfunction. mtDNA abundance and cardiac functional changes were related to TG expression of mitochondrially related genes, mutations thereof, and NRTIs...
  21. pmc Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy
    James J Kohler
    Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA, 30322, USA
    Cardiovasc Toxicol 8:57-69. 2008
    ..Mutations in genes for mtDNA biogenesis increase risk for defective mtDNA replication, leading to LV hypertrophy...
  22. pmc Mitochondrial DNA impairment in nucleoside reverse transcriptase inhibitor-associated cardiomyopathy
    James J Kohler
    Department of Pathology, Emory University, 101 Woodruff Circle, WMB, Atlanta, Georgia 30322, USA
    Chem Res Toxicol 21:990-6. 2008
    ..Clinical observations and in vitro and in vivo studies support various mechanisms of CM. This perspective highlights some of the hypotheses and focuses on mitochondrial-associated pathways of NRTI- related CM...
  23. pmc Transgenic cardiac-targeted overexpression of human thymidylate kinase
    James J Kohler
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Lab Invest 90:383-90. 2010
    ..In all cohorts, LV end-diastolic dimension remained unchanged. This novel cardiac-targeted overexpression of hTMPK helps define the role of TMPK in mitochondrial toxicity of antiretrovirals...
  24. pmc Tenofovir renal toxicity targets mitochondria of renal proximal tubules
    James J Kohler
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Lab Invest 89:513-9. 2009
    ..LCM-captured renal proximal tubules from TGs showed decreased mtDNA abundance with tenofovir. The results indicate that tenofovir targets mitochondrial toxicity on the renal proximal tubule in an AIDS model...
  25. doi request reprint Absence of mitochondrial toxicity in hearts of transgenic mice treated with abacavir
    James J Kohler
    Department of Pathology, Emory University School of Medicine, 7126 Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Cardiovasc Toxicol 10:146-51. 2010
    ..These results indicate that treatment with ABC has no visible cardiotoxicity in these adult mice exposed for 5 weeks compared to findings with other antiretroviral NRTI studies and support some claims for its relative safety...
  26. pmc Therapeutic targeting of mitochondrial superoxide in hypertension
    Anna E Dikalova
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circ Res 107:106-16. 2010
    ..It is possible that these agents are not adequately delivered to the subcellular sites of superoxide production...
  27. ncbi request reprint Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide
    Roy L Sutliff
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 283:H2363-70. 2002
    ..These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome...
  28. ncbi request reprint HIV viral protein R causes atrial cardiomyocyte mitosis, mesenchymal tumor, dysrhythmia, and heart failure
    William Lewis
    Department of Pathology, Emory University, Atlanta, GA, USA
    Lab Invest 85:182-92. 2005
    ..Since some Vpr cardiomyocytic effects resemble those found in terminally differentiated immunocytes, some pathogenetic mechanisms may be shared at the subcellular level...
  29. ncbi request reprint Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy
    Lihong Cheng
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Nat Med 10:1245-50. 2004
    ..We suggest that PPAR-delta is a potential therapeutic target in treating lipotoxic cardiomyopathy and other heart diseases...
  30. pmc Mice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death
    Hong D Xiao
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Am J Pathol 165:1019-32. 2004
    ..In conclusion, increased local production of angiotensin II in the heart is not sufficient to induce ventricular hypertrophy or fibrosis. Instead, it leads to atrial morphological changes, cardiac arrhythmia, and sudden death...
  31. ncbi request reprint Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective
    William Lewis
    Emory University, Department of Pathology, 1639 Pierce Drive, Room 7117, Atlanta, Georgia 30322, USA
    Nat Rev Drug Discov 2:812-22. 2003
    ..This review characterizes the pharmacological mechanisms and pathways that are involved in mitochondrial dysfunction caused by NRTIs, and suggests opportunities for future pharmacological research...
  32. ncbi request reprint Oxidative stress in NRTI-induced toxicity: evidence from clinical experience and experiments in vitro and in vivo
    Brian J Day
    Department of Medicine, National Jewish Medical and ResearchCenter, Denver, CO 80206, USA
    Cardiovasc Toxicol 4:207-16. 2004
    ..The impact of oxidative stress on cardiovascular disease is likely to increase because patients with HIV infection are living longer as a result of effective antiretroviral therapy...
  33. ncbi request reprint Defective mitochondrial DNA replication and NRTIs: pathophysiological implications in AIDS cardiomyopathy
    William Lewis
    Am J Physiol Heart Circ Physiol 284:H1-9. 2003
  34. ncbi request reprint Mitochondrial oxidative stress in human hepatoma cells exposed to stavudine
    Leonard W Velsor
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Toxicol Appl Pharmacol 199:10-9. 2004
    ..These deleterious events may be potentiated in acquired immunodeficiency syndrome (AIDS) by human immunodeficiency virus (HIV) infection itself, coinfection (e.g., viral hepatitis), aging, substance, and alcohol use...
  35. ncbi request reprint Strain-dependent beta-adrenergic receptor function influences myocardial responses to isoproterenol stimulation in mice
    Michael D Faulx
    Division of Cardiology, Dept of Medicine, Univ Hospitals of Cleveland and Case Western Reserve Univ, MS 5038, 11100 Euclid Ave, Cleveland, OH 44106 5038, USA
    Am J Physiol Heart Circ Physiol 289:H30-6. 2005
    ..Abnormalities in beta-adrenergic regulation may contribute to strain-related differences in the vulnerability to isoproterenol-induced cardiac changes...
  36. ncbi request reprint Pharmacogenomics, toxicogenomics, and DNA polymerase gamma
    William Lewis
    J Infect Dis 195:1399-401. 2007
  37. ncbi request reprint Risk of congestive heart failure in an elderly population treated with peripheral alpha-1 antagonists
    Chris L Bryson
    VA Puget Sound Health Services Research and Development, VAMC, Seattle, Washington 98108, USA
    J Am Geriatr Soc 52:1648-54. 2004
    ....

Research Grants39

  1. CARDIAC DYSFUNCTION, AIDS AND COCAINE
    William Lewis; Fiscal Year: 1999
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  2. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2005
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  3. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2005
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  4. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2005
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  5. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2005
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  6. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2006
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  7. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2006
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  8. Cardiomyocyte Cell Cycle, Antiretrovirals and AIDS
    William Lewis; Fiscal Year: 2006
    ..Experiments offer insights into improving therapy with antiretrovirals used in AIDS. ..
  9. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2007
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  10. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2006
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  11. Acquired mtDNA depletion and nucleoside reverse transciptase inhibitors
    William Lewis; Fiscal Year: 2007
    ..Experiments offer insights into improving therapy with antiretrovirals used in AIDS. ..
  12. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2009
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  13. Acquired mtDNA depletion and nucleoside reverse transciptase inhibitors
    William Lewis; Fiscal Year: 2009
    ..Experiments offer insights into improving therapy with antiretrovirals used in AIDS. ..
  14. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2009
    ..HYPOTHESIS 4: mtDNA depletion (from any above) causes or results from oxidative stress. Antioxidants ameliorate oxidative stress from NRTIs by decreasing oxidation of mtDNA. ..
  15. Acquired mtDNA depletion and nucleoside reverse transciptase inhibitors
    William Lewis; Fiscal Year: 2010
    ..Experiments offer insights into improving therapy with antiretrovirals used in AIDS. ..
  16. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2003
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  17. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2004
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  18. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2004
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  19. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 1999
    ..Biosynthetic labeling of polypeptides is determined in isolated mitochondria. Altered expression of mtRNA and mitochondrial proteins reflect altered energy genesis. (End of Abstract) ..
  20. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2000
    ..Biosynthetic labeling of polypeptides is determined in isolated mitochondria. Altered expression of mtRNA and mitochondrial proteins reflect altered energy genesis. (End of Abstract) ..
  21. CARDIAC DYSFUNCITON, AIDS AND COCAINE
    William Lewis; Fiscal Year: 2000
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  22. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2000
    ..Biosynthetic labeling of polypeptides is determined in isolated mitochondria. Altered expression of mtRNA and mitochondrial proteins reflect altered energy genesis. (End of Abstract) ..
  23. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2001
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  24. CARDIOMYOPATHY IN AIDS
    William Lewis; Fiscal Year: 2001
    ..Biosynthetic labeling of polypeptides is determined in isolated mitochondria. Altered expression of mtRNA and mitochondrial proteins reflect altered energy genesis. (End of Abstract) ..
  25. CARDIAC DYSFUNCITON, AIDS AND COCAINE
    William Lewis; Fiscal Year: 2001
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  26. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2001
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  27. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2002
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  28. CARDIAC DYSFUNCTION, AIDS AND COCAINE
    William Lewis; Fiscal Year: 2002
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  29. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2002
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  30. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2002
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  31. CARDIAC DYSFUNCTION, AIDS AND COCAINE
    William Lewis; Fiscal Year: 2003
    ..Immuno-LM and immuno-TEM identify cellular and subcellular alterations. ..
  32. AIDS and Alcohol and Cardiomyopathy
    William Lewis; Fiscal Year: 2003
    ..Myofibrillar, nuclear and mitochondrial volumes are analyzed quantitatively (by transmission electron microscopy [TEM]). Volume fractions of extracellular matrix and of myocytes are determined morphometrically (light and TEM). ..
  33. Hepatic mitochondrial oxidative stress, AIDS and alcohol
    William Lewis; Fiscal Year: 2003
    ..Biochemical, molecular and pathological changes (above) are ameliorated. This serves as a "proof of principle". ..
  34. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2003
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  35. Nucleoside analogs, mitochondria and AIDS cardiomyopathy
    William Lewis; Fiscal Year: 2004
    ..AIM 2: to define CM from HAART microscopically and ultrastructurally using morphometric methods. AIM 3: to define cardiac performance in CM from HAART echocardiographically and using Langendorff preparations. ..
  36. Cocaine HIV/AIDS, and Antiretrovirals
    William Lewis; Fiscal Year: 2010
    ..Ultimately, information obtained may help to formulate testable hypotheses about pathogenesis and treatment of cardiomyopathy in HIV/AIDS and cocaine. ..