BRUCE RICHARD LEVIN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc The population and evolutionary dynamics of phage and bacteria with CRISPR-mediated immunity
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 9:e1003312. 2013
  2. pmc The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response
    Elisa Margolis
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    BMC Microbiol 10:59. 2010
  3. pmc Dynamics of success and failure in phage and antibiotic therapy in experimental infections
    J J Bull
    1Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712 1023, USA
    BMC Microbiol 2:35. 2002
  4. pmc Antibiotic control of antibiotic resistance in hospitals: a simulation study
    Michael Haber
    Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, USA
    BMC Infect Dis 10:254. 2010
  5. pmc Population dynamics of antibiotic treatment: a mathematical model and hypotheses for time-kill and continuous-culture experiments
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 54:3414-26. 2010
  6. pmc Nasty viruses, costly plasmids, population dynamics, and the conditions for establishing and maintaining CRISPR-mediated adaptive immunity in bacteria
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 6:e1001171. 2010
  7. ncbi request reprint Non-inherited antibiotic resistance
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30307, USA
    Nat Rev Microbiol 4:556-62. 2006
  8. ncbi request reprint Microbiology. Noninherited resistance to antibiotics
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Science 305:1578-9. 2004
  9. pmc Cycling antibiotics may not be good for your health
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13101-2. 2004
  10. ncbi request reprint Population and evolutionary dynamics of phage therapy
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30307, USA
    Nat Rev Microbiol 2:166-73. 2004

Detail Information

Publications37

  1. pmc The population and evolutionary dynamics of phage and bacteria with CRISPR-mediated immunity
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 9:e1003312. 2013
    ..We present evidence in support of these hypotheses and discuss the implications of these results for the ecology and (co)evolution of bacteria and phage...
  2. pmc The ecology of nasal colonization of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus: the role of competition and interactions with host's immune response
    Elisa Margolis
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    BMC Microbiol 10:59. 2010
    ..Here, we use a neonatal rat model to explore these elements of the ecology of nasal colonization by these occasionally invasive bacteria...
  3. pmc Dynamics of success and failure in phage and antibiotic therapy in experimental infections
    J J Bull
    1Section of Integrative Biology and Institute for Cellular and Molecular Biology, University of Texas, Austin, TX 78712 1023, USA
    BMC Microbiol 2:35. 2002
    ....
  4. pmc Antibiotic control of antibiotic resistance in hospitals: a simulation study
    Michael Haber
    Department of Biostatistics and Bioinformatics, Emory University School of Public Health, Atlanta, GA, USA
    BMC Infect Dis 10:254. 2010
    ..In our analysis of the properties of this model we give particular consideration different regimes of using second-line drugs in this process...
  5. pmc Population dynamics of antibiotic treatment: a mathematical model and hypotheses for time-kill and continuous-culture experiments
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 54:3414-26. 2010
    ..These hypotheses are presented, suggestions are made about how they can be tested, and the existing statuses of these tests are briefly discussed...
  6. pmc Nasty viruses, costly plasmids, population dynamics, and the conditions for establishing and maintaining CRISPR-mediated adaptive immunity in bacteria
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia, United States of America
    PLoS Genet 6:e1001171. 2010
    ..I suggest protocols for estimating these parameters and outline the design of experiments to evaluate the validity of these models and test these hypotheses...
  7. ncbi request reprint Non-inherited antibiotic resistance
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30307, USA
    Nat Rev Microbiol 4:556-62. 2006
    ....
  8. ncbi request reprint Microbiology. Noninherited resistance to antibiotics
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Science 305:1578-9. 2004
  9. pmc Cycling antibiotics may not be good for your health
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 101:13101-2. 2004
  10. ncbi request reprint Population and evolutionary dynamics of phage therapy
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30307, USA
    Nat Rev Microbiol 2:166-73. 2004
    ....
  11. pmc The population and evolutionary dynamics of homologous gene recombination in bacterial populations
    Bruce R Levin
    Department of Biology, Emory University, Atlanta, GA, USA
    PLoS Genet 5:e1000601. 2009
    ..On the other hand, increasing rates of adaptive evolution by HGR is unlikely to be the sole or even a dominant selective pressure responsible for the original evolution of transformation...
  12. pmc Bacteria are different: observations, interpretations, speculations, and opinions about the mechanisms of adaptive evolution in prokaryotes
    B R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 97:6981-5. 2000
    ..We conclude with speculations about the evolution of accessory elements and their role in the adaptive evolution of bacteria...
  13. pmc Compensatory mutations, antibiotic resistance and the population genetics of adaptive evolution in bacteria
    B R Levin
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 154:985-97. 2000
    ....
  14. ncbi request reprint Minimizing potential resistance: a population dynamics view
    B R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Clin Infect Dis 33:S161-9. 2001
    ....
  15. ncbi request reprint Resistance to antimicrobial chemotherapy: a prescription for research and action
    B R Levin
    Emory University, Atlanta, Georgia 30322, USA
    Am J Med Sci 315:87-94. 1998
    ..It concludes with an update on the theoretical and empirical research on the between- and within-host population biology and evolution of resistance to antimicrobial chemotherapy most of which has been done since that meeting...
  16. ncbi request reprint Why we don't get sick: the within-host population dynamics of bacterial infections
    B R Levin
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Science 292:1112-5. 2001
    ..Why don't these microbes invade and proliferate in the culture media within the soft, thin-walled flask that envelops us? Why don't they cause disease and lead to our rapid demise?..
  17. pmc Epidemiology, evolution, and future of the HIV/AIDS pandemic
    B R Levin
    Emory University, Atlanta, Georgia 30322, USA
    Emerg Infect Dis 7:505-11. 2001
    ....
  18. pmc Phenotypic tolerance: antibiotic enrichment of noninherited resistance in bacterial populations
    C Wiuff
    Department of Biology, Emory University, 1510 Clifton Rd, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 49:1483-94. 2005
    ....
  19. ncbi request reprint Population dynamics of tuberculosis treatment: mathematical models of the roles of non-compliance and bacterial heterogeneity in the evolution of drug resistance
    M Lipsitch
    Department of Biology, Emory University, Atlanta, Georgia, USA
    Int J Tuberc Lung Dis 2:187-99. 1998
    ..Patient non-compliance and/or spatial heterogeneity in drug concentration or effectiveness may contribute to the emergence of drug resistance during multiple-drug chemotherapy of tuberculosis...
  20. pmc Natural selection, infectious transfer and the existence conditions for bacterial plasmids
    C T Bergstrom
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 155:1505-19. 2000
    ..Second, plasmids may persist because of their ability to shuttle intermittently favored genes back and forth between various (noncompeting) bacterial strains, ecotypes, or even species...
  21. pmc The evolution and maintenance of virulence in microparasites
    B R Levin
    Emory University, Atlanta, Georgia 30322, USA
    Emerg Infect Dis 2:93-102. 1996
    ..These hypotheses for the evolution and maintenance of microparasite virulence are critically reviewed, and suggestions are made for testing them experimentally...
  22. pmc The epidemiology of antibiotic resistance in hospitals: paradoxes and prescriptions
    M Lipsitch
    Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 97:1938-43. 2000
    ..The predictions of the model are compared with those of other models and published data. The implications for resistance control and study design are discussed, along with the limitations and assumptions of the model...
  23. pmc Effects of antiviral usage on transmission dynamics of herpes simplex virus type 1 and on antiviral resistance: predictions of mathematical models
    M Lipsitch
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Antimicrob Agents Chemother 44:2824-35. 2000
    ..The predictions of this model contrast with the more rapid increases in antimicrobial resistance anticipated by models and observed for other pathogenic bacteria and viruses. The reasons for these contrasting predictions are discussed...
  24. ncbi request reprint Models for the spread of resistant pathogens
    B R Levin
    Emory University, Department of Biology, Atlanta, GA 30322, USA
    Neth J Med 60:58-64; discussion 64-6. 2002
    ....
  25. ncbi request reprint Within-host evolution for the invasiveness of commensal bacteria: an experimental study of bacteremias resulting from Haemophilus influenzae nasal carriage
    Elisa Margolis
    Department of Biology, Emory University, Atlanta, GA, 30322, USA
    J Infect Dis 196:1068-75. 2007
    ..Here we test the third of these hypotheses for the rare invasiveness of commensal bacteria: within-host evolution...
  26. pmc Grazing protozoa and the evolution of the Escherichia coli O157:H7 Shiga toxin-encoding prophage
    Karyn Meltz Steinberg
    Graduate Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, GA 30322, USA
    Proc Biol Sci 274:1921-9. 2007
    ..coli O157:H7 and may well contribute to the evolution of the virulence of these bacteria to colonize humans...
  27. pmc Pharmacodynamic functions: a multiparameter approach to the design of antibiotic treatment regimens
    Roland R Regoes
    Department of Biology, Emory University, 1510 Clifton Rd NE, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 48:3670-6. 2004
    ..We discuss the clinical implications and limitations of these results...
  28. pmc The evolution of mutator genes in bacterial populations: the roles of environmental change and timing
    Mark M Tanaka
    Department of Biology, Emory University, Atlanta, Georgia 30322, USA
    Genetics 164:843-54. 2003
    ..In this manner, mutators can increase in frequency over successive selective sweeps. We discuss the implications and predictions of these theoretical results in relation to antibiotic resistance and the evolution of mutation rates...
  29. pmc Epidemiology, hypermutation, within-host evolution and the virulence of Neisseria meningitidis
    Lauren Ancel Meyers
    Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712 0253, USA
    Proc Biol Sci 270:1667-77. 2003
    ..We present evidence for and suggest experimental and retrospective tests of these hypotheses...
  30. ncbi request reprint One enzyme inactivates two antibiotics
    Keith P Klugman
    Nat Med 12:19-20. 2006
  31. pmc Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infections
    Antonio Oliver
    Servicio de Microbiologia, Hospital Son Dureta, C Andrea Doria N 55, 07014 Palma de Mallorca, Spain
    Antimicrob Agents Chemother 48:4226-33. 2004
    ..We discuss the clinical implications of our analysis of these observations...
  32. pmc The evolution of contact-dependent inhibition in non-growing populations of Escherichia coli
    Marc Lemonnier
    Department of Molecular Microbiology, Centro de Investigaciones Biologicas CSIC, 28040 Madrid, Spain
    Proc Biol Sci 275:3-10. 2008
    ....
  33. pmc Antiviral resistance and the control of pandemic influenza
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, United States of America
    PLoS Med 4:e15. 2007
    ..Nonetheless, antiviral resistance has received little attention when evaluating these plans...
  34. pmc Fitness costs of fluoroquinolone resistance in Streptococcus pneumoniae
    Daniel E Rozen
    Department of Biology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Antimicrob Agents Chemother 51:412-6. 2007
    ..We discuss the implications of these results for the epidemiology of fluoroquinolone resistance and the evolution of acquired resistance in treated patients...
  35. pmc Modeling the role of bacteriophage in the control of cholera outbreaks
    Mark A Jensen
    Department of Biology, Emory University, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 103:4652-7. 2006
    ..cholerae. Our theoretical results make a number of empirically testable predictions...
  36. ncbi request reprint Biological and biomedical implications of the co-evolution of pathogens and their hosts
    Mark E J Woolhouse
    Centre for Infectious Diseases, College of Medicine and Veterinary Medicine, University of Edinburgh, Easter Bush, Roslin, Midlothian EH25 9RG, UK
    Nat Genet 32:569-77. 2002
    ....
  37. pmc Antibiotics in agriculture: when is it time to close the barn door?
    Marc Lipsitch
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 99:5752-4. 2002

Research Grants20

  1. POPULATION BIOLOGY OF BACTERIAL VIRUSES AND PLASMIDS
    Bruce Levin; Fiscal Year: 2002
    ....
  2. POPULATION GENETICS & EVOLUTION OF ANTIBIOTIC RESISTANCE
    Bruce Levin; Fiscal Year: 2007
    ..abstract_text> ..
  3. Theoretical and experimental strudy of the population and evolutionary dynamics o
    Bruce Levin; Fiscal Year: 2009
    ..To achieve this end, we will use mathematical models, computer simulations and experiments with Staphylococcus aureus and E.coli. Particular consideration will be given to methicillin resistant S. aureus infections (MRSA). ..
  4. POPULATION GENETICS & EVOLUTION OF ANTIBIOTIC RESISTANCE
    Bruce Levin; Fiscal Year: 2000
    ....
  5. POPULATION BIOLOGY OF BACTERIAL VIRUSES AND PLASMIDS
    Bruce Levin; Fiscal Year: 1992
    ..The ability to identify pathogenic strains of bacteria by typing methods is contingent on the stability of bacteria genotypes, which, in turn depends on the amount of recombination between clones...
  6. Theoretical and experimental strudy of the population and evolutionary dynamics o
    BRUCE RICHARD LEVIN; Fiscal Year: 2010
    ..To achieve this end, we will use mathematical models, computer simulations and experiments with Staphylococcus aureus and E.coli. Particular consideration will be given to methicillin resistant S. aureus infections (MRSA). ..