Research Topics
Genomes and GenesSpecies | Andrew KowalczykSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Cellular levels of p120 catenin function as a set point for cadherin expression levels in microvascular endothelial cellsKanyan Xiao
Department of Dermatology, School of Medicine, Emory University, Atlanta, GA 30322, USA
J Cell Biol 163:535-45. 2003..These results demonstrate that cellular levels of p120ctn function as a set point mechanism that regulates cadherin expression levels, and that a major function of p120ctn is to control cadherin internalization and degradation...
VE-cadherin: adhesion at arm's lengthPeter A Vincent
Dept of Dermatology, Emory Univ School of Medicine, Woodruff Memorial Bldg, 1639 Pierce Drive, Atlanta, GA 30322, USA
Am J Physiol Cell Physiol 286:C987-97. 2004..These recent studies place p120(ctn) at the hub of a cadherin-catenin regulatory mechanism that controls cadherin plasma membrane levels in cells of both epithelial and endothelial origin...
Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recyclingAndrew P Kowalczyk
Department of Cell Biology, Emory University School of Medicine, 30332, Atlanta, GA, USA
Subcell Biochem 60:197-222. 2012..Lastly, we discuss the proteolytic cleavage of cadherins at the plasma membrane...- VE-cadherin and desmoplakin are assembled into dermal microvascular endothelial intercellular junctions: a pivotal role for plakoglobin in the recruitment of desmoplakin to intercellular junctionsA P Kowalczyk
Departments of Dermatology, Pathology, and the Robert H Lurie Cancer Center, Northwestern University Medical School, Chicago, IL, USA
J Cell Sci 111:3045-57. 1998..These results suggest that endothelial cells assemble unique junctional complexes that couple VE-cadherin to both the actin and intermediate filament cytoskeleton... - Protecting your tail: regulation of cadherin degradation by p120-cateninAndrew P Kowalczyk
Departments of Dermatology and Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Curr Opin Cell Biol 16:522-7. 2004.... - Desmoglein endocytosis and desmosome disassembly are coordinated responses to pemphigus autoantibodiesCatharine C Calkins
Departments of Dermatology and Cell Biology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
J Biol Chem 281:7623-34. 2006..These findings demonstrate that Dsg3 endocytosis, keratin filament retraction, and the loss of keratinocyte cell-cell adhesion are coordinated responses to PV IgG... 
p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanismChristine M Chiasson
Graduate Program in Biochemistry, Cell, and Developmental Biology, and Department of Cell Biology, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 20:1970-80. 2009....- Role of p120-catenin in cadherin traffickingKanyan Xiao
Department of Cell Biology and Dermatology, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
Biochim Biophys Acta 1773:8-16. 2007..Through these mechanisms p120 exerts influence over a wide range of biological processes that are dependent upon tight regulation of cell surface cadherin levels... - Anthrax toxin receptor 1/tumor endothelium marker 8 mediates cell spreading by coupling extracellular ligands to the actin cytoskeletonErica Werner
Department of Cell Biology, Emory University, Atlanta, Georgia 30322 3030, USA
J Biol Chem 281:23227-36. 2006..Thus, our results indicate that TEM8 is a new adhesion molecule linking collagen I or PA to the actin cytoskeleton... - p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherinKanyan Xiao
Department of Dermatology, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 16:5141-51. 2005.... - Mechanisms of VE-cadherin processing and degradation in microvascular endothelial cellsKanyan Xiao
Department of Dermatology and Emory Skin Diseases Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 278:19199-208. 2003..These results provide new insights into the mechanisms of VE-cadherin processing and degradation in microvascular endothelial cells... - Intermediate filaments and vesicular membrane traffic: the odd couple's first dance?Melanie L Styers
Department of Cell Biology, Emory University, Atlanta, GA, USA
Traffic 6:359-65. 2005..Furthermore, we will discuss potential mechanisms by which IFs may regulate the localization and function of organelles... - Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-cateninKala Venkiteswaran
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am J Physiol Cell Physiol 283:C811-21. 2002..These observations suggest that intercellular junction proteins function as components of an adhesion and signaling system that regulates vascular barrier function and growth... - The Armadillo family protein p0071 is a VE-cadherin- and desmoplakin-binding proteinCatharine C Calkins
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 278:1774-83. 2003.... - Regulation of cadherin traffickingEmmanuella Delva
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30332, USA
Traffic 10:259-67. 2009..Particular emphasis is placed on the regulation of cadherin trafficking by catenins and the interplay between growth factor signaling pathways and cadherin endocytosis... - Architecture of the vimentin cytoskeleton is modified by perturbation of the GTPase ARF1Melanie L Styers
Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA 30322, USA
J Cell Sci 119:3643-54. 2006..These observations indicate that perturbation of the vesicular membrane transport machinery lead to reciprocal changes in the architecture of vimentin networks... - Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migrationShannon V Setzer
Departments of Dermatology and Cell Biology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
J Invest Dermatol 123:426-33. 2004..These results suggest that p120ctn/plakophilin family proteins interact with intercellular junction binding partners to differentially modulate the adhesive and migratory behavior of epithelial cells... - Pemphigus vulgaris IgG-induced desmoglein-3 endocytosis and desmosomal disassembly are mediated by a clathrin- and dynamin-independent mechanismEmmanuella Delva
Graduate Program in Biochemistry, Cell, and Developmental Biology, Department of Cell Biology, Emory University, Atlanta, GA 30332, USA
J Biol Chem 283:18303-13. 2008..Altogether, these results suggest that PV IgG-induced Dsg3 internalization is mediated through a clathrin- and dynamin-independent pathway and that Dsg3 endocytosis is tightly coupled to the pathogenic activity of PV IgG... - p120-Catenin is required for mouse vascular developmentRebecca G Oas
Department of Cell Biology, 615 Michael St, Room 465, Atlanta, GA 30322, USA
Circ Res 106:941-51. 2010..p120-catenin (p120) is an armadillo family protein that binds to the cytoplasmic domain of classical cadherins and prevents cadherin endocytosis. The role of p120 in vascular development is unknown... - Mechanisms of plakoglobin-dependent adhesion: desmosome-specific functions in assembly and regulation by epidermal growth factor receptorTaofei Yin
Department of Pathology and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
J Biol Chem 280:40355-63. 2005..As a target for modulation by EGF, regulation of PG-dependent adhesion may play an important role during wound healing and tumor metastasis... - Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanismsTaofei Yin
Departments of Pathology and Cell and Molecular Biology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 102:5420-5. 2005.... - Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signalingAmy K Gira
Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Invest Dermatol 129:723-9. 2009..These data suggest that the target for chelator effects may be through iron requirements for oxygen-requiring dioxygenase enzymes... - The desmosomeEmmanuella Delva
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cold Spring Harb Perspect Biol 1:a002543. 2009..This article outlines the structure and function of the major desmosomal proteins, and explores the contributions of this protein complex to tissue architecture and morphogenesis... - Cadherin-mediated cell-cell contact regulates keratinocyte differentiationJoseph L Charest
George W Woodruff School of Mechanical Engineering, Atlanta, GA, USA
J Invest Dermatol 129:564-72. 2009..These results demonstrate that cadherin-mediated cell-cell contact regulates early keratinocyte differentiation independently from changes in cell shape... - Different mechanisms regulate lysophosphatidic acid (LPA)-dependent versus phorbol ester-dependent internalization of the LPA1 receptorNikhil M Urs
School of Biology, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
J Biol Chem 283:5249-57. 2008..These results indicate that distinct molecular mechanisms regulate agonist-dependent and PMA-dependent internalization of the LPA 1 receptor... - E-cadherin is a receptor for the common protein pneumococcal surface adhesin A (PsaA) of Streptococcus pneumoniaeJulie M Anderton
Division of Bacterial Diseases, National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, 1600 Clifton Road, Bldg 18 B104, M S G 05, Atlanta, GA 30333, USA
Microb Pathog 42:225-36. 2007..This work identifies E-cadherin as a receptor on human epithelial cells for the pneumococcal surface adhesin, PsaA... - The desmosome: cell science lessons from human diseasesMargaret D Kottke
Department of Dermatology, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
J Cell Sci 119:797-806. 2006..These human diseases reveal key roles for desmosomes in maintaining tissue integrity, but also suggest functions for desmosomal components in signal transduction pathways and epidermal organization... - Photoreceptor cells in flies and mammals: Crumby homology?Andrew P Kowalczyk
Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
Dev Cell 2:253-4. 2002..This supports the previous observation that disruption of CRB1 function can cause retinal degeneration in humans... - The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeletonMelanie L Styers
Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 15:5369-82. 2004..Our results reveal a novel role of the intermediate filament cytoskeleton in organelle/adaptor positioning and in regulation of the adaptor complex AP-3... - Assessment of splice variant-specific functions of desmocollin 1 in the skinXing Cheng
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 77030, USA
Mol Cell Biol 24:154-63. 2004..However, a comparison of our mutants with dsc1-null mice suggests that the Dsc1 extracellular domain is necessary to maintain structural integrity of the skin...
Research Grants
- Role of p0071 in Cutaneous Intercellular JunctionsAndrew Kowalczyk; Fiscal Year: 2006..abstract_text> ..
- Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease PemphigusAndrew P Kowalczyk; Fiscal Year: 2010....
- Mechanisms of Desmosome Regulation and Disassembly in the Skin Disease PemphigusAndrew Kowalczyk; Fiscal Year: 2007..abstract_text> ..
- Cadherin Regulation in Dermal Endothelial CellsAndrew Kowalczyk; Fiscal Year: 2007..abstract_text> ..
- Pemphigus IgG Internalization and Desmosome DisassemblyAndrew Kowalczyk; Fiscal Year: 2004..The long-term goal of these studies is to expose new cellular pathways that might be targeted therapeutically to make keratinocytes more resistant to PV IgG in patients suffering from this devastating disease. ..
- Cadherin Regulation in Dermal Endothelial CellsAndrew P Kowalczyk; Fiscal Year: 2010....