Christopher A Koczor
Affiliation: Emory University
Koczor C, White R, Zhao P, Zhu L, Fields E, Lewis W. p53 and mitochondrial DNA: their role in mitochondrial homeostasis and toxicity of antiretrovirals. Am J Pathol. 2012;180:2276-83 pubmed publisher
..Data herein indicate that overexpression of p53 in the mitochondria reduces mtDNA abundance and increases the sensitivity of mammalian cells to NRTI exposure by reducing mitochondrial function. ..
Koczor C, Fields E, Jedrzejczak M, Jiao Z, Ludaway T, Russ R, et al
. Methamphetamine and HIV-Tat alter murine cardiac DNA methylation and gene expression. Toxicol Appl Pharmacol. 2015;288:409-19 pubmed publisher
..Data implicate Cav1.2 in calcium dysregulation and hypercontractility in the murine LV exposed to METH. They suggest a pathogenetic role for METH exposure to promote LV dysfunction that outweighs Tat-induced effects. ..
Koczor C, Jiao Z, Fields E, Russ R, Ludaway T, Lewis W. AZT-induced mitochondrial toxicity: an epigenetic paradigm for dysregulation of gene expression through mitochondrial oxidative stress. Physiol Genomics. 2015;47:447-54 pubmed publisher
..This mechanism for NRTI toxicity offers insight into long-term side effects from these commonly used antiviral agents. ..
Koczor C, Ludlow I, Hight R, Jiao Z, Fields E, Ludaway T, et al
. Ecstasy (MDMA) Alters Cardiac Gene Expression and DNA Methylation: Implications for Circadian Rhythm Dysfunction in the Heart. Toxicol Sci. 2015;148:183-91 pubmed publisher
..Moreover, MDMA induced gene expression of key elements of circadian rhythm regulatory genes. This suggests a fundamental organism-level event to explain some of the etiologies of MDMA dysfunction in the heart. ..
Koczor C, Ludlow I, Fields E, Jiao Z, Ludaway T, Russ R, et al
. Mitochondrial polymerase gamma dysfunction and aging cause cardiac nuclear DNA methylation changes. Physiol Genomics. 2016;48:274-80 pubmed publisher
..Cardiac mitochondrial polymerase dysfunction alters nuclear DNA methylation. Furthermore, aging causes a robust change in cardiac DNA methylation that is partially associated with mitochondrial polymerase dysfunction. ..