Janet D Klein

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct
    Janet D Klein
    Emory University School of Medicine, Department of Medicine, Renal Division, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 302:F1098-103. 2012
  2. ncbi request reprint Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney
    J D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Renal Division 1639 Pierce Drive, NE, WMB Room 3313B, Atlanta, GA, 30322, USA
    J Membr Biol 212:139-44. 2006
  3. ncbi request reprint Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts
    Janet D Klein
    Emory University School of Medicine, Renal Division, WMB Room 3319B, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    J Am Soc Nephrol 17:2680-6. 2006
  4. ncbi request reprint Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension
    Janet D Klein
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Rm 3319B, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 291:F952-9. 2006
  5. pmc Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells
    Janet D Klein
    Department of Medicine, Renal Division, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 298:F935-40. 2010
  6. pmc Syntaxin specificity of aquaporins in the inner medullary collecting duct
    Abinash C Mistry
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 297:F292-300. 2009
  7. pmc Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts
    Yanhua Wang
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 20:2018-24. 2009
  8. pmc Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding
    Abinash C Mistry
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 298:C1431-7. 2010
  9. doi request reprint Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium
    Otto Fröhlich
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 294:F518-24. 2008
  10. pmc MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, WMRB Rm 338, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1528-34. 2008

Collaborators

Detail Information

Publications70

  1. pmc Protein kinase C-α mediates hypertonicity-stimulated increase in urea transporter phosphorylation in the inner medullary collecting duct
    Janet D Klein
    Emory University School of Medicine, Department of Medicine, Renal Division, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 302:F1098-103. 2012
    ..Hypertonicity significantly increased UT-A1 phosphorylation in wild-type mice but not in PKC-α knockout mice. We conclude that PKC-α mediates the hypertonicity-stimulated increase in UT-A1 phosphorylation in the IMCD...
  2. ncbi request reprint Adrenalectomy blocks the compensatory increases in UT-A1 and AQP2 in diabetic rat kidney
    J D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Renal Division 1639 Pierce Drive, NE, WMB Room 3313B, Atlanta, GA, 30322, USA
    J Membr Biol 212:139-44. 2006
    ....
  3. ncbi request reprint Vasopressin increases plasma membrane accumulation of urea transporter UT-A1 in rat inner medullary collecting ducts
    Janet D Klein
    Emory University School of Medicine, Renal Division, WMB Room 3319B, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    J Am Soc Nephrol 17:2680-6. 2006
    ..These findings suggest that vasopressin regulates urea transport by increasing UT-A1 accumulation in the plasma membrane and/or UT-A1 phosphorylation...
  4. ncbi request reprint Urea transporter UT-A1 and aquaporin-2 proteins decrease in response to angiotensin II or norepinephrine-induced acute hypertension
    Janet D Klein
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Rm 3319B, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 291:F952-9. 2006
    ....
  5. pmc Phosphorylation of UT-A1 on serine 486 correlates with membrane accumulation and urea transport activity in both rat IMCDs and cultured cells
    Janet D Klein
    Department of Medicine, Renal Division, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 298:F935-40. 2010
    ....
  6. pmc Syntaxin specificity of aquaporins in the inner medullary collecting duct
    Abinash C Mistry
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 297:F292-300. 2009
    ..Snapin plays an important role as a linker between the water channel and the t-SNARE complex, leading to the fusion event, and the pairing with specific t-SNAREs is essential for the specificity of membrane recognition and fusion...
  7. pmc Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts
    Yanhua Wang
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 20:2018-24. 2009
    ..Taken together, activation of Epac increases urea transport, accumulation of UT-A1 at the plasma membrane, and UT-A1 phosphorylation, the latter of which is mediated by the MEK-ERK pathway...
  8. pmc Functional characterization of the central hydrophilic linker region of the urea transporter UT-A1: cAMP activation and snapin binding
    Abinash C Mistry
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 298:C1431-7. 2010
    ..In addition, the Lc segment also gave UT-A2 the ability to bind snapin and, in Xenopus oocytes, to be stimulated in its urea transport activity by snapin and syntaxins 3 and 4, in the same way as UT-A1...
  9. doi request reprint Stimulation of UT-A1-mediated transepithelial urea flux in MDCK cells by lithium
    Otto Fröhlich
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 294:F518-24. 2008
    ..These results suggest that the effect of Li in this MDCK model of renal cells does not involve cAMP or at least utilizes an additional signaling pathway independent of cAMP...
  10. pmc MDM2 E3 ubiquitin ligase mediates UT-A1 urea transporter ubiquitination and degradation
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, WMRB Rm 338, 1639 Pierce Dr, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1528-34. 2008
    ..The mechanism is likely to be physiologically important as UT-A1 ubiquitination was identified in kidney inner medullary tissue. The ubiquitin-proteasome degradation pathway provides an important novel mechanism for UT-A1 regulation...
  11. pmc Urea transporters UT-A1 and UT-A3 accumulate in the plasma membrane in response to increased hypertonicity
    Nathan W Blessing
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, NE, WMB Rm 3319B, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1336-41. 2008
    ..Furthermore, this movement is accompanied by, and may require, increased phosphorylation in response to hypertonicity...
  12. ncbi request reprint Regulation of UT-A1-mediated transepithelial urea flux in MDCK cells
    Otto Fröhlich
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 291:C600-6. 2006
    ....
  13. pmc Regulation of renal urea transport by vasopressin
    Jeff M Sands
    Emory University School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Room 338, Atlanta, GA 30322, USA
    Trans Am Clin Climatol Assoc 122:82-92. 2011
    ..In summary, vasopressin regulates urea transport acutely by increasing UT-A1 phosphorylation and the apical plasma-membrane accumulation of UT-A1 through two cAMP-dependent pathways...
  14. pmc Vasopressin increases urea permeability in the initial IMCD from diabetic rats
    Vladimir Pech
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Dr, NE, WMB Rm 338, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 289:F531-5. 2005
    ..This suggests that the 117-kDa UT-A1 glycoprotein is necessary for vasopressin-stimulated urea transport...
  15. pmc Phosphorylation of UT-A1 urea transporter at serines 486 and 499 is important for vasopressin-regulated activity and membrane accumulation
    Mitsi A Blount
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F295-9. 2008
    ..We conclude that the phosphorylation of UT-A1 on both serines 486 and 499 is important for activity and that this phosphorylation may be involved in UT-A1 membrane accumulation...
  16. pmc XIAP reduces muscle proteolysis induced by CKD
    Junping Hu
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 21:1174-83. 2010
    ..In summary, these results demonstrate that XIAP inhibits multiple aspects of protein degradation in skeletal muscle during CKD...
  17. pmc Urine concentration in the diabetic mouse requires both urea and water transporters
    Titilayo O Ilori
    Emory Univ Renal Division, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 304:F103-11. 2013
    ..Furthermore, UT-A1 may be maximally membrane associated in diabetic rat inner medulla, making additional stimulation by vasopressin ineffective...
  18. pmc Mature N-linked glycans facilitate UT-A1 urea transporter lipid raft compartmentalization
    Guangping Chen
    Renal Division, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    FASEB J 25:4531-9. 2011
    ..Taken together, our study reveals a new role of N-linked glycosylation in regulating UT-A1 activity by promoting UT-A1 trafficking into membrane lipid raft subdomains...
  19. pmc Expression of transporters involved in urine concentration recovers differently after cessation of lithium treatment
    Mitsi A Blount
    Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Physiol Renal Physiol 298:F601-8. 2010
    ..In summary, the rapid restoration of UT-A1 and UT-A3 as well as the increased expression of NKCC2 are critical components to the reestablishment of urine concentration after lithium treatment...
  20. pmc Candesartan augments compensatory changes in medullary transport proteins in the diabetic rat kidney
    Mitsi A Blount
    Emory Univ School of Medicine, Renal Division, 1639 Pierce Drive, NE, WMB Rm 3319B, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 294:F1448-52. 2008
    ..These changes may represent a previously unrecognized beneficial effect of type 1 ARBs in DM...
  21. pmc Lack of protein kinase C-α leads to impaired urine concentrating ability and decreased aquaporin-2 in angiotensin II-induced hypertension
    Tiffany L Thai
    Renal Division, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 303:F37-44. 2012
    ..We conclude that PKC-α protects against ANG II-induced decreases in urine concentrating ability by maintaining AQP2 levels through CREB phosphorylation...
  22. pmc Acute calcineurin inhibition with tacrolimus increases phosphorylated UT-A1
    Titilayo O Ilori
    Renal Division, Dept of Medicine, Emory University, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 302:F998-F1004. 2012
    ..This is the first documentation of the role of phosphatases and the specific site of phosphorylation of UT-A1, in response to tacrolimus...
  23. ncbi request reprint Forskolin stimulates phosphorylation and membrane accumulation of UT-A3
    Mitsi A Blount
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 293:F1308-13. 2007
    ....
  24. ncbi request reprint Urea may regulate urea transporter protein abundance during osmotic diuresis
    Dongun Kim
    Emory University School of Medicine, Department of Medicine, Renal Division, 1639 Pierce Dr, NE, WMB Rm 338, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 288:F188-97. 2005
    ..These findings suggest that a reduction in urine or interstitial urea results in an increase in UT-A1 protein abundance in an attempt to restore inner medullary interstitial urea and preserve urine-concentrating ability...
  25. ncbi request reprint Tissue distribution of UT-A and UT-B mRNA and protein in rat
    John J Doran
    Emory Univ School of Medicine, Renal Div, 1639 Pierce Dr NE, WMB Rm 338, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 290:R1446-59. 2006
    ..We found that both UT-A and UT-B are ubiquitously expressed as numerous tissue-specific mRNA transcripts and protein forms that are localized to cell membranes, cytoplasm, or nuclei...
  26. pmc Role of protein kinase C-α in hypertonicity-stimulated urea permeability in mouse inner medullary collecting ducts
    Yanhua Wang
    Emory Univ School of Medicine, Renal Division, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 304:F233-8. 2013
    ..We conclude that PKCα mediates hypertonicity-stimulated urea transport but is not necessary for vasopressin stimulation of urea permeability in mouse IMCDs...
  27. ncbi request reprint Loss of N-linked glycosylation reduces urea transporter UT-A1 response to vasopressin
    Guangping Chen
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:27436-42. 2006
    ..In vivo, inner medullary collecting duct cells may regulate urea uptake by altering UT-A1 glycosylation in response to AVP stimulation...
  28. ncbi request reprint Urea transport in MDCK cells that are stably transfected with UT-A1
    Otto Fröhlich
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 286:C1264-70. 2004
    ..This new polarized epithelial cell line stably expresses UT-A1 and reproduces several of the physiological responses observed in rat terminal inner medullary collecting ducts...
  29. ncbi request reprint Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA
    Chi Zhang
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 282:F85-90. 2002
    ..This suggests that phosphorylation of UT-A1 may be the mechanism by which vasopressin rapidly increases urea permeability in vivo...
  30. ncbi request reprint The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein
    Abinash C Mistry
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:30097-106. 2007
    ..We conclude that UT-A1 may be linked to the SNARE machinery via snapin and that this interaction may be functionally and physiologically important for urea transport...
  31. ncbi request reprint Upregulation of urea transporter UT-A2 and water channels AQP2 and AQP3 in mice lacking urea transporter UT-B
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia
    J Am Soc Nephrol 15:1161-7. 2004
    ..However, UT-B null mice have a selective increase in UT-A2 protein abundance. This may be an adaptive response to the loss of UT-B, because UT-B and UT-A2 are involved in different intrarenal urea recycling pathways...
  32. ncbi request reprint Acidosis mediates the upregulation of UT-A protein in livers from uremic rats
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 13:581-7. 2002
    ..It was, therefore, concluded that acidosis, either directly or through a change in ammonium concentration, rather than other dietary components, stimulates the upregulation of UT-A protein in liver and kidney inner medulla...
  33. ncbi request reprint Role of vasopressin in diabetes mellitus-induced changes in medullary transport proteins involved in urine concentration in Brattleboro rats
    Dongun Kim
    Emory Univ School of Medicine, Renal Division, WMRB Rm 338, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 286:F760-6. 2004
    ....
  34. ncbi request reprint Changes in renal medullary transport proteins during uncontrolled diabetes mellitus in rats
    Dongun Kim
    Renal Division, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 285:F303-9. 2003
    ..UT-B and ROMK were unchanged at any time point. The increases in UT-A1, AQP2, and NKCC2/BSC1 proteins during uncontrolled DM would tend to limit the loss of fluid and solute during uncontrolled diabetes...
  35. pmc N-methyl-D-aspartate receptor subunit NR3a expression and function in principal cells of the collecting duct
    Adrian Sproul
    Department of Medicine, Medical University of South Carolina, Charleston, SC 29403, USA
    Am J Physiol Renal Physiol 301:F44-54. 2011
    ....
  36. pmc Caveolin-1 directly interacts with UT-A1 urea transporter: the role of caveolae/lipid rafts in UT-A1 regulation at the cell membrane
    Xiuyan Feng
    Emory Univ School of Medicine, Renal Division, WMRB Rm 338, 1639 Pierce Drive, NE, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 296:F1514-20. 2009
    ..Our results indicate that lipid rafts/caveolae participate in UT-A1 membrane regulation and this effect is mediated via a direct interaction of caveolin-1 with UT-A1...
  37. pmc Internalization of UT-A1 urea transporter is dynamin dependent and mediated by both caveolae- and clathrin-coated pit pathways
    Haidong Huang
    Department of Medicine, Renal Division, School of Medicine, Emory University, Atlanta, Georgia, USA
    Am J Physiol Renal Physiol 299:F1389-95. 2010
    ..We conclude that UT-A1 endocytosis is dynamin-dependent and mediated by both caveolae- and clathrin-coated pit pathways...
  38. ncbi request reprint Impaired urine concentration and absence of tissue ACE: involvement of medullary transport proteins
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 283:F517-24. 2002
    ..We conclude that the urine-concentrating defect in ACE.2 mice is associated with, and may result from, downregulation of some or all of these key urea, salt, and water transport proteins...
  39. pmc Protein kinase C regulates urea permeability in the rat inner medullary collecting duct
    Yanhua Wang
    Emory Univ School of Medicine, Renal Div, 1639 Pierce Dr, NE, WMB Rm 3304, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 299:F1401-6. 2010
    ..Whether PKC directly phosphorylates UT-A1 and/or UT-A3 or phosphorylates it as a consequence of a cascade of activations remains to be determined...
  40. pmc Protein abundance of urea transporters and aquaporin 2 change differently in nephrotic pair-fed vs. non-pair-fed rats
    Raed N Bou Matar
    Department of Pediatric Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Renal Physiol 302:F1545-53. 2012
    ..However, α- and β-ENaC subunits were unaltered. NKCC2 and AQP2 mRNA levels were similar in treated vs. control rats. We conclude that dietary protein intake affects the response of medullary transport proteins to NS...
  41. ncbi request reprint Aldosterone decreases UT-A1 urea transporter expression via the mineralocorticoid receptor
    Randy A Gertner
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Am Soc Nephrol 15:558-65. 2004
    ..In conclusion, either mineralocorticoids or glucocorticoids can downregulate UT-A1 protein. The decrease in UT-A1 does not require both steroid hormones, and each works through a different receptor...
  42. ncbi request reprint Down-regulation of urea transporters in the renal inner medulla of lithium-fed rats
    Janet D Klein
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA, USA
    Kidney Int 61:995-1002. 2002
    ..Lithium is commonly used to treat bipolar psychiatric disorders but can cause reduced urine concentrating ability...
  43. ncbi request reprint Aldosterone regulates the Na-K-2Cl cotransporter in vascular smooth muscle
    Gengru Jiang
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 41:1131-5. 2003
    ..This could account for the increase in Na+, K+, and Cl- fluxes previously observed in vascular smooth muscle from mineralocorticoid-treated animals and may contribute to increased vascular tone...
  44. pmc Regulation of caspase-3 activity by insulin in skeletal muscle cells involves both PI3-kinase and MEK-1/2
    Yongmei Gao
    Renal Division, Rm 338, Woodruff Memorial Research Bldg, 1639 Pierce Dr, Emory Univ, Atlanta, GA 30322, USA
    J Appl Physiol 105:1772-8. 2008
    ..In summary, our findings indicate that insulin regulates caspase-3 activity by a multistep process that is unique to skeletal muscle, thus providing insights about the muscle-specific nature of the atrophy process...
  45. pmc Molecular mechanisms of urea transport in health and disease
    Janet D Klein
    Renal Division, Department of Medicine, and Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pflugers Arch 464:561-72. 2012
    ..Exciting new genetically engineered mouse models are being developed to study these transporters...
  46. pmc Erlotinib preserves renal function and prevents salt retention in doxorubicin treated nephrotic rats
    Raed N Bou Matar
    Department of Pediatric Medicine, Emory University, and Children s Healthcare of Atlanta, Atlanta, Georgia, USA
    PLoS ONE 8:e54738. 2013
    ..In conclusion, Erlotinib preserved renal function and prevented salt retention in nephrotic rats. The observed effects do not appear to be mediated by direct blockade of EGFR...
  47. pmc Neuronal expression of sodium/bicarbonate cotransporter NBCn1 (SLC4A7) and its response to chronic metabolic acidosis
    Hae Jeong Park
    Dept of Physiology, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 298:C1018-28. 2010
    ..Administering N-methyl-d-aspartate also inhibited NBCn1 upregulation in acidotic rats. We conclude that NBCn1 in neurons is upregulated by chronic acid loads, and this upregulation is associated with glutamate excitotoxicity...
  48. doi request reprint Exercise ameliorates chronic kidney disease-induced defects in muscle protein metabolism and progenitor cell function
    XIAONAN H WANG
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Kidney Int 76:751-9. 2009
    ..Treadmill running corrects muscle proteolysis but not protein synthesis or progenitor cell function. Our results provide a basis for evaluating different types of exercise on muscle atrophy in patients with chronic kidney disease...
  49. pmc Cardiac muscle protein catabolism in diabetes mellitus: activation of the ubiquitin-proteasome system by insulin deficiency
    Junping Hu
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Endocrinology 149:5384-90. 2008
    ..We conclude that insulinopenia accelerates proteolysis in cardiac muscle by reducing IRS-1/Akt signaling, which leads to activation of the ubiquitin-proteasome proteolytic pathway...
  50. pmc Decreased miR-29 suppresses myogenesis in CKD
    XIAONAN H WANG
    Renal Division, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 22:2068-76. 2011
    ..These data suggest a potential mechanism for the impaired muscle cell differentiation associated with CKD...
  51. pmc Changes in aquaporin-2 protein contribute to the urine concentrating defect in rats fed a low-protein diet
    J M Sands
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 97:2807-14. 1996
    ..We conclude that water reabsorption, like urea reabsorption, responds to dietary protein restriction in a manner that would limit urine concentrating capacity...
  52. pmc X-chromosome linked inhibitor of apoptosis protein inhibits muscle proteolysis in insulin-deficient mice
    X H Wang
    Renal Division, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Gene Ther 14:711-20. 2007
    ..The ability of XIAP to prevent the loss of muscle protein suggests that XIAP could be a therapeutic reagent for muscle atrophy in catabolic diseases...
  53. ncbi request reprint Identification and characterization of a Kidd antigen/UT-B urea transporter expressed in human colon
    Hideki Inoue
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 287:C30-5. 2004
    ..We conclude that the Kidd antigen/UT-B urea transporter is physiologically expressed in the human colon epithelium, where it could participate in the transport of urea across the colon mucosa...
  54. doi request reprint Urea transport in the kidney
    Janet D Klein
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia, USA
    Compr Physiol 1:699-729. 2011
    ..Here we introduce urea and describe the current knowledge of the urea transporter proteins, their regulation, and their role in the kidney...
  55. pmc The role of nitric oxide in the dysregulation of the urine concentration mechanism in diabetes mellitus
    Penelope Cipriani
    Renal Division, Department of Medicine, Emory University Atlanta, GA, USA
    Front Physiol 3:176. 2012
    ..While the role of NO in urine concentration remains unclear, lowered NO associated with diabetes may be deleterious to the transporters' response to the subsequent osmotic diuresis...
  56. pmc Cyclooxygenase-2 in the kidney: good, BAD, or both?
    S Russ Price
    Renal Division, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Kidney Int 80:905-7. 2011
    ..However, the PGE(2)/PKA pathway is not the only means to inactivate BAD and limit cell death. This Commentary shows a broader picture of this pathway to examine the kidney's BAD options...
  57. ncbi request reprint Calcineurin phosphatase activity: activation by glucocorticoids and role of intracellular calcium
    David C Tong
    Renal Division, Emory University School of Medicine, 1364 Clifton Road, N E, Atlanta, GA 30322, USA
    Transplantation 77:259-67. 2004
    ..Glucocorticoids stimulate release of intracellular calcium in peripheral lymphocytes, but their effects on calcineurin phosphatase activity are unknown...
  58. ncbi request reprint Cloning and characterization of two new isoforms of the rat kidney urea transporter: UT-A3 and UT-A4
    A Karakashian
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Soc Nephrol 10:230-7. 1999
    ..It is concluded that there are at least four different rat UT-A urea transporters...
  59. ncbi request reprint Localization of the urea transporter UT-B protein in human and rat erythrocytes and tissues
    R T Timmer
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 281:C1318-25. 2001
    ..UT-B protein is detected in cultured bovine endothelial cells. We conclude that UT-B protein is expressed in more rat tissues than previously reported, as well as in erythrocytes...
  60. doi request reprint Corin: an ANP protease that may regulate sodium reabsorption in nephrotic syndrome
    Janet D Klein
    Department of Renal Medicine, Emory University, Atlanta, Georgia 30322, USA
    Kidney Int 78:635-7. 2010
    ..They propose that decreases in cGMP resulting from the reduced corin may be responsible for the Na(+) retention and volume expansion that are hallmarks of these kidney diseases...
  61. ncbi request reprint Renal ENaC subunit, Na-K-2Cl and Na-Cl cotransporter abundances in aged, water-restricted F344 x Brown Norway rats
    Y Tian
    Department of Medicine, Division of Endocrinology and Metabolism, Georgetown University, Washington, District of Columbia 20057 1412, USA
    Kidney Int 69:304-12. 2006
    ..Aged F344 x BN rats have reduced basal distal tubular renal sodium transporter abundances and blunted upregulation during water restriction, which may contribute to decreased urinary concentrating capacity...
  62. ncbi request reprint UT-A urea transporter protein in heart: increased abundance during uremia, hypertension, and heart failure
    R Duchesne
    Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 89:139-45. 2001
    ....
  63. ncbi request reprint Regulated expression of renal and intestinal UT-B urea transporter in response to varying urea load
    Hideki Inoue
    Department of Pathology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am J Physiol Renal Physiol 289:F451-8. 2005
    ..These findings indicate that UT-B expression is regulated in response to different loads of urea, with a pattern that suggests involvement of tissue-specific regulatory mechanism in kidney and colon...
  64. pmc Urea transporters are distributed in endothelial cells and mediate inhibition of L-arginine transport
    Laszlo Wagner
    Department of Physiology, West Virginia University, Morgantown, West Virginia 26506 9229, USA
    Am J Physiol Renal Physiol 283:F578-82. 2002
    ..In view of the wide distribution of UT-B in rat vasculature, elevated blood urea nitrogen may lead to endothelial L-Arg deficiency in vivo...
  65. ncbi request reprint Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis
    Ramanathan M Seshadri
    Division of Nephrology, Hypertension, and Transplantation, Univ of Florida College of Medicine, Gainesville, FL, USA
    Am J Physiol Renal Physiol 290:F1443-52. 2006
    ....
  66. ncbi request reprint Altered expression of urea transporters in response to ureteral obstruction
    Chunling Li
    The Water and Salt Research Center Institute of Experimental Clinical Research, Aarhus Univ Hospital Skejby, DK 8200 Aarhus, Denmark
    Am J Physiol Renal Physiol 286:F1154-62. 2004
    ..In conclusion, reduced expression of UT-A1, UT-A3, and UT-B levels in both BUO and UUO rats suggests that urea transporters play important roles in the impaired urinary concentrating capacity in response to urinary tract obstruction...
  67. ncbi request reprint Genetic restoration of aldose reductase to the collecting tubules restores maturation of the urine concentrating mechanism
    James Y Yang
    Institute of Molecular Biology and Department of Physiology, University of Hong Kong, and Division of Clinical Biochemistry, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China
    Am J Physiol Renal Physiol 291:F186-95. 2006
    ..Together, these results suggest that aldose reductase not only plays important roles in osmoregulation and medullary cell survival but may also be essential for the full maturation of the urine concentrating mechanism...
  68. ncbi request reprint Effects of water restriction on gene expression in mouse renal medulla: identification of 3betaHSD4 as a collecting duct protein
    Qi Cai
    Department of Physiology, College of Medicine, 1501 N Campbell Ave, University of Arizona, Tucson, AZ 85724 5051, USA
    Am J Physiol Renal Physiol 291:F218-24. 2006
    ..These studies have identified several transcripts whose abundances are regulated in mouse inner medulla in response to an increase in endogenous vasopressin levels and could play roles in the regulation of salt and water excretion...
  69. ncbi request reprint Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis
    Ramanathan M Seshadri
    University of Florida College of Medicine, P O Box 100224, Gainesville, FL 32610 0224, USA
    Am J Physiol Renal Physiol 290:F397-408. 2006
    ..We conclude that chronic metabolic acidosis increases Rhcg protein expression in intercalated cells in the OMCD and in the IMCD, where it is likely to mediate an important role in the increased urinary ammonia excretion...
  70. doi request reprint Amiloride restores renal medullary osmolytes in lithium-induced nephrogenic diabetes insipidus
    Jennifer J Bedford
    Department of Physiology, University of Otago, Dunedin, New Zealand
    Am J Physiol Renal Physiol 294:F812-20. 2008
    ..Data presented here provide further understanding of how amiloride may substantially restore the lithium-induced impaired renal concentrating mechanism...