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Genomes and GenesSpecies | Heather L KimmelSummaryAffiliation: Emory University Country: USA Publications
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Publications
Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatumHeather L Kimmel
Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30341, USA
J Pharmacol Exp Ther 304:15-21. 2003..2 days in the nucleus accumbens. The results indicate the complex and long-lasting effects of cocaine administration on cellular processes. The mechanism(s) of these effects remains to be elucidated...
Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeysHeather L Kimmel
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 90:453-62. 2008..Collectively, these results indicate that the rate of drug entry in brain can play an important role in the behavioral pharmacology of psychomotor stimulants...- Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkeyHeather L Kimmel
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, United States
Pharmacol Biochem Behav 94:278-84. 2009..In addition, these results support further investigation of PAL-313 and similar compounds as a potential medication for treating psychostimulant abuse... - Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeysHeather L Kimmel
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
Pharmacol Biochem Behav 86:45-54. 2007..Hence, there was a general trend for compounds that had a faster onset and/or DAT selectivity to produce significant behavioral-stimulant and reinforcing effects... - Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeysRayna M Bauzo
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
Pharmacol Biochem Behav 94:204-10. 2009..Moreover, reinstatement of previously extinguished cocaine self-administration was not significantly attenuated by LY379268. Hence, drug interactions on neurochemistry did not correlate well with behavioral measures... - In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeysKristin M Wilcox
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
Synapse 58:220-8. 2005..Overall, reinforcing effects were consistent with DAT effects determined with in vivo techniques. The results further support a role for the DAT in the abuse liability of local anesthetics... - Neurobiological changes mediating the effects of chronic fluoxetine on cocaine useEileen K Sawyer
Neuroscience Program, Emory University, Atlanta, GA, USA
Neuropsychopharmacology 37:1816-24. 2012..Fluoxetine may not be useful for treatment of ongoing cocaine abuse but may be useful in relapse prevention... - Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeysDaniel F Manvich
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
J Pharmacol Exp Ther 341:424-34. 2012.... - Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeysLeonard L Howell
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
J Pharmacol Exp Ther 320:757-65. 2007..Collectively, the results indicate that combined inhibition of DAT and SERT warrants consideration as a viable approach in the development of cocaine medications... 
Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeysHeather L Kimmel
Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
Synapse 66:501-8. 2012..These studies also indicate that acute cocaine administration decreases the availability of plasma membrane DAT for binding, even after cocaine is no longer blocking DA uptake as evidence by a return to basal DA levels...- Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeysBrett C Ginsburg
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Pharmacol Biochem Behav 80:481-91. 2005..Importantly, there was little evidence of additivity on behavioral or neurochemical measures when cocaine was administered in combination with behavioral-stimulant doses of the DAT inhibitors... - The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeysDaniel F Manvich
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
J Pharmacol Exp Ther 342:761-9. 2012..The observed interactions with cocaine and the substitution for cocaine self-administration may be indicative of some degree of abuse potential in humans... - Changes in extracellular dopamine during cocaine self-administration in squirrel monkeysHeather L Kimmel
Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
Synapse 56:129-34. 2005..The results suggest that the environmental context associated with drug self-administration can modulate cocaine-induced elevations in extracellular dopamine... - The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeysRayna M Bauzo
Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, NE, Atlanta, GA 30329 4208, USA
Pharmacol Biochem Behav 101:288-96. 2012..The present results in nonhuman primates do not support the use of NAC as a pharmacotherapy for cocaine abuse, although rodent and clinical studies suggest otherwise... - Olanzapine-induced suppression of cocaine self-administration in rhesus monkeysLeonard L Howell
Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
Neuropsychopharmacology 31:585-93. 2006..The results indicate that olanzapine can effectively suppress cocaine self-administration behavior in nonhuman primates at doses that enhance dopamine release but do not maintain drug self-administration... - Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysisJason N Jaworski
Yerkes National Primate Research Center of Emory University, Neuroscience Division, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Neuropeptides 41:65-72. 2007..This has implications for the physiological significance of CART-DA (dopamine) interactions and for medications development... - Monoamine transporters and psychostimulant addictionLeonard L Howell
Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
Biochem Pharmacol 75:196-217. 2008..However, additional clinical studies are required in order to identify safe and efficacious pharmacotherapies...