Heather L Kimmel

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum
    Heather L Kimmel
    Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30341, USA
    J Pharmacol Exp Ther 304:15-21. 2003
  2. pmc Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
    Heather L Kimmel
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 90:453-62. 2008
  3. pmc Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey
    Heather L Kimmel
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, United States
    Pharmacol Biochem Behav 94:278-84. 2009
  4. pmc Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
    Pharmacol Biochem Behav 86:45-54. 2007
  5. pmc Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys
    Rayna M Bauzo
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
    Pharmacol Biochem Behav 94:204-10. 2009
  6. ncbi request reprint In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys
    Kristin M Wilcox
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Synapse 58:220-8. 2005
  7. pmc Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys
    Daniel F Manvich
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    J Pharmacol Exp Ther 341:424-34. 2012
  8. pmc Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use
    Eileen K Sawyer
    Neuroscience Program, Emory University, Atlanta, GA, USA
    Neuropsychopharmacology 37:1816-24. 2012
  9. ncbi request reprint Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys
    Leonard L Howell
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 320:757-65. 2007
  10. doi request reprint Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Synapse 66:501-8. 2012

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Withdrawal from repeated cocaine alters dopamine transporter protein turnover in the rat striatum
    Heather L Kimmel
    Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30341, USA
    J Pharmacol Exp Ther 304:15-21. 2003
    ..2 days in the nucleus accumbens. The results indicate the complex and long-lasting effects of cocaine administration on cellular processes. The mechanism(s) of these effects remains to be elucidated...
  2. pmc Relationship between rate of drug uptake in brain and behavioral pharmacology of monoamine transporter inhibitors in rhesus monkeys
    Heather L Kimmel
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 90:453-62. 2008
    ..Collectively, these results indicate that the rate of drug entry in brain can play an important role in the behavioral pharmacology of psychomotor stimulants...
  3. pmc Behavioral and neurochemical effects of amphetamine analogs that release monoamines in the squirrel monkey
    Heather L Kimmel
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, United States
    Pharmacol Biochem Behav 94:278-84. 2009
    ..In addition, these results support further investigation of PAL-313 and similar compounds as a potential medication for treating psychostimulant abuse...
  4. pmc Faster onset and dopamine transporter selectivity predict stimulant and reinforcing effects of cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
    Pharmacol Biochem Behav 86:45-54. 2007
    ..Hence, there was a general trend for compounds that had a faster onset and/or DAT selectivity to produce significant behavioral-stimulant and reinforcing effects...
  5. pmc Interactions between the mGluR2/3 agonist, LY379268, and cocaine on in vivo neurochemistry and behavior in squirrel monkeys
    Rayna M Bauzo
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, NE, Atlanta, GA 30329, USA
    Pharmacol Biochem Behav 94:204-10. 2009
    ..Moreover, reinstatement of previously extinguished cocaine self-administration was not significantly attenuated by LY379268. Hence, drug interactions on neurochemistry did not correlate well with behavioral measures...
  6. ncbi request reprint In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys
    Kristin M Wilcox
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30322, USA
    Synapse 58:220-8. 2005
    ..Overall, reinforcing effects were consistent with DAT effects determined with in vivo techniques. The results further support a role for the DAT in the abuse liability of local anesthetics...
  7. pmc Effects of serotonin 2C receptor agonists on the behavioral and neurochemical effects of cocaine in squirrel monkeys
    Daniel F Manvich
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    J Pharmacol Exp Ther 341:424-34. 2012
    ....
  8. pmc Neurobiological changes mediating the effects of chronic fluoxetine on cocaine use
    Eileen K Sawyer
    Neuroscience Program, Emory University, Atlanta, GA, USA
    Neuropsychopharmacology 37:1816-24. 2012
    ..Fluoxetine may not be useful for treatment of ongoing cocaine abuse but may be useful in relapse prevention...
  9. ncbi request reprint Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-administration in rhesus monkeys
    Leonard L Howell
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 320:757-65. 2007
    ..Collectively, the results indicate that combined inhibition of DAT and SERT warrants consideration as a viable approach in the development of cocaine medications...
  10. doi request reprint Simultaneous measurement of extracellular dopamine and dopamine transporter occupancy by cocaine analogs in squirrel monkeys
    Heather L Kimmel
    Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Synapse 66:501-8. 2012
    ..These studies also indicate that acute cocaine administration decreases the availability of plasma membrane DAT for binding, even after cocaine is no longer blocking DA uptake as evidence by a return to basal DA levels...
  11. ncbi request reprint Interaction of cocaine and dopamine transporter inhibitors on behavior and neurochemistry in monkeys
    Brett C Ginsburg
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Pharmacol Biochem Behav 80:481-91. 2005
    ..Importantly, there was little evidence of additivity on behavioral or neurochemical measures when cocaine was administered in combination with behavioral-stimulant doses of the DAT inhibitors...
  12. pmc Chronic interferon-α decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates
    Jennifer C Felger
    1 Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA 2 The Winship Cancer Institute, Emory University, Atlanta, GA, USA
    Neuropsychopharmacology 38:2179-87. 2013
    ..Future studies examining the mechanisms of cytokine effects on DA release and potential therapeutic strategies to reverse these changes are warranted. ..
  13. pmc The serotonin 2C receptor antagonist SB 242084 exhibits abuse-related effects typical of stimulants in squirrel monkeys
    Daniel F Manvich
    Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    J Pharmacol Exp Ther 342:761-9. 2012
    ..The observed interactions with cocaine and the substitution for cocaine self-administration may be indicative of some degree of abuse potential in humans...
  14. ncbi request reprint Changes in extracellular dopamine during cocaine self-administration in squirrel monkeys
    Heather L Kimmel
    Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    Synapse 56:129-34. 2005
    ..The results suggest that the environmental context associated with drug self-administration can modulate cocaine-induced elevations in extracellular dopamine...
  15. pmc The cystine-glutamate transporter enhancer N-acetyl-L-cysteine attenuates cocaine-induced changes in striatal dopamine but not self-administration in squirrel monkeys
    Rayna M Bauzo
    Division of Neuropharmacology and Neurologic Diseases, Yerkes National Primate Research Center, Emory University, 954 Gatewood Rd, NE, Atlanta, GA 30329 4208, USA
    Pharmacol Biochem Behav 101:288-96. 2012
    ..The present results in nonhuman primates do not support the use of NAC as a pharmacotherapy for cocaine abuse, although rodent and clinical studies suggest otherwise...
  16. pmc Intra-VTA CART 55-102 reduces the locomotor effect of systemic cocaine in rats: an isobolographic analysis
    Jason N Jaworski
    Yerkes National Primate Research Center of Emory University, Neuroscience Division, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Neuropeptides 41:65-72. 2007
    ..This has implications for the physiological significance of CART-DA (dopamine) interactions and for medications development...
  17. ncbi request reprint Olanzapine-induced suppression of cocaine self-administration in rhesus monkeys
    Leonard L Howell
    Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Neuropsychopharmacology 31:585-93. 2006
    ..The results indicate that olanzapine can effectively suppress cocaine self-administration behavior in nonhuman primates at doses that enhance dopamine release but do not maintain drug self-administration...
  18. ncbi request reprint Monoamine transporters and psychostimulant addiction
    Leonard L Howell
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30329, USA
    Biochem Pharmacol 75:196-217. 2008
    ..However, additional clinical studies are required in order to identify safe and efficacious pharmacotherapies...
  19. ncbi request reprint Effects of Pharmacologic Dopamine β-Hydroxylase Inhibition on Cocaine-Induced Reinstatement and Dopamine Neurochemistry in Squirrel Monkeys
    Debra A Cooper
    Yerkes National Primate Research Center, Division of Neuropharmacology and Neurologic Diseases D A C, H L K, L L H, Department of Pharmacology H L K, L L H, Department of Human Genetics D A C, D F M, K T S, D W, and Department of Psychiatry and Behavioral Sciences L L H, Emory University, Atlanta, Georgia
    J Pharmacol Exp Ther 350:144-52. 2014
    ..Overall, the reported behavioral effects of DBH inhibition in rodent models of relapse did not extend to nonhuman primates under the conditions used in the current studies. ..