Research Topics
Genomes and GenesSpecies | Clinton KiltsSummaryAffiliation: Emory University Country: USA Publications
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Publications
The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter densitySidney H VanNess
Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
BMC Genet 6:55. 2005....
In vivo neuroimaging correlates of the efficacy of paroxetine in the treatment of mood and anxiety disordersClinton Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Psychopharmacol Bull 37:19-28. 2003....- The neural correlates of social anxiety disorder and response to pharmacotherapyClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 31:2243-53. 2006.... - Potential new drug delivery systems for antidepressants: an overviewClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
J Clin Psychiatry 64:31-3. 2003..Iontophoresis appears to be a promising and perhaps the most efficient assisted-delivery technique for future antidepressant transdermal delivery... - The neural correlates of cue-induced craving in cocaine-dependent womenClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 161:233-41. 2004..While cocaine dependence is prevalent and disabling in women, and certain clinically relevant sex differences exist, there is an absence of knowledge related to the neural correlates of cocaine craving in cocaine-dependent women... - The simultaneous determination of neurotensin and its major fragments by on-line trace enrichment HPLC with electrochemical detectionC D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Life Sci 59:911-20. 1996..The improvements in assay specificity, signal-to-noise ratios, biomatrix compatibility and assayable sample volume compared to non-enrichment HPLC-EC are discussed... - Understanding psychiatric disorders through functional brain imagingClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA
Psychopharmacol Bull 38:21-4. 2004..This technology also has the potential to identify new treatments and novel uses for existing treatments. Psychopharmacology Bulletin. 2004;38(Suppl 1): 21-24... - Neural activity related to drug craving in cocaine addictionC D Kilts
Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, 1639 Pierce Dr, Suite 4000, PO Drawer AF, Atlanta, GA 30322, USA
Arch Gen Psychiatry 58:334-41. 2001..Crack cocaine dependence and addiction is typically associated with frequent and intense drug wanting or craving triggered by internal or environmental cues associated with past drug use... - In vivo imaging of the pharmacodynamics and pharmacokinetics of lithiumC D Kilts
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Atlanta, GA, USA
J Clin Psychiatry 61:41-6. 2000.... - Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporterJonathan McConathy
Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 31:705-18. 2004..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies... - Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transportersNachwa Jarkas
Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 32:211-24. 2005..Arterial plasma metabolites of HOMADAM were analyzed in a rhesus monkey by HPLC and displayed a single peak that corresponded to unmetabolized HOMADAM. CONCLUSION: HOMADAM is an excellent candidate for PET primate imaging of brain SERTs... - Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomographyNachwa Jarkas
Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 32:75-86. 2005..These results support the candidacy of [11C]EADAM as a radioligand for visualizing brain SERT using PET... - Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNTMargaret R Davis
PET Center, Emory University, Atlanta, Georgia, USA
J Nucl Med 44:855-61. 2003..Having picked up presymptomatic changes in the hemisphere opposite the unaffected side of the body in our early-stage (unilateral) PD patients, it appears that, like other DAT radioligands, it may be able to identify presymptomatic PD... - Dissociable neural pathways are involved in the recognition of emotion in static and dynamic facial expressionsClinton D Kilts
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Neuroimage 18:156-68. 2003..Static displays of facial emotional expression may represent noncanonical stimuli that are processed for emotion content by mental strategies and neural events distinct from their more ecologically relevant dynamic counterparts... - Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNTJohn R Votaw
Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Synapse 44:203-10. 2002..Two advantages of this technique are: reduced variability in dose-response curves because the subject is his/her own control, and the (18)F label allows evaluation of longer-acting drugs... - Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agentsJonathan McConathy
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 32:593-605. 2005..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists... - Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PETChristophe Plisson
Department of Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
J Med Chem 49:942-6. 2006..Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging... - The neural processing of moral sensitivity to issues of justice and careDiana Robertson
Goizueta Business School, Emory University, Atlanta, GA 30322, USA
Neuropsychologia 45:755-66. 2007.... - Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporterFanxing Zeng
Department of Radiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
J Med Chem 52:62-73. 2009..PET imaging in awake monkeys suggested that anesthesia influenced the binding potential of [(11)C]1 and [(11)C]4 at the NET... - Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brainJonathon A Nye
Department of Radiology, Emory University, Atlanta, Georgia, USA
J Nucl Med 49:2018-25. 2008..The purpose of this study was to develop a reliable kinetic model to describe the uptake of (11)C-HOMADAM in the healthy human brain... - From clinical research to clinical practice: a 4-year review of ziprasidoneCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
CNS Spectr 10:1-20. 2005..This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania... - Modeling the spatial and temporal dependence in FMRI dataGordana Derado
Department of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Biometrics 66:949-57. 2010..Using our proposed method, we analyze fMRI data from a study of inhibitory control in cocaine addicts... - The neural correlates of mate competition in dominant male rhesus macaquesJames K Rilling
Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
Biol Psychiatry 56:364-75. 2004..Male sexual jealousy provoked by threatened exclusive access to a female mate is a frequently reported motive in cases involving spousal abuse. Dominant male rhesus macaques also respond aggressively to threats to mating exclusivity... - Ecstasy and agony: activation of the human amygdala in positive and negative emotionStephan B Hamann
Department of Psychology, Emory University, Atlanta, GA 30322, USA
Psychol Sci 13:135-41. 2002..Although the amygdala appears to play a more extensive role in negative emotion, it is involved in positive emotion as well... - Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomographyMark M Goodman
Department of Radiology, Emory University, Atlanta, Georgia 30320, USA
J Med Chem 46:925-35. 2003..The high specific activity one-step radiolabeling preparation and high selectivity of [(123)I]ZIENT for SERT support its candidacy as a radioligand for mapping brain SERT sites... - A Bayesian hierarchical framework for spatial modeling of fMRI dataF DuBois Bowman
Department of Biostatistics, The Rollins School of Public Health, Emory University, USA
Neuroimage 39:146-56. 2008..We apply our Bayesian hierarchical model to two novel fMRI data sets: one considering inhibitory control in cocaine-dependent men and the second considering verbal memory in subjects at high risk for Alzheimer's disease... - Predicting the brain response to treatment using a Bayesian hierarchical model with application to a study of schizophreniaYing Guo
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Hum Brain Mapp 29:1092-109. 2008..The proposed method is applicable to both PET and fMRI studies. We illustrate its use with a PET study of working memory in patients with schizophrenia and an fMRI data example is also provided... - Modeling intra-subject correlation among repeated scans in positron emission tomography (PET) neuroimaging dataF DuBois Bowman
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Hum Brain Mapp 20:59-70. 2003..We illustrate the application of our model using data from a study of social anxiety and highlight analytical advantages over the spherical GLM... - Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporterFanxing Zeng
Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
Bioorg Med Chem 16:783-93. 2008..4) was measured. These new C-11- and F-18-labeled tracers will be utilized in comparative microPET studies to evaluate their potential as PET radioligands for imaging brain NET in nonhuman primates... - Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agentsFanxing Zeng
Department of Radiology, Division of Radiological Sciences, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
Bioorg Med Chem Lett 17:3044-7. 2007..Despite high in vitro affinity for the human NET, the high uptake of [(11)C]1 in the caudate and putamen excludes its use as an in vivo PET imaging agent for the NET... - A neural basis for social cooperationJames Rilling
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
Neuron 35:395-405. 2002..We propose that activation of this neural network positively reinforces reciprocal altruism, thereby motivating subjects to resist the temptation to selfishly accept but not reciprocate favors... - Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-positionFanxing Zeng
Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
Bioorg Med Chem Lett 16:4661-3. 2006..09 nM) and selectivity versus NET (65-fold) and DAT (94-fold)... - Baseline severity of depression predicts antidepressant drug response relative to escitalopramClinton D Kilts
Emory University School of Medicine, Atlanta, GA, USA
Expert Opin Pharmacother 10:927-36. 2009.... - A positron emission tomography study of methylphenidate in adults with ADHD: alterations in resting blood flow and predicting treatment responseJulie B Schweitzer
Maryland Psychiatric Research Center and Division of Child Psychiatry, University of Maryland School of Medicine, White Building, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychopharmacology 28:967-73. 2003..The majority of these brain regions are involved in the planning and execution of motor behavior. These data suggest that MPH modulates brain regions associated with motor function to achieve a reduction in ADHD symptoms... - Amygdaloid D1 receptors are not linked to stimulation of adenylate cyclaseSarah K Leonard
Neuroscience Center, Departments of Psychiatry and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599-7250, USA
Synapse 50:320-33. 2003.... - Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activityJulie B Schweitzer
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
Biol Psychiatry 56:597-606. 2004..We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD)... - Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley ratsElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Psychopharmacology (Berl) 161:288-95. 2002..A critical test of this hypothesis would be to determine if NT is involved in the expression of latent inhibition (LI), a psychophysiological and pharmacological model of schizophrenia...
Research Grants
- An fMRI Study of the Impact of Stress on Drug AddictionClinton Kilts; Fiscal Year: 2007....
- Cocaine Dependence and Cognitive Control of BehaviorClinton Kilts; Fiscal Year: 2006..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. ..
- Imaging the Neural Correlates of Genetic Risk for ADHDClinton Kilts; Fiscal Year: 2005..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
- BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIAClinton Kilts; Fiscal Year: 2002..abstract_text> ..
- An fMRI Study of the Impact of Stress on Drug AddictionClinton D Kilts; Fiscal Year: 2010....