Clinton Kilts

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
  2. ncbi request reprint In vivo neuroimaging correlates of the efficacy of paroxetine in the treatment of mood and anxiety disorders
    Clinton Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychopharmacol Bull 37:19-28. 2003
  3. ncbi request reprint The neural correlates of social anxiety disorder and response to pharmacotherapy
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:2243-53. 2006
  4. ncbi request reprint Potential new drug delivery systems for antidepressants: an overview
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:31-3. 2003
  5. ncbi request reprint The neural correlates of cue-induced craving in cocaine-dependent women
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 161:233-41. 2004
  6. ncbi request reprint The simultaneous determination of neurotensin and its major fragments by on-line trace enrichment HPLC with electrochemical detection
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Life Sci 59:911-20. 1996
  7. ncbi request reprint Understanding psychiatric disorders through functional brain imaging
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Psychopharmacol Bull 38:21-4. 2004
  8. ncbi request reprint Neural activity related to drug craving in cocaine addiction
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, 1639 Pierce Dr, Suite 4000, PO Drawer AF, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 58:334-41. 2001
  9. ncbi request reprint In vivo imaging of the pharmacodynamics and pharmacokinetics of lithium
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Atlanta, GA, USA
    J Clin Psychiatry 61:41-6. 2000
  10. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004

Detail Information

Publications37

  1. pmc The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density
    Sidney H VanNess
    Laboratory of Biological Psychopathology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    BMC Genet 6:55. 2005
    ....
  2. ncbi request reprint In vivo neuroimaging correlates of the efficacy of paroxetine in the treatment of mood and anxiety disorders
    Clinton Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychopharmacol Bull 37:19-28. 2003
    ....
  3. ncbi request reprint The neural correlates of social anxiety disorder and response to pharmacotherapy
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 31:2243-53. 2006
    ....
  4. ncbi request reprint Potential new drug delivery systems for antidepressants: an overview
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    J Clin Psychiatry 64:31-3. 2003
    ..Iontophoresis appears to be a promising and perhaps the most efficient assisted-delivery technique for future antidepressant transdermal delivery...
  5. ncbi request reprint The neural correlates of cue-induced craving in cocaine-dependent women
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 161:233-41. 2004
    ..While cocaine dependence is prevalent and disabling in women, and certain clinically relevant sex differences exist, there is an absence of knowledge related to the neural correlates of cocaine craving in cocaine-dependent women...
  6. ncbi request reprint The simultaneous determination of neurotensin and its major fragments by on-line trace enrichment HPLC with electrochemical detection
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Life Sci 59:911-20. 1996
    ..The improvements in assay specificity, signal-to-noise ratios, biomatrix compatibility and assayable sample volume compared to non-enrichment HPLC-EC are discussed...
  7. ncbi request reprint Understanding psychiatric disorders through functional brain imaging
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, 30322, USA
    Psychopharmacol Bull 38:21-4. 2004
    ..This technology also has the potential to identify new treatments and novel uses for existing treatments. Psychopharmacology Bulletin. 2004;38(Suppl 1): 21-24...
  8. ncbi request reprint Neural activity related to drug craving in cocaine addiction
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, 1639 Pierce Dr, Suite 4000, PO Drawer AF, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 58:334-41. 2001
    ..Crack cocaine dependence and addiction is typically associated with frequent and intense drug wanting or craving triggered by internal or environmental cues associated with past drug use...
  9. ncbi request reprint In vivo imaging of the pharmacodynamics and pharmacokinetics of lithium
    C D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Atlanta, GA, USA
    J Clin Psychiatry 61:41-6. 2000
    ....
  10. ncbi request reprint Synthesis and biological evaluation of [11C]talopram and [11C]talsupram: candidate PET ligands for the norepinephrine transporter
    Jonathan McConathy
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 31:705-18. 2004
    ..Although both compounds displayed high affinity and selectivity for the human NET in vitro, these compounds did not enter the CNS in adequate amounts to be used in PET imaging studies...
  11. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  12. ncbi request reprint Synthesis and characterization of EADAM: a selective radioligand for mapping the brain serotonin transporters by positron emission tomography
    Nachwa Jarkas
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:75-86. 2005
    ..These results support the candidacy of [11C]EADAM as a radioligand for visualizing brain SERT using PET...
  13. ncbi request reprint Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT
    Margaret R Davis
    PET Center, Emory University, Atlanta, Georgia, USA
    J Nucl Med 44:855-61. 2003
    ....
  14. ncbi request reprint Dissociable neural pathways are involved in the recognition of emotion in static and dynamic facial expressions
    Clinton D Kilts
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Neuroimage 18:156-68. 2003
    ..Static displays of facial emotional expression may represent noncanonical stimuli that are processed for emotion content by mental strategies and neural events distinct from their more ecologically relevant dynamic counterparts...
  15. ncbi request reprint Measurement of dopamine transporter occupancy for multiple injections of cocaine using a single injection of [F-18]FECNT
    John R Votaw
    Department of Radiology, Emory University, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Synapse 44:203-10. 2002
    ..Two advantages of this technique are: reduced variability in dose-response curves because the subject is his/her own control, and the (18)F label allows evaluation of longer-acting drugs...
  16. ncbi request reprint Synthesis and biological evaluation of trans-3-phenyl-1-indanamines as potential norepinephrine transporter imaging agents
    Jonathan McConathy
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:593-605. 2005
    ..Despite high in vitro affinity for the human NET, the uptake of [(11)C]3-BrPA in the brain and the heart was not displaceable with pharmacological doses of NET antagonists...
  17. ncbi request reprint Evaluation of carbon-11-labeled 2beta-carbomethoxy-3beta-[4'-((Z)-2-iodoethenyl)phenyl]nortropane as a potential radioligand for imaging the serotonin transporter by PET
    Christophe Plisson
    Department of Radiology, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
    J Med Chem 49:942-6. 2006
    ..Synthesis of the labeling precursor, radiosynthesis of [(11)C]ZIENT, and in vivo evaluation in anesthetized and awake monkeys have been performed to determine the suitability of [(11)C]ZIENT as a PET agent for SERT imaging...
  18. ncbi request reprint The neural processing of moral sensitivity to issues of justice and care
    Diana Robertson
    Goizueta Business School, Emory University, Atlanta, GA 30322, USA
    Neuropsychologia 45:755-66. 2007
    ....
  19. pmc Synthesis, radiosynthesis, and biological evaluation of carbon-11 and fluorine-18 labeled reboxetine analogues: potential positron emission tomography radioligands for in vivo imaging of the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    J Med Chem 52:62-73. 2009
    ..PET imaging in awake monkeys suggested that anesthesia influenced the binding potential of [(11)C]1 and [(11)C]4 at the NET...
  20. pmc Compartmental modeling of 11C-HOMADAM binding to the serotonin transporter in the healthy human brain
    Jonathon A Nye
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Nucl Med 49:2018-25. 2008
    ..The purpose of this study was to develop a reliable kinetic model to describe the uptake of (11)C-HOMADAM in the healthy human brain...
  21. ncbi request reprint From clinical research to clinical practice: a 4-year review of ziprasidone
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    CNS Spectr 10:1-20. 2005
    ..This monograph summarizes the efficacy, tolerability, and safety of oral ziprasidone in the treatment of schizophrenia, schizoaffective disorder, and bipolar mania...
  22. pmc Modeling the spatial and temporal dependence in FMRI data
    Gordana Derado
    Department of Biostatistics and Bioinformatics, The Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Biometrics 66:949-57. 2010
    ..Using our proposed method, we analyze fMRI data from a study of inhibitory control in cocaine addicts...
  23. ncbi request reprint The neural correlates of mate competition in dominant male rhesus macaques
    James K Rilling
    Department of Psychiatry and Behavioral Sciences, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Biol Psychiatry 56:364-75. 2004
    ..Male sexual jealousy provoked by threatened exclusive access to a female mate is a frequently reported motive in cases involving spousal abuse. Dominant male rhesus macaques also respond aggressively to threats to mating exclusivity...
  24. ncbi request reprint Ecstasy and agony: activation of the human amygdala in positive and negative emotion
    Stephan B Hamann
    Department of Psychology, Emory University, Atlanta, GA 30322, USA
    Psychol Sci 13:135-41. 2002
    ..Although the amygdala appears to play a more extensive role in negative emotion, it is involved in positive emotion as well...
  25. ncbi request reprint Synthesis and characterization of iodine-123 labeled 2beta-carbomethoxy-3beta-(4'-((Z)-2-iodoethenyl)phenyl)nortropane. A ligand for in vivo imaging of serotonin transporters by single-photon-emission tomography
    Mark M Goodman
    Department of Radiology, Emory University, Atlanta, Georgia 30320, USA
    J Med Chem 46:925-35. 2003
    ..The high specific activity one-step radiolabeling preparation and high selectivity of [(123)I]ZIENT for SERT support its candidacy as a radioligand for mapping brain SERT sites...
  26. pmc A Bayesian hierarchical framework for spatial modeling of fMRI data
    F DuBois Bowman
    Department of Biostatistics, The Rollins School of Public Health, Emory University, USA
    Neuroimage 39:146-56. 2008
    ..We apply our Bayesian hierarchical model to two novel fMRI data sets: one considering inhibitory control in cocaine-dependent men and the second considering verbal memory in subjects at high risk for Alzheimer's disease...
  27. pmc Predicting the brain response to treatment using a Bayesian hierarchical model with application to a study of schizophrenia
    Ying Guo
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Hum Brain Mapp 29:1092-109. 2008
    ..The proposed method is applicable to both PET and fMRI studies. We illustrate its use with a PET study of working memory in patients with schizophrenia and an fMRI data example is also provided...
  28. ncbi request reprint Modeling intra-subject correlation among repeated scans in positron emission tomography (PET) neuroimaging data
    F DuBois Bowman
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Hum Brain Mapp 20:59-70. 2003
    ..We illustrate the application of our model using data from a study of social anxiety and highlight analytical advantages over the spherical GLM...
  29. ncbi request reprint Synthesis, in vitro characterization, and radiolabeling of reboxetine analogs as potential PET radioligands for imaging the norepinephrine transporter
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem 16:783-93. 2008
    ..4) was measured. These new C-11- and F-18-labeled tracers will be utilized in comparative microPET studies to evaluate their potential as PET radioligands for imaging brain NET in nonhuman primates...
  30. ncbi request reprint Synthesis and biological evaluation of 2beta,3alpha-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, 1364 Clifton Road, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:3044-7. 2007
    ..Despite high in vitro affinity for the human NET, the high uptake of [(11)C]1 in the caudate and putamen excludes its use as an in vivo PET imaging agent for the NET...
  31. ncbi request reprint A neural basis for social cooperation
    James Rilling
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Neuron 35:395-405. 2002
    ..We propose that activation of this neural network positively reinforces reciprocal altruism, thereby motivating subjects to resist the temptation to selfishly accept but not reciprocate favors...
  32. ncbi request reprint Synthesis and monoamine transporter affinity of front bridged tricyclic 3beta-(4'-halo or 4'-methyl)phenyltropanes bearing methylene or carbomethoxymethylene on the bridge to the 2beta-position
    Fanxing Zeng
    Department of Radiology, Division of Radiological Sciences, Emory University, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 16:4661-3. 2006
    ..09 nM) and selectivity versus NET (65-fold) and DAT (94-fold)...
  33. ncbi request reprint Baseline severity of depression predicts antidepressant drug response relative to escitalopram
    Clinton D Kilts
    Emory University School of Medicine, Atlanta, GA, USA
    Expert Opin Pharmacother 10:927-36. 2009
    ....
  34. ncbi request reprint A positron emission tomography study of methylphenidate in adults with ADHD: alterations in resting blood flow and predicting treatment response
    Julie B Schweitzer
    Maryland Psychiatric Research Center and Division of Child Psychiatry, University of Maryland School of Medicine, White Building, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 28:967-73. 2003
    ..The majority of these brain regions are involved in the planning and execution of motor behavior. These data suggest that MPH modulates brain regions associated with motor function to achieve a reduction in ADHD symptoms...
  35. ncbi request reprint Amygdaloid D1 receptors are not linked to stimulation of adenylate cyclase
    Sarah K Leonard
    Neuroscience Center, Departments of Psychiatry and Pharmacology, University of North Carolina, Chapel Hill, North Carolina 27599 7250, USA
    Synapse 50:320-33. 2003
    ....
  36. ncbi request reprint Effect of methylphenidate on executive functioning in adults with attention-deficit/hyperactivity disorder: normalization of behavior but not related brain activity
    Julie B Schweitzer
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Biol Psychiatry 56:597-606. 2004
    ..We examined the effect of prolonged methylphenidate (MPH) treatment on the functional neuroanatomy of executive functioning in adult men with attention-deficit/hyperactivity disorder (ADHD)...
  37. ncbi request reprint Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley rats
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    Psychopharmacology (Berl) 161:288-95. 2002
    ..A critical test of this hypothesis would be to determine if NT is involved in the expression of latent inhibition (LI), a psychophysiological and pharmacological model of schizophrenia...

Research Grants17

  1. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton Kilts; Fiscal Year: 2007
    ....
  2. Cocaine Dependence and Cognitive Control of Behavior
    Clinton Kilts; Fiscal Year: 2006
    ..The long-term goal of these studies is to develop a novel understanding of the processes related to the acquisition, maintenance and social consequences of cocaine addiction. ..
  3. Imaging the Neural Correlates of Genetic Risk for ADHD
    Clinton Kilts; Fiscal Year: 2005
    ..By uniquely defining the impact of the dat1 VNTR polymorphism on DAT, these findings will generate knowledge of how genes confer vulnerability to ADHD and medication nonresponse. ..
  4. BEHAVIORAL GENETICS--MODELS/MECHANISMS OF SCHIZOPHRENIA
    Clinton Kilts; Fiscal Year: 2002
    ..abstract_text> ..
  5. An fMRI Study of the Impact of Stress on Drug Addiction
    Clinton D Kilts; Fiscal Year: 2010
    ....