Sumin Kang

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 44:864-77. 2011
  2. doi request reprint Targeting RSK2 in human malignancies
    Sumin Kang
    Emory University School of Medicine, Winship Cancer Institute of Emory, Department of Hematology and Medical Oncology, Atlanta, GA 30322, USA
    Expert Opin Ther Targets 15:11-20. 2011
  3. pmc p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells
    Sumin Kang
    Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1165-77. 2010
  4. pmc Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 53:534-48. 2014
  5. pmc Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:4652-7. 2008
  6. pmc Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
    Taro Hitosugi
    Department of Haematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 4:1790. 2013
  7. pmc Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 29:2105-17. 2009
  8. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
  9. pmc The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis
    Dan Li
    From the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322
    J Biol Chem 288:32528-38. 2013
  10. pmc Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 31:4938-50. 2011

Collaborators

Detail Information

Publications17

  1. pmc Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 44:864-77. 2011
    ..Together, tyrosine phosphorylation activates PDHK1 to promote the Warburg effect and tumor growth...
  2. doi request reprint Targeting RSK2 in human malignancies
    Sumin Kang
    Emory University School of Medicine, Winship Cancer Institute of Emory, Department of Hematology and Medical Oncology, Atlanta, GA 30322, USA
    Expert Opin Ther Targets 15:11-20. 2011
    ..Recent advances reveal a crucial role of RSK2 in oncogenesis and tumor progression, making RSK2 an attractive therapeutic target for cancer treatment...
  3. pmc p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells
    Sumin Kang
    Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1165-77. 2010
    ..Moreover, targeting RSK2 markedly attenuates in vitro invasion and in vivo metastasis of HNSCC cells, suggesting that RSK2 may represent a therapeutic target in the treatment of metastatic HNSCC...
  4. pmc Tyr Phosphorylation of PDP1 Toggles Recruitment between ACAT1 and SIRT3 to Regulate the Pyruvate Dehydrogenase Complex
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 53:534-48. 2014
    ..Together, hierarchical, distinct posttranslational modifications act in concert to control molecular composition of PDC and contribute to the Warburg effect. ..
  5. pmc Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:4652-7. 2008
    ..Together, our findings suggest that Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway...
  6. pmc Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
    Taro Hitosugi
    Department of Haematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 4:1790. 2013
    ....
  7. pmc Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 29:2105-17. 2009
    ..Our current and previous findings represent a paradigm for tyrosine phosphorylation-dependent regulation of serine-threonine kinases...
  8. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
    ..Our findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth...
  9. pmc The prometastatic ribosomal S6 kinase 2-cAMP response element-binding protein (RSK2-CREB) signaling pathway up-regulates the actin-binding protein fascin-1 to promote tumor metastasis
    Dan Li
    From the Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322
    J Biol Chem 288:32528-38. 2013
    ..Therefore, protein effectors of the RSK2-CREB-Fascin-1 pathway represent promising biomarkers and therapeutic targets in the clinical prognosis and treatment of metastatic human cancers. ..
  10. pmc Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 31:4938-50. 2011
    ....
  11. pmc FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 12:201-14. 2007
    ..Our findings suggest that FGFR3 mediates hematopoietic transformation by activating RSK2 in a two-step fashion, promoting both the ERK-RSK2 interaction and subsequent phosphorylation of RSK2 by ERK...
  12. pmc p90 RSK2 mediates antianoikis signals by both transcription-dependent and -independent mechanisms
    Lingtao Jin
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Mol Cell Biol 33:2574-85. 2013
    ....
  13. pmc Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 22:585-600. 2012
    ....
  14. pmc p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia
    Shannon Elf
    Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory, Atlanta, GA, USA
    Blood 117:6885-94. 2011
    ..RSK2 may thus represent an alternative therapeutic target in the treatment of FLT3-ITD-positive leukemia...
  15. pmc Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival
    Xia Liu
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:9679-84. 2007
    ..Surprisingly, K230R mutant strongly binds to phosphatidylinositol-3,4,5-trisphosphate and suppresses DNA fragmentation. Thus, B23 sumoylation regulates its subcellular localization, cell proliferation, and survival activities...
  16. pmc ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1
    You Take Oh
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
    J Biol Chem 285:41310-9. 2010
    ..Collectively, we conclude that small molecules such as celecoxib induce DR5 expression through activating ERK/RSK signaling and subsequent Elk1 activation and ATF4-dependent CHOP induction...
  17. pmc 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells
    Shaozhong Dong
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 110:360-9. 2007
    ..Our findings suggest that 14-3-3 integrates prosurvival signals in FGFR1 fusion-transformed hematopoietic cells. Disrupting 14-3-3-ligand association may represent an effective therapeutic strategy to treat 8p11 stem cell MPD...