Research Topics
Genomes and Genes
| Sumin KangSummaryAffiliation: Emory University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Targeting RSK2 in human malignanciesSumin Kang
Emory University School of Medicine, Winship Cancer Institute of Emory, Department of Hematology and Medical Oncology, Atlanta, GA 30322, USA
Expert Opin Ther Targets 15:11-20. 2011..Recent advances reveal a crucial role of RSK2 in oncogenesis and tumor progression, making RSK2 an attractive therapeutic target for cancer treatment...
p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cellsSumin Kang
Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
J Clin Invest 120:1165-77. 2010..Moreover, targeting RSK2 markedly attenuates in vitro invasion and in vivo metastasis of HNSCC cells, suggesting that RSK2 may represent a therapeutic target in the treatment of metastatic HNSCC...- Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529Sumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 283:4652-7. 2008..Together, our findings suggest that Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway... - Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformationSumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell Biol 29:2105-17. 2009..Our current and previous findings represent a paradigm for tyrosine phosphorylation-dependent regulation of serine-threonine kinases... - Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolismTaro Hitosugi
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell 44:864-77. 2011..Together, tyrosine phosphorylation activates PDHK1 to promote the Warburg effect and tumor growth... - Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growthTaro Hitosugi
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Sci Signal 2:ra73. 2009..Our findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth... - Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cellsJun Fan
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell Biol 31:4938-50. 2011.... - FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathwaySumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Cell 12:201-14. 2007..Our findings suggest that FGFR3 mediates hematopoietic transformation by activating RSK2 in a two-step fashion, promoting both the ERK-RSK2 interaction and subsequent phosphorylation of RSK2 by ERK... - Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growthTaro Hitosugi
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Cell 22:585-600. 2012.... - p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemiaShannon Elf
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute of Emory, Atlanta, GA, USA
Blood 117:6885-94. 2011..RSK2 may thus represent an alternative therapeutic target in the treatment of FLT3-ITD-positive leukemia... - Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformationTaro Hitosugi
1 Department of Haematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA 2
Nat Commun 4:1790. 2013.... - Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survivalXia Liu
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:9679-84. 2007..Surprisingly, K230R mutant strongly binds to phosphatidylinositol-3,4,5-trisphosphate and suppresses DNA fragmentation. Thus, B23 sumoylation regulates its subcellular localization, cell proliferation, and survival activities... - ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1You Take Oh
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
J Biol Chem 285:41310-9. 2010..Collectively, we conclude that small molecules such as celecoxib induce DR5 expression through activating ERK/RSK signaling and subsequent Elk1 activation and ATF4-dependent CHOP induction... - 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cellsShaozhong Dong
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 110:360-9. 2007..Our findings suggest that 14-3-3 integrates prosurvival signals in FGFR1 fusion-transformed hematopoietic cells. Disrupting 14-3-3-ligand association may represent an effective therapeutic strategy to treat 8p11 stem cell MPD...