Richard Kahn

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Toward a model for Arf GTPases as regulators of traffic at the Golgi
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    FEBS Lett 583:3872-9. 2009
  2. ncbi Consensus nomenclature for the human ArfGAP domain-containing proteins
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 182:1039-44. 2008
  3. ncbi Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 172:645-50. 2006
  4. ncbi Arf family GTPases: roles in membrane traffic and microtubule dynamics
    R A Kahn
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322 3050, USA
    Biochem Soc Trans 33:1269-72. 2005
  5. ncbi Cellular hijacking: a common strategy for microbial infection
    Richard A Kahn
    Dept of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Trends Biochem Sci 27:308-14. 2002
  6. ncbi Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane
    M M Cavenagh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 271:21767-74. 1996
  7. ncbi ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins
    H Van Valkenburgh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 276:22826-37. 2001
  8. ncbi Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases
    J C Amor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322-3050, USA
    J Biol Chem 276:42477-84. 2001
  9. ncbi A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi
    A L Boman
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    Mol Biol Cell 11:1241-55. 2000
  10. ncbi ARF binds the C-terminal region of the Escherichia coli heat-labile toxin (LTA1) and competes for the binding of LTA2
    X Zhu
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322-3050, USA
    Biochemistry 40:4560-8. 2001

Research Grants

  1. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard A Kahn; Fiscal Year: 2010
  2. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard Kahn; Fiscal Year: 2009
  3. ARL2: Regulator of Cytoskeleton and Mitochondria
    Richard Kahn; Fiscal Year: 2007
  4. Regulation of vesicular membrane traffic by ARF proteins
    Richard Kahn; Fiscal Year: 2006
  5. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
  6. The regulation and cellular activities of the Arl2 GTPase
    Richard A Kahn; Fiscal Year: 2010

Collaborators

  • Annette L Boman
  • Sean Munro
  • Marek Elias
  • Paul A Randazzo
  • Jiong Chen
  • Allan I Levey
  • Craig Roy
  • Yihong Li
  • Richard Premont
  • Anne G Rosenwald
  • Xiaodong Cheng
  • J Cherfils
  • J Bradford Bowzard
  • Hiroki Nagai
  • X Zhu
  • Ronald D Seidel
  • Jack F Shern
  • J Daniel Sharer
  • Chun jiang Zhang
  • Juan Carlos Amor
  • Xinjun Zhu
  • Chun-Jiang Zhang
  • Punya Shrivastava-Ranjan
  • Sara E Dodson
  • Chengjing Zhou
  • James J Lah
  • Laura A Volpicelli-Daley
  • J Carlos Amor
  • Matthew A Bennett
  • Melissa M McKay
  • James H Prestegard
  • Jonathan C Kagan
  • Karen Hill
  • Aimee Anido
  • Jun Kuai
  • C j Zhang
  • H Van Valkenburgh
  • J C Amor
  • M M Cavenagh
  • Guofu Fang
  • Victor Faundez
  • HOWARD REES
  • Junmin Peng
  • Dongmei Cheng
  • Craig J Heilman
  • Leslie Cunningham
  • Adam I Marcus
  • Jennifer Swails
  • Eric D Cambronne
  • Alyssa Ingmundson
  • Matt Bennett
  • Nicholas J Cowan
  • Francesca Bartolini
  • David C Pallas
  • Melissa McKay
  • Matthew S Reed
  • Jack Shern
  • Jan Pohl
  • Enrique Torre
  • Katherine Stearns
  • Hillary Van Valkenburgh
  • Douglas C Wallace
  • Michelle Greene
  • J D Sharer
  • D Ringe
  • J F Shern
  • Y Wang
  • E Kim
  • A Hodel
  • W Cieplak
  • C Sullards
  • J R Horton
  • I Mellman
  • J A Whitney
  • K Carroll

Detail Information

Publications34

  1. ncbi Toward a model for Arf GTPases as regulators of traffic at the Golgi
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    FEBS Lett 583:3872-9. 2009
    ..Though incomplete, the molecular model of carrier biogenesis has developed rapidly in recent years and promises richness in understanding this essential process...
  2. ncbi Consensus nomenclature for the human ArfGAP domain-containing proteins
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 182:1039-44. 2008
    ..This article describes the resulting consensus nomenclature and provides a brief description of each of the 10 subfamilies of 31 human genes encoding proteins containing the ArfGAP domain...
  3. ncbi Nomenclature for the human Arf family of GTP-binding proteins: ARF, ARL, and SAR proteins
    Richard A Kahn
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 172:645-50. 2006
    ..We propose a more consistent nomenclature for the human members of the Arf family that may also serve as a guide for nomenclature in other species...
  4. ncbi Arf family GTPases: roles in membrane traffic and microtubule dynamics
    R A Kahn
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322 3050, USA
    Biochem Soc Trans 33:1269-72. 2005
    ....
  5. ncbi Cellular hijacking: a common strategy for microbial infection
    Richard A Kahn
    Dept of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322, USA
    Trends Biochem Sci 27:308-14. 2002
    ..Such studies provide a rich source of cell biological data that will probably prove essential for future efforts designed to either thwart these attacks or learn from them...
  6. ncbi Intracellular distribution of Arf proteins in mammalian cells. Arf6 is uniquely localized to the plasma membrane
    M M Cavenagh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 271:21767-74. 1996
    ....
  7. ncbi ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins
    H Van Valkenburgh
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 276:22826-37. 2001
    ..These data reveal a complex network of interactions between GTPases in the ARF family and their effectors and reveal a potential for cross-talk not demonstrated previously...
  8. ncbi Structures of yeast ARF2 and ARL1: distinct roles for the N terminus in the structure and function of ARF family GTPases
    J C Amor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322-3050, USA
    J Biol Chem 276:42477-84. 2001
    ....
  9. ncbi A family of ADP-ribosylation factor effectors that can alter membrane transport through the trans-Golgi
    A L Boman
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    Mol Biol Cell 11:1241-55. 2000
    ....
  10. ncbi ARF binds the C-terminal region of the Escherichia coli heat-labile toxin (LTA1) and competes for the binding of LTA2
    X Zhu
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, Georgia 30322-3050, USA
    Biochemistry 40:4560-8. 2001
    ....
  11. ncbi The Escherichia coli heat labile toxin binds to Golgi membranes and alters Golgi and cell morphologies using ADP-ribosylation factor-dependent processes
    X Zhu
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322-3050, USA
    J Biol Chem 276:25014-21. 2001
    ....
  12. ncbi A family of Arf effectors defined as suppressors of the loss of Arf function in the yeast Saccharomyces cerevisiae
    C j Zhang
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    J Biol Chem 273:19792-6. 1998
    ....
  13. ncbi Arf proteins bind to mitotic kinesin-like protein 1 (MKLP1) in a GTP-dependent fashion
    A L Boman
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    Cell Motil Cytoskeleton 44:119-32. 1999
    ..Taken together, these data are all supportive of the conclusion that activated Arf proteins bind to the C-terminal "tail" domain of MKLP1...
  14. ncbi Isoform-selective effects of the depletion of ADP-ribosylation factors 1-5 on membrane traffic
    Laura A Volpicelli-Daley
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 16:4495-508. 2005
    ....
  15. ncbi Functional genomic analysis of the ADP-ribosylation factor family of GTPases: phylogeny among diverse eukaryotes and function in C. elegans
    Yawei Li
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    FASEB J 18:1834-50. 2004
    ..elegans, at least three are required for embryogenesis. These data represent the first analysis of the role(s) of multiple members of this family in the development of a multicellular organism...
  16. ncbi Cytosolic Arl2 is complexed with cofactor D and protein phosphatase 2A
    Jack F Shern
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:40829-36. 2003
    ..Our data suggest functional roles for the cytosolic Arl2 complex in modulating tubulin and microtubule behavior as well as a possible role in apoptosis...
  17. ncbi Arl2 and Arl3 regulate different microtubule-dependent processes
    Chengjing Zhou
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Mol Biol Cell 17:2476-87. 2006
    ..We conclude that Arl2 and Arl3 have related but distinct roles at centrosomes and in regulating microtubule-dependent processes...
  18. ncbi ELMOD2 is an Arl2 GTPase-activating protein that also acts on Arfs
    J Bradford Bowzard
    Department of Biochemistry, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:17568-80. 2007
    ....
  19. ncbi ARL1 and membrane traffic in Saccharomyces cerevisiae
    Anne G Rosenwald
    Department of Biology, Georgetown University, Washington, DC 20057, USA
    Yeast 19:1039-56. 2002
    ..These findings demonstrate that ARL1 encodes a regulator of membrane traffic...
  20. ncbi Assays used in the analysis of Arl2 and its binding partners
    J Bradford Bowzard
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, USA
    Methods Enzymol 404:453-67. 2005
    ..These methods may also prove useful for studies of other Arls or other GTPases...
  21. ncbi Mint3/X11gamma is an ADP-ribosylation factor-dependent adaptor that regulates the traffic of the Alzheimer's Precursor protein from the trans-Golgi network
    Punya Shrivastava-Ranjan
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Mol Biol Cell 19:51-64. 2008
    ..Together, our data implicate Mint3 activity as a critical determinant of post-Golgi APP traffic...
  22. ncbi Production of antisera using fusion proteins
    Sara E Dodson
    Emory University, Atlanta, Georgia, USA
    Curr Protoc Neurosci . 2007
    ..Support protocols describe the purification of His-tagged insoluble fusion proteins for animal immunization and the construction and use of affinity columns for purifying antibodies using soluble fusion proteins...
  23. ncbi A C-terminal translocation signal required for Dot/Icm-dependent delivery of the Legionella RalF protein to host cells
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, Room 354b, 295 Congress Avenue, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 102:826-31. 2005
    ..Thus, Legionella has the ability to engage synthesized substrate proteins and transfer them into host cells on contact, enabling Legionella to rapidly alter transport of the vacuole in which it resides...
  24. ncbi Structural perturbations in human ADP ribosylation factor-1 accompanying the binding of phosphatidylinositides
    Ronald D Seidel
    Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, Georgia 30602 4712, USA
    Biochemistry 43:15393-403. 2004
    ..The identified binding site and the resultant structural changes are discussed in terms of a possible influence of phosphatidylinositides on the binding of Arf1 to Arf1-GEF and subsequent nucleotide release...
  25. ncbi Assays of ADP-ribosylation factor function
    Jun Kuai
    Genetics Institute, Cambridge, Massachusetts 02140, USA
    Methods Enzymol 345:359-70. 2002
  26. ncbi ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter
    J Daniel Sharer
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 13:71-83. 2002
    ..We conclude that the amount of ARL2 in mitochondria is subject to regulation via an ANT1-sensitive pathway in muscle tissues...
  27. ncbi A bacterial guanine nucleotide exchange factor activates ARF on Legionella phagosomes
    Hiroki Nagai
    Section of Microbial Pathogenesis, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    Science 295:679-82. 2002
    ..pneumophila. Translocation of RalF protein through the phagosomal membrane is a dot/icm-dependent process. Thus, RalF is a substrate of the Dot/Icm secretion apparatus...
  28. ncbi Genetic interactions link ARF1, YPT31/32 and TRS130
    Chun jiang Zhang
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322 3050, USA
    Yeast 19:1075-86. 2002
    ..Thus, these genetic interactions provide initial evidence for linkage of Arf and TRAPP signalling and for Ypt31/32 proteins functioning downstream of both components in the TRAPP complex and of Arf signalling via the Gcs1 Arf GAP...
  29. ncbi Four ARF GAPs in Saccharomyces cerevisiae have both overlapping and distinct functions
    Chun jiang Zhang
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322 3050, USA
    Yeast 20:315-30. 2003
    ..The description of the specificities of the ARF GAPs for the different responses is viewed as a necessary first step in dissecting biologically relevant pathways through a functionally overlapping family of signalling proteins...
  30. ncbi Munc18 interacting proteins: ADP-ribosylation factor-dependent coat proteins that regulate the traffic of beta-Alzheimer's precursor protein
    Karen Hill
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia 30322-3050, USA
    J Biol Chem 278:36032-40. 2003
    ..We propose that MINTs are a family of Arf-dependent, vesicle-coat proteins that can regulate the traffic of beta-APP...
  31. ncbi Reverse two-hybrid techniques in the yeast Saccharomyces cerevisiae
    Matthew A Bennett
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
    Methods Mol Biol 261:313-26. 2004
    ....
  32. ncbi Conformational changes in human Arf1 on nucleotide exchange and deletion of membrane-binding elements
    Ronald D Seidel
    Complex Carbohydrate Research Center, University of Georgia, Athens, Georgia 30602 4712, USA
    J Biol Chem 279:48307-18. 2004
    ..Results from NMR experiments presented here on Arf1.GDP and Delta17Arf1.GDP in solution reveal substantial structural differences that can only be associated with N-terminal truncation...
  33. ncbi The structure of RalF, an ADP-ribosylation factor guanine nucleotide exchange factor from Legionella pneumophila, reveals the presence of a cap over the active site
    J Carlos Amor
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:1392-400. 2005
    ..These data highlight the functional importance of domains other than Sec7 in Arf guanine nucleotide exchange factors to biological activities and suggest novel mechanisms of regulation of those activities...
  34. ncbi Multiple phosphorylation events regulate the subcellular localization of GGA1
    Melissa M McKay
    Department of Biochemistry, Emory University School of Medicine, 1510 Clifton Rd, Atlanta, GA 30322 3050, USA
    Traffic 5:102-16. 2004
    ..We conclude that phosphorylation of the GAT domain can stabilize the coat proteins bound and thus regulate the rate of coat protein dissociation...

Research Grants16

  1. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard A Kahn; Fiscal Year: 2010
    ....
  2. Regulation of post-Golgi traffic by Arf and Arf-dependent adaptors
    Richard Kahn; Fiscal Year: 2009
    ....
  3. ARL2: Regulator of Cytoskeleton and Mitochondria
    Richard Kahn; Fiscal Year: 2007
    ..And finally, relating these functions and mechanisms to those of the Arfs should also reveal important similarities and differences within the Arf family. ..
  4. Regulation of vesicular membrane traffic by ARF proteins
    Richard Kahn; Fiscal Year: 2006
    ..abstract_text> ..
  5. ARF BINDING IN THE ACTION OF CHOLERA AND E COLI TOXINS
    Richard Kahn; Fiscal Year: 2002
    ....
  6. The regulation and cellular activities of the Arl2 GTPase
    Richard A Kahn; Fiscal Year: 2010
    ....