T Jovanovic

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Behav Neurosci 120:995-1004. 2006
  2. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010
  3. pmc Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Depress Anxiety 30:217-24. 2013
  4. pmc Impaired safety signal learning may be a biomarker of PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Neuropharmacology 62:695-704. 2012
  5. pmc Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder
    Asante Kamkwalala
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Psychosom Med 74:153-9. 2012
  6. pmc Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 36:1540-52. 2011
  7. pmc Physiological markers of anxiety are increased in children of abused mothers
    Tanja Jovanovic
    Emory University School of Medicine, Dept of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, USA
    J Child Psychol Psychiatry 52:844-52. 2011
  8. pmc How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 167:648-62. 2010
  9. pmc Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 35:846-57. 2010
  10. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009

Research Grants

  1. Fear inhibition in posttraumatic stress disorder
    Tanja Jovanovic; Fiscal Year: 2006

Detail Information

Publications21

  1. pmc Contingency awareness and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Behav Neurosci 120:995-1004. 2006
    ..A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition...
  2. pmc Impaired fear inhibition is a biomarker of PTSD but not depression
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
    Depress Anxiety 27:244-51. 2010
    ..Given the high comorbidity between PTSD and depression, our goal was to see whether this impairment is specific to PTSD, or a non-specific symptom associated with both disorders...
  3. pmc Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since trauma
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Depress Anxiety 30:217-24. 2013
    ..This is the first study to use a conditioned inhibition paradigm with traumatized individuals within a month of trauma exposure. We hypothesized that impaired fear inhibition would be evident in PTSD, but not ASD...
  4. pmc Impaired safety signal learning may be a biomarker of PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Neuropharmacology 62:695-704. 2012
    ..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'...
  5. pmc Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorder
    Asante Kamkwalala
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
    Psychosom Med 74:153-9. 2012
    ..5 times larger in men than in women...
  6. pmc Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorder
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 36:1540-52. 2011
    ..46, p=0.01. These results suggest that transient suppression of HPA function via dexamethasone suppression may reduce exaggerated fear in patients with PTSD...
  7. pmc Physiological markers of anxiety are increased in children of abused mothers
    Tanja Jovanovic
    Emory University School of Medicine, Dept of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, USA
    J Child Psychol Psychiatry 52:844-52. 2011
    ..The current study employed psychophysiological methods to describe biomarkers of anxiety in children of traumatized mothers...
  8. pmc How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 167:648-62. 2010
    ..The authors also discuss different pharmacological approaches that enhance fear inhibition and may improve treatment outcomes for patients with PTSD...
  9. pmc Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSD
    Tanja Jovanovic
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
    Psychoneuroendocrinology 35:846-57. 2010
    ..These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD...
  10. pmc Childhood abuse is associated with increased startle reactivity in adulthood
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Depress Anxiety 26:1018-26. 2009
    ..The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress...
  11. pmc Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severity
    Tanja Jovanovic
    Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Psychiatry Res 167:151-60. 2009
    ..However, the high-symptom PTSD group did not show fear inhibition: these subjects had significantly greater fear potentiation on the AB trials than both the controls and the low-symptom PTSD patients...
  12. pmc Altered resting psychophysiology and startle response in Croatian combat veterans with PTSD
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30303, USA
    Int J Psychophysiol 71:264-8. 2009
    ..Startle habituation and baseline heart-rate appear to offer the most reliable psychophysiological indices of PTSD. This finding replicates trends in the literature in a new population of PTSD patients...
  13. ncbi request reprint Menstrual cycle phase effects on prepulse inhibition of acoustic startle
    Tanja Jovanovic
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Psychophysiology 41:401-6. 2004
    ..PPI in follicular phase women did not differ significantly from PPI in men. However, PPI was reduced in luteal women compared to follicular women. These data provide evidence that ovarian hormones affect sensorimotor gating...
  14. ncbi request reprint Fear potentiation and fear inhibition in a human fear-potentiated startle paradigm
    Tanja Jovanovic
    Emory University School of Medicine, Atlanta, GA, USA
    Biol Psychiatry 57:1559-64. 2005
    ..For this reason, we sought to develop a behavioral procedure in humans that would render a stimulus primarily inhibitory...
  15. ncbi request reprint Effects of nonmaternal restraint on the vocalizations of infant rhesus monkeys (Macaca mulatta)
    T Jovanovic
    Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
    Am J Primatol 53:33-45. 2001
    ....
  16. pmc Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSD
    N Fani
    Department of Psychology, Georgia State University, Atlanta, GA, USA
    Psychol Med 42:533-43. 2012
    ..However, the relationship between these processes has not been established, particularly in highly traumatized populations; understanding their interaction can help inform neural network models and treatments for PTSD...
  17. pmc Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humans
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Behav Neurosci 122:1016-30. 2008
    ..Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans...
  18. pmc Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor
    Kerry J Ressler
    Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
    Nature 470:492-7. 2011
    ..These sex-specific effects may occur via oestrogen regulation of ADCYAP1R1. PACAP levels and ADCYAP1R1 SNPs may serve as useful biomarkers to further our mechanistic understanding of PTSD...
  19. pmc Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigm
    Seth D Norrholm
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Learn Mem 13:681-5. 2006
    ..This is the first demonstration of fear extinction and reinstatement in humans using startle measures...
  20. ncbi request reprint Medication status affects the relationship of symptoms to prepulse inhibition of acoustic startle in schizophrenia
    Erica J Duncan
    Atlanta Veterans Administration Medical Center, Decatur, GA, USA
    Psychiatry Res 145:137-45. 2006
    ..These data indicate that more severe symptoms are associated with lower PPI, but that medication status is an important factor in the relationship between symptom severity and sensorimotor gating...
  21. ncbi request reprint An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent men
    Erica Duncan
    Atlanta VA Medical Center, Decatur, GA 30033, USA
    Am J Addict 16:174-82. 2007
    ..These data suggest that stress may precipitate relapse in cocaine addiction by activating brain areas that mediate reward processing and the attentional and mnemonic bias for drug use reminders...

Research Grants1

  1. Fear inhibition in posttraumatic stress disorder
    Tanja Jovanovic; Fiscal Year: 2006
    ..The present study will investigate how awareness interacts with startle in PTSD subjects. Finally, the present study will examine the relationship between contingency awareness and fear inhibition. ..