Research Topics
| T JovanovicSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Contingency awareness and fear inhibition in a human fear-potentiated startle paradigmTanja Jovanovic
Mental Health Service 116A, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
Behav Neurosci 120:995-1004. 2006..A response keypad was used to assess contingency awareness on a trial-by-trial basis. Both aware and unaware subjects showed fear-potentiated startle. However, awareness was related to stimulus discrimination and fear inhibition...
Impaired fear inhibition is a biomarker of PTSD but not depressionTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Drive, Atlanta, GA 30303
Depress Anxiety 27:244-51. 2010..Given the high comorbidity between PTSD and depression, our goal was to see whether this impairment is specific to PTSD, or a non-specific symptom associated with both disorders...
Acute stress disorder versus chronic posttraumatic stress disorder: inhibition of fear as a function of time since traumaTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Depress Anxiety 30:217-24. 2013..This is the first study to use a conditioned inhibition paradigm with traumatized individuals within a month of trauma exposure. We hypothesized that impaired fear inhibition would be evident in PTSD, but not ASD...- Impaired safety signal learning may be a biomarker of PTSDTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
Neuropharmacology 62:695-704. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'... - Dark-enhanced startle responses and heart rate variability in a traumatized civilian sample: putative sex-specific correlates of posttraumatic stress disorderAsante Kamkwalala
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 49 Jesse Hill Jr Dr, Atlanta, GA 30303, USA
Psychosom Med 74:153-9. 2012..5 times larger in men than in women... - Cortisol suppression by dexamethasone reduces exaggerated fear responses in posttraumatic stress disorderTanja Jovanovic
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
Psychoneuroendocrinology 36:1540-52. 2011..46, p=0.01. These results suggest that transient suppression of HPA function via dexamethasone suppression may reduce exaggerated fear in patients with PTSD... - Physiological markers of anxiety are increased in children of abused mothersTanja Jovanovic
Emory University School of Medicine, Dept of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, USA
J Child Psychol Psychiatry 52:844-52. 2011..The current study employed psychophysiological methods to describe biomarkers of anxiety in children of traumatized mothers... - How the neurocircuitry and genetics of fear inhibition may inform our understanding of PTSDTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Psychiatry 167:648-62. 2010..The authors also discuss different pharmacological approaches that enhance fear inhibition and may improve treatment outcomes for patients with PTSD... - Fear potentiation is associated with hypothalamic-pituitary-adrenal axis function in PTSDTanja Jovanovic
Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30303, United States
Psychoneuroendocrinology 35:846-57. 2010..These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD... - Childhood abuse is associated with increased startle reactivity in adulthoodTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Depress Anxiety 26:1018-26. 2009..The acoustic startle response (ASR) is a subcortical reflex modulated by neural systems implicated in posttraumatic stress disorder (PTSD). The ASR is conserved across species and is increased in rodent models of developmental stress... - Posttraumatic stress disorder may be associated with impaired fear inhibition: relation to symptom severityTanja Jovanovic
Mental Health Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
Psychiatry Res 167:151-60. 2009..However, the high-symptom PTSD group did not show fear inhibition: these subjects had significantly greater fear potentiation on the AB trials than both the controls and the low-symptom PTSD patients... - Altered resting psychophysiology and startle response in Croatian combat veterans with PTSDTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30303, USA
Int J Psychophysiol 71:264-8. 2009..Startle habituation and baseline heart-rate appear to offer the most reliable psychophysiological indices of PTSD. This finding replicates trends in the literature in a new population of PTSD patients... - Menstrual cycle phase effects on prepulse inhibition of acoustic startleTanja Jovanovic
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Psychophysiology 41:401-6. 2004..PPI in follicular phase women did not differ significantly from PPI in men. However, PPI was reduced in luteal women compared to follicular women. These data provide evidence that ovarian hormones affect sensorimotor gating... - Fear potentiation and fear inhibition in a human fear-potentiated startle paradigmTanja Jovanovic
Emory University School of Medicine, Atlanta, GA, USA
Biol Psychiatry 57:1559-64. 2005..For this reason, we sought to develop a behavioral procedure in humans that would render a stimulus primarily inhibitory... - Effects of nonmaternal restraint on the vocalizations of infant rhesus monkeys (Macaca mulatta)T Jovanovic
Department of Psychology, Emory University, Atlanta, Georgia 30322, USA
Am J Primatol 53:33-45. 2001.... - Attention bias toward threat is associated with exaggerated fear expression and impaired extinction in PTSDN Fani
Department of Psychology, Georgia State University, Atlanta, GA, USA
Psychol Med 42:533-43. 2012..However, the relationship between these processes has not been established, particularly in highly traumatized populations; understanding their interaction can help inform neural network models and treatments for PTSD... - Timing of extinction relative to acquisition: a parametric analysis of fear extinction in humansSeth D Norrholm
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Behav Neurosci 122:1016-30. 2008..Thus, the results remain inconclusive regarding spontaneous recovery and the timing of extinction and are discussed in terms of performing translational studies of fear in humans... - Post-traumatic stress disorder is associated with PACAP and the PAC1 receptorKerry J Ressler
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
Nature 470:492-7. 2011..These sex-specific effects may occur via oestrogen regulation of ADCYAP1R1. PACAP levels and ADCYAP1R1 SNPs may serve as useful biomarkers to further our mechanistic understanding of PTSD... - Conditioned fear extinction and reinstatement in a human fear-potentiated startle paradigmSeth D Norrholm
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Learn Mem 13:681-5. 2006..This is the first demonstration of fear extinction and reinstatement in humans using startle measures... - Medication status affects the relationship of symptoms to prepulse inhibition of acoustic startle in schizophreniaErica J Duncan
Atlanta Veterans Administration Medical Center, Decatur, GA, USA
Psychiatry Res 145:137-45. 2006..These data indicate that more severe symptoms are associated with lower PPI, but that medication status is an important factor in the relationship between symptom severity and sensorimotor gating... - An fMRI study of the interaction of stress and cocaine cues on cocaine craving in cocaine-dependent menErica Duncan
Atlanta VA Medical Center, Decatur, GA 30033, USA
Am J Addict 16:174-82. 2007..These data suggest that stress may precipitate relapse in cocaine addiction by activating brain areas that mediate reward processing and the attentional and mnemonic bias for drug use reminders...
Research Grants
- Fear inhibition in posttraumatic stress disorderTanja Jovanovic; Fiscal Year: 2006..The present study will investigate how awareness interacts with startle in PTSD subjects. Finally, the present study will examine the relationship between contingency awareness and fear inhibition. ..