Research Topics
| C D JosephsonSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Transfusion in the patient with sickle cell disease: a critical review of the literature and transfusion guidelinesCassandra D Josephson
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Transfus Med Rev 21:118-33. 2007..Our objectives were to provide an in-depth review of the current literature on transfusion therapy in SCD and to provide a set of guidelines for the transfusion management of patients with SCD...
ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodiesCassandra D Josephson
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfus Apher Sci 42:83-8. 2010..The progress in this European strategy may serve the US to stimulate a re-examination of its practices and policies for the advancement of platelet transfusion safety...- Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤1500 g) using cytomegalovirus-seronegative and leukoreduced transfusionsCassandra D Josephson
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Transfus Med Rev 25:125-32. 2011..Conducted in Atlanta, GA, this study has been registered at the US National Institutes of Health (ClinicalTrials.gov no. NCT00907686)... - The new albumin-free recombinant factor VIII concentrates for treatment of hemophilia: do they represent an actual incremental improvement?Cassandra D Josephson
Children s Healthcare of Atlanta Blood Banks, Atlanta, GA, USA
Clin Adv Hematol Oncol 2:441-6. 2004..Thus, the initial cost of the product may be a minimal issue in the medical decision process when selecting rFVIII replacement therapy... - Significant numbers of apheresis-derived group O platelet units have "high-titer" anti-A/A,B: implications for transfusion policyC D Josephson
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 44:805-8. 2004..Based on these data, a policy was instituted to test anti-A/A,B titers in O SDPs prior to "out-of-group" transfusion... - A multidisciplinary "think tank": the top 10 clinical trial opportunities in transfusion medicine from the National Heart, Lung, and Blood Institute-sponsored 2009 state-of-the-science symposiumCassandra D Josephson
Emory University, Atlanta, Georgia, USA
Transfusion 51:828-41. 2011.... - Partners for life: the transfusion program for patients with sickle cell disease offered at the American Red Cross Blood Services, Southern Region, Atlanta, GeorgiaK L Hillyer
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Emory University Hospital, Atlanta, Georgia 30324, USA
Immunohematology 22:108-11. 2006 - Description and investigation of white particulate matter in additive solution-1 red blood cell unitsChristopher D Hillyer
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Transfusion 44:977-83. 2004..Because the increased rate of appearance of WPM was a transient phenomenon, it is not clear whether this is a newly noticed or a new and different phenomenon from "aggregates" observed in the past... - Granulocyte transfusion: revisitedMichael A Briones
Division Hematology and Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, AFLAC Cancer Center and Blood Disorders, 2040 Ridgewood Drive, Suite 100, Atlanta, GA 30322, USA
Curr Hematol Rep 2:522-7. 2003.... - Pediatric transfusion medicine: development of a critical massChristopher D Hillyer
Pediatric Transfusion Medicine Academic Awardees Program PedsTMAA, EUH Blood Bank, Atlanta, GA 30322, USA
Transfusion 49:596-601. 2009..Indeed, several issues regarding the subspecialty of pediatric transfusion medicine (PTM) are particularly timely, and it appears that a critical mass, or a nidus capable of becoming a critical mass, is developing in PTM... - Transfusion practices for patients with sickle cell disease at major academic medical centers participating in the Atlanta Sickle Cell ConsortiumA M Winkler
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Medical Director, Grady Health System Transfusion Service, Atlanta, GA 30322, USA
Immunohematology 28:24-6. 2012..With increasing availability, red blood cell genotyping will be used in the near future both for determination of predicted patient phenotypes and for provision of genotypically matched donor units... - Nonfatal intravascular hemolysis in a pediatric patient after transfusion of a platelet unit with high-titer anti-AShealynn B Harris
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Transfusion 47:1412-7. 2007..Group A patients transfused with group O single-donor PLTs (SDPs) with "high-titer" anti-A are at greatest risk for hemolysis... - CD36 immunization in a patient undergoing hematopoietic stem cell transplantationElizabeth E Culler
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 50:660-2. 2008..The patient responded adequately to transfusion of crossmatch compatible platelets and successfully underwent HSCT. The presence of anti-CD36 antibodies does not exclude potential candidates from HSCT... - Transfusion management of sickle cell patients during bone marrow transplantation with matched sibling donorMarianne E McPherson
Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Transfusion 49:1977-86. 2009..Characterization of transfusion requirements is important for blood bank and clinician patient management... - Unappreciated risk factors for transplant patients: HLA antibodies in blood componentsRobert A Bray
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
Hum Immunol 65:240-4. 2004..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss... - Minor antigens on transfused RBCs crossprime CD8 T cells but do not induce full effector functionM Desmarets
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Am J Transplant 11:1825-34. 2011..Together, these data indicate that RBCs may not be the component of RBC units that induces BMT rejection, and suggest that contaminating platelets or leukocytes may be responsible... - Clinical uses of plasma and plasma fractions: plasma-derived products for hemophilias A and B, and for von Willebrand diseaseCassandra D Josephson
Division of Hematology/Oncology/Bone Marrow Transplant, Pathology, Laboratory Medicine, Pediatrics, Emory University School of Medicine, 2015 Uppergate Dr. NE, Atlanta, GA 30322, USA
Best Pract Res Clin Haematol 19:35-49. 2006..This chapter discusses safety strategies for plasma-derived clotting factor, its availability, economics, efficacy, and inhibitor formation... 
Effects of storage duration and volume on the quality of leukoreduced apheresis-derived platelets: implications for pediatric transfusion medicineAnne M Winkler
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Transfusion 50:2193-8. 2010..However, limited data exist regarding the impact of storage on residual small-volume LR-ADP...- HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseMarianne E McPherson
AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 54:552-8. 2010..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown... - Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?Cassandra D Josephson
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, USA
J Pediatr 157:972-978.e1-3. 2010.... - Platelet transfusion practices among neonatologists in the United States and Canada: results of a surveyCassandra D Josephson
Aflac Cancer Center and Blood Disorders Services at Children s Healthcare of Atlanta, Atlanta, Georgia, USA
Pediatrics 123:278-85. 2009..We hypothesized that there would be significant diversity in platelet transfusion triggers, product selection, and dosing among neonatologists in the United States and Canada... - Factor VIII expression in azoxymethane-induced murine fulminant hepatic failureChristopher B Doering
Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
Blood 100:143-7. 2002..These results indicate that the contribution of the liver to factor VIII biosynthesis is not replaced or significantly supplemented by other tissues in this model of FHF... - Should hemophilia treaters switch to albumin-free recombinant factor VIII concentratesShannon L Meeks
Aflac Cancer Center and Blood Disorders Service, Emory University Children s Healthcare of Atlanta, USA
Curr Opin Hematol 13:457-61. 2006..To discuss the advantages and disadvantages of the albumin-free recombinant factor VIII concentrates in the treatment of hemophilia A...
Research Grants
- Pediatric Transfusion Medicine Academic Career AwardCASSANDRA JOSEPHSON; Fiscal Year: 2007..End of Abstract) ..