Douglas C Jones

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi Regulation of cocaine- and amphetamine-regulated transcript mRNA expression by calcium-mediated signaling in GH3 cells
    D C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, 945 Gatewood Road, Atlanta, GA 30329, USA
    Neuroscience 160:339-47. 2009
  2. doi The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction
    Douglas C Jones
    Neuroscience Division, Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Biochem Pharmacol 76:569-81. 2008
  3. ncbi Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system
    Douglas C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 317:454-61. 2006
  4. ncbi CART receptor binding in primary cell cultures of the rat nucleus accumbens
    Douglas C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd NE, Atlanta, Georgia 30329, USA
    Synapse 62:122-7. 2008
  5. pmc Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo
    GEORGE A ROGGE
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Yerkes Primate Center, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Brain Res 1251:42-52. 2009
  6. pmc CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system
    George W Hubert
    Division of Neuroscience, The Yerkes National Primate Research Center of Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Biochem Pharmacol 75:57-62. 2008
  7. ncbi The CART (cocaine- and amphetamine-regulated transcript) system in appetite and drug addiction
    Aleksandra Vicentic
    Yerkes National Primate Research Center of Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 320:499-506. 2007
  8. ncbi The role of CART in the reward/reinforcing properties of psychostimulants
    Jason N Jaworski
    Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Sciences University, Portland, OR 97239, USA
    Peptides 27:1993-2004. 2006
  9. ncbi Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells
    Douglas C Jones
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, USA
    J Pharmacol Exp Ther 311:298-306. 2004
  10. ncbi Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress
    Douglas C Jones
    Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 47907 1333, West Lafayette, IN, USA
    Neurotoxicology 24:333-42. 2003

Research Grants

Detail Information

Publications11

  1. doi Regulation of cocaine- and amphetamine-regulated transcript mRNA expression by calcium-mediated signaling in GH3 cells
    D C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, 945 Gatewood Road, Atlanta, GA 30329, USA
    Neuroscience 160:339-47. 2009
    ..To our knowledge, this is the first study providing evidence that the CART gene is, in part, regulated by Ca(2+)/CaM/CREB-dependent cell signaling...
  2. doi The effects of environmental neurotoxicants on the dopaminergic system: A possible role in drug addiction
    Douglas C Jones
    Neuroscience Division, Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Biochem Pharmacol 76:569-81. 2008
    ....
  3. ncbi Cocaine-amphetamine-regulated transcript expression in the rat nucleus accumbens is regulated by adenylyl cyclase and the cyclic adenosine 5'-monophosphate/protein kinase a second messenger system
    Douglas C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 317:454-61. 2006
    ..These results suggest that CART expression in vivo in the rat nucleus accumbens is regulated by adenylyl cyclase and cAMP/PKA-mediating signaling and, likely, through the activation of CREB...
  4. ncbi CART receptor binding in primary cell cultures of the rat nucleus accumbens
    Douglas C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd NE, Atlanta, Georgia 30329, USA
    Synapse 62:122-7. 2008
    ..This is the first demonstration of CART peptide receptor binding in primary cell cultures of the rat brain...
  5. pmc Regulation of CART peptide expression by CREB in the rat nucleus accumbens in vivo
    GEORGE A ROGGE
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, Yerkes Primate Center, 954 Gatewood Rd NE, Atlanta, GA 30329, USA
    Brain Res 1251:42-52. 2009
    ..The finding that CREB can regulate the levels of CART mRNA and peptides in vivo in the NAc supports a role for CART peptides in psychostimulant-induced reward and reinforcement...
  6. pmc CART peptides as modulators of dopamine and psychostimulants and interactions with the mesolimbic dopaminergic system
    George W Hubert
    Division of Neuroscience, The Yerkes National Primate Research Center of Emory University, 954 Gatewood Road, NE, Atlanta, GA 30329, USA
    Biochem Pharmacol 75:57-62. 2008
    ..A hypothesis is that CART is homeostatic in the accumbens and tends to oppose large increases in dopamine signaling. These actions would therefore be able to regulate the effects of some abused drugs such as the psychostimulants...
  7. ncbi The CART (cocaine- and amphetamine-regulated transcript) system in appetite and drug addiction
    Aleksandra Vicentic
    Yerkes National Primate Research Center of Emory University, Atlanta, GA 30329, USA
    J Pharmacol Exp Ther 320:499-506. 2007
    ..Given the enormous public health burden of both obesity and drug addiction, future studies exploring the pharmacotherapies targeting CART peptide represent an exciting and challenging research area...
  8. ncbi The role of CART in the reward/reinforcing properties of psychostimulants
    Jason N Jaworski
    Department of Behavioral Neuroscience, School of Medicine, Oregon Health and Sciences University, Portland, OR 97239, USA
    Peptides 27:1993-2004. 2006
    ..This review discusses the anatomical, pharmacological, and behavioral evidence implicating a role for CART peptide in the rewarding and reinforcing properties of psychostimulants...
  9. ncbi Thioether metabolites of 3,4-methylenedioxyamphetamine and 3,4-methylenedioxymethamphetamine inhibit human serotonin transporter (hSERT) function and simultaneously stimulate dopamine uptake into hSERT-expressing SK-N-MC cells
    Douglas C Jones
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, USA
    J Pharmacol Exp Ther 311:298-306. 2004
    ....
  10. ncbi Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress
    Douglas C Jones
    Neurotoxicology Laboratory, Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, 47907 1333, West Lafayette, IN, USA
    Neurotoxicology 24:333-42. 2003
    ..Subsequent cytochrome c release activates the caspase effector component of apoptosis. Cyanide potentiates the neurotoxicity of DA by enhancing the generation of ROS and impairing mitochondrial function...
  11. ncbi The metabolism and toxicity of quinones, quinonimines, quinone methides, and quinone-thioethers
    Terrence J Monks
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712 1074, USA
    Curr Drug Metab 3:425-38. 2002
    ..Specific examples will be discussed to illustrate the diverse manner by which quinones interact with biological systems to initiate and propagate a toxic response...

Research Grants1

  1. Regulation of CART Expression in Rat Nucleus Accumbens
    Douglas Jones; Fiscal Year: 2007
    ..abstract_text> ..