D P Jones

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data
    Karan Uppal
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 14:15. 2013
  2. ncbi Nutritional metabolomics: progress in addressing complexity in diet and health
    Dean P Jones
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Nutr 32:183-202. 2012
  3. ncbi Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses
    Dean P Jones
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, GA, USA
    Free Radic Biol Med 33:1290-300. 2002
  4. ncbi Measuring the poise of thiol/disulfide couples in vivo
    Dean P Jones
    Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 47:1329-38. 2009
  5. ncbi Radical-free biology of oxidative stress
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Clinical Biomarkers Laboratory, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 295:C849-68. 2008
  6. ncbi Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
    Dean P Jones
    Department of Medicine, 4131 Rollins Research Center, Emory University, Atlanta, GA 30322, USA
    FASEB J 18:1246-8. 2004
  7. ncbi Extracellular redox state: refining the definition of oxidative stress in aging
    Dean P Jones
    Clinical Biomarkers Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
    Rejuvenation Res 9:169-81. 2006
  8. ncbi Redefining oxidative stress
    Dean P Jones
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Whitehead Biomedical Research Center, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 8:1865-79. 2006
  9. ncbi Redox state of glutathione in human plasma
    D P Jones
    Department of Biochemistry, Atlanta, GA, USA
    Free Radic Biol Med 28:625-35. 2000
  10. ncbi Disruption of mitochondrial redox circuitry in oxidative stress
    Dean P Jones
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA
    Chem Biol Interact 163:38-53. 2006

Research Grants

  1. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
  2. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2007
  3. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2009
  4. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2010
  5. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean P Jones; Fiscal Year: 2010
  6. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2011
  7. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
  8. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2005
  9. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
  10. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2001

Collaborators

Detail Information

Publications96

  1. ncbi xMSanalyzer: automated pipeline for improved feature detection and downstream analysis of large-scale, non-targeted metabolomics data
    Karan Uppal
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA, USA
    BMC Bioinformatics 14:15. 2013
    ..abstract:..
  2. ncbi Nutritional metabolomics: progress in addressing complexity in diet and health
    Dean P Jones
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Nutr 32:183-202. 2012
    ....
  3. ncbi Redox analysis of human plasma allows separation of pro-oxidant events of aging from decline in antioxidant defenses
    Dean P Jones
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, GA, USA
    Free Radic Biol Med 33:1290-300. 2002
    ..In principle, such analyses can be used to assess efficacy of intervention strategies against oxidative stress prior to or early after onset of clinical symptoms in aging and age-related disease...
  4. ncbi Measuring the poise of thiol/disulfide couples in vivo
    Dean P Jones
    Clinical Biomarkers Laboratory, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 47:1329-38. 2009
    ....
  5. ncbi Radical-free biology of oxidative stress
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Clinical Biomarkers Laboratory, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 295:C849-68. 2008
    ..Considerable opportunity exists to elucidate specific thiol control pathways and develop interventional strategies to restore normal redox control and protect against oxidative stress in aging and age-related disease...
  6. ncbi Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
    Dean P Jones
    Department of Medicine, 4131 Rollins Research Center, Emory University, Atlanta, GA 30322, USA
    FASEB J 18:1246-8. 2004
    ..Moreover, inclusion of cysteine/cystine as a signaling node distinct from GSH and Trx1 significantly expands the redox range over which protein thiol/disulfide couples may operate to control physiologically relevant processes...
  7. ncbi Extracellular redox state: refining the definition of oxidative stress in aging
    Dean P Jones
    Clinical Biomarkers Laboratory, Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
    Rejuvenation Res 9:169-81. 2006
    ....
  8. ncbi Redefining oxidative stress
    Dean P Jones
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Whitehead Biomedical Research Center, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 8:1865-79. 2006
    ..Adoption of such a definition could redirect research to identify key perturbations of redox signaling and control and lead to new treatments for oxidative stress-related disease processes...
  9. ncbi Redox state of glutathione in human plasma
    D P Jones
    Department of Biochemistry, Atlanta, GA, USA
    Free Radic Biol Med 28:625-35. 2000
    ..These results suggest that E(h) values for GSSG/2GSH and CySS-mono-Gly/(Cys. CysGly) may provide useful means to quantitatively express the oxidant/antioxidant balance in clinical and epidemiologic studies...
  10. ncbi Disruption of mitochondrial redox circuitry in oxidative stress
    Dean P Jones
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA
    Chem Biol Interact 163:38-53. 2006
    ....
  11. ncbi Glutathione measurement in human plasma. Evaluation of sample collection, storage and derivatization conditions for analysis of dansyl derivatives by HPLC
    D P Jones
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Chim Acta 275:175-84. 1998
    ..Results from 59 healthy individuals (20-43 years) provided a mean (+/-1 SD) GSH value of 2.09+/-1.14 micromolar...
  12. ncbi Redox sensing: orthogonal control in cell cycle and apoptosis signalling
    D P Jones
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    J Intern Med 268:432-48. 2010
    ..Recent findings that thiol-disulphide pools in humans are oxidized with age, environmental exposures and disease risk suggest that redox-sensing thiols could provide a central mechanistic link in disease development and progression...
  13. ncbi Redox compartmentalization and cellular stress
    D P Jones
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, GA 30322, USA
    Diabetes Obes Metab 12:116-25. 2010
    ....
  14. ncbi Mapping the cysteine proteome: analysis of redox-sensing thiols
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Curr Opin Chem Biol 15:103-12. 2011
    ..Complementary databases and Cys proteome maps are needed to describe thiol redox circuits and connect these to functional redox-dependent pathways. This article summarizes progress in quantitative redox proteomics to develop such maps...
  15. ncbi Dietary sulfur amino acid effects on fasting plasma cysteine/cystine redox potential in humans
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia, USA
    Nutrition 27:199-205. 2011
    ..The present study examined the effect of dietary SAA intake level on free Cys, free CySS, and E(h)CySS in human plasma under fasting conditions...
  16. ncbi H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
    ..Thus, "redox signaling" resulting in kinase signaling pathways is distinct from "oxidative stress," and is mediated by discrete, localized redox circuitry...
  17. ncbi Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:363-70. 2007
    ..These results further suggest that energy and/or substrate supply may contribute to sensitivity of mitochondrial and cytoplasmic systems to oxidative damage...
  18. ncbi Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase
    Patrick J Halvey
    Division of Pulmonary, Allergy, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Antioxid Redox Signal 9:807-16. 2007
    ..Furthermore, the attenuation of NF-kappaB reporter activity in the absence of nuclear Trx1 oxidation suggests that critical nuclear redox proteins are subject to control by S-glutathionylation during oxidative stress in the nucleus...
  19. ncbi Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis
    Y Chen
    Program of Biochemistry, Cell Biology and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Appl Pharmacol 170:172-80. 2001
    ..These results support the interpretation that mitochondrial release of cyt c and cyt c-dependent activation of caspase-3 could have a central role in nephrotoxicity due to haloalkene-derived cysteine S-conjugates...
  20. ncbi Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state
    Young-Mi Go
    Department of Medicine, Divisions of Cardiology and Pulmonary, Emory University, Atlanta, GA 30322, USA
    Circulation 111:2973-80. 2005
    ..CONCLUSIONS: The extracellular thiol/disulfide E(h) of the Cys/CySS couple plays a key role in regulating early events of atherosclerosis and could be useful as a potential marker for vascular disease risk...
  21. ncbi Protective effect of the dimer of 16,16-diMePGB1 against KCN-induced mitochondrial failure in hepatocytes
    Y Park
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322
    Am J Physiol 263:C405-11. 1992
    ..These results demonstrate that dicalciphor protects against KCN-induced damage and that this protection is associated with regulation of specific mitochondrial ion transport functions...
  22. ncbi Control of extracellular cysteine/cystine redox state by HT-29 cells is independent of cellular glutathione
    Corinna L Anderson
    Department of Medicine Pulmonary, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1069-75. 2007
    ..The results suggest that transport systems for Cys and CySS and/or membranal oxidoreductases could be more important than cellular GSH in regulation of extracellular Cys/CySS E(h)...
  23. ncbi Intestinal redox status of major intracellular thiols in a rat model of chronic alcohol consumption
    Junqiang Tian
    Nutrition and Health Science Program, Graduate School of Arts and Science, Emory University, Atlanta, Georgia, USA
    JPEN J Parenter Enteral Nutr 33:662-8. 2009
    ..In this study, we investigated the redox status of 2 major intracellular redox regulating couples: glutathione (GSH)/glutathione disulfide (GSSG) and cysteine (Cys)/cystine (CySS) in a rat model of chronic alcohol ingestion...
  24. ncbi Oxidative damage and protection of the RPE
    J Cai
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Prog Retin Eye Res 19:205-21. 2000
    ..These results indicate that therapeutic or nutritional intervention to enhance the GSH antioxidant capacity of RPE may provide an effective way to prevent or treat AMD...
  25. ncbi Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
    Jason M Hansen
    Department of Medicine and Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Toxicol Sci 82:308-17. 2004
    ..In contrast, the ARE reporter was principally controlled by nuclear-targeted Trx-1 and not by GSH. The data show that the GSH and TRX systems have unique, compartmented functions in the control of transcriptional regulation by Nrf-2/ARE...
  26. ncbi Characterization of apical and basal thiol-disulfide redox regulation in human colonic epithelial cells
    Yanci O Mannery
    Dept of Medicine, Emory Univ, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 299:G523-30. 2010
    ....
  27. ncbi Extracellular thiol/disulfide redox state affects proliferation rate in a human colon carcinoma (Caco2) cell line
    Carolyn R Jonas
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA
    Free Radic Biol Med 33:1499-506. 2002
    ..The results show that extracellular thiol/disulfide redox state modulates cell proliferation rate and that this control interacts with growth factor signaling apparently independently of cellular glutathione...
  28. ncbi Diurnal variation in glutathione and cysteine redox states in human plasma
    Roberto A Blanco
    Division of Endocrinology, Metabolism and Lipids, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Clin Nutr 86:1016-23. 2007
    ..Animal studies show that both pools undergo diurnal variations associated with dietary intake of sulfur amino acids...
  29. ncbi Antioxidant supplements prevent oxidation of cysteine/cystine redox in patients with age-related macular degeneration
    Siobhan E Moriarty-Craige
    Department of Ophthalmology, Biochemistry, and Medicine, Emory University, Atlanta, Georgia, USA
    Am J Ophthalmol 140:1020-6. 2005
    ....
  30. ncbi Stimulation of colonic mucosal growth associated with oxidized redox status in rats
    Junqiang Tian
    General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1081-91. 2007
    ..The data also suggest that GSH is required to maintain normal colonic and plasma Cys/CySS homeostasis in these animal models...
  31. ncbi Mitochondrial thioredoxin in regulation of oxidant-induced cell death
    Yan Chen
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    FEBS Lett 580:6596-602. 2006
    ..The data indicate that the redox status of mtTrx is a regulatory mechanism underlying the vulnerability of mitochondria to oxidative injury...
  32. ncbi Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
    ..Results showed that only cytosolic Trx1 undergoes significant oxidation. Thus EGF signalling involves subcellular compartmental oxidation of Trx1 in the absence of a generalized cellular oxidation...
  33. ncbi Glutamine and KGF each regulate extracellular thiol/disulfide redox and enhance proliferation in Caco-2 cells
    Carolyn R Jonas
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1421-9. 2003
    ....
  34. ncbi Oxidation of extracellular cysteine/cystine redox state in bleomycin-induced lung fibrosis
    Smita S Iyer
    Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 296:L37-45. 2009
    ..Thus the data show that decreased precursor availability and enhanced oxidation of Cys each contribute to the oxidation of extracellular Cys/CySS redox state in bleomycin-induced lung fibrosis...
  35. ncbi Dietary sulfur amino acid supplementation reduces small bowel thiol/disulfide redox state and stimulates ileal mucosal growth after massive small bowel resection in rats
    Yvonne Shyntum
    Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta GA 30322, USA
    J Nutr 139:2272-8. 2009
    ..These data suggest that SAA supplementation has a trophic effect on ileal adaptation after massive small bowel resection in rats. This finding may have translational relevance as a therapeutic strategy in human SBS...
  36. ncbi Oxidative stress markers are associated with persistent atrial fibrillation
    Robert B Neuman
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Clin Chem 53:1652-7. 2007
    ..We compared serum markers of oxidation and associated inflammation in individuals with or without AF...
  37. ncbi Glutamine prevents cytokine-induced apoptosis in human colonic epithelial cells
    Mary E Evans
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 133:3065-71. 2003
    ..These results show that Gln specifically protects intestinal epithelial cells against cytokine-induced apoptosis, and that this occurs by a mechanism that is distinct from the protection against oxidative stress mediated by cellular GSH...
  38. ncbi Overexpressed human mitochondrial thioredoxin confers resistance to oxidant-induced apoptosis in human osteosarcoma cells
    Yan Chen
    Program of Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 277:33242-8. 2002
    ..Thus, human mtTrx is a member of the thioredoxin family of proteins localized to mitochondria and may play important roles in protection against oxidant-induced apoptosis...
  39. ncbi A model of redox kinetics implicates the thiol proteome in cellular hydrogen peroxide responses
    Nnenna J Adimora
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Antioxid Redox Signal 13:731-43. 2010
    ....
  40. ncbi Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion
    Young Mi Go
    Department of Medicine Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 171:1670-81. 2007
    ..Chemical modification of Trx1 by common environmental and endogenously generated reactive aldehydes can contribute to atherosclerosis development by interfering with antioxidant and redox signaling functions of Trx1...
  41. ncbi Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome
    Junqiang Tian
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 296:G348-55. 2009
    ..These indexes of gut barrier dysfunction are ameliorated or blunted by administration of dietary GLN or oral ABX, respectively. Dietary GLN upregulates small bowel sIgA in this model...
  42. ncbi Extracellular cysteine/cystine redox potential controls lung fibroblast proliferation and matrix expression through upregulation of transforming growth factor-beta
    Allan Ramirez
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 293:L972-81. 2007
    ..These studies suggest that extracellular oxidant stress activates redox-sensitive pathways that stimulate lung fibroblast proliferation and matrix expression through upregulation of TGF-beta1...
  43. ncbi Effects of long-term zinc supplementation on plasma thiol metabolites and redox status in patients with age-related macular degeneration
    Siobhan E Moriarty Craige
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Ophthalmol 143:206-211. 2007
    ..To determine the effects of zinc supplementation on plasma thiol metabolites and their redox status in a cohort of patients with age-related macular degeneration (AMD)...
  44. ncbi Oxidation of plasma cysteine/cystine redox state in endotoxin-induced lung injury
    Smita S Iyer
    Department of Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 40:90-8. 2009
    ..Taken together, the results indicate that enhanced oxidation of Cys, altered transport of Cys and CySS, and decreased food intake each contribute to the oxidation of plasma Cys/CySS redox state in endotoxemia...
  45. ncbi Reactive species and mitochondrial dysfunction: mechanistic significance of 4-hydroxynonenal
    JAMES R ROEDE
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, USA
    Environ Mol Mutagen 51:380-90. 2010
    ..Furthermore, application of improved mass spectrometry-based proteomic methods will lead to further understanding of the critical targets contributing to disease risk...
  46. ncbi Increased oxidant-induced apoptosis in cultured nondividing human retinal pigment epithelial cells
    Shunai Jiang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Invest Ophthalmol Vis Sci 43:2546-53. 2002
    ..These results suggest that an increase in FasL may contribute to the vulnerability of nondividing hRPE cells to oxidant-induced apoptosis...
  47. ncbi Glutathione and thioredoxin redox during differentiation in human colon epithelial (Caco-2) cells
    Yvonne S Nkabyo
    Department of Biochemistry, the Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 283:G1352-9. 2002
    ..Therefore, the measured 40-mV oxidation of the cellular GSH/GSSG couple or the 28-mV oxidation of the extracellular cysteine/cystine couple should be sufficient to function in signaling or regulation of differentiation in Caco-2 cells...
  48. ncbi Redox potential of GSH/GSSG couple: assay and biological significance
    Dean P Jones
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    Methods Enzymol 348:93-112. 2002
  49. ncbi Glutathione depletion enforces the mitochondrial permeability transition and causes cell death in Bcl-2 overexpressing HL60 cells
    Jeffrey S Armstrong
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322 3050, USA
    FASEB J 16:1263-5. 2002
    ..The results also suggest a new model for MPT in which the central pore protein ANT is regulated by adenine nucleotide and the activity of mitochondrial respiratory complex III...
  50. ncbi Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling
    Yvonne S Nkabyo
    Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 289:G70-8. 2005
    ....
  51. ncbi Oxidation of the glutathione/glutathione disulfide redox state is induced by cysteine deficiency in human colon carcinoma HT29 cells
    Lauren T Miller
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Nutr 132:2303-6. 2002
    ..If redox changes occur in vivo in association with variations in dietary Cys and its precursors, these changes could have important physiologic effects through altered redox signaling and control of cell proliferation and apoptosis...
  52. ncbi Protection of hepatocytes against death due to mitochondrial failure: effect of di-Calciphor on antimycin A-induced toxicity
    Y Park
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322
    Toxicol Appl Pharmacol 126:33-8. 1994
    ..In addition, the results suggest that the protection of the mitochondria involves preservation of mitochondrial ionic and osmotic stability and does not involve improved ATP supply...
  53. ncbi Protection of retinal pigment epithelial cells from oxidative damage by oltipraz, a cancer chemopreventive agent
    Kasey C Nelson
    Departments of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 43:3550-4. 2002
    ..Dietary supplementation with oltipraz or other dithiolethiones may help protect the hRPE against oxidant induced injury...
  54. ncbi Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction
    Erik R Kline
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine Atlanta VA Medical Center, Atlanta, GA 30033, USA
    Cardiovasc Toxicol 9:1-12. 2009
    ..Endothelial cells are more susceptible to AZT-induced toxicity than HepG2 cells, and AZT caused greater endothelial dysfunction than d4T because of its pro-oxidative effects...
  55. ncbi Association between adherence to the Mediterranean diet and oxidative stress
    Jun Dai
    Department of Medicine, Division of Cardiology, Emory Program in Cardiovascular Outcomes Research and Epidemiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Am J Clin Nutr 88:1364-70. 2008
    ..The cardioprotective property of the Mediterranean diet has been attributed to its antioxidant capacity, but direct investigation of this mechanism has been limited...
  56. ncbi Oxidant-induced apoptosis in human retinal pigment epithelial cells: dependence on extracellular redox state
    Shunai Jiang
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA
    Invest Ophthalmol Vis Sci 46:1054-61. 2005
    ....
  57. ncbi Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress
    Hong Zhang
    Department of Medicine, Emory University School of Medicine, Whitehead Biomedical Research Center, 615 Michael Street, Suite 205P, Atlanta, GA 30322, USA
    Arch Biochem Biophys 465:119-26. 2007
    ..The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions...
  58. ncbi Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration
    Erik R Kline
    Division of Pulmonary, Allergy and Critical Care Medicine, Free Radicals in Medicine Core, Emory University School of Medicine Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 294:H2792-804. 2008
    ..Restoring glutathione levels reverses HIV-1 protein-mediated effects on superoxide, NO, and vasorelaxation...
  59. ncbi Oxidative stress modulates PPAR gamma in vascular endothelial cells
    Carmelo Blanquicett
    Department of Medicine, Emory University, and Atlanta VA Medical Centers, Atlanta, GA 30033, USA
    Free Radic Biol Med 48:1618-25. 2010
    ....
  60. ncbi Thiol/disulfide redox status is oxidized in plasma and small intestinal and colonic mucosa of rats with inadequate sulfur amino acid intake
    Yvonne S Nkabyo
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    J Nutr 136:1242-8. 2006
    ..Thus, dietary SAA deficiency could contribute to the progression of disease by causing an oxidation of these components...
  61. ncbi Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress
    B Chandrasekharan
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Neurogastroenterol Motil 23:131-8, e26. 2011
    ..Gastrointestinal dysfunction is very common in diabetic patients. We assessed the changes in the colonic enteric nervous system using colectomy specimens and intestinal biopsies from diabetic subjects and age-matched controls...
  62. ncbi Extracellular thiols and thiol/disulfide redox in metabolism
    Siobhan E Moriarty-Craige
    Nutrition and Health Sciences Program, Emory University, Atlanta, Georgia 30322, USA
    Annu Rev Nutr 24:481-509. 2004
    ..Consequently, extracellular redox can have important influences on health status and disease states and thus could be a target for nutritional interventions...
  63. ncbi A rapid LC-FTMS method for the analysis of cysteine, cystine and cysteine/cystine steady-state redox potential in human plasma
    Jennifer M Johnson
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 30322, USA
    Clin Chim Acta 396:43-8. 2008
    ..The steady-state redox potential of the cysteine/cystine couple in human plasma provides a measure of oxidative stress, yet available assays are limited by either specificity or speed of assay...
  64. ncbi Inhibition of influenza infection by glutathione
    Jiyang Cai
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 34:928-36. 2003
    ..Oxidative stress or other conditions that deplete GSH in the epithelium of the oral, nasal, and upper airway may, therefore, enhance susceptibility to influenza infection...
  65. ncbi apLCMS--adaptive processing of high-resolution LC/MS data
    Tianwei Yu
    Department of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Bioinformatics 25:1930-6. 2009
    ..Significant challenges exist in the analysis of LC/MS data, including noise reduction, feature identification/ quantification, feature alignment and computation efficiency...
  66. ncbi A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 48:275-83. 2010
    ..Together, the data show that the proinflammatory effects of oxidized plasma E(h)CySS are due to a mitochondrial signaling pathway that is mediated through redox control of downstream effector proteins...
  67. ncbi Antioxidant micronutrients and biomarkers of oxidative stress and inflammation in colorectal adenoma patients: results from a randomized, controlled clinical trial
    Myfanwy H Hopkins
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Cancer Epidemiol Biomarkers Prev 19:850-8. 2010
    ....
  68. ncbi Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
    Thomas R Ziegler
    General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 294:R402-10. 2008
    ..We conclude that adults with PN-dependent SBS are systemically exposed to flagellin and LPS, presumably from the gut lumen. This likely regulates innate and adaptive immune responses to these specific bacterial products...
  69. ncbi Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis
    Jason M Hansen
    Division of Pulmonary, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 91:643-50. 2006
    ..These findings support the interpretation that mitochondrial-generated ROS is a principal component in TNF-alpha-induced effects and that Trx2 blocks TNF-alpha-induced ROS generation and downstream NF-kappaB activation and apoptosis...
  70. ncbi Prohibitin protects against oxidative stress in intestinal epithelial cells
    Arianne L Theiss
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    FASEB J 21:197-206. 2007
    ..Thus, strategies to modulate PHB levels may constitute a novel therapeutic approach for intestinal inflammatory diseases, wherein oxidative stress plays a critical role in tissue injury and inflammation...
  71. ncbi Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease
    Jerome L Abramson
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Briarcliff Complex, Atlanta, GA 30322, USA
    Atherosclerosis 178:115-21. 2005
    ..The causes of increased CRP, however, are not completely understood. Studies suggest that oxidative stress may have pro-inflammatory effects, but data on the relationship between oxidative stress and CRP in healthy persons is sparse...
  72. ncbi Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
    ..This can promotes thiol loss during states of increased glutathione oxidation. We investigated how MRP1 modulates blood pressure and vascular function during angiotensin II-induced hypertension...
  73. ncbi Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities
    Jason M Hansen
    Department of Pediatrics, Emory School of Medicine, Emory University, 2015 Uppergate Drive 350, Atlanta, GA 30322, USA
    Free Radic Biol Med 43:282-8. 2007
    ..Such spatial resolution and protein-specific redox differences imply that the balance of peroxide generation/metabolism in microcompartments provides an important specific component of redox signaling...
  74. ncbi Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species
    Amrita Kumar
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    EMBO J 26:4457-66. 2007
    ....
  75. ncbi Inflammation is related to coronary flow reserve detected by positron emission tomography in asymptomatic male twins
    Viola Vaccarino
    Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA
    J Am Coll Cardiol 57:1271-9. 2011
    ..This study sought to examine the relationship between inflammation and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR)...
  76. ncbi Regulation of glutathione redox status in lung and liver by conditioning regimens and keratinocyte growth factor in murine allogeneic bone marrow transplantation
    T R Ziegler
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Transplantation 72:1354-62. 2001
    ..Keratinocyte growth factor (KGF) ameliorates graft-versus-host disease (GVHD)-associated organ injury in murine BMT models...
  77. ncbi Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked
    J Yang
    Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Science 275:1129-32. 1997
    ..Overexpression of Bcl-2 prevented the efflux of cytochrome c from the mitochondria and the initiation of apoptosis. Thus, one possible role of Bcl-2 in prevention of apoptosis is to block cytochrome c release from mitochondria...
  78. ncbi Altered carbohydrate, lipid, and xenobiotic metabolism by liver from rats flown on Cosmos 1887
    A H Merrill
    Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322
    FASEB J 4:95-100. 1990
    ..These results support the earlier finding of differences in these parameters and suggest that altered hepatic function could be important during spaceflight and/or the postflight recovery period...
  79. ncbi Mitochondrial dysfunction during anoxia and acute cell injury
    D P Jones
    Department of Biochemistry, Emory University, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1271:29-33. 1995
    ....
  80. ncbi Oxidation of nuclear thioredoxin during oxidative stress
    Walter H Watson
    Emory University School of Medicine, Department of Biochemistry, 1510 Clifton Road, Atlanta, GA 30322, USA
    FEBS Lett 543:144-7. 2003
    ..Thus, the increase in nuclear Trx1 levels did not correspond to an increase in the overall reducing capacity of Trx1 in the nucleus...
  81. ncbi Protection against oxidant-induced apoptosis by mitochondrial thioredoxin in SH-SY5Y neuroblastoma cells
    Yan Chen
    The Vanderbilt Eye Institute, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Toxicol Appl Pharmacol 216:256-62. 2006
    ..These data indicate that mtTrx controls the mitochondrial redox status independently of GSH and is a key component of the defensive mechanism against oxidative stress in cultured neuronal cells...
  82. ncbi Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
    Jason M Hansen
    Department of Medicine and Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:215-34. 2006
    ..The new methods are applicable to a broad range of experimental systems and their use will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants...
  83. ncbi Dietary supplementation with orotate and uracil increases adaptive growth of jejunal mucosa after massive small bowel resection in rats
    Mary E Evans
    Department of Medicine and the Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, GA 30322, USA
    JPEN J Parenter Enteral Nutr 29:315-20; discussion 320-1. 2005
    ..Dietary supplementation with orotate and uracil represents a novel nutrition approach to enhance small-bowel mucosal adaptive growth and absorptive capacity in SBS...
  84. ncbi The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, Kansas, USA
    J Am Coll Cardiol 47:1005-11. 2006
    ..This finding supports a role for oxidative stress in the pathogenesis of premature atherosclerosis, and its measurement may help in the early identification of asymptomatic subjects at risk of atherosclerotic disease...
  85. ncbi Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions
    Jason M Hansen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, 615 Michael Street, 225 Whitehead Biomedical Research Building, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 40:138-45. 2006
    ....
  86. ncbi Glutamine inhibits cytokine-induced apoptosis in human colonic epithelial cells via the pyrimidine pathway
    Mary E Evans
    Department of Medicine, Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, GA, USA
    Am J Physiol Gastrointest Liver Physiol 289:G388-96. 2005
    ..Our data also demonstrate the novel antiapoptotic effects of pyrimidine bases and their precursor orotate in these human intestinal cells...
  87. ncbi Trophic and cytoprotective nutrition for intestinal adaptation, mucosal repair, and barrier function
    Thomas R Ziegler
    Department of Medicine, Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Nutr 23:229-61. 2003
    ..Results of these investigations should define new nutritional methods for trophic and cytoprotective effects on the intestine in conditions such as inflammatory bowel disease, malnutrition, and short bowel syndrome...
  88. ncbi The redox regulation of intermediary metabolism by a superoxide-aconitase rheostat
    Jeffrey S Armstrong
    Department of Biochemistry, Faculty of Medicine, National University of Singapore, Republic of Singapore
    Bioessays 26:894-900. 2004
    ..In this setting, the mitochondrial redox state influences metabolic decisions via a superoxide-aconitase rheostat...
  89. ncbi Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, USA
    Hypertension 52:80-5. 2008
    ....
  90. ncbi Cysteine starvation activates the redox-dependent mitochondrial permeability transition in retinal pigment epithelial cells
    Jeffrey S Armstrong
    Department of Biochemistry, National University of Singapore, Singapore
    Invest Ophthalmol Vis Sci 45:4183-9. 2004
    ..CONCLUSIONS: These results show that cysteine is a required component for normal GSH metabolism and protection against oxidative stress in hRPE cells...
  91. ncbi HIV-1-induced pulmonary oxidative and nitrosative stress: exacerbated response to endotoxin administration in HIV-1 transgenic mouse model
    Barbara A Jacob
    Department of Pulmonary and Critical Care Medicine, Center for Clinical and Molecular Nutrition, Emory University School of Medicine, Veterans Affairs Medical Center, 1670 Clairmont Rd, Atlanta, GA 30033, USA
    Am J Physiol Lung Cell Mol Physiol 291:L811-9. 2006
    ..These results indicate that HIV-1 proteins may increase pulmonary complications subsequent to a secondary infection by altering the lung redox potential...
  92. ncbi Comparative effects of glucagon-like peptide-2 (GLP-2), growth hormone (GH), and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats
    Naohiro Washizawa
    Department of Surgery, Toho University School of Medicine, Tokyo, Japan
    JPEN J Parenter Enteral Nutr 28:399-409. 2004
    ..Future research should address the use of these agents in combination in short bowel syndrome...
  93. ncbi Redox potential of human thioredoxin 1 and identification of a second dithiol/disulfide motif
    Walter H Watson
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 278:33408-15. 2003
    ....
  94. ncbi Local glutathione redox status does not regulate ileal mucosal growth after massive small bowel resection in rats
    Junqiang Tian
    Nutrition and Health Science Program, Graduate School of Arts and Sciences, Emory University, Atlanta, GA 30322, USA
    J Nutr 137:320-5. 2007
    ..Collectively, our in vivo data show that marked depletion of ileal GSH and oxidation of the GSH redox pool does not alter indices of ileal epithelial proliferation or SBR-induced ileal mucosal adaptive growth...
  95. ncbi Oxidation of glutathione and cysteine in human plasma associated with smoking
    Siobhan E Moriarty
    Department of Biochemistry, Vanderbilt School of Medicine, Nashville, TN, USA
    Free Radic Biol Med 35:1582-8. 2003
    ....
  96. ncbi The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III
    Jeffrey S Armstrong
    Department of Biochemistry, National University of Singapore, Singapore 117597, Singapore
    J Biol Chem 278:49079-84. 2003
    ....

Research Grants23

  1. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2007
    ..Aims 1 and 2 will substantially add to basic knowledge of human mtTrx and Aims 3 and 4 will define whether mtTrx has a central function in protection against chemical-induced toxicity. ..
  2. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2007
    ....
  3. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2009
    ....
  4. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2010
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  5. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean P Jones; Fiscal Year: 2010
    ....
  6. Thioredoxin-2 protection against mitochondrial oxidative toxicity
    Dean P Jones; Fiscal Year: 2011
    ..This is of considerable importance because therapeutic agents which eliminate reactive species could also disrupt normal signaling. ..
  7. Metabolic effects of chemical interactions in toxicity
    Dean Jones; Fiscal Year: 2005
    ....
  8. Nuclear and Cytoplasmic Redox in Oxidative Stress
    Dean Jones; Fiscal Year: 2005
    ....
  9. Metabolic analysis in human sulfur amino acid deficiency
    Dean Jones; Fiscal Year: 2005
    ..g., 300 samples/day with a flow cell), results will show whether this approach could be useful for nutritional assessment of complex metabolic effects of SAA intake. ..
  10. MITOCHONDRIA IN CHEMICAL-INDUCED APOPTOSIS
    Dean Jones; Fiscal Year: 2001
    ..These studies will clarify the role of mitochondria in chemical-induced cell death and provide important new information concerning the mechanistic basis for apoptotic cell death induced by mitochondrial toxicants. ..
  11. A metabolomic model of aging in the common marmoset
    DANIEL EDWARD LEE PROMISLOW; Fiscal Year: 2010
    ..The acquired knowledge has the potential to explain causes of variation in traits of aging within individuals and also differences in aging among individuals in human populations. ..