Peng Jin

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 16:2326-32. 2007
  2. doi request reprint Fragile X mental retardation protein and stem cells
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Results Probl Cell Differ 54:157-64. 2012
  3. pmc Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome
    Peng Jin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 55:556-64. 2007
  4. pmc Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeats
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Genet 7:e1002102. 2011
  5. pmc Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
    Zihui Xu
    Department of Human Genetics, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 110:7778-83. 2013
  6. pmc Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum
    Tao Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 21:5500-10. 2012
  7. pmc Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
    Taro Hitosugi
    Department of Haematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 4:1790. 2013
  8. pmc Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency
    Tao Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Cell Biol 15:700-11. 2013
  9. ncbi request reprint Fragile X protein functions with lgl and the par complex in flies and mice
    Daniela C Zarnescu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Cell 8:43-52. 2005
  10. ncbi request reprint Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
    Peng Jin
    Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA
    Nat Neurosci 7:113-7. 2004

Collaborators

Detail Information

Publications53

  1. ncbi request reprint Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeat
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Hum Mol Genet 16:2326-32. 2007
    ..These data support the concept that RNA toxicity is the mechanism of neuronal toxicity and suggests potential reversal of RNA-mediated phenotypes with complementary RNA molecules...
  2. doi request reprint Fragile X mental retardation protein and stem cells
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Results Probl Cell Differ 54:157-64. 2012
    ..Recently, the role of Fmrp in stem cell biology has been explored in both Drosophila and the mouse. In this chapter, we discuss the role of FMRP in regulating the proliferation and differentiation of stem cells...
  3. pmc Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndrome
    Peng Jin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 55:556-64. 2007
    ..These findings support the disease mechanism of FXTAS of rCGG repeat sequestration of specific RBPs, leading to neuronal cell death, and implicate that Pur alpha plays an important role in the pathogenesis of FXTAS...
  4. pmc Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeats
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Genet 7:e1002102. 2011
    ..Together these findings suggest that abnormal nuclear accumulation of these mRNAs, likely as a result of impaired nuclear export, could contribute to FXTAS pathogenesis...
  5. pmc Expanded GGGGCC repeat RNA associated with amyotrophic lateral sclerosis and frontotemporal dementia causes neurodegeneration
    Zihui Xu
    Department of Human Genetics, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 110:7778-83. 2013
    ..Taken together, these findings suggest that the expanded rGGGGCC repeats could cause neurodegeneration, and that Pur α may play a role in the pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia...
  6. pmc Genome-wide DNA hydroxymethylation changes are associated with neurodevelopmental genes in the developing human cerebellum
    Tao Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 21:5500-10. 2012
    ..Accession number: Sequencing data have been deposited to GEO with accession number GSE40539...
  7. pmc Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation
    Taro Hitosugi
    Department of Haematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Commun 4:1790. 2013
    ....
  8. pmc Subtelomeric hotspots of aberrant 5-hydroxymethylcytosine-mediated epigenetic modifications during reprogramming to pluripotency
    Tao Wang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Cell Biol 15:700-11. 2013
    ..Our results suggest that TET1-mediated 5hmC modification could contribute to the epigenetic variation of iPSCs and iPSC-hESC differences...
  9. ncbi request reprint Fragile X protein functions with lgl and the par complex in flies and mice
    Daniela C Zarnescu
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dev Cell 8:43-52. 2005
    ..Our data suggest that Lgl may regulate Fmrp/mRNA sorting, transport, and anchoring via the PAR complex...
  10. ncbi request reprint Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathway
    Peng Jin
    Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA
    Nat Neurosci 7:113-7. 2004
    ..Our results suggest that FMRP may regulate neuronal translation via microRNAs and links microRNAs with human disease...
  11. ncbi request reprint RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
    Peng Jin
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Neuron 39:739-47. 2003
    ..These results demonstrate that neurodegenerative phenotype associated with fragile X premutation is indeed caused by the lengthened rCGG repeats and provide the first in vivo experimental demonstration of RNA-mediated neurodegeneration...
  12. pmc Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Metab 15:895-904. 2012
    ..Our findings reveal a role of iron homeostasis in the regulation of miRNA biogenesis...
  13. pmc 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging
    Keith E Szulwach
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Neurosci 14:1607-16. 2011
    ..These data suggest that 5-hmC-mediated epigenetic modification is critical in neurodevelopment and diseases...
  14. pmc Stable isotope labeling with amino acids in Drosophila for quantifying proteins and modifications
    Ping Xu
    Department of Human Genetics, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Proteome Res 11:4403-12. 2012
    ..Together, the data demonstrate the application of the SILAC principle in D. melanogaster, facilitating the integration of powerful fly genomics with emerging proteomics...
  15. pmc MicroRNA-277 modulates the neurodegeneration caused by Fragile X premutation rCGG repeats
    Huiping Tan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS Genet 8:e1002681. 2012
    ....
  16. pmc A small molecule enhances RNA interference and promotes microRNA processing
    Ge Shan
    Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
    Nat Biotechnol 26:933-40. 2008
    ..Our results provide a proof-of-principle demonstration that small molecules can be used to modulate the activity of the RNAi pathway. RNAi enhancers may be useful in the development of research tools and therapeutics...
  17. doi request reprint Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila
    Shuang Chang
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street Suite 300, Atlanta, Georgia 30322, USA
    Nat Chem Biol 4:256-63. 2008
    ..These results point to potential therapeutic approaches for treating fragile X syndrome...
  18. pmc Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in Drosophila
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 21:2068-75. 2012
    ..Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA(2) as a possible therapeutic target to treat FXTAS...
  19. pmc Cross talk between microRNA and epigenetic regulation in adult neurogenesis
    Keith E Szulwach
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 189:127-41. 2010
    ..Coexpression of Ezh2 can rescue phenotypes associated with miR-137 overexpression. These results demonstrate that cross talk between miRNA and epigenetic regulation contributes to the modulation of adult neurogenesis...
  20. pmc RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndrome
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
    Brain Res 1462:112-7. 2012
    ..In this review, we will discuss the recent progress towards understanding the molecular basis of RNA-mediated neurodegeneration in FXTAS. This article is part of a Special Issue entitled: RNA-Binding Proteins...
  21. ncbi request reprint Integrating DNA methylation dynamics into a framework for understanding epigenetic codes
    Keith E Szulwach
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
    Bioessays 36:107-17. 2014
    ....
  22. pmc SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's disease
    Yi Hong
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 32:17262-72. 2012
    ..Therefore, our study suggests SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD...
  23. ncbi request reprint Fragile X mental retardation protein modulates the fate of germline stem cells in Drosophila
    Lele Yang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Hum Mol Genet 16:1814-20. 2007
    ..Thus dFmr1 could modulate the fate of GSCs, likely via the miRNA pathway. Our results provide the first evidence that FMRP might be involved in the regulation of adult stem cells...
  24. ncbi request reprint Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA
    Ranhui Duan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 16:1124-31. 2007
    ..Thus, our study reveals an additional structural requirement for pri-miRNA processing and emphasizes the importance of identifying new miRNA SNPs and their contributions to miRNA biogenesis and human genetic disease...
  25. ncbi request reprint RNA and microRNAs in fragile X mental retardation
    Peng Jin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Cell Biol 6:1048-53. 2004
    ..FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general...
  26. ncbi request reprint Toward pluripotency by reprogramming: mechanisms and application
    Tao Wang
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA Genetics and Molecular Biology Graduate Program, Emory University, Atlanta, GA 30322, USA
    Protein Cell 4:820-32. 2013
    ..Here we discuss the progress and current perspectives in the field. Research into the reprogramming process today will pave the way for great advances in regenerative medicine in the future...
  27. pmc Genome-wide alteration of 5-hydroxymethylcytosine in a mouse model of fragile X-associated tremor/ataxia syndrome
    Bing Yao
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 23:1095-107. 2014
    ..Taken together, our data strongly indicate a functional role for 5hmC-mediated epigenetic modulation in the etiology of FXTAS, possibly through the regulation of transcription. ..
  28. pmc Dynamics of DNA methylation in aging and Alzheimer's disease
    Hasan A Irier
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    DNA Cell Biol 31:S42-8. 2012
    ....
  29. pmc Emergence of chemical biology approaches to the RNAi/miRNA pathway
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Chem Biol 17:584-9. 2010
    ....
  30. doi request reprint Small RNA-mediated gene regulation in neurodevelopmental disorders
    Abrar Qurashi
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 12:154-61. 2010
    ..We also discuss an intriguing, albeit elusive area of study: the potential impact of newly discovered classes of small RNAs in the nervous system...
  31. ncbi request reprint Physiological identification of human transcripts translationally regulated by a specific microRNA
    Mika Nakamoto
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 14:3813-21. 2005
    ..These data suggest that the functional interaction between miRNAs and mRNA targets is more complex than previously realized and describe an approach to refine predictive algorithms...
  32. pmc Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cells
    Keith E Szulwach
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Genet 7:e1002154. 2011
    ..In addition, our results provide a detailed epigenomic map of 5-hmC from which to pursue future functional studies on the diverse regulatory roles associated with 5-hmC...
  33. ncbi request reprint Identification of messenger RNAs and microRNAs associated with fragile X mental retardation protein
    Ranhui Duan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    Methods Mol Biol 342:267-76. 2006
    ..In this chapter, we describe the protocol to identify the mRNAs and miRNAs associated with FMRP in vivo. The same method could also be applied to other RNA-binding proteins interacting with specific mRNAs or miRNAs...
  34. ncbi request reprint Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1
    Eun Ah Choe
    Department of Human Genetics, Center for Neurodegenerative Diseases, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:9503-12. 2007
    ..The data strongly support that the negative interplay between Mib1 and p35/CDK5 may integrate the activities of multiple pathways during neuronal development...
  35. pmc Small regulatory RNAs in neurodevelopmental disorders
    Shuang Chang
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 18:R18-26. 2009
    ..Here, we will review recent progress made toward understanding roles of small regulatory RNAs in neurodevelopmental disorders and discuss the potential involvement of newly discovered classes of small RNAs in these disorders...
  36. pmc Probing the microRNA pathway with small molecules
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Bioorg Med Chem 21:6119-23. 2013
    ..Herein we highlight the high-throughput reporter assays developed in recent years and the resulting discovery of miRNA/RNAi enhancers and inhibitors. ..
  37. pmc Cytosine modifications in neurodevelopment and diseases
    Bing Yao
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA, 30322, USA
    Cell Mol Life Sci 71:405-18. 2014
    ..Here, we review the latest research into these cytosine modifications, focusing mainly on their roles in neurodevelopment and diseases. ..
  38. pmc Role of noncoding RNAs in trinucleotide repeat neurodegenerative disorders
    Huiping Tan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 235:469-75. 2012
    ....
  39. ncbi request reprint New insights into fragile X syndrome: from molecules to neurobehaviors
    Peng Jin
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Biochem Sci 28:152-8. 2003
    ....
  40. pmc Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:16329-34. 2007
    ..Thus, gambogic amide might not only establish a powerful platform for dissection of the physiological roles of NGF and TrkA receptor but also provide effective treatments for neurodegenerative diseases and stroke...
  41. doi request reprint Roles of small regulatory RNAs in determining neuronal identity
    Xuekun Li
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia 30322, USA
    Nat Rev Neurosci 11:329-38. 2010
    ..These new observations suggest that small regulatory RNAs could function at many levels to regulate self-renewal of neural stem cells and neuronal fate specification, implicating small regulatory RNAs in the complexity of neurogenesis...
  42. doi request reprint Macro role(s) of microRNAs in fragile X syndrome?
    Xuekun Li
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia, 30322, USA
    Neuromolecular Med 11:200-7. 2009
    ..Here we review the current state of knowledge about the microRNA pathway in neural development and the emergence of possible roles for miRNAs in FXS...
  43. pmc The microRNA pathway and fragile X mental retardation protein
    Yujing Li
    Department of Human Genetics, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1779:702-5. 2008
    ..In addition, we go on to discuss how the miRNA pathway may be involved in mental retardation...
  44. pmc Argonaute2 is essential for mammalian gastrulation and proper mesoderm formation
    Reid S Alisch
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Genet 3:e227. 2007
    ....
  45. pmc RNA-mediated pathogenesis in fragile X-associated disorders
    Huiping Tan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
    Neurosci Lett 466:103-8. 2009
    ..Here we will review our current knowledge on the role(s) of noncoding RNAs in FXS and FXTAS, particularly the role of the microRNA pathway in FXS and the role of noncoding riboCGG (rCGG) repeat in FXTAS...
  46. pmc Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 22:585-600. 2012
    ....
  47. ncbi request reprint Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cell
    Benjamin D Mersey
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 14:3371-7. 2005
    ....
  48. pmc FXTAS: a bad RNA and a hope for a cure
    Ge Shan
    Emory University School of Medicine, Department of Human Genetics, Atlanta, GA 30322, USA
    Expert Opin Biol Ther 8:249-53. 2008
    ..Recently, proteins that bind specifically to rCGG repeats were identified. Progress in understanding the molecular pathogenesis of FXTAS, plus the availability of different animal models are discussed...
  49. pmc RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTAS
    Oyinkan A Sofola
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Neuron 55:565-71. 2007
    ..Furthermore, we show that hnRNP A2/B1 directly interacts with riboCGG repeats and that the CUGBP1 protein interacts with the riboCGG repeats via hnRNP A2/B1...
  50. pmc The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficits
    Andrea M Allan
    Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
    Hum Mol Genet 17:2047-57. 2008
    ..Understanding how the loss of Mbd1 could lead to autism-like behavioral phenotypes would reveal much-needed information about the molecular pathogenesis of autism...
  51. ncbi request reprint Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrow
    Xiaodan Jiang
    Neuromedical Institute, Zhujiang Hospital of Southern Medical University, 253 Gongye Road, Guangzhou, P R China
    Cell Mol Neurobiol 28:689-711. 2008
    ..The transplanted BMSCs-D-NSCs displayed neither toxicity nor neoplasia up to 6 months in vivo, but could play an important role in improving the symptoms of the animals with degenerative diseases like PD...
  52. pmc Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006
    Xinyu Zhao
    Department of Neuroscience, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Epigenetics 2:126-34. 2007
    ....
  53. ncbi request reprint Argonaute 1 regulates the fate of germline stem cells in Drosophila
    Lele Yang
    State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology
    Development 134:4265-72. 2007
    ..Given that AGO1 serves as a key component of the miRNA pathway, we propose that an AGO1-dependent miRNA pathway probably plays an instructive role in repressing GSC/cystoblast differentiation...