Research Topics
Genomes and Genes | Peng JinSummaryAffiliation: Emory University Country: USA Publications
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Publications
Argonaute-2-dependent rescue of a Drosophila model of FXTAS by FRAXE premutation repeatOyinkan A Sofola
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
Hum Mol Genet 16:2326-32. 2007..These data support the concept that RNA toxicity is the mechanism of neuronal toxicity and suggests potential reversal of RNA-mediated phenotypes with complementary RNA molecules...
Fragile X mental retardation protein and stem cellsAbrar Qurashi
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Results Probl Cell Differ 54:157-64. 2012..Recently, the role of Fmrp in stem cell biology has been explored in both Drosophila and the mouse. In this chapter, we discuss the role of FMRP in regulating the proliferation and differentiation of stem cells...
Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile X tremor/ataxia syndromePeng Jin
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuron 55:556-64. 2007..These findings support the disease mechanism of FXTAS of rCGG repeat sequestration of specific RBPs, leading to neuronal cell death, and implicate that Pur alpha plays an important role in the pathogenesis of FXTAS...- Nuclear accumulation of stress response mRNAs contributes to the neurodegeneration caused by Fragile X premutation rCGG repeatsAbrar Qurashi
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
PLoS Genet 7:e1002102. 2011..Together these findings suggest that abnormal nuclear accumulation of these mRNAs, likely as a result of impaired nuclear export, could contribute to FXTAS pathogenesis... - Fragile X protein functions with lgl and the par complex in flies and miceDaniela C Zarnescu
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
Dev Cell 8:43-52. 2005..Our data suggest that Lgl may regulate Fmrp/mRNA sorting, transport, and anchoring via the PAR complex... - RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in DrosophilaPeng Jin
Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
Neuron 39:739-47. 2003..These results demonstrate that neurodegenerative phenotype associated with fragile X premutation is indeed caused by the lengthened rCGG repeats and provide the first in vivo experimental demonstration of RNA-mediated neurodegeneration... - Biochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathwayPeng Jin
Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, Georgia 30322, USA
Nat Neurosci 7:113-7. 2004..Our results suggest that FMRP may regulate neuronal translation via microRNAs and links microRNAs with human disease... - Iron homeostasis regulates the activity of the microRNA pathway through poly(C)-binding protein 2Yujing Li
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Cell Metab 15:895-904. 2012..Our findings reveal a role of iron homeostasis in the regulation of miRNA biogenesis... - 5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and agingKeith E Szulwach
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
Nat Neurosci 14:1607-16. 2011..These data suggest that 5-hmC-mediated epigenetic modification is critical in neurodevelopment and diseases... - MicroRNA-277 modulates the neurodegeneration caused by Fragile X premutation rCGG repeatsHuiping Tan
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
PLoS Genet 8:e1002681. 2012.... - A small molecule enhances RNA interference and promotes microRNA processingGe Shan
Department of Human Genetics, Emory University School of Medicine, 615 Michael St, Atlanta, Georgia 30322, USA
Nat Biotechnol 26:933-40. 2008..Our results provide a proof-of-principle demonstration that small molecules can be used to modulate the activity of the RNAi pathway. RNAi enhancers may be useful in the development of research tools and therapeutics... - Chemical screen reveals small molecules suppressing fragile X premutation rCGG repeat-mediated neurodegeneration in DrosophilaAbrar Qurashi
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Mol Genet 21:2068-75. 2012..Our results demonstrate the utility of Drosophila models for unbiased small molecule screens and point to PLA(2) as a possible therapeutic target to treat FXTAS... - Cross talk between microRNA and epigenetic regulation in adult neurogenesisKeith E Szulwach
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
J Cell Biol 189:127-41. 2010..Coexpression of Ezh2 can rescue phenotypes associated with miR-137 overexpression. These results demonstrate that cross talk between miRNA and epigenetic regulation contributes to the modulation of adult neurogenesis... - RNA-mediated neurodegeneration in fragile X-associated tremor/ataxia syndromeYujing Li
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
Brain Res 1462:112-7. 2012..In this review, we will discuss the recent progress towards understanding the molecular basis of RNA-mediated neurodegeneration in FXTAS. This article is part of a Special Issue entitled: RNA-Binding Proteins... - Identification of small molecules rescuing fragile X syndrome phenotypes in DrosophilaShuang Chang
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street Suite 300, Atlanta, Georgia 30322, USA
Nat Chem Biol 4:256-63. 2008..These results point to potential therapeutic approaches for treating fragile X syndrome... - Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNARanhui Duan
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Mol Genet 16:1124-31. 2007..Thus, our study reveals an additional structural requirement for pri-miRNA processing and emphasizes the importance of identifying new miRNA SNPs and their contributions to miRNA biogenesis and human genetic disease... - RNA and microRNAs in fragile X mental retardationPeng Jin
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Nat Cell Biol 6:1048-53. 2004..FMRP was also recently linked to the microRNA pathway. These advances provide mechanistic insight into this disorder, and into learning and memory in general... - Fragile X mental retardation protein modulates the fate of germline stem cells in DrosophilaLele Yang
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
Hum Mol Genet 16:1814-20. 2007..Thus dFmr1 could modulate the fate of GSCs, likely via the miRNA pathway. Our results provide the first evidence that FMRP might be involved in the regulation of adult stem cells... - Dynamics of DNA methylation in aging and Alzheimer's diseaseHasan A Irier
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
DNA Cell Biol 31:S42-8. 2012.... - Stable isotope labeling with amino acids in Drosophila for quantifying proteins and modificationsPing Xu
Department of Human Genetics, Center for Neurodegenerative Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Proteome Res 11:4403-12. 2012..Together, the data demonstrate the application of the SILAC principle in D. melanogaster, facilitating the integration of powerful fly genomics with emerging proteomics... - Small regulatory RNAs in neurodevelopmental disordersShuang Chang
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Mol Genet 18:R18-26. 2009..Here, we will review recent progress made toward understanding roles of small regulatory RNAs in neurodevelopmental disorders and discuss the potential involvement of newly discovered classes of small RNAs in these disorders... - Identification of messenger RNAs and microRNAs associated with fragile X mental retardation proteinRanhui Duan
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
Methods Mol Biol 342:267-76. 2006..In this chapter, we describe the protocol to identify the mRNAs and miRNAs associated with FMRP in vivo. The same method could also be applied to other RNA-binding proteins interacting with specific mRNAs or miRNAs... - Small RNA-mediated gene regulation in neurodevelopmental disordersAbrar Qurashi
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Curr Psychiatry Rep 12:154-61. 2010..We also discuss an intriguing, albeit elusive area of study: the potential impact of newly discovered classes of small RNAs in the nervous system... - Neuronal morphogenesis is regulated by the interplay between cyclin-dependent kinase 5 and the ubiquitin ligase mind bomb 1Eun Ah Choe
Department of Human Genetics, Center for Neurodegenerative Diseases, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 27:9503-12. 2007..The data strongly support that the negative interplay between Mib1 and p35/CDK5 may integrate the activities of multiple pathways during neuronal development... - Emergence of chemical biology approaches to the RNAi/miRNA pathwayYujing Li
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Chem Biol 17:584-9. 2010.... - Physiological identification of human transcripts translationally regulated by a specific microRNAMika Nakamoto
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Mol Genet 14:3813-21. 2005..These data suggest that the functional interaction between miRNAs and mRNA targets is more complex than previously realized and describe an approach to refine predictive algorithms... - Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cellsKeith E Szulwach
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS Genet 7:e1002154. 2011..In addition, our results provide a detailed epigenomic map of 5-hmC from which to pursue future functional studies on the diverse regulatory roles associated with 5-hmC... - Role of noncoding RNAs in trinucleotide repeat neurodegenerative disordersHuiping Tan
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Exp Neurol 235:469-75. 2012.... - Roles of small regulatory RNAs in determining neuronal identityXuekun Li
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia 30322, USA
Nat Rev Neurosci 11:329-38. 2010..These new observations suggest that small regulatory RNAs could function at many levels to regulate self-renewal of neural stem cells and neuronal fate specification, implicating small regulatory RNAs in the complexity of neurogenesis... - The microRNA pathway and fragile X mental retardation proteinYujing Li
Department of Human Genetics, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Suite 301, Atlanta, GA 30322, USA
Biochim Biophys Acta 1779:702-5. 2008..In addition, we go on to discuss how the miRNA pathway may be involved in mental retardation... - Argonaute2 is essential for mammalian gastrulation and proper mesoderm formationReid S Alisch
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, United States of America
PLoS Genet 3:e227. 2007.... - Macro role(s) of microRNAs in fragile X syndrome?Xuekun Li
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Suite 301, Atlanta, Georgia, 30322, USA
Neuromolecular Med 11:200-7. 2009..Here we review the current state of knowledge about the microRNA pathway in neural development and the emergence of possible roles for miRNAs in FXS... - Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell deathSung Wuk Jang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:16329-34. 2007..Thus, gambogic amide might not only establish a powerful platform for dissection of the physiological roles of NGF and TrkA receptor but also provide effective treatments for neurodegenerative diseases and stroke... - New insights into fragile X syndrome: from molecules to neurobehaviorsPeng Jin
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Trends Biochem Sci 28:152-8. 2003.... - RNA-mediated pathogenesis in fragile X-associated disordersHuiping Tan
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
Neurosci Lett 466:103-8. 2009..Here we will review our current knowledge on the role(s) of noncoding RNAs in FXS and FXTAS, particularly the role of the microRNA pathway in FXS and the role of noncoding riboCGG (rCGG) repeat in FXTAS... - SRPK2 phosphorylates tau and mediates the cognitive defects in Alzheimer's diseaseYi Hong
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 32:17262-72. 2012..Therefore, our study suggests SRPK2 may contribute to the formation of hyperphosphorylated tau and the pathogenesis of AD... - Human microRNA (miR29b) expression controls the amount of branched chain alpha-ketoacid dehydrogenase complex in a cellBenjamin D Mersey
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Hum Mol Genet 14:3371-7. 2005.... - FXTAS: a bad RNA and a hope for a cureGe Shan
Emory University School of Medicine, Department of Human Genetics, Atlanta, GA 30322, USA
Expert Opin Biol Ther 8:249-53. 2008..Recently, proteins that bind specifically to rCGG repeats were identified. Progress in understanding the molecular pathogenesis of FXTAS, plus the availability of different animal models are discussed... - RNA-binding proteins hnRNP A2/B1 and CUGBP1 suppress fragile X CGG premutation repeat-induced neurodegeneration in a Drosophila model of FXTASOyinkan A Sofola
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
Neuron 55:565-71. 2007..Furthermore, we show that hnRNP A2/B1 directly interacts with riboCGG repeats and that the CUGBP1 protein interacts with the riboCGG repeats via hnRNP A2/B1... - Epigenetics and Neural developmental disorders: Washington DC, September 18 and 19, 2006Xinyu Zhao
Department of Neuroscience, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
Epigenetics 2:126-34. 2007.... - The loss of methyl-CpG binding protein 1 leads to autism-like behavioral deficitsAndrea M Allan
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA
Hum Mol Genet 17:2047-57. 2008..Understanding how the loss of Mbd1 could lead to autism-like behavioral phenotypes would reveal much-needed information about the molecular pathogenesis of autism... - Argonaute 1 regulates the fate of germline stem cells in DrosophilaLele Yang
State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology
Development 134:4265-72. 2007..Given that AGO1 serves as a key component of the miRNA pathway, we propose that an AGO1-dependent miRNA pathway probably plays an instructive role in repressing GSC/cystoblast differentiation... - Experimental study on trace marking and oncogenicity of neural stem cells derived from bone marrowXiaodan Jiang
Neuromedical Institute, Zhujiang Hospital of Southern Medical University, 253 Gongye Road, Guangzhou, P R China
Cell Mol Neurobiol 28:689-711. 2008..The transplanted BMSCs-D-NSCs displayed neither toxicity nor neoplasia up to 6 months in vivo, but could play an important role in improving the symptoms of the animals with degenerative diseases like PD...