Research Topics
| T A JacobsonSummaryAffiliation: Emory University Country: USA Publications
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Publications
A new pure ω-3 eicosapentaenoic acid ethyl ester (AMR101) for the management of hypertriglyceridemia: the MARINE trialTerry A Jacobson
Department of Medicine, Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA, USA
Expert Rev Cardiovasc Ther 10:687-95. 2012..1% (p < 0.0001), and AMR101 2 g/day reduced TG levels by 19.7% (p = 0.0051). Changes in LDL-C were minimal and nonsignificant. AMR101 may offer substantial TG lowering without increases in LDL-C levels...
Effects of eicosapentaenoic acid and docosahexaenoic acid on low-density lipoprotein cholesterol and other lipids: a reviewTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Faculty Office Building, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
J Clin Lipidol 6:5-18. 2012....
Maximizing the cost-effectiveness of lipid-lowering therapyT A Jacobson
Department of Medicine, Emory University, Atlanta, GA 30303, USA
Arch Intern Med 158:1977-89. 1998....
Comparative pharmacokinetic interaction profiles of pravastatin, simvastatin, and atorvastatin when coadministered with cytochrome P450 inhibitorsTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Am J Cardiol 94:1140-6. 2004..Pravastatin has a neutral drug interaction profile relative to cytochrome P450-3A4 inhibitors, but these substrates markedly increase systemic exposure to simvastatin and atorvastatin...
Role of n-3 fatty acids in the treatment of hypertriglyceridemia and cardiovascular diseaseTerry A Jacobson
Office of Health Promotion and Disease Prevention, The Department of Medicine, Emory University, Atlanta, GA 30303, USA
Am J Clin Nutr 87:1981S-90S. 2008..Future clinical trials need to determine whether the TG-lowering doses of n-3 FAs (3-4 g/d) result in additional risk reduction...
Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgiaTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University, Faculty Office Building, 49 Jessie Hill Jr Dr SE, Atlanta, GA 30303, USA
Mayo Clin Proc 83:687-700. 2008....
Fibrates in combination with statins in the management of dyslipidemiaTerry A Jacobson
Emory University School of Medicine, Atlanta, GA 30303, USA
J Clin Hypertens (Greenwich) 8:35-41; quiz 42-3. 2006..Combination therapy with a fibrate and a statin is a potentially useful therapy for patients with atherogenic lipid profiles, for which fenofibrate appears to be a more appropriate choice due to less myopathic potential...
Secondary prevention of coronary artery disease with omega-3 fatty acidsTerry A Jacobson
Department of Medicine, Office of Health Promotion and Disease Prevention, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Am J Cardiol 98:61i-70i. 2006..The totality of evidence supports a strong role for omega-3 fatty acids derived from fish oil in secondary prevention through a presumptive role as an antiarrhythmic agent and through an ability to promote plaque stabilization...
Beyond lipids: the role of omega-3 fatty acids from fish oil in the prevention of coronary heart diseaseTerry A Jacobson
Department of Medicine, Emory University, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Curr Atheroscler Rep 9:145-53. 2007..The totality of evidence suggests greater benefits with omega-3 fatty acids in secondary prevention than primary prevention and in populations consuming low amounts of omega-3 fatty acids...
Statin safety: lessons from new drug applications for marketed statinsTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University, Atlanta, Georgia 30303, USA
Am J Cardiol 97:44C-51C. 2006..Overall, currently marketed statins have a very favorable benefit-to-risk relation with respect to liver, muscle, and renal issues...
Hypertriglyceridemia and cardiovascular risk reductionTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA 30303, USA
Clin Ther 29:763-77. 2007..There is evidence that elevated TG levels may be a significant independent risk factor for coronary heart disease (CHD), particularly in women...
Overcoming 'ageism' bias in the treatment of hypercholesterolaemia : a review of safety issues with statins in the elderlyTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University School of Medicine, Atlanta, GA 30303, USA
Drug Saf 29:421-48. 2006....
Effects of a global risk educational tool on primary coronary prevention: the Atherosclerosis Assessment Via Total Risk (AVIATOR) studyTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University School of Medicine, Atlanta, GA 30303, USA
Curr Med Res Opin 22:1065-73. 2006..The aim of this study was to determine the effects of providing global risk scores to physicians on the prescription of lipid-lowering therapy for patients at increased coronary risk...
Safety considerations with gastrointestinally active lipid-lowering drugsTerry A Jacobson
Emory University, Office of Health Promotion and Disease Prevention, Atlanta, Georgia 30303, USA
Am J Cardiol 99:47C-55C. 2007..Overall, CAIs and BAS have excellent systemic safety profiles when used alone or in combination with other lipid-lowering drugs...
Comparison of cardiovascular event rates in patients without cardiovascular disease in whom atorvastatin or simvastatin was newly initiatedTerry A Jacobson
Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA 30303, USA
Mayo Clin Proc 83:1316-25. 2008..To compare cardiovascular (CV) event rates and risk in patients without previous CV disease in whom atorvastatin or simvastatin was newly initiated in a managed care setting...
Myopathy with statin-fibrate combination therapy: clinical considerationsTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Nat Rev Endocrinol 5:507-18. 2009..On the basis of currently available data, fenofibrate or fenofibric acid is the fibrate of choice when used in combination with a statin because each is, in theory, associated with a lower risk of myopathy than gemfibrozil...
The safety of aggressive statin therapy: how much can low-density lipoprotein cholesterol be lowered?Terry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Mayo Clin Proc 81:1225-31. 2006....
Use of a low-literacy patient education tool to enhance pneumococcal vaccination rates. A randomized controlled trialT A Jacobson
Department of Medicine, Emory University School of Medicine, Grady Health System, Atlanta, GA 30303, USA
JAMA 282:646-50. 1999..Limited or marginal literacy, which affects nearly 100 million Americans, especially the elderly, may contribute to these low rates of immunization...
"The lower the better" in hypercholesterolemia therapy: a reliable clinical guideline?T A Jacobson
Department of Medicine, Emory University, Atlanta, Georgia, USA
Ann Intern Med 133:549-54. 2000....
Combination lipid-altering therapy: an emerging treatment paradigm for the 21st centuryT A Jacobson
Department of Medicine, Emory University School of Medicine, Thomas K Glenn Memorial Bldg, 69 Butler St S E, Atlanta, GA 30303, USA
Curr Atheroscler Rep 3:373-82. 2001....
An assessment of obesity among African-American women in an inner city primary care clinicTerry A Jacobson
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
J Natl Med Assoc 94:1049-57. 2002..Counselors should emphasize the value and ease of adopting a moderate regimen of physical activity and not just reducing caloric intake when advising African-American women and their peer network...
Opening a new lipid "apo-thecary": incorporating apolipoproteins as potential risk factors and treatment targets to reduce cardiovascular riskTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University, Atlanta, GA 30303, USA
Mayo Clin Proc 86:762-80. 2011..In future consensus lipid-lowering treatment guidelines, Apo B should be considered as an index of residual risk, a potential parameter of treatment efficacy, and a treatment target to minimize risk of coronary heart disease...
'Trig-onometry': non-high-density lipoprotein cholesterol as a therapeutic target in dyslipidaemiaT A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Int J Clin Pract 65:82-101. 2011..g. combination regimens); and (iii) associations between such reductions and clinical, angiographic, and/or imaging end-points...
Combination lipid-lowering therapy with statins: safety issues in the postcerivastatin eraTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Expert Opin Drug Saf 2:269-86. 2003..These agents should be considered initially when contemplating combination lipid-lowering regimens for coronary prevention...
A "hot" topic in dyslipidemia management--"how to beat a flush": optimizing niacin tolerability to promote long-term treatment adherence and coronary disease preventionTerry A Jacobson
Office of Health Promotion and Disease Prevention, Department of Medicine, Emory University, Faculty Office Building, 49 Jessie Hill Jr Dr SE, Atlanta, GA 30303, USA
Mayo Clin Proc 85:365-79. 2010..Wider implementation of these measures should enable higher proportions of patients to reach sufficient niacin doses over time to prevent cardiovascular events...
Quality of care in African-American patients admitted for congestive heart failure at a university teaching hospitalNurcan Ilksoy
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Cardiol 97:690-3. 2006....
Clinical context: current concepts of coronary heart disease managementT A Jacobson
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Am J Med 110:3S-11S. 2001..Optimizing the cost-effectiveness of statin therapy is a particular concern to managed care organizations in light of the large number of patients who are now considered candidates for this treatment...
Managing dyslipidemia in chronic kidney diseaseCharles R Harper
Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
J Am Coll Cardiol 51:2375-84. 2008..After reviewing the safety and dose alterations required in managing dyslipidemia in patients with CKD, a practical treatment algorithm is proposed...
Characteristics of US adults with the metabolic syndrome and therapeutic implicationsT A Jacobson
Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Diabetes Obes Metab 6:353-62. 2004..Instead, high triglycerides and low HDL-C are more common; clinical trial data are needed to determine whether optimal therapy should focus on reductions in LDL-C or on comprehensive improvements to the lipid profile...
Evidence-based management of statin myopathyCharles R Harper
Department of Medicine, Emory University, 49 Jesse Hill Jr Drive SE, Atlanta, GA 30303, USA
Curr Atheroscler Rep 12:322-30. 2010..An algorithm is presented to assist the clinician in managing myopathy in patients with dyslipidemia...
Development and psychometric evaluation of the Self-efficacy for Appropriate Medication Use Scale (SEAMS) in low-literacy patients with chronic diseaseJessica Risser
Emory University School of Medicine, Atlanta, GA 30317, USA
J Nurs Meas 15:203-19. 2007..The SEAMS is a reliable and valid instrument that may provide a valuable assessment of medication self-efficacy in chronic disease management, and appears appropriate for use in patients with low literacy skills...
Low-literacy interventions to promote discussion of prostate cancer: a randomized controlled trialSunil Kripalani
Division of General Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
Am J Prev Med 33:83-90. 2007..However, few studies have tested strategies to encourage such discussions, particularly among high-risk populations. We examined the effects of two low-literacy interventions on the frequency of prostate cancer discussion and screening...
Therapeutic options to further lower C-reactive protein for patients on statin treatmentParag H Joshi
Department of Medicine, Emory University, 69 Jesse Hill Jr Drive, Atlanta, GA 30303, USA
Curr Atheroscler Rep 12:34-42. 2010..Until these trials are completed, current evidence suggests focusing on low-density lipoprotein cholesterol targets...
The broad spectrum of statin myopathy: from myalgia to rhabdomyolysisCharles R Harper
Office of Health Promotion and Disease Prevention, Emory University Department of Medicine, Atlanta, Georgia 30303, USA
Curr Opin Lipidol 18:401-8. 2007..The diagnosis and management of patients with statin-induced myopathy will be reviewed...
Development of an illustrated medication schedule as a low-literacy patient education toolSunil Kripalani
Division of General Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
Patient Educ Couns 66:368-77. 2007..This article describes the development, implementation, and preliminary evaluation of an illustrated medication schedule (a "pill card") that depicts a patient's daily medication regimen using pill images and icons...
Flaxseed oil supplementation does not affect plasma lipoprotein concentration or particle size in human subjectsCharles R Harper
Department of Medicine, Emory University, Atlanta, GA 30303, USA
J Nutr 136:2844-8. 2006..058) and LDL2 (P = 0.083) subfractions tended to be greater in the ALA group. In conclusion, ALA does not decrease CVD risk by altering lipoprotein particle size or plasma lipoprotein concentrations...
Comparison of African-American patients with systolic heart failure versus preserved ejection fractionNurcan Ilksoy
Emory University School of Medicine, Department of Medicine, Atlanta, Georgia, USA
Am J Cardiol 98:806-8. 2006..08) or diuretics (58% vs 82.%, p = 0.03). In conclusion, differences exist in African-American patients who present with HF; optimal therapeutic approaches will require a better understanding of their underlying pathophysiology...
Beyond the Mediterranean diet: the role of omega-3 Fatty acids in the prevention of coronary heart diseaseCharles R Harper
Department of Medicine, Emory University, Atlanta, GA 30303, USA
Prev Cardiol 6:136-46. 2003..Fish is an important source of the n-3 PUFA in the US diet; however, vegetable sources including grains and oils offer an alternative source for those who are unable to regularly consume fish...
Cardiovascular disease prevention counseling in residency: resident and attending physician attitudes and practicesJudith I Tsui
Division of General Medicine, Emory University School of Medicine, Atlanta, GA, USA
J Natl Med Assoc 96:1080-3, 1088-91. 2004..This study seeks to establish resident and attending physician attitudes and practice patterns with regard to cardiovascular disease (CVD) preventive counseling within a teaching hospital setting...
Predictors of medication self-management skill in a low-literacy populationSunil Kripalani
Division of General Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
J Gen Intern Med 21:852-6. 2006..Patients' ability to manage medications is critical to chronic disease control. Also known as medication management capacity (MMC), it includes the ability to correctly identify medications and describe how they should be taken...
Prostate cancer screening in a low-literacy population: does informed decision making occur?Sunil Kripalani
Emory University School of Medicine, Atlanta, GA 30303, USA
Cancer Control 12:116-7. 2005
Health care providers' training, perceptions, and practices regarding stress and health outcomesHolly Avey
Grady Health System, Office of Health Promotion, 80 Jesse Hill Jr Drive SE, P O Box 26101, Atlanta, GA 30303, USA
J Natl Med Assoc 95:833, 836-45. 2003..There is a need for curriculum reform that emphasizes new knowledge about stress and disease, new skills in stress reduction, and more positive beliefs about mind/body medicine and its integration into the existing health care structure...
Flaxseed oil increases the plasma concentrations of cardioprotective (n-3) fatty acids in humansCharles R Harper
Department of Medicine, Office of Health Promotion and Disease Prevention, Emory University, Atlanta, GA, USA
J Nutr 136:83-7. 2006..This study demonstrates the efficacy of the conversion of ALA to EPA and DPA in a minority population with chronic disease. ALA may be an alternative to fish oil; however, additional clinical trials with ALA are warranted...
The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart diseaseC R Harper
Department of Medicine, Emory University, Thomas Glenn Building, 69 Butler St SE, Atlanta, GA 30303, USA
Arch Intern Med 161:2185-92. 2001..Fish is an important source of omega-3 PUFAs in the US diet; however, vegetable sources, including grains and oils, offer an alternative source for those who are unable to regularly consume fish...
Effects of race on lipid-lowering management in hospitalized patients with coronary heart diseaseDaniel D Dressler
Department of Medicine, Division of General Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Cardiol 93:1167-70. 2004..3% vs 16.7%, p = 0.021). The disparity in the clinical management of black patients with CHD may help explain the differential in health outcomes seen between black and white patients...
Initiating statins in the elderly: the evolving challengeD Benson Walker
Department of Medicine, Emory University, Atlanta, Georgia 30303, USA
Curr Opin Endocrinol Diabetes Obes 15:182-7. 2008..Our review will focus on statins in primary prevention, newer assessment tools for risk stratification, and statin safety...
Missed opportunity in the treatment of hyperlipidemia in patients with coronary heart disease: the primary care settingMichael H Hoskins
Emory University, Atlanta, GA, USA
J Natl Med Assoc 98:58-62. 2006..The primary care outpatient setting may represent an ideal opportunity to improve control of hyperlipidemia in CHD patients...
Usefulness of omega-3 fatty acids and the prevention of coronary heart diseaseCharles R Harper
Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Cardiol 96:1521-9. 2005..The data on ALA have been limited by studies of smaller sample size and limited quality...
Patient literacy and question-asking behavior during the medical encounter: a mixed-methods analysisMarra G Katz
Emory University School of Medicine, Atlanta, Georgia 30303, USA
J Gen Intern Med 22:782-6. 2007..Patients' literacy level may affect their level of participation and question-asking behaviors...
Management of persons with high risk of coronary heart disease but low serum low-density lipoprotein cholesterolChristopher C Case
Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
Am J Cardiol 91:1134-6. 2003
Patient education strategies to improve pneumococcal vaccination rates: randomized trialDonna M Thomas
Department of Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
J Investig Med 51:141-8. 2003..We recommend that patient education initiatives to increase vaccination rates not focus solely on audiovisual media...
Chronic kidney disease and statins: improving cardiovascular outcomesD Benson Walker
Office of Health Promotion and Disease Prevention, Emory Faculty Office Building, Atlanta, GA 30303, USA
Curr Atheroscler Rep 11:301-8. 2009....
Risk for myopathy with statin therapy in high-risk patientsChristie M Ballantyne
Center for Cardiovascular Disease Prevention, Baylor College of Medicine, 6565 Fannin, Mail Station A601, Suite A656, Houston, TX 77030, USA
Arch Intern Med 163:553-64. 2003..Clinicians should be alert to the potential for drug-drug interactions to minimize the risk of myopathy during long-term statin therapy in patients at high risk for coronary heart disease...
Fluvastatin: clinical and safety profileAlberto Corsini
University of Milan, Milan, Italy
Drugs 64:1305-23. 2004..Taken together, these clinical outcomes and safety data suggest a strong benefit-to-risk profile for fluvastatin...
Clinical characterization and molecular mechanisms of statin myopathyPeter P Toth
Sterling Rock Falls Clinic, Ltd, 101 East Miller Road, Sterling, IL 61081, USA
Expert Rev Cardiovasc Ther 6:955-69. 2008....
Safety considerations with fibrate therapyMichael H Davidson
Rush University Medical Center, Chicago, Illinois, USA
Am J Cardiol 99:3C-18C. 2007....
Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task ForceJames M McKenney
National Clinical Research, Virginia Commonwealth University, Richmond, Virginia 23294, USA
Am J Cardiol 97:89C-94C. 2006..Practical guidance in the form of recommendations to health professionals who manage the coronary artery disease risk of patients with statin therapy is provided...
Statin safety: an assessment using an administrative claims databaseMark J Cziraky
HealthCore, Inc, Wilmington, Delaware 19801, USA
Am J Cardiol 97:61C-68C. 2006..No hospitalized cases of the index AEs were observed in study subjects during the 6-month period before initiation of the lipid-lowering drug. Statin monotherapy as currently prescribed is generally well tolerated and safe...
Effects of niacin on glucose control in patients with dyslipidemiaRonald B Goldberg
Lipid Disorders Clinic, Division of Endocrinology, Diabetes, and Metabolism, University of Miami Leonard M Miller School of Medicine, 1450 NW 10th Ave, Miami, FL 33136, USA
Mayo Clin Proc 83:470-8. 2008..Consensus guidelines recommend monitoring glycemic control after initiating niacin treatment or increasing its dosage...
Identifying and assisting low-literacy patients with medication use: a survey of community pharmaciesJessica L Praska
Department of Veterans Affairs, Pharmacy Service, Denver, CO 80220 3808, USA
Ann Pharmacother 39:1441-5. 2005..Low patient literacy is associated with poor medication adherence and health outcomes. However, little is known about how pharmacies address literacy-related needs among patrons...
Conclusions and recommendations from the symposium, Beyond Cholesterol: Prevention and Treatment of Coronary Heart Disease with n-3 Fatty AcidsRichard J Deckelbaum
Institute of Human Nutrition, Department of Pediatrics, Columbia University Medical Center, New York, NY 10032, USA
Am J Clin Nutr 87:2010S-2S. 2008..Additional references for these conclusions can be found in the articles included in the supplement...
Medication use among inner-city patients after hospital discharge: patient-reported barriers and solutionsSunil Kripalani
Division of General Internal Medicine and Public Health, Vanderbilt Center for Health Services Research, 1215 21st Ave S, Ste 6000 Medical Center East, Nashville, TN 37232, USA
Mayo Clin Proc 83:529-35. 2008..To better characterize medication-related problems among inner-city patients after hospital discharge and to suggest potential interventions...
Clinical research in low-literacy populations: using teach-back to assess comprehension of informed consent and privacy informationSunil Kripalani
Section of Hospital Medicine, Division of General Internal Medicine and Public Health, Vanderbilt University, Nashville, TN, USA
IRB 30:13-9. 2008
Cost-effectiveness of fluvastatin following successful first percutaneous coronary interventionThomas E Delea
Policy Analysis Inc PAI, Brookline, MA 02245 7629, USA
Ann Pharmacother 39:610-6. 2005..01) following successful first percutaneous coronary intervention (PCI) in patients with stable or unstable angina or silent ischemia. The cost-effectiveness of such therapy is unknown...
