T R Insel

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Neuropeptides and the evolution of social behavior
    T R Insel
    954 Gatewood Road NE, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Curr Opin Neurobiol 10:784-9. 2000
  2. ncbi request reprint The neurobiology of attachment
    T R Insel
    Center for Behavioral Neuroscience, 954 Gatewood Road Northeast, Emory University, Atlanta, Georgia 30329, USA
    Nat Rev Neurosci 2:129-36. 2001
  3. ncbi request reprint Oxytocin: who needs it?
    T R Insel
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
    Prog Brain Res 133:59-66. 2001
  4. ncbi request reprint A neurobiological basis of social attachment
    T R Insel
    Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 154:726-35. 1997
  5. ncbi request reprint Molecular aspects of monogamy
    T R Insel
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 807:302-16. 1997
  6. ncbi request reprint Gene targeting approaches to neuroendocrinology: oxytocin, maternal behavior, and affiliation
    L J Young
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Horm Behav 31:221-31. 1997
  7. ncbi request reprint Social amnesia in mice lacking the oxytocin gene
    J N Ferguson
    The Center for Behavioural Neuroscience, Department of Psychiatry and Behavioural Sciences and Yerkes Regional Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Genet 25:284-8. 2000
  8. ncbi request reprint Oxytocin in the medial amygdala is essential for social recognition in the mouse
    J N Ferguson
    Center for Behavioral Neuroscience and the Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 21:8278-85. 2001
  9. ncbi request reprint Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain
    M M Sanchez
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 408:365-77. 1999
  10. ncbi request reprint The social deficits of the oxytocin knockout mouse
    J T Winslow
    Center for Behavioral Neuroscience, Yerkes Regional Primate Center, Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Neuropeptides 36:221-9. 2002

Research Grants

  1. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 1999
  2. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 2000
  3. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 2001

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Neuropeptides and the evolution of social behavior
    T R Insel
    954 Gatewood Road NE, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
    Curr Opin Neurobiol 10:784-9. 2000
    ..Second, species variations in receptor gene structure can alter neuropeptide receptor distribution and thereby contribute to species differences in social behavior...
  2. ncbi request reprint The neurobiology of attachment
    T R Insel
    Center for Behavioral Neuroscience, 954 Gatewood Road Northeast, Emory University, Atlanta, Georgia 30329, USA
    Nat Rev Neurosci 2:129-36. 2001
    ..This review describes some of the important insights from this work...
  3. ncbi request reprint Oxytocin: who needs it?
    T R Insel
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
    Prog Brain Res 133:59-66. 2001
    ..Most important, in considering the behavioral or cognitive functions of oxytocin, one cannot accurately extrapolate across species unless one knows the species have the same neuroanatomical location of oxytocin receptors...
  4. ncbi request reprint A neurobiological basis of social attachment
    T R Insel
    Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA
    Am J Psychiatry 154:726-35. 1997
    ..The primary purpose of this article is to describe a novel approach to the neurobiology of attachment...
  5. ncbi request reprint Molecular aspects of monogamy
    T R Insel
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 807:302-16. 1997
    ..Acad. Sci USA 93: 12501). The correct sequence shows greater homology with the vole oxytocin receptor gene sequences, but the remaining differences support the argument made herein for species differences in regional receptor expression...
  6. ncbi request reprint Gene targeting approaches to neuroendocrinology: oxytocin, maternal behavior, and affiliation
    L J Young
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Horm Behav 31:221-31. 1997
    ..Analysis of the expression pattern suggests that it should be possible to manipulate receptor expression in the vole brain in order to examine the effects of receptor distribution on behavior...
  7. ncbi request reprint Social amnesia in mice lacking the oxytocin gene
    J N Ferguson
    The Center for Behavioural Neuroscience, Department of Psychiatry and Behavioural Sciences and Yerkes Regional Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Nat Genet 25:284-8. 2000
    ..Our data indicate that OT is necessary for the normal development of social memory in mice and support the hypothesis that social memory has a neural basis distinct from other forms of memory...
  8. ncbi request reprint Oxytocin in the medial amygdala is essential for social recognition in the mouse
    J N Ferguson
    Center for Behavioral Neuroscience and the Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 21:8278-85. 2001
    ..With site-specific injections of OT and an OT antagonist, we demonstrate that OT receptor activation in the medial amygdala is both necessary and sufficient for social recognition in the mouse...
  9. ncbi request reprint Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brain
    M M Sanchez
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 408:365-77. 1999
    ....
  10. ncbi request reprint The social deficits of the oxytocin knockout mouse
    J T Winslow
    Center for Behavioral Neuroscience, Yerkes Regional Primate Center, Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    Neuropeptides 36:221-9. 2002
    ..These studies may provide valuable new perspectives on diseases characterized by social deficits, such as autism or reactive attachment disorder...
  11. ncbi request reprint Species differences in vasopressin receptor binding are evident early in development: comparative anatomic studies in prairie and montane voles
    Z Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 378:535-46. 1997
    ....
  12. ncbi request reprint Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouse
    J T Winslow
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Horm Behav 37:145-55. 2000
    ..We conclude that the absence of exposure to OT during development was associated with abnormalities in the development of emotional behavior...
  13. ncbi request reprint Vasopressin in the forebrain of common marmosets (Callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiography
    Z Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 768:147-56. 1997
    ..Together, these data provide a comprehensive picture of AVP pathways in the marmoset brain, demonstrating differences from rodents in the distribution of cell bodies, fibers and receptors...
  14. ncbi request reprint Species differences in V1a receptor gene expression in monogamous and nonmonogamous voles: behavioral consequences
    L J Young
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Behav Neurosci 111:599-605. 1997
    ..Together, these data suggest that the phylogenetic plasticity of central neurohypophyseal peptide receptor expression may contribute to the evolution of species-typical social behaviors...
  15. ncbi request reprint Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous vole
    L J Young
    Department of Psychiatry and Behavioural Sciences, Emory University, Atlanta, Georgia 30322, USA
    Nature 400:766-8. 1999
    ..These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates...
  16. ncbi request reprint Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differences
    D D Francis
    Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA
    J Neuroendocrinol 14:349-53. 2002
    ..These findings suggest that variations in maternal care may influence the expression of oxytocin and vasopressin receptors in a gender-specific manner...
  17. ncbi request reprint Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous vole
    L J Pitkow
    Center for Behavioral Neuroscience and Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 21:7392-6. 2001
    ..These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization...
  18. ncbi request reprint Sexual and social experience is associated with different patterns of behavior and neural activation in male prairie voles
    Z Wang
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 767:321-32. 1997
    ..Finally, the MPO was activated at different magnitudes by social or sexual experience but did not respond to intruder-related cues as measured by Fos-ir...
  19. ncbi request reprint Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding?
    Z Wang
    Department of Psychiatry and Behavioral Sciences and Graduate Program in Neuroscience, Emory University, USA
    Behav Neurosci 113:602-11. 1999
    ..Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior...
  20. ncbi request reprint The primate neocortex in comparative perspective using magnetic resonance imaging
    J K Rilling
    Department of Anthropology and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
    J Hum Evol 37:191-223. 1999
    ..These modifications may constitute part of the neurobiological substrate that supports some of our species most distinctive cognitive abilities...
  21. ncbi request reprint Cellular mechanisms of social attachment
    L J Young
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Horm Behav 40:133-8. 2001
    ..Therefore, we hypothesize that oxytocin and vasopressin may be facilitating affiliation and social attachment in monogamous species by modulating these reward pathways...
  22. ncbi request reprint Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation
    M M Sanchez
    Department of Psychiatry and Behavioral Sciences, and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322
    J Neurosci 20:4657-68. 2000
    ..Alternatively, it is also possible that glucocorticoid effects are mediated through the MRs present in the hippocampal formation...
  23. ncbi request reprint Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys
    James T Winslow
    Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuropsychopharmacology 28:910-8. 2003
    ..These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation...
  24. ncbi request reprint Vaginocervical stimulation releases oxytocin within the spinal cord in rats
    Giorgio R Sansone
    Department of Psychology, Rutgers, The State University of New Jersey, Newark 07102, USA
    Neuroendocrinology 75:306-15. 2002
    ..The present findings provide evidence of a direct estrogen-dependent release of OT within the spinal cord in response to VS, presumably via descending oxytocinergic neurons...
  25. ncbi request reprint The neuroendocrine basis of social recognition
    Jennifer N Ferguson
    Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    Front Neuroendocrinol 23:200-24. 2002
    ..These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science...
  26. ncbi request reprint Is social attachment an addictive disorder?
    Thomas R Insel
    Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
    Physiol Behav 79:351-7. 2003
    ..The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit...
  27. ncbi request reprint Neuroendocrine basis of social recognition
    James T Winslow
    National Institute of Mental Health, National Institutes of Health Animal Center, Building 110, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Curr Opin Neurobiol 14:248-53. 2004
    ..Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation...
  28. ncbi request reprint How the brain processes social information: searching for the social brain
    Thomas R Insel
    National Institute of Mental Health, Bethesda, Maryland 20892, USA
    Annu Rev Neurosci 27:697-722. 2004
    ....

Research Grants5

  1. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 1999
    ....
  2. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 2000
    ....
  3. OXYTOCIN AND SOCIAL ATTACHMENT
    Thomas Insel; Fiscal Year: 2001
    ....