Research Topics
| T R InselSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Neuropeptides and the evolution of social behaviorT R Insel
954 Gatewood Road NE, Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30329, USA
Curr Opin Neurobiol 10:784-9. 2000..Second, species variations in receptor gene structure can alter neuropeptide receptor distribution and thereby contribute to species differences in social behavior...- The neurobiology of attachmentT R Insel
Center for Behavioral Neuroscience, 954 Gatewood Road Northeast, Emory University, Atlanta, Georgia 30329, USA
Nat Rev Neurosci 2:129-36. 2001..This review describes some of the important insights from this work... - Oxytocin: who needs it?T R Insel
Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30322, USA
Prog Brain Res 133:59-66. 2001..Most important, in considering the behavioral or cognitive functions of oxytocin, one cannot accurately extrapolate across species unless one knows the species have the same neuroanatomical location of oxytocin receptors... - A neurobiological basis of social attachmentT R Insel
Yerkes Primate Center, Emory University, Atlanta, GA 30322, USA
Am J Psychiatry 154:726-35. 1997..The primary purpose of this article is to describe a novel approach to the neurobiology of attachment... - Molecular aspects of monogamyT R Insel
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
Ann N Y Acad Sci 807:302-16. 1997..Acad. Sci USA 93: 12501). The correct sequence shows greater homology with the vole oxytocin receptor gene sequences, but the remaining differences support the argument made herein for species differences in regional receptor expression... - Gene targeting approaches to neuroendocrinology: oxytocin, maternal behavior, and affiliationL J Young
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Horm Behav 31:221-31. 1997..Analysis of the expression pattern suggests that it should be possible to manipulate receptor expression in the vole brain in order to examine the effects of receptor distribution on behavior... - Social amnesia in mice lacking the oxytocin geneJ N Ferguson
The Center for Behavioural Neuroscience, Department of Psychiatry and Behavioural Sciences and Yerkes Regional Primate Research Center, Emory University School of Medicine, Atlanta, Georgia, USA
Nat Genet 25:284-8. 2000..Our data indicate that OT is necessary for the normal development of social memory in mice and support the hypothesis that social memory has a neural basis distinct from other forms of memory... - Oxytocin in the medial amygdala is essential for social recognition in the mouseJ N Ferguson
Center for Behavioral Neuroscience and the Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 21:8278-85. 2001..With site-specific injections of OT and an OT antagonist, we demonstrate that OT receptor activation in the medial amygdala is both necessary and sufficient for social recognition in the mouse... - Autoradiographic and in situ hybridization localization of corticotropin-releasing factor 1 and 2 receptors in nonhuman primate brainM M Sanchez
Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
J Comp Neurol 408:365-77. 1999.... - The social deficits of the oxytocin knockout mouseJ T Winslow
Center for Behavioral Neuroscience, Yerkes Regional Primate Center, Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
Neuropeptides 36:221-9. 2002..These studies may provide valuable new perspectives on diseases characterized by social deficits, such as autism or reactive attachment disorder... - Species differences in vasopressin receptor binding are evident early in development: comparative anatomic studies in prairie and montane volesZ Wang
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Comp Neurol 378:535-46. 1997.... - Infant vocalization, adult aggression, and fear behavior of an oxytocin null mutant mouseJ T Winslow
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Horm Behav 37:145-55. 2000..We conclude that the absence of exposure to OT during development was associated with abnormalities in the development of emotional behavior... - Vasopressin in the forebrain of common marmosets (Callithrix jacchus): studies with in situ hybridization, immunocytochemistry and receptor autoradiographyZ Wang
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res 768:147-56. 1997..Together, these data provide a comprehensive picture of AVP pathways in the marmoset brain, demonstrating differences from rodents in the distribution of cell bodies, fibers and receptors... - Species differences in V1a receptor gene expression in monogamous and nonmonogamous voles: behavioral consequencesL J Young
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Behav Neurosci 111:599-605. 1997..Together, these data suggest that the phylogenetic plasticity of central neurohypophyseal peptide receptor expression may contribute to the evolution of species-typical social behaviors... - Increased affiliative response to vasopressin in mice expressing the V1a receptor from a monogamous voleL J Young
Department of Psychiatry and Behavioural Sciences, Emory University, Atlanta, Georgia 30322, USA
Nature 400:766-8. 1999..These data indicate that the pattern of V1a-receptor gene expression in the brain may be functionally associated with species-typical social behaviours in male vertebrates... - Naturally occurring differences in maternal care are associated with the expression of oxytocin and vasopressin (V1a) receptors: gender differencesD D Francis
Center for Behavioral Neuroscience, Emory University, Atlanta, GA 30329, USA
J Neuroendocrinol 14:349-53. 2002..These findings suggest that variations in maternal care may influence the expression of oxytocin and vasopressin receptors in a gender-specific manner... - Facilitation of affiliation and pair-bond formation by vasopressin receptor gene transfer into the ventral forebrain of a monogamous voleL J Pitkow
Center for Behavioral Neuroscience and Department of Psychiatry, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 21:7392-6. 2001..These data demonstrate a role for ventral pallidal V1aR in affiliation and social attachment and provide a potential molecular mechanism for species differences in social organization... - Sexual and social experience is associated with different patterns of behavior and neural activation in male prairie volesZ Wang
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res 767:321-32. 1997..Finally, the MPO was activated at different magnitudes by social or sexual experience but did not respond to intruder-related cues as measured by Fos-ir... - Dopamine D2 receptor-mediated regulation of partner preferences in female prairie voles (Microtus ochrogaster): a mechanism for pair bonding?Z Wang
Department of Psychiatry and Behavioral Sciences and Graduate Program in Neuroscience, Emory University, USA
Behav Neurosci 113:602-11. 1999..Together, these data suggest that mating-induced PP requires activation of D2 receptors and that social experience may activate dopaminergic pathways, with enduring effects on behavior... - The primate neocortex in comparative perspective using magnetic resonance imagingJ K Rilling
Department of Anthropology and Yerkes Regional Primate Research Center, Emory University, Atlanta, GA 30322, USA
J Hum Evol 37:191-223. 1999..These modifications may constitute part of the neurobiological substrate that supports some of our species most distinctive cognitive abilities... - Cellular mechanisms of social attachmentL J Young
Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
Horm Behav 40:133-8. 2001..Therefore, we hypothesize that oxytocin and vasopressin may be facilitating affiliation and social attachment in monogamous species by modulating these reward pathways... - Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formationM M Sanchez
Department of Psychiatry and Behavioral Sciences, and Yerkes Regional Primate Research Center, Emory University, Atlanta, Georgia 30322
J Neurosci 20:4657-68. 2000..Alternatively, it is also possible that glucocorticoid effects are mediated through the MRs present in the hippocampal formation... - Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeysJames T Winslow
Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
Neuropsychopharmacology 28:910-8. 2003..These results are consistent with earlier reports from studies of rodents suggesting an important role for central OT pathways in the development of social affiliation... - Vaginocervical stimulation releases oxytocin within the spinal cord in ratsGiorgio R Sansone
Department of Psychology, Rutgers, The State University of New Jersey, Newark 07102, USA
Neuroendocrinology 75:306-15. 2002..The present findings provide evidence of a direct estrogen-dependent release of OT within the spinal cord in response to VS, presumably via descending oxytocinergic neurons... - The neuroendocrine basis of social recognitionJennifer N Ferguson
Center for Behavioral Neuroscience, Emory University, Atlanta, Georgia 30322, USA
Front Neuroendocrinol 23:200-24. 2002..These findings support the hypothesis that vasopressin and oxytocin are essential for social memory, although they appear to influence different cognitive processes and may modulate different neural systems. (c) Elsevier Science... - Is social attachment an addictive disorder?Thomas R Insel
Center for Behavioral Neuroscience, Emory University, Altanta, GA, USA
Physiol Behav 79:351-7. 2003..The neuropeptides oxytocin (OT) and vasopressin (AVP) appear to be critical for linking social signals to the mesocorticolimbic circuit... - Neuroendocrine basis of social recognitionJames T Winslow
National Institute of Mental Health, National Institutes of Health Animal Center, Building 110, 9000 Rockville Pike, Bethesda, MD 20892, USA
Curr Opin Neurobiol 14:248-53. 2004..Several lines of evidence have emerged that indicate that neuropeptide regulation is significantly modulated by gonadal and corticosteroid activation... - How the brain processes social information: searching for the social brainThomas R Insel
National Institute of Mental Health, Bethesda, Maryland 20892, USA
Annu Rev Neurosci 27:697-722. 2004....
Research Grants
- OXYTOCIN AND SOCIAL ATTACHMENTThomas Insel; Fiscal Year: 2001....