Fang Hua

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 390:678-83. 2009
  2. pmc Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury
    Fang Hua
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 61:642-51. 2012
  3. pmc Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1262:100-8. 2009
  4. pmc Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
    J Neuroinflammation 8:42. 2011
  5. pmc Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Neuroimmunol 190:101-11. 2007
  6. pmc TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 298:H984-91. 2010
  7. ncbi Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7317-24. 2007
  8. ncbi Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 338:1118-25. 2005
  9. pmc Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, United States
    J Neuroimmunol 199:75-82. 2008
  10. pmc Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats
    Huiling Tang
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 64:527-38. 2013

Collaborators

Detail Information

Publications22

  1. pmc The TRIF-dependent signaling pathway is not required for acute cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 390:678-83. 2009
    ..Our results demonstrate that the TRIF-dependent signaling pathway is not required for the activation of NF-kappaB signaling and brain injury after acute cerebral I/R...
  2. pmc Progesterone and low-dose vitamin D hormone treatment enhances sparing of memory following traumatic brain injury
    Fang Hua
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 61:642-51. 2012
    ..This effect may be one of the mechanisms underlying PROG's neuroprotective effects in combination with VDH...
  3. pmc Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Brain Res 1262:100-8. 2009
    ..Specifically, TLR4 contributes to cerebral I/R injury, while TLR2 appears to be neuroprotective by enhancing the activation of protective signaling in response to cerebral I/R...
  4. pmc Genomic profile of Toll-like receptor pathways in traumatically brain-injured mice: effect of exogenous progesterone
    Fang Hua
    Department of Emergency Medicine, Brain Research Laboratory, Emory University School of Medicine, 1365B Clifton Rd, Atlanta, GA 30322, USA
    J Neuroinflammation 8:42. 2011
    ..Therefore, in the present study, we examined the genomic profiles of TLR-mediated pathways in traumatically injured brain and PROG's effects on these genes...
  5. pmc Activation of Toll-like receptor 4 signaling contributes to hippocampal neuronal death following global cerebral ischemia/reperfusion
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Neuroimmunol 190:101-11. 2007
    ..These data suggest that activation of TLR4 signaling contributes to ischemia-induced hippocampal neuronal death. In addition, these data suggest that modulation of TLR4 signaling may attenuate ischemic injury in hippocampal neurons...
  6. pmc TLR2 ligands attenuate cardiac dysfunction in polymicrobial sepsis via a phosphoinositide 3-kinase-dependent mechanism
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 298:H984-91. 2010
    ..More significantly, Pam3 therapeutic treatment will have a potential clinical relevance...
  7. ncbi Protection against myocardial ischemia/reperfusion injury in TLR4-deficient mice is mediated through a phosphoinositide 3-kinase-dependent mechanism
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    J Immunol 178:7317-24. 2007
    ..These data also suggest that modulation of TLR4/PI3K/Akt-dependent signaling pathways may be a viable strategy for reducing myocardial I/R injury...
  8. ncbi Blocking the MyD88-dependent pathway protects the myocardium from ischemia/reperfusion injury in rat hearts
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, USA
    Biochem Biophys Res Commun 338:1118-25. 2005
    ..The results demonstrate that both inhibition of the NFkappaB activation pathway and activation of the Akt signaling pathway may be responsible for the protective effect of transfection of dominant negative MyD88...
  9. pmc Preconditioning with a TLR2 specific ligand increases resistance to cerebral ischemia/reperfusion injury
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614, United States
    J Neuroimmunol 199:75-82. 2008
    ..These results suggest that TLR2 is a new target of ischemic preconditioning in the brain and preconditioning with a TLR2 specific ligand will protect the brain from I/R injury...
  10. pmc Progesterone and vitamin D: Improvement after traumatic brain injury in middle-aged rats
    Huiling Tang
    Department of Emergency Medicine, Emory University, Atlanta, GA 30322, USA
    Horm Behav 64:527-38. 2013
    ..VDH+PROG combination therapy may attenuate some of the potential long-term, subtle, pathophysiological consequences of brain injury in older subjects...
  11. doi Lipopolysaccharide-induced myocardial protection against ischaemia/reperfusion injury is mediated through a PI3K/Akt-dependent mechanism
    Tuanzhu Ha
    Department of Surgery, James H Quillen College of Medicine, East Tennessee State University, Johnson City, PO Box 70575, TN 37614 0575, USA
    Cardiovasc Res 78:546-53. 2008
    ..We hypothesized that activation of PI3K/Akt signalling plays a critical role in LPS-induced cardioprotection...
  12. pmc Scavenger receptor class-A has a central role in cerebral ischemia-reperfusion injury
    Chen Lu
    Department of Surgery, East Tennessee State University, Johnson City, Tennessee, USA
    J Cereb Blood Flow Metab 30:1972-81. 2010
    ..These data suggest that SR-A has a central role in cerebral I/R injury and that suppression of SR-A may be a useful approach for ameliorating brain injury in stroke patients...
  13. pmc Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischemia by regulating the expression of matrix metalloproteinases
    Tauheed Ishrat
    Department of Emergency Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 226:183-90. 2010
    ..We conclude that PROG and ALLO can help to protect BBB disruption following pMCAO...
  14. pmc Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection
    Fahim Atif
    Department of Emergency Medicine, Brain Research Laboratory, 1365B Clifton Road NE, Suite 5100, Emory University, Atlanta, GA 30322, USA
    Neuropharmacology 67:78-87. 2013
    ..Under specific conditions VDH potentiates P4's neuroprotective efficacy and should be considered as a potential partner of P4 in a low-cost, safe and effective combinatorial treatment for stroke...
  15. ncbi Glucan phosphate attenuates cardiac dysfunction and inhibits cardiac MIF expression and apoptosis in septic mice
    Tuanzhu Ha
    Dept of Surgery, East Tennessee State Univ, Campus Box 70575, Johnson City, TN 37614 0575, USA
    Am J Physiol Heart Circ Physiol 291:H1910-8. 2006
    ..GP administration also activates the phosphoinositide 3-kinase/Akt pathway, decreases myocardial MIF expression, and reduces cardiomyocyte apoptosis...
  16. pmc Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis
    Chuanfu Li
    Department of Surgery, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee, United States of America
    PLoS ONE 7:e44712. 2012
    ..Finally, these data suggest that modulation of the PI3K/p110α signaling pathway may be beneficial in the prevention and/or management of septic cardiomyopathy and septic shock...
  17. ncbi Blockade of MyD88 attenuates cardiac hypertrophy and decreases cardiac myocyte apoptosis in pressure overload-induced cardiac hypertrophy in vivo
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Campus Box 70575, Johnson City, Tennessee 37614 0575, USA
    Am J Physiol Heart Circ Physiol 290:H985-94. 2006
    ..Blockade of MyD88 significantly reduced cardiac hypertrophy, cardiac myocyte apoptosis, and improved cardiac function in vivo...
  18. ncbi The development of a novel mouse model of transient global cerebral ischemia
    Fang Hua
    Department of Surgery, East Tennessee State University, Johnson City, TN 37614 0575, USA
    Neurosci Lett 400:69-74. 2006
    ....
  19. pmc Progesterone inhibits the growth of human neuroblastoma: in vitro and in vivo evidence
    Fahim Atif
    Departments of Emergency Medicine Brain Research Laboratory, Emory University, Atlanta, Georgia, USA
    Mol Med 17:1084-94. 2011
    ....
  20. ncbi Reduced cardiac hypertrophy in toll-like receptor 4-deficient mice following pressure overload
    Tuanzhu Ha
    Department of Surgery, East Tennessee State University, Johnson City, 37614 0575, USA
    Cardiovasc Res 68:224-34. 2005
    ..NFkappaB is a downstream transcription factor in the Toll-like receptor (TLR)-mediated signaling pathway; therefore, we investigated a role of TLR4 in cardiac hypertrophy in vivo...
  21. pmc Glibenclamide Administration Attenuates Infarct Volume, Hemispheric Swelling, and Functional Impairments following Permanent Focal Cerebral Ischemia in Rats
    Bushra Wali
    Department of Emergency Medicine, School of Medicine Emory University, Atlanta, GA 30322, USA
    Stroke Res Treat 2012:460909. 2012
    ..Taken together, these data indicate that Glib has strong neuroprotective effects following ischemic stroke and may warrant further testing in future clinical trials for human stroke...
  22. pmc C2 spinal cord stimulation induces dynorphin release from rat T4 spinal cord: potential modulation of myocardial ischemia-sensitive neurons
    Xiaohui Ding
    Dept of Physiology, East Tennessee State Univ, Stanton Gerber Hall B137, P O Box 70576, Johnson City, TN 37614 1708, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1519-28. 2008
    ..These results suggest that activation of cervical propriospinal pathways induces DYN release in the thoracic spinal cord, thereby modulating nociceptive signals from the ischemic heart...