Research Topics
| STEPHEN HOLTZMANSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated ratsClifford C Michaels
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 86:784-96. 2007..These results indicate that early postnatal stress alters both sucrose consumption, a non-drug measure of reward, and apparently the brain opioid systems that mediate naltrexone-induced drinking suppression...
Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, have a dopamine component in monkeysS G Holtzman
Rollins Research Center, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
Eur J Pharmacol 376:7-15. 1999....- Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaineS G Holtzman
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 155:180-6. 2001..Inhibitors of neuronal dopamine uptake, such as GBR 12909, decrease IV cocaine self-administration by laboratory animals and have been proposed as potential therapeutic agents for abuse of psychomotor stimulant drugs... - Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependenceStephen G Holtzman
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Pharmacol Exp Ther 304:1033-41. 2003..Interoceptive stimuli from naltrexone-precipitated opioid withdrawal are more similar across morphine-like agonists during chronic dependence than they are during acute dependence... - Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumptionDavid A White
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res Bull 76:597-604. 2008..In conclusion, kappa-opioid and delta-opioid receptors appear to contribute to the manifestation of acute opioid dependence, albeit to a lesser degree than mu-opioid receptors... - Long-lasting changes in morphine-induced locomotor sensitization and tolerance in Long-Evans mother rats as a result of periodic postpartum separation from the litter: a novel model of increased vulnerability to drug abuse?Mikhail Kalinichev
Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA, USA
Neuropsychopharmacology 28:317-28. 2003.... - Periadolescent male but not female rats have higher motor activity in response to morphine than do adult ratsDavid A White
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, United States
Pharmacol Biochem Behav 89:188-99. 2008..Lastly, following morphine exposure, activity was dependent on age of treatment and treatment regimen, with the greatest effects in 5-day periadolescent-treated animals... - Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependenceMikhail Kalinichev
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Pharmacol Exp Ther 304:603-9. 2003..Differences in withdrawal signs between acute and chronic dependence suggest that the neural substrates that mediate those particular components of the withdrawal syndrome are affected differently in the two states of dependence... 
Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonistsClifford C Michaels
Emory University, Department of Pharmacology, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322
J Pharmacol Exp Ther 325:313-8. 2008..These findings indicate that early postnatal stress can significantly alter the rewarding or aversive value of mu- and kappa-opioid agonists when measured using place conditioning...- Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behaviorClifford C Michaels
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res Bull 73:310-8. 2007..These results indicate that maternal separation during the first two postnatal weeks can have long-term effects on responding for ICSS, but these effects do not appear tied to endogenous opioid systems in the lateral hypothalamus... - Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the ratDavid A White
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Brain Res 1149:141-8. 2007..The exact nature of this link depends upon the model of anxiety used and may reflect the heterogeneous nature of anxiety-like reactivity in the rat... - Neonatal stress and litter composition alter sucrose intake in both rat dam and offspringClifford C Michaels
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Physiol Behav 89:735-41. 2006..These results indicate that early postnatal and postpartum stress can lead to changes in sucrose consumption, a non-drug measure of reward, indicating that such stress may alter the underlying brain reward mechanisms... - Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult ratsDavid A White
Emory University School of Medicine, Department of Pharmacology, O W Rollins Research Building, 1510 Clifton Road, NE, Atlanta, GA 30322, USA
Eur J Pharmacol 528:119-23. 2005.... - Naltrexone-induced conditioned place aversion following a single dose of morphine in the ratDavid A White
Emory University School of Medicine, Department of Pharmacology, O W Rollins Research Building, 1510 Clifton Road, NE Suite 5074, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 81:451-8. 2005.... - Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterizationDavid A White
Department of Pharmacology, Emory University School of Medicine, O Wayne Rollins Research Bldg, 1510 Clifton Rd NE, Atlanta, GA 30322, USA
J Pharmacol Exp Ther 314:374-82. 2005..However, in some cases this requirement can be overcome with higher doses of naltrexone... - Early neonatal experience of Long-Evans rats results in long-lasting changes in reactivity to a novel environment and morphine-induced sensitization and toleranceMikhail Kalinichev
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322, USA
Neuropsychopharmacology 27:518-33. 2002.... - Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans ratsMikhail Kalinichev
Rollins Research Centre, Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Room 5074, Atlanta, GA 30322, USA
Pharmacol Biochem Behav 73:131-40. 2002..Therefore, experiencing maternal separation results in a long-lasting increase in anxiety-like behaviors that occurs in a sex-dependent manner... - Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkeyDavid A White
Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road NE, Suite 5074, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 167:203-10. 2003..The discriminative stimulus effects of a combination of acute morphine followed by naltrexone have been described in rats. OBJECTIVE. The purpose of this study was to extend observations to a non-human primate... - In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulationKeith W Easterling
Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
Psychopharmacology (Berl) 175:287-95. 2004..Lower (0.001-1.0 mg/kg) doses of the opioid antagonist naltrexone produce few behavioral effects in otherwise drug-free rats responding for ICSS, but reduce response rates by up to 75% after a single dose of morphine... - Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. II. Agonist-induced antinociception and antagonist-induced suppression of fluid consumptionDavid A White
Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, NE, Suite 5074, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 177:68-78. 2004..In a companion article, we reported that HRs and LRs differ in sensitivity to morphine-induced locomotor sensitization... - Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. I. Expression of morphine-induced locomotor sensitizationMikhail Kalinichev
Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322, USA
Psychopharmacology (Berl) 177:61-7. 2004.... - The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawalKelly H Skelton
Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Eur J Pharmacol 571:17-24. 2007.... - Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regionsChristina A Schad
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
J Pharmacol Exp Ther 300:932-8. 2002.... - Modeling the onset of drug dependence: a consideration of the requirement for protein synthesisAndrew R Joyce
Bioinformatics Program, University of California San Diego, La Jolla CA 92093, USA
J Theor Biol 240:531-7. 2006..It is also possible that individual components of the withdrawal syndrome have individual and unique rate limiting mechanisms. In any case, time course analysis may be helpful in revealing underlying mechanisms of change... - Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonistsRaka Jain
National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi 110029, India
Brain Res Bull 65:415-21. 2005..Thus, caffeine produces differential cross tolerance to the amphetamine-like discriminative effects of dopaminergic drugs, a phenomenon in which the dopamine D(1) receptor appears to have an important role...
Research Grants
- BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTSSTEPHEN HOLTZMAN; Fiscal Year: 2002..Acute agonist-induced sensitization to opioid antagonists appears to be an exquisite example of neuronal plasticity, reflecting the first hours of the drug-receptor interactions that lead to chronic physical dependence upon opioids. ..
- BEHAVIORAL PHARMACOLOGY OF OPIOIDSSTEPHEN HOLTZMAN; Fiscal Year: 2004....
- BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTSSTEPHEN HOLTZMAN; Fiscal Year: 1980..Finally, discriminative stimulus properties of mixed agonist-antagonists will be evaluated in squirrel monkeys trained to discriminate between saline and pentazocine (3.0 mg/kg). ..
- Maternal Separation: Rat Model of Opioid VulnerabilitySTEPHEN HOLTZMAN; Fiscal Year: 2006..abstract_text> ..