STEPHEN HOLTZMAN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats
    Clifford C Michaels
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 86:784-96. 2007
  2. ncbi request reprint Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, have a dopamine component in monkeys
    S G Holtzman
    Rollins Research Center, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Eur J Pharmacol 376:7-15. 1999
  3. ncbi request reprint Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine
    S G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 155:180-6. 2001
  4. ncbi request reprint Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence
    Stephen G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:1033-41. 2003
  5. pmc Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumption
    David A White
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Bull 76:597-604. 2008
  6. ncbi request reprint Long-lasting changes in morphine-induced locomotor sensitization and tolerance in Long-Evans mother rats as a result of periodic postpartum separation from the litter: a novel model of increased vulnerability to drug abuse?
    Mikhail Kalinichev
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychopharmacology 28:317-28. 2003
  7. pmc Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats
    David A White
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, United States
    Pharmacol Biochem Behav 89:188-99. 2008
  8. ncbi request reprint Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependence
    Mikhail Kalinichev
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:603-9. 2003
  9. doi request reprint Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists
    Clifford C Michaels
    Emory University, Department of Pharmacology, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322
    J Pharmacol Exp Ther 325:313-8. 2008
  10. ncbi request reprint Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behavior
    Clifford C Michaels
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Bull 73:310-8. 2007

Research Grants

  1. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
  2. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    STEPHEN HOLTZMAN; Fiscal Year: 2004
  3. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 1980
  4. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006

Detail Information

Publications25

  1. pmc Enhanced sensitivity to naltrexone-induced drinking suppression of fluid intake and sucrose consumption in maternally separated rats
    Clifford C Michaels
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 86:784-96. 2007
    ..These results indicate that early postnatal stress alters both sucrose consumption, a non-drug measure of reward, and apparently the brain opioid systems that mediate naltrexone-induced drinking suppression...
  2. ncbi request reprint Discriminative effects of CGS 15943, a competitive adenosine receptor antagonist, have a dopamine component in monkeys
    S G Holtzman
    Rollins Research Center, Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Eur J Pharmacol 376:7-15. 1999
    ....
  3. ncbi request reprint Differential interaction of GBR 12909, a dopamine uptake inhibitor, with cocaine and methamphetamine in rats discriminating cocaine
    S G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 155:180-6. 2001
    ..Inhibitors of neuronal dopamine uptake, such as GBR 12909, decrease IV cocaine self-administration by laboratory animals and have been proposed as potential therapeutic agents for abuse of psychomotor stimulant drugs...
  4. ncbi request reprint Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence
    Stephen G Holtzman
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:1033-41. 2003
    ..Interoceptive stimuli from naltrexone-precipitated opioid withdrawal are more similar across morphine-like agonists during chronic dependence than they are during acute dependence...
  5. pmc Acute delta- and kappa-opioid agonist pretreatment potentiates opioid antagonist-induced suppression of water consumption
    David A White
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Bull 76:597-604. 2008
    ..In conclusion, kappa-opioid and delta-opioid receptors appear to contribute to the manifestation of acute opioid dependence, albeit to a lesser degree than mu-opioid receptors...
  6. ncbi request reprint Long-lasting changes in morphine-induced locomotor sensitization and tolerance in Long-Evans mother rats as a result of periodic postpartum separation from the litter: a novel model of increased vulnerability to drug abuse?
    Mikhail Kalinichev
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychopharmacology 28:317-28. 2003
    ....
  7. pmc Periadolescent male but not female rats have higher motor activity in response to morphine than do adult rats
    David A White
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, United States
    Pharmacol Biochem Behav 89:188-99. 2008
    ..Lastly, following morphine exposure, activity was dependent on age of treatment and treatment regimen, with the greatest effects in 5-day periadolescent-treated animals...
  8. ncbi request reprint Changes in urination/defecation, auditory startle response, and startle-induced ultrasonic vocalizations in rats undergoing morphine withdrawal: similarities and differences between acute and chronic dependence
    Mikhail Kalinichev
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:603-9. 2003
    ..Differences in withdrawal signs between acute and chronic dependence suggest that the neural substrates that mediate those particular components of the withdrawal syndrome are affected differently in the two states of dependence...
  9. doi request reprint Early postnatal stress alters place conditioning to both mu- and kappa-opioid agonists
    Clifford C Michaels
    Emory University, Department of Pharmacology, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322
    J Pharmacol Exp Ther 325:313-8. 2008
    ..These findings indicate that early postnatal stress can significantly alter the rewarding or aversive value of mu- and kappa-opioid agonists when measured using place conditioning...
  10. ncbi request reprint Maternal separation alters ICSS responding in adult male and female rats, but morphine and naltrexone have little affect on that behavior
    Clifford C Michaels
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res Bull 73:310-8. 2007
    ..These results indicate that maternal separation during the first two postnatal weeks can have long-term effects on responding for ICSS, but these effects do not appear tied to endogenous opioid systems in the lateral hypothalamus...
  11. pmc Locomotor response to novelty as a predictor of reactivity to aversive stimuli in the rat
    David A White
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Res 1149:141-8. 2007
    ..The exact nature of this link depends upon the model of anxiety used and may reflect the heterogeneous nature of anxiety-like reactivity in the rat...
  12. ncbi request reprint Neonatal stress and litter composition alter sucrose intake in both rat dam and offspring
    Clifford C Michaels
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Physiol Behav 89:735-41. 2006
    ..These results indicate that early postnatal and postpartum stress can lead to changes in sucrose consumption, a non-drug measure of reward, indicating that such stress may alter the underlying brain reward mechanisms...
  13. ncbi request reprint Periadolescent morphine exposure alters subsequent behavioral sensitivity to morphine in adult rats
    David A White
    Emory University School of Medicine, Department of Pharmacology, O W Rollins Research Building, 1510 Clifton Road, NE, Atlanta, GA 30322, USA
    Eur J Pharmacol 528:119-23. 2005
    ....
  14. ncbi request reprint Naltrexone-induced conditioned place aversion following a single dose of morphine in the rat
    David A White
    Emory University School of Medicine, Department of Pharmacology, O W Rollins Research Building, 1510 Clifton Road, NE Suite 5074, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 81:451-8. 2005
    ....
  15. ncbi request reprint Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey: a further characterization
    David A White
    Department of Pharmacology, Emory University School of Medicine, O Wayne Rollins Research Bldg, 1510 Clifton Rd NE, Atlanta, GA 30322, USA
    J Pharmacol Exp Ther 314:374-82. 2005
    ..However, in some cases this requirement can be overcome with higher doses of naltrexone...
  16. ncbi request reprint Early neonatal experience of Long-Evans rats results in long-lasting changes in reactivity to a novel environment and morphine-induced sensitization and tolerance
    Mikhail Kalinichev
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322, USA
    Neuropsychopharmacology 27:518-33. 2002
    ....
  17. ncbi request reprint Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long-Evans rats
    Mikhail Kalinichev
    Rollins Research Centre, Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Room 5074, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 73:131-40. 2002
    ..Therefore, experiencing maternal separation results in a long-lasting increase in anxiety-like behaviors that occurs in a sex-dependent manner...
  18. ncbi request reprint Discriminative stimulus effects of acute morphine followed by naltrexone in the squirrel monkey
    David A White
    Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, 1510 Clifton Road NE, Suite 5074, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 167:203-10. 2003
    ..The discriminative stimulus effects of a combination of acute morphine followed by naltrexone have been described in rats. OBJECTIVE. The purpose of this study was to extend observations to a non-human primate...
  19. ncbi request reprint In rats, acute morphine dependence results in antagonist-induced response suppression of intracranial self-stimulation
    Keith W Easterling
    Department of Pharmacology, School of Medicine, Emory University, Atlanta, GA, USA
    Psychopharmacology (Berl) 175:287-95. 2004
    ..Lower (0.001-1.0 mg/kg) doses of the opioid antagonist naltrexone produce few behavioral effects in otherwise drug-free rats responding for ICSS, but reduce response rates by up to 75% after a single dose of morphine...
  20. ncbi request reprint Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. II. Agonist-induced antinociception and antagonist-induced suppression of fluid consumption
    David A White
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, NE, Suite 5074, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 177:68-78. 2004
    ..In a companion article, we reported that HRs and LRs differ in sensitivity to morphine-induced locomotor sensitization...
  21. ncbi request reprint Individual differences in locomotor reactivity to a novel environment and sensitivity to opioid drugs in the rat. I. Expression of morphine-induced locomotor sensitization
    Mikhail Kalinichev
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, 1510 Clifton Road, Suite 5074, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 177:61-7. 2004
    ....
  22. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
    ....
  23. ncbi request reprint Endogenous opioids in dopaminergic cell body regions modulate amphetamine-induced increases in extracellular dopamine levels in the terminal regions
    Christina A Schad
    Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 300:932-8. 2002
    ....
  24. ncbi request reprint Modeling the onset of drug dependence: a consideration of the requirement for protein synthesis
    Andrew R Joyce
    Bioinformatics Program, University of California San Diego, La Jolla CA 92093, USA
    J Theor Biol 240:531-7. 2006
    ..It is also possible that individual components of the withdrawal syndrome have individual and unique rate limiting mechanisms. In any case, time course analysis may be helpful in revealing underlying mechanisms of change...
  25. ncbi request reprint Caffeine induces differential cross tolerance to the amphetamine-like discriminative stimulus effects of dopaminergic agonists
    Raka Jain
    National Drug Dependence Treatment Centre, Department of Psychiatry, All India Institute of Medical Sciences, New Delhi 110029, India
    Brain Res Bull 65:415-21. 2005
    ..Thus, caffeine produces differential cross tolerance to the amphetamine-like discriminative effects of dopaminergic drugs, a phenomenon in which the dopamine D(1) receptor appears to have an important role...

Research Grants21

  1. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 2002
    ..Acute agonist-induced sensitization to opioid antagonists appears to be an exquisite example of neuronal plasticity, reflecting the first hours of the drug-receptor interactions that lead to chronic physical dependence upon opioids. ..
  2. BEHAVIORAL PHARMACOLOGY OF OPIOIDS
    STEPHEN HOLTZMAN; Fiscal Year: 2004
    ....
  3. BEHAVIORAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS
    STEPHEN HOLTZMAN; Fiscal Year: 1980
    ..Finally, discriminative stimulus properties of mixed agonist-antagonists will be evaluated in squirrel monkeys trained to discriminate between saline and pentazocine (3.0 mg/kg). ..
  4. Maternal Separation: Rat Model of Opioid Vulnerability
    STEPHEN HOLTZMAN; Fiscal Year: 2006
    ..abstract_text> ..