Paul Holtzheimer

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Stuck in a rut: rethinking depression and its treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
    Trends Neurosci 34:1-9. 2011
  2. doi request reprint Deep brain stimulation for psychiatric disorders
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Neurosci 34:289-307. 2011
  3. pmc Utility of the Beck Depression Inventory to screen for and track depression in injection drug users seeking hepatitis C treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gen Hosp Psychiatry 32:426-32. 2010
  4. ncbi request reprint Novel targets for antidepressant therapies
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle Northeast, Suite 4000, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 10:465-73. 2008
  5. ncbi request reprint A double blind, placebo-controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression
    Paul E Holtzheimer
    Emory University School of Medicine, Atlanta, GA 30329, USA
    Int J Geriatr Psychiatry 23:625-31. 2008
  6. ncbi request reprint Emerging treatments for depression
    Paul E Holtzheimer
    Emory University School of Medicine, Department of Psychiatry and Behavioural Sciences, 1841 Clifton Rd NE, 4th Floor, Atlanta, Georgia 30329, USA
    Expert Opin Pharmacother 7:2323-39. 2006
  7. ncbi request reprint Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients
    Paul Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Brain Lang 94:274-7. 2005
  8. ncbi request reprint Validity of the 30-item geriatric depression scale in patients with Parkinson's disease
    William M McDonald
    Fuqua Center for Late Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329 5102, USA
    Mov Disord 21:1618-22. 2006
  9. pmc Factors associated with functional recovery in bipolar disorder patients
    Aliza P Wingo
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 12:319-26. 2010
  10. pmc Disease state prediction from resting state functional connectivity
    R Cameron Craddock
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Magn Reson Med 62:1619-28. 2009

Detail Information

Publications21

  1. pmc Stuck in a rut: rethinking depression and its treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
    Trends Neurosci 34:1-9. 2011
    ..We also discuss the implications of this revised definition for future clinical and basic research...
  2. doi request reprint Deep brain stimulation for psychiatric disorders
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Neurosci 34:289-307. 2011
    ..In this review, we describe the development and justification for testing DBS for various psychiatric disorders, carefully consider the available clinical data, and briefly discuss potential mechanisms of action...
  3. pmc Utility of the Beck Depression Inventory to screen for and track depression in injection drug users seeking hepatitis C treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gen Hosp Psychiatry 32:426-32. 2010
    ..Effective screening strategies are needed to help non-psychiatric clinicians identify depressive disorders...
  4. ncbi request reprint Novel targets for antidepressant therapies
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle Northeast, Suite 4000, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 10:465-73. 2008
    ..Developments in therapeutic focal brain stimulation include vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, and deep brain stimulation...
  5. ncbi request reprint A double blind, placebo-controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression
    Paul E Holtzheimer
    Emory University School of Medicine, Atlanta, GA 30329, USA
    Int J Geriatr Psychiatry 23:625-31. 2008
    ....
  6. ncbi request reprint Emerging treatments for depression
    Paul E Holtzheimer
    Emory University School of Medicine, Department of Psychiatry and Behavioural Sciences, 1841 Clifton Rd NE, 4th Floor, Atlanta, Georgia 30329, USA
    Expert Opin Pharmacother 7:2323-39. 2006
    ..A major goal that remains to be achieved is the identification of predictors of response to the various antidepressant treatments that have diverse mechanisms of action...
  7. ncbi request reprint Repetitive transcranial magnetic stimulation may induce language switching in bilingual patients
    Paul Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    Brain Lang 94:274-7. 2005
    ..These preliminary findings support the role of the DLPFC in language switching in polyglots and highlight the potential value of rTMS for non-invasively investigating language function in humans. Further investigation is warranted...
  8. ncbi request reprint Validity of the 30-item geriatric depression scale in patients with Parkinson's disease
    William M McDonald
    Fuqua Center for Late Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329 5102, USA
    Mov Disord 21:1618-22. 2006
    ..54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients...
  9. pmc Factors associated with functional recovery in bipolar disorder patients
    Aliza P Wingo
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 12:319-26. 2010
    ..As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors...
  10. pmc Disease state prediction from resting state functional connectivity
    R Cameron Craddock
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Magn Reson Med 62:1619-28. 2009
    ..The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression...
  11. doi request reprint Emerging targets for antidepressant therapies
    Jeffrey J Rakofsky
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2004 Ridgewood Dr, Suite 218, Atlanta, GA 30322, United States
    Curr Opin Chem Biol 13:291-302. 2009
    ..Focal brain stimulation therapies include vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), magnetic seizure therapy (MST), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS)...
  12. pmc Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjects
    G Andrew James
    Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30322 4600, USA
    Neuroimage 45:778-87. 2009
    ..These results suggest that exploratory SEM is a viable technique for neuroimaging connectivity analyses of individual subjects' resting-state fMRI data...
  13. doi request reprint A tractography analysis of two deep brain stimulation white matter targets for depression
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:276-82. 2009
    ..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets...
  14. pmc Advances in the treatment of depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    NeuroRx 3:42-56. 2006
    ..However, it is clear that further study of the neurobiology of depression will continue to provide a rationale for developing innovative targets for antidepressant therapies...
  15. ncbi request reprint A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression
    David H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, 98104 2499, USA
    Biol Psychiatry 59:187-94. 2006
    ..Repetitive transcranial magnetic stimulation (TMS) as a treatment for depression has shown statistically significant effects, but the clinical significance of these effects has been questioned...
  16. ncbi request reprint Shorter duration of depressive episode may predict response to repetitive transcranial magnetic stimulation
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Harborview Medical Center, Seattle, Washington 98104, USA
    Depress Anxiety 19:24-30. 2004
    ..Patients may need more than 10 treatments to obtain full benefit from rTMS. The design of future rTMS studies should consider these issues...
  17. ncbi request reprint Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study
    David H Avery
    Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    J Nerv Ment Dis 195:378-81. 2007
    ..Compared with sham, TMS was associated with a significant (p < 0.05) reduction in the SAFTEE pain item during the study. The reduction in pain could not be explained by the antidepressant effects...
  18. pmc Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought
    Peter Rabins
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 66:931-7. 2009
    ....
  19. ncbi request reprint The impact of comorbid posttraumatic stress disorder on short-term clinical outcome in hospitalized patients with depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Harborview Medical Center, 325 Ninth Ave, Box 359911, Seattle, WA 98104 2499, USA
    Am J Psychiatry 162:970-6. 2005
    ..The effects of PTSD comorbidity are unclear, especially in patients with severe mental illness. The authors assessed short-term clinical outcome in severely depressed psychiatric inpatients with and without comorbid PTSD...
  20. ncbi request reprint Treatment of acute mania
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    CNS Spectr 8:917-20, 924-8. 2003
    ....
  21. pmc Future prospects in depression research
    Paul E Holtzheimer
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dialogues Clin Neurosci 8:175-89. 2006
    ..This review highlights these future prospects for depression research with a specific focus on lines of investigation likely to generate novel, more effective treatment options...

Research Grants1

  1. Investigating structural-functional brain abnormalities in late-life depression
    Paul Holtzheimer; Fiscal Year: 2007
    ..It is hoped that a better understanding of the pathophysiology of late-life depression will lead to improvements in its diagnosis, prevention and treatment. ..