Paul E Holtzheimer

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Advances in the treatment of depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    NeuroRx 3:42-56. 2006
  2. doi request reprint Toward a neuroimaging treatment selection biomarker for major depressive disorder
    Callie L McGrath
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    JAMA Psychiatry 70:821-9. 2013
  3. pmc Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Depress Anxiety 27:960-3. 2010
  4. pmc Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study
    James M Broadway
    School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332 0170, USA
    Neuropsychopharmacology 37:1764-72. 2012
  5. pmc Reconciling variable findings of white matter integrity in major depressive disorder
    Ki Sueng Choi
    1 Department of Psychiatry, Emory University, Atlanta, GA, USA 2 The Wallace H Coulter, Department of Biomedical Engineering, Biomedical, Imaging Technology Center, Georgia Institute of Technology, Emory University, Atlanta, GA, USA
    Neuropsychopharmacology 39:1332-9. 2014
  6. pmc The Illness Density Index (IDI): A longitudinal measure of treatment efficacy
    Mary E Kelley
    Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA
    Clin Trials 9:596-604. 2012
  7. pmc Disease state prediction from resting state functional connectivity
    R Cameron Craddock
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Magn Reson Med 62:1619-28. 2009
  8. pmc Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: a review
    Jared L Moreines
    Emory College, Emory University, Atlanta, Georgia, USA
    Brain Stimul 4:17-27. 2011
  9. ncbi request reprint Novel targets for antidepressant therapies
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle Northeast, Suite 4000, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 10:465-73. 2008
  10. doi request reprint Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for treatment-resistant depression
    Patricio Riva-Posse
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA Electronic address
    World Neurosurg 80:S27.e25-34. 2013

Detail Information

Publications29

  1. pmc Advances in the treatment of depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    NeuroRx 3:42-56. 2006
    ..However, it is clear that further study of the neurobiology of depression will continue to provide a rationale for developing innovative targets for antidepressant therapies...
  2. doi request reprint Toward a neuroimaging treatment selection biomarker for major depressive disorder
    Callie L McGrath
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30322, USA
    JAMA Psychiatry 70:821-9. 2013
    ..Currently, fewer than 40% of patients treated for major depressive disorder achieve remission with initial treatment. Identification of a biological marker that might improve these odds could have significant health and economic impact...
  3. pmc Accelerated repetitive transcranial magnetic stimulation for treatment-resistant depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Depress Anxiety 27:960-3. 2010
    ..Accelerated TMS, with all treatments delivered over a few days, would have significant advantages in terms of access and patient acceptance...
  4. pmc Frontal theta cordance predicts 6-month antidepressant response to subcallosal cingulate deep brain stimulation for treatment-resistant depression: a pilot study
    James M Broadway
    School of Psychology, Georgia Institute of Technology, Atlanta, GA 30332 0170, USA
    Neuropsychopharmacology 37:1764-72. 2012
    ..Thus, results from this pilot study suggest that baseline FTC and changes early in treatment each have utility as biomarkers for predicting 6-month clinical response to SCC DBS for TRD...
  5. pmc Reconciling variable findings of white matter integrity in major depressive disorder
    Ki Sueng Choi
    1 Department of Psychiatry, Emory University, Atlanta, GA, USA 2 The Wallace H Coulter, Department of Biomedical Engineering, Biomedical, Imaging Technology Center, Georgia Institute of Technology, Emory University, Atlanta, GA, USA
    Neuropsychopharmacology 39:1332-9. 2014
    ....
  6. pmc The Illness Density Index (IDI): A longitudinal measure of treatment efficacy
    Mary E Kelley
    Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA 30322, USA
    Clin Trials 9:596-604. 2012
    ....
  7. pmc Disease state prediction from resting state functional connectivity
    R Cameron Craddock
    School of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA
    Magn Reson Med 62:1619-28. 2009
    ..The proposed framework for applying support vector classification to functional connectivity data is applicable to other disease states beyond major depression...
  8. pmc Neuropsychologic effects of neuromodulation techniques for treatment-resistant depression: a review
    Jared L Moreines
    Emory College, Emory University, Atlanta, Georgia, USA
    Brain Stimul 4:17-27. 2011
    ....
  9. ncbi request reprint Novel targets for antidepressant therapies
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle Northeast, Suite 4000, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 10:465-73. 2008
    ..Developments in therapeutic focal brain stimulation include vagus nerve stimulation, transcranial magnetic stimulation, magnetic seizure therapy, transcranial direct current stimulation, and deep brain stimulation...
  10. doi request reprint Practical considerations in the development and refinement of subcallosal cingulate white matter deep brain stimulation for treatment-resistant depression
    Patricio Riva-Posse
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA Electronic address
    World Neurosurg 80:S27.e25-34. 2013
    ..Deep brain stimulation has been investigated in the past decade as a viable intervention for treatment-resistant depression...
  11. ncbi request reprint A double blind, placebo-controlled pilot study of galantamine augmentation of antidepressant treatment in older adults with major depression
    Paul E Holtzheimer
    Emory University School of Medicine, Atlanta, GA 30329, USA
    Int J Geriatr Psychiatry 23:625-31. 2008
    ....
  12. doi request reprint A tractography analysis of two deep brain stimulation white matter targets for depression
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:276-82. 2009
    ..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets...
  13. ncbi request reprint Validity of the 30-item geriatric depression scale in patients with Parkinson's disease
    William M McDonald
    Fuqua Center for Late Life Depression, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia 30329 5102, USA
    Mov Disord 21:1618-22. 2006
    ..54; P < 0.001). The GDS is useful in screening for dPD. A cutoff score of 9/10 has acceptable discriminant validity for dPD, and the GDS has a moderate correlation with the HDRS in PD patients...
  14. doi request reprint Improving the antidepressant efficacy of transcranial magnetic stimulation: maximizing the number of stimulations and treatment location in treatment-resistant depression
    William M McDonald
    Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, Georgia, USA
    Depress Anxiety 28:973-80. 2011
    ..And, to determine if patients who do not remit to fast left will remit using slow right rTMS (1 Hz @ 120% MT over the right DLPFC)...
  15. doi request reprint Emerging targets for antidepressant therapies
    Jeffrey J Rakofsky
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 2004 Ridgewood Dr, Suite 218, Atlanta, GA 30322, United States
    Curr Opin Chem Biol 13:291-302. 2009
    ..Focal brain stimulation therapies include vagus nerve stimulation (VNS), transcranial magnetic stimulation (TMS), magnetic seizure therapy (MST), transcranial direct current stimulation (tDCS), and deep brain stimulation (DBS)...
  16. doi request reprint Deep brain stimulation for psychiatric disorders
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Neurosci 34:289-307. 2011
    ..In this review, we describe the development and justification for testing DBS for various psychiatric disorders, carefully consider the available clinical data, and briefly discuss potential mechanisms of action...
  17. pmc Stuck in a rut: rethinking depression and its treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle NE, Suite 4000, Atlanta, GA 30322, USA
    Trends Neurosci 34:1-9. 2011
    ..We also discuss the implications of this revised definition for future clinical and basic research...
  18. pmc Bupropion decreases resting motor threshold: a case report
    Mustafa A Mufti
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Brain Stimul 3:177-80. 2010
    ..This effect could correlate with a change in motor cortex excitability. Transcranial magnetic stimulation (TMS) can assess changes in motor cortical excitability by measuring resting motor threshold (RMT)...
  19. ncbi request reprint Shorter duration of depressive episode may predict response to repetitive transcranial magnetic stimulation
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Harborview Medical Center, Seattle, Washington 98104, USA
    Depress Anxiety 19:24-30. 2004
    ..Patients may need more than 10 treatments to obtain full benefit from rTMS. The design of future rTMS studies should consider these issues...
  20. ncbi request reprint A controlled study of repetitive transcranial magnetic stimulation in medication-resistant major depression
    David H Avery
    Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Harborview Medical Center, Seattle, 98104 2499, USA
    Biol Psychiatry 59:187-94. 2006
    ..Repetitive transcranial magnetic stimulation (TMS) as a treatment for depression has shown statistically significant effects, but the clinical significance of these effects has been questioned...
  21. pmc Utility of the Beck Depression Inventory to screen for and track depression in injection drug users seeking hepatitis C treatment
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gen Hosp Psychiatry 32:426-32. 2010
    ..Effective screening strategies are needed to help non-psychiatric clinicians identify depressive disorders...
  22. pmc Factors associated with functional recovery in bipolar disorder patients
    Aliza P Wingo
    Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 12:319-26. 2010
    ..As several factors have tentatively been implicated in outcomes in BPD, we investigated predictors of functional recovery among BPD patients, including demographic, clinical, and neurocognitive factors...
  23. ncbi request reprint Emerging treatments for depression
    Paul E Holtzheimer
    Emory University School of Medicine, Department of Psychiatry and Behavioural Sciences, 1841 Clifton Rd NE, 4th Floor, Atlanta, Georgia 30329, USA
    Expert Opin Pharmacother 7:2323-39. 2006
    ..A major goal that remains to be achieved is the identification of predictors of response to the various antidepressant treatments that have diverse mechanisms of action...
  24. pmc Exploratory structural equation modeling of resting-state fMRI: applicability of group models to individual subjects
    G Andrew James
    Biomedical Imaging Technology Center, Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA 30322 4600, USA
    Neuroimage 45:778-87. 2009
    ..These results suggest that exploratory SEM is a viable technique for neuroimaging connectivity analyses of individual subjects' resting-state fMRI data...
  25. ncbi request reprint Transcranial magnetic stimulation reduces pain in patients with major depression: a sham-controlled study
    David H Avery
    Department of Psychiatry and Behavioral Sciences, Harborview Medical Center, Seattle, Washington 98104 2499, USA
    J Nerv Ment Dis 195:378-81. 2007
    ..Compared with sham, TMS was associated with a significant (p < 0.05) reduction in the SAFTEE pain item during the study. The reduction in pain could not be explained by the antidepressant effects...
  26. pmc Scientific and ethical issues related to deep brain stimulation for disorders of mood, behavior, and thought
    Peter Rabins
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins Hospital, Baltimore, MD 21205, USA
    Arch Gen Psychiatry 66:931-7. 2009
    ....
  27. ncbi request reprint The impact of comorbid posttraumatic stress disorder on short-term clinical outcome in hospitalized patients with depression
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington Medical Center, Harborview Medical Center, 325 Ninth Ave, Box 359911, Seattle, WA 98104 2499, USA
    Am J Psychiatry 162:970-6. 2005
    ..The effects of PTSD comorbidity are unclear, especially in patients with severe mental illness. The authors assessed short-term clinical outcome in severely depressed psychiatric inpatients with and without comorbid PTSD...
  28. ncbi request reprint Treatment of acute mania
    Paul E Holtzheimer
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    CNS Spectr 8:917-20, 924-8. 2003
    ....
  29. pmc Future prospects in depression research
    Paul E Holtzheimer
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Dialogues Clin Neurosci 8:175-89. 2006
    ..This review highlights these future prospects for depression research with a specific focus on lines of investigation likely to generate novel, more effective treatment options...