Research Topics
Species | Christopher HillyerSummaryAffiliation: Emory University Country: USA Publications
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Publications
Donor lymphocyte infusion therapyKaren S Roush
Department of Pathology and Laboratory Medicine, Transfusion Medicine Program, Emory University School of Medicine, 1362 Clifton Road NE, Atlanta, GA 30322, USA
Transfus Med Rev 16:161-76. 2002..It also examines tools that have been developed to more accurately describe survival benefits attributable to DLI...
Pediatric transfusion medicine: development of a critical massChristopher D Hillyer
Pediatric Transfusion Medicine Academic Awardees Program PedsTMAA, EUH Blood Bank, Atlanta, GA 30322, USA
Transfusion 49:596-601. 2009..Indeed, several issues regarding the subspecialty of pediatric transfusion medicine (PTM) are particularly timely, and it appears that a critical mass, or a nidus capable of becoming a critical mass, is developing in PTM...- Description and investigation of white particulate matter in additive solution-1 red blood cell unitsChristopher D Hillyer
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Transfusion 44:977-83. 2004..Because the increased rate of appearance of WPM was a transient phenomenon, it is not clear whether this is a newly noticed or a new and different phenomenon from "aggregates" observed in the past... - Transfusion recipient epidemiology and outcomes research: possibilities for the futureChristopher D Hillyer
Blood Bank, Emory University Hospital, Atlanta, Georgia, USA
Transfusion 48:1530-7. 2008..This group was asked to discuss the current status of the field, identify critical research needs, and make recommendations to the NHLBI program staff... - Integrating molecular technologies for red blood cell typing and compatibility testing into blood centers and transfusion servicesChristopher D Hillyer
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30321, USA
Transfus Med Rev 22:117-32. 2008..A stepwise plan for progressive introduction into the donor centers and transfusion services must be established. In conclusion, the field of transfusion medicine is ready to expand the use of molecular diagnostics... - Recipient inflammation affects the frequency and magnitude of immunization to transfused red blood cellsJeanne E Hendrickson
Department of Pediatric Hematology/Oncology, Emory University School of Medicine, Children's Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia 30322, USA
Transfusion 46:1526-36. 2006..Moreover, these data suggest that the inflammatory status of human transfusion recipients may regulate the immunogenicity of transfused RBCs... 
Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigenJeanne E Hendrickson
Division of Pediatric Hematology Oncology, Aflac Cancer Center and Blood Disorders Service, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 50:642-8. 2010..To test the hypothesis that storage time alters RBC immunogenicity, we utilized a murine model of RBC storage and alloimmunization...- Photochemical treatment of platelet concentrates with amotosalen hydrochloride and ultraviolet A light inactivates free and latent cytomegalovirus in a murine transfusion modelCetherine T Jordan
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 44:1159-65. 2004..These results suggest that PCT of human PLTs with amotosalen/UVA should also effectively abrogate TT-CMV in the clinical setting... - CD36 immunization in a patient undergoing hematopoietic stem cell transplantationElizabeth E Culler
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 50:660-2. 2008..The patient responded adequately to transfusion of crossmatch compatible platelets and successfully underwent HSCT. The presence of anti-CD36 antibodies does not exclude potential candidates from HSCT... - HLA alloimmunization is associated with RBC antibodies in multiply transfused patients with sickle cell diseaseMarianne E McPherson
AFLAC Cancer Center and Blood Disorders Services, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
Pediatr Blood Cancer 54:552-8. 2010..The prevalence and risk factors for HLA alloimmunization in multiply transfused pediatric SCD patients are unknown... - Unappreciated risk factors for transplant patients: HLA antibodies in blood componentsRobert A Bray
Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, GA 30322, United States
Hum Immunol 65:240-4. 2004..This unappreciated frequency of HLA alloantibodies in blood components may pose a risk to transplant patients requiring transfusions by promoting allograft dysfunction or loss... - Transfusion-induced autoantibodies and differential immunogenicity of blood group antigens: a novel hypothesisJames C Zimring
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 47:2189-96. 2007..The scientific basis, existing evidence, approaches to testing, and predicted biology of this hypothesis are presented... - Nonhemolytic antigen loss from red blood cells requires cooperative binding of multiple antibodies recognizing different epitopesJames C Zimring
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Blood 110:2201-8. 2007..Together, these data lead to the hypothesis that antigen-antibody crosslinking is required for nonhemolytic antigen loss to occur... - Discrete Toll-like receptor agonists have differential effects on alloimmunization to transfused red blood cellsJeanne E Hendrickson
Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, Georgia, USA
Transfusion 48:1869-77. 2008..To determine whether a different subtype of inflammation also enhances RBC alloimmunization, we investigated the effects of the bacterial endotoxin lipopolysaccharide (LPS) on alloimmunization... - Blood donation and blood transfusion: special considerations for African AmericansBeth H Shaz
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Transfus Med Rev 22:202-14. 2008.... - Animal models of transfusion-related acute lung injuryLennart E Lögdberg
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30308, USA
Transfus Med Rev 23:13-24. 2009..This article reviews the current status of the known experimental models of TRALI, with particular emphasis on efforts to establish in vivo animal models of this important pulmonary transfusion reaction... - Critical evaluation of informed consent forms for adult and minor aged whole blood donation used by United States blood centersBeth H Shaz
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA 30322, USA
Transfusion 49:1136-45. 2009..The goal of the study was to determine if the majority of the generally accepted elements of informed consent are provided to volunteer allogeneic whole blood donors in the United States... - Noninfectious serious hazards of transfusionJeanne E Hendrickson
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, 1364 Clifton Rd, NE, Atlanta, GA 30322, USA
Anesth Analg 108:759-69. 2009..In this article, we review NISHOTs, focusing on the most recent concerns and literature... - Transfusion management of trauma patientsBeth H Shaz
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Anesth Analg 108:1760-8. 2009..Future prospective clinical trials will allow continued improvement in MTPs and thus in the overall management of patients with trauma... - Transfusion management of sickle cell patients during bone marrow transplantation with matched sibling donorMarianne E McPherson
Aflac Cancer Center and Blood Disorders Service, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
Transfusion 49:1977-86. 2009..Characterization of transfusion requirements is important for blood bank and clinician patient management... - Racial differences in motivators and barriers to blood donation among blood donorsBeth H Shaz
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Arch Pathol Lab Med 133:1444-7. 2009..Nationally, African Americans are underrepresented in community blood donation programs. To increase blood donation by African Americans, differences between motivators and barriers to blood donation between races should be investigated... - Motivators and barriers to blood donation in African American college studentsBeth H Shaz
Emory University School of Medicine, Department of Pathology and Laboratory Medicine, United States B H Shaz
Transfus Apher Sci 41:191-7. 2009..This study investigated the differences in motivators and barriers to blood donation between donor and non-donor African American college students... - Increased number of coagulation products in relationship to red blood cell products transfused improves mortality in trauma patientsBeth H Shaz
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 50:493-500. 2010..This study investigates the relationship of plasma:RBC, PLT:RBC, and cryoprecipitate:RBC transfusion ratios to mortality in massively transfused patients at a civilian Level 1 trauma center... - ABO-mismatched platelet transfusions: strategies to mitigate patient exposure to naturally occurring hemolytic antibodiesCassandra D Josephson
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfus Apher Sci 42:83-8. 2010..The progress in this European strategy may serve the US to stimulate a re-examination of its practices and policies for the advancement of platelet transfusion safety... - Prevention of transfusion-transmitted cytomegalovirus in low-birth weight infants (≤1500 g) using cytomegalovirus-seronegative and leukoreduced transfusionsCassandra D Josephson
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
Transfus Med Rev 25:125-32. 2011..Conducted in Atlanta, GA, this study has been registered at the US National Institutes of Health (ClinicalTrials.gov no. NCT00907686)... - Transfusion in the patient with sickle cell disease: a critical review of the literature and transfusion guidelinesCassandra D Josephson
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
Transfus Med Rev 21:118-33. 2007..Our objectives were to provide an in-depth review of the current literature on transfusion therapy in SCD and to provide a set of guidelines for the transfusion management of patients with SCD... - Effect of mediators of innate immunity and inflammation on CD8+ veto cellsJames C Zimring
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Room 7301, 101 Woodruff Circle, Atlanta, GA 30322, USA
Transplantation 78:1597-600. 2004..Unlike other strategies, veto cells promote long-term allograft survival in primates. Accordingly, the authors hypothesized that veto cells are resistant to the effects of innate immune activation... - Improved method for fluorescence cytometric immunohematology testingJohn D Roback
Department of Pathology and Laboratory Medicine, Emory Univerity School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 44:187-96. 2004..Nevertheless, the use of vacuum filtration to wash RBCs and a standard-flow cytometer for data acquisition hindered efforts to incorporate this method into an automated platform... - Allogeneic T cells treated with amotosalen prevent lethal cytomegalovirus disease without producing graft-versus-host disease following bone marrow transplantationJohn D Roback
Department of Pathology and Laboratory Medicine, Transfusion Medicine Program, Emory University School of Medicine, Atlanta, GA 30322, USA
J Immunol 171:6023-31. 2003..Thus, amotosalen treatment rapidly eliminates the GVHD activity of polyclonal T cells, while preserving long-term antiviral and graft facilitation effects, and may be clinically useful for routine adoptive immunotherapy... - Nonhemolytic antibody-induced loss of erythrocyte surface antigenJames C Zimring
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Bldg Ste 7301, 101 Woodruff Cir, Atlanta, GA 30322, USA
Blood 106:1105-12. 2005..These studies provide mechanistic insight into the phenomenon of antigen loss during incompatible transfusion in humans... - Transfusion medicine illustrated. Detection of mixed-field agglutination due to loss of red cell antigen in hematopoietic malignancyChelsea A Sheppard
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 46:1463-4. 2006 - Granulocyte transfusion: revisitedMichael A Briones
Division Hematology and Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, AFLAC Cancer Center and Blood Disorders, 2040 Ridgewood Drive, Suite 100, Atlanta, GA 30322, USA
Curr Hematol Rep 2:522-7. 2003.... - An automatable format for accurate immunohematology testing by flow cytometryJohn D Roback
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Transfusion 43:918-27. 2003..Furthermore, current automated and semiautomated workstations cannot accommodate many other tests relevant to blood transfusion... - Islet transplantation, stem cells, and transfusion medicineLennart Logdberg
Department of Pathology, The Carlos and Marguerite Mason Transplantation Biology Research Center, Emory University School of Medicine, Atlanta 30322, GA, USA
Transfus Med Rev 17:95-109. 2003.... - CMV DNA is rarely detected in healthy blood donors using validated PCR assaysJohn D Roback
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 43:314-21. 2003..NAT of blood components for CMV DNA has been proposed to further reduce the risks of TT-CMV. However, large-scale studies to determine the utility of validated CMV NAT assays for donor screening have not been reported... - Transfusion-transmitted cytomegalovirus (CMV) infections in a murine model: characterization of CMV-infected donor miceJohn D Roback
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Transfusion 46:889-95. 2006..These donor kinetics suggest that the experimental MCMV system can be used to effectively model the mechanisms of TT-CMV infections in humans... - Comparison of cytomegalovirus polymerase chain reaction and serology for screening umbilical cord blood componentsJohn D Roback
Transfusion Medicine Program, The Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Transfusion 45:1722-8. 2005..A prospective clinical trial to further evaluate the role of CMV NAT in UCB transplantation appears warranted... - Nonfatal intravascular hemolysis in a pediatric patient after transfusion of a platelet unit with high-titer anti-AShealynn B Harris
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Transfusion 47:1412-7. 2007..Group A patients transfused with group O single-donor PLTs (SDPs) with "high-titer" anti-A are at greatest risk for hemolysis... - Inflammation enhances consumption and presentation of transfused RBC antigens by dendritic cellsJeanne E Hendrickson
Department of Pediatric Hematology Oncology, Emory University School of Medicine, Children s Healthcare of Atlanta, Aflac Cancer Center and Blood Disorders Service, Atlanta, GA 30322, USA
Blood 110:2736-43. 2007..Together, these data provide additional insight into the nature of transfused RBCs as an immunogen and provide a mechanism by which viral-like inflammation enhances alloimmunization to transfused RBCs... - Leukoreduction filtration of blood with sickle cell traitAudrey N Schuetz
Transfusion Medicine Program, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Transfus Med Rev 18:168-76. 2004..This review concludes with a discussion of different approaches to screening blood units for sickle cell trait... - Transfusion-transmitted cytomegalovirus: lessons from a murine modelJohn D Roback
Department of Pathology and Laboratory Medicine, Transfusion Medicine Program, Emory University School of Medicine, Atlanta, GA 30322, USA
Transfus Med Rev 21:26-36. 2007..In this review, we discuss a mouse blood transfusion model, which can be used to investigate these issues as well as to validate methods to prevent TT-CMV in at-risk patients... - Amotosalen-treated donor T cells have polyclonal antigen-specific long-term function without graft-versus-host disease after allogeneic bone marrow transplantationMohammad Sohrab Hossain
Department of Hematology and Oncology, Division of Stem Cell and Bone Marrow Transplantation, Winship Cancer Institute, Emory Universiy School of Medicine, Atlanta, Georgia, USA
Biol Blood Marrow Transplant 11:169-80. 2005..This is a novel approach to adoptive immunotherapy in allogeneic BMT... - Effects of storage duration and volume on the quality of leukoreduced apheresis-derived platelets: implications for pediatric transfusion medicineAnne M Winkler
Center for Transfusion and Cellular Therapies, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
Transfusion 50:2193-8. 2010..However, limited data exist regarding the impact of storage on residual small-volume LR-ADP... - Blood donors and factors impacting the blood donation decisionTheresa W Gillespie
Winship Cancer Institute, Emory University, 1365B Clifton Road, Atlanta, GA 30322, USA
Transfus Med Rev 16:115-30. 2002..Investigations are needed also to assess research questions and to develop well-designed interventions to test hypotheses and to produce generalizable findings applicable to future donor decision making... - Transfusion-related acute lung injuryChelsea A Sheppard
Department of Pathology and Laboratory Medicine, Room D 655, Emory University School of Medicine, 1364 Clifton Road N E, Atlanta, GA 30322, USA
Hematol Oncol Clin North Am 21:163-76. 2007..This article reviews the clinical manifestations, evolving definition, incidence, pathophysiology, animal modeling, and donor screening and deferral algorithms as they relate to transfusion-related acute lung injury... - Platelet transfusion practices among neonatologists in the United States and Canada: results of a surveyCassandra D Josephson
Aflac Cancer Center and Blood Disorders Services at Children s Healthcare of Atlanta, Atlanta, Georgia, USA
Pediatrics 123:278-85. 2009..We hypothesized that there would be significant diversity in platelet transfusion triggers, product selection, and dosing among neonatologists in the United States and Canada... - Do red cell transfusions increase the risk of necrotizing enterocolitis in premature infants?Cassandra D Josephson
Department of Pathology and Laboratory Medicine, Center for Transfusion and Cellular Therapies, Emory University School of Medicine, Atlanta, GA, USA
J Pediatr 157:972-978.e1-3. 2010.... - Prevalence of selected viral infections among blood donors deferred for potential risk to blood safetyShimian Zou
Jerome H Holland Laboratory, American Red Cross Blood Services, Rockville, Maryland 20855, USA
Transfusion 46:1997-2003. 2006..This study assesses the current impact of some of these questions on blood safety as reflected by infectious disease markers... - Adverse reactions to allogeneic whole blood donation by 16- and 17-year-oldsAnne F Eder
Biomedical Services, Medical Office, National Headquarters, American Red Cross, 2025 E St NW, Washington, DC 20006, USA
JAMA 299:2279-86. 2008.... - Tissue oversight in hospitals: the role of the transfusion servicesChristopher D Hillyer
Transfusion 47:185-7. 2007
Research Grants
- Transfusion Medicine/Hemostasis Clinical Trails NetworkChristopher Hillyer; Fiscal Year: 2007..The Emory Core Clinical Center has developed the personnel and procedures to ensure optimal participation and future productivity. EMORY UNIVERSITY CRITIQUES ..
- Training Grant in Transfusion MedicineChristopher Hillyer; Fiscal Year: 2007..abstract_text> ..
- "Development of a Laboratory Test for TTP"Christopher Hillyer; Fiscal Year: 2003..abstract_text> ..
- PCR Screening for CMV in Umbilical Cord Blood Stem CellsChristopher Hillyer; Fiscal Year: 2003....
- TRANSFUSION TRANSMISSION OF CELL-ASSOCIATED INFECTIONSChristopher Hillyer; Fiscal Year: 2003..He predicts that allogeneic leukocyte interactions mediate reactivation of MCMV in the recipient and that g IFN inhibits this process. ..