My N Helms

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells
    Ling Yu
    The Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 293:F1666-77. 2007
  2. pmc Chronic alcohol ingestion changes the landscape of the alveolar epithelium
    Charles A Downs
    Department of Pediatrics, Emory Children Center for Developmental Lung Biology, 2015 Uppergate Drive, Suite 316K, Atlanta, GA 30322, USA
    Biomed Res Int 2013:470217. 2013
  3. doi request reprint Regulation of ion transport by oxidants
    Charles A Downs
    2015 Upper Gate Dr, Ste 316 K, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 305:L595-603. 2013
  4. pmc Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells
    David Trac
    Dept of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322
    Am J Physiol Renal Physiol 305:F995-F1005. 2013
  5. pmc Ethanol alters alveolar fluid balance via Nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung
    Charles A Downs
    Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA
    PLoS ONE 8:e54750. 2013
  6. pmc Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling
    Preston Goodson
    Department of Physiology, Center for Developmental Lung Biology at Children s Healthcare of Atlanta, USA
    Am J Physiol Lung Cell Mol Physiol 302:L410-9. 2012
  7. ncbi request reprint Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations
    My N Helms
    Department of Physiology, The Center for Cell and Molecular Signalling, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 291:L610-8. 2006
  8. pmc β-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo
    Charles A Downs
    Department of Physiology, School of Medicine, Emory University, Atlanta, GA, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1167-78. 2012
  9. pmc H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8
    Charles A Downs
    Nell Hodgson Woodruff School of Nursing, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:8136-45. 2013
  10. pmc Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells
    Yoshizumi Takemura
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 304:L428-37. 2013

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Aldosterone-induced increases in superoxide production counters nitric oxide inhibition of epithelial Na channel activity in A6 distal nephron cells
    Ling Yu
    The Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 293:F1666-77. 2007
    ....
  2. pmc Chronic alcohol ingestion changes the landscape of the alveolar epithelium
    Charles A Downs
    Department of Pediatrics, Emory Children Center for Developmental Lung Biology, 2015 Uppergate Drive, Suite 316K, Atlanta, GA 30322, USA
    Biomed Res Int 2013:470217. 2013
    ..A better understanding of how alcohol changes the landscape of the alveolar epithelium can lead to improvements in treating acute respiratory distress syndrome (ARDS) for which hospitalized alcoholics are at an increased risk...
  3. doi request reprint Regulation of ion transport by oxidants
    Charles A Downs
    2015 Upper Gate Dr, Ste 316 K, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 305:L595-603. 2013
    ....
  4. pmc Fulvene-5 inhibition of Nadph oxidases attenuates activation of epithelial sodium channels in A6 distal nephron cells
    David Trac
    Dept of Pediatrics, 2015 Uppergate Dr, Atlanta, GA 30322
    Am J Physiol Renal Physiol 305:F995-F1005. 2013
    ....
  5. pmc Ethanol alters alveolar fluid balance via Nadph oxidase (NOX) signaling to epithelial sodium channels (ENaC) in the lung
    Charles A Downs
    Nell Hodgson Woodruff School of Nursing, Emory University, Atlanta, Georgia, USA
    PLoS ONE 8:e54750. 2013
    ..Collectively these data suggest that chronic EtOH consumption may lead to altered regulation of ENaC, contributing to a 'pro-injury' environment in the alcohol lung...
  6. pmc Nadph oxidase regulates alveolar epithelial sodium channel activity and lung fluid balance in vivo via O⁻₂ signaling
    Preston Goodson
    Department of Physiology, Center for Developmental Lung Biology at Children s Healthcare of Atlanta, USA
    Am J Physiol Lung Cell Mol Physiol 302:L410-9. 2012
    ..04 ± 0.03. These data demonstrate that, in vivo, ROS has the capacity to stimulate lung fluid clearance by increasing ENaC activity...
  7. ncbi request reprint Dopamine activates amiloride-sensitive sodium channels in alveolar type I cells in lung slice preparations
    My N Helms
    Department of Physiology, The Center for Cell and Molecular Signalling, Emory University School of Medicine, Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 291:L610-8. 2006
    ..31+/-0.19 to 0.60+/-0.21 (P<0.001). The D1 receptor antagonist SCH-23390 (10 microM) blocked the stimulatory effect of dopamine on AT1 cells, but the D2 receptor antagonist sulpiride did not...
  8. pmc β-Adrenergic agonists differentially regulate highly selective and nonselective epithelial sodium channels to promote alveolar fluid clearance in vivo
    Charles A Downs
    Department of Physiology, School of Medicine, Emory University, Atlanta, GA, USA
    Am J Physiol Lung Cell Mol Physiol 302:L1167-78. 2012
    ..In summary, β-AR agonists differentially regulate HSC and NSC in T1 and T2 cells to promote lung fluid clearance in vivo, and the mode of drug delivery is critical for maximizing β-AR agonist efficacy...
  9. pmc H2O2 regulates lung epithelial sodium channel (ENaC) via ubiquitin-like protein Nedd8
    Charles A Downs
    Nell Hodgson Woodruff School of Nursing, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 288:8136-45. 2013
    ....
  10. pmc Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells
    Yoshizumi Takemura
    Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 304:L428-37. 2013
    ..Our results showed that muscarinic agonists activated ENaC in rat AT2 cells through M2 and/or M3 mAChRs probably via a RhoA/ROCK signaling pathway...
  11. ncbi request reprint Effect of divalent heavy metals on epithelial Na+ channels in A6 cells
    Ling Yu
    Dept of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 293:F236-44. 2007
    ....
  12. pmc Redox regulation of epithelial sodium channels examined in alveolar type 1 and 2 cells patch-clamped in lung slice tissue
    My N Helms
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:22875-83. 2008
    ..levels with Ethiolat, a superoxide dismutase inhibitor, prevented NO inhibition of ENaC activity in type 2 cells, supporting the novel hypothesis that O2. and NO signaling plays an important role in maintaining lung fluid balance...
  13. pmc Acute effects of cigarette smoke extract on alveolar epithelial sodium channel activity and lung fluid clearance
    Charles A Downs
    Nell Hodgson Woodruff School of Nursing, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 49:251-9. 2013
    ..In vivo studies show that tracheal instillation of CSE promoted alveolar fluid clearance after 105 minutes compared with vehicle control (n = 10/group; P < 0.05). ..
  14. ncbi request reprint The contribution of epithelial sodium channels to alveolar function in health and disease
    Douglas C Eaton
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Physiol 71:403-23. 2009
    ..In lung, ENaC is regulated by many transmitter and hormonal agents. Regulation depends upon the type of sodium channel but involves controlling the number of apical channels and/or the activity of individual channels...
  15. pmc Rac1-mediated NADPH oxidase release of O2- regulates epithelial sodium channel activity in the alveolar epithelium
    Yoshizumi Takemura
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Am J Physiol Lung Cell Mol Physiol 298:L509-20. 2010
    ..In conclusion, we report that Rac1-mediated NOX2 activity is an important component in O(2)(-) regulation of ENaC...
  16. ncbi request reprint Dopamine regulation of amiloride-sensitive sodium channels in lung cells
    My N Helms
    Dept of Physiology, Emory Univ School of Medicine, 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 290:L710-L722. 2006
    ..In summary, dopamine increases ENaC activity by a cAMP-mediated alternative signaling pathway involving EPAC and Rap1, signaling molecules usually associated with growth-factor-activated receptors...
  17. pmc Single-channel analysis of functional epithelial sodium channel (ENaC) stability at the apical membrane of A6 distal kidney cells
    Ling Yu
    Center for Cell and Molecular Signaling, Department of Physiology, Emory University School of Medicine, Whitehead Biomedical Research Bldg 615 Michael St, Atlanta, GA 30322, USA
    Am J Physiol Renal Physiol 295:F1519-27. 2008
    ....
  18. ncbi request reprint Phosphatidylinositol 3,4,5-trisphosphate mediates aldosterone stimulation of epithelial sodium channel (ENaC) and interacts with gamma-ENaC
    My N Helms
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:40885-91. 2005
    ..Additionally, we demonstrated a novel interaction between gamma-ENaC and PIP(3)...
  19. pmc Extracellular matrix influences alveolar epithelial claudin expression and barrier function
    Michael Koval
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael St, Suite 205, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 42:172-80. 2010
    ..Thus, although alveolar epithelial cells on fibronectin formed rapid barriers, it was at the expense of producing an optimized barrier...
  20. ncbi request reprint Chronic ethanol exposure alters the lung proteome and leads to mitochondrial dysfunction in alveolar type 2 cells
    Abdel A Alli
    Department of Physiology, Emory University School of Medicine, Atlanta, Georgia
    Am J Physiol Lung Cell Mol Physiol 306:L1026-35. 2014
    ....
  21. pmc Hyperoxia induces alveolar epithelial-to-mesenchymal cell transition
    Shilpa Vyas-Read
    2015 Uppergate Dr NE, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 306:L326-40. 2014
    ..Additionally, SB-431542 treatment attenuated changes in alveolar histology caused by hyperoxia. Our studies indicate that hyperoxia promotes alveolar EMT through a mechanism that is dependent on activation of TGF-β1 signaling. ..
  22. pmc Loss of desmocollin-2 confers a tumorigenic phenotype to colonic epithelial cells through activation of Akt/β-catenin signaling
    Keli Kolegraff
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Mol Biol Cell 22:1121-34. 2011
    ..Taken together, our results provide evidence that loss of Dsc2 contributes to the growth of colorectal cancer cells and highlight a novel mechanism by which the desmosomal cadherins regulate β-catenin signaling...
  23. ncbi request reprint Role of SGK1 in nitric oxide inhibition of ENaC in Na+-transporting epithelia
    My N Helms
    Dept of Physiology, Emory University of School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 289:C717-26. 2005
    ..Our study also identified iNOS as a novel SGK1 phosphorylated protein (at S733 and S903 residues in miNOS) suggesting that one way in which SGK1 could increase Na(+) transport is by altering iNOS production of NO...