C Heim

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
  2. ncbi request reprint Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001
    Christine Heim
    Division of Viral and Rickettsial Diseases, Viral Exanthems and Herpesvirus Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Psychosom Med 66:672-8. 2004
  3. ncbi request reprint Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    Thaddeus W W Pace
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1630-3. 2006
  4. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
  5. doi request reprint A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 25:6-13. 2011
  6. pmc Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study
    William C Reeves
    Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Neurol 6:41. 2006
  7. pmc Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study
    Matthias Majer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, USA
    BMC Neurol 7:40. 2007
  8. pmc Chronic fatigue syndrome--a clinically empirical approach to its definition and study
    William C Reeves
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med 3:19. 2005
  9. ncbi request reprint The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 63:398-405. 2008
  10. doi request reprint The link between childhood trauma and depression: insights from HPA axis studies in humans
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:693-710. 2008

Research Grants

Detail Information

Publications23

  1. pmc Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 100:14293-6. 2003
    ..Our results suggest that psychotherapy may be an essential element in the treatment of patients with chronic forms of major depression and a history of childhood trauma...
  2. ncbi request reprint Regional prevalence of fatiguing illnesses in the United States before and after the terrorist attacks of September 11, 2001
    Christine Heim
    Division of Viral and Rickettsial Diseases, Viral Exanthems and Herpesvirus Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Psychosom Med 66:672-8. 2004
    ..We used data obtained during this survey to estimate the effect of the coincidentally occurring terrorist attacks of September 11, 2001, on the regional prevalence of fatiguing illnesses...
  3. ncbi request reprint Increased stress-induced inflammatory responses in male patients with major depression and increased early life stress
    Thaddeus W W Pace
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Psychiatry 163:1630-3. 2006
    ..The authors sought to determine innate immune system activation following psychosocial stress in patients with major depression and increased early life stress...
  4. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  5. doi request reprint A short review on the psychoneuroimmunology of posttraumatic stress disorder: from risk factors to medical comorbidities
    Thaddeus W W Pace
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 25:6-13. 2011
    ..This short article reviews immune alterations in PTSD, and considers possible mechanisms by which such changes may be related to neuroendocrine alterations and medical comorbidities of PTSD...
  6. pmc Sleep characteristics of persons with chronic fatigue syndrome and non-fatigued controls: results from a population-based study
    William C Reeves
    Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Neurol 6:41. 2006
    ....
  7. pmc Perception versus polysomnographic assessment of sleep in CFS and non-fatigued control subjects: results from a population-based study
    Matthias Majer
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, USA
    BMC Neurol 7:40. 2007
    ..We conducted this study to determine whether alterations in objective sleep characteristics are associated with subjective measures of poor sleep quality in persons with CFS...
  8. pmc Chronic fatigue syndrome--a clinically empirical approach to its definition and study
    William C Reeves
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Med 3:19. 2005
    ..The lack of standardized criteria for defining chronic fatigue syndrome (CFS) has constrained research. The objective of this study was to apply the 1994 CFS criteria by standardized reproducible criteria...
  9. ncbi request reprint The dexamethasone/corticotropin-releasing factor test in men with major depression: role of childhood trauma
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 63:398-405. 2008
    ..We determined the impact of childhood trauma on dexamethasone/CRF test results in patients with MDD...
  10. doi request reprint The link between childhood trauma and depression: insights from HPA axis studies in humans
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, WMRB, Suite 4311, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 33:693-710. 2008
    ..Taken together, this line of evidence demonstrates that psychoneuroendocrine research may ultimately promote optimized clinical care and help prevent the adverse outcomes of childhood trauma...
  11. doi request reprint Lower CSF oxytocin concentrations in women with a history of childhood abuse
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, WMRB, Atlanta, GA 30322, USA
    Mol Psychiatry 14:954-8. 2009
    ..If replicated, the association of lower adult CSF OT levels with childhood trauma might indicate that alterations in central OT function may be involved in the adverse outcomes of childhood adversity...
  12. doi request reprint Childhood trauma and risk for chronic fatigue syndrome: association with neuroendocrine dysfunction
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Woodruff Memorial Research Bldg, Ste 4311, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 66:72-80. 2009
    ..However, the contribution of childhood trauma to neuroendocrine dysfunction in CFS remains obscure...
  13. ncbi request reprint Neurobiology of posttraumatic stress disorder
    Christine Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    CNS Spectr 14:13-24. 2009
    ..On the basis of these findings, important hypotheses for developing novel strategies to identify subjects at risk, promote resilience, and devise targets for the prevention or treatment of PTSD can be derived...
  14. ncbi request reprint Early adverse experience and risk for chronic fatigue syndrome: results from a population-based study
    Christine Heim
    Viral Exanthems and Herpesvirus Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 63:1258-66. 2006
    ..Identification of developmental risk factors for CFS is critical to inform pathophysiological research and devise targets for primary prevention...
  15. ncbi request reprint Altered pituitary-adrenal axis responses to provocative challenge tests in adult survivors of childhood abuse
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Psychiatry 158:575-81. 2001
    ..On subsequent stress exposure, women with a history of childhood abuse may hypersecrete CRF, resulting in down-regulation of adenohypophyseal CRF receptors and symptoms of depression and anxiety...
  16. ncbi request reprint Neurobiological effects of childhood abuse: implications for the pathophysiology of depression and anxiety
    K M Penza
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Womens Ment Health 6:15-22. 2003
    ..These physiological maladaptations likely represent long-term risk factors for the development of psychopathology after exposure to additional stress...
  17. ncbi request reprint The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies
    C Heim
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 49:1023-39. 2001
    ..The identification of the neurobiological substrates of early adverse experience is of paramount importance for the development of novel treatments for children, adolescents, and adults...
  18. ncbi request reprint Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
    J Douglas Bremner
    Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    J Psychopharmacol 19:159-65. 2005
    ..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD...
  19. ncbi request reprint Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot study
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    J Clin Psychiatry 65:1559-64. 2004
    ..The purpose of this study was to assess the effects of phenytoin on symptoms of PTSD...
  20. ncbi request reprint Glucocorticoid receptor polymorphisms and haplotypes associated with chronic fatigue syndrome
    M S Rajeevan
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Genes Brain Behav 6:167-76. 2007
    ....
  21. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  22. ncbi request reprint Assessing cortisol reactivity to a linguistic task as a marker of stress in individuals with left-hemisphere stroke and aphasia
    Jacqueline Laures-Gore
    Department of Educational Psychology and Special Education, Communication Disorders Program, Georgia State University, P O Box 3979, Atlanta, Georgia 30302 3979, USA
    J Speech Lang Hear Res 50:493-507. 2007
    ....
  23. ncbi request reprint Higher heart rate and reduced heart rate variability persist during sleep in chronic fatigue syndrome: a population-based study
    Roumiana S Boneva
    Chronic Viral Diseases Branch, National Center for Zoonotic, Vector Borne and Enteric Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA
    Auton Neurosci 137:94-101. 2007
    ..Future research on the underlying pathophysiologic mechanisms of the association is needed...

Research Grants2

  1. Neural Substrates of Depression Risk after Child Abuse
    Christine Heim; Fiscal Year: 2007
    ..This K01 award will provide the candidate with depth and breadth in distinct disciplines, which is critical for considering the multifactorial contributors to complex psychiatric disorders in the future. ..