David Harrison

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Endothelial mechanotransduction, nitric oxide and vascular inflammation
    D G Harrison
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Intern Med 259:351-63. 2006
  2. pmc Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension
    Antony Vinh
    Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circulation 122:2529-37. 2010
  3. pmc Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription
    Wei Chen
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30022, USA
    J Biol Chem 283:16293-8. 2008
  4. pmc Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
    Tomasz J Guzik
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30033, USA
    J Exp Med 204:2449-60. 2007
  5. pmc Cellular and molecular mechanisms of endothelial cell dysfunction
    D G Harrison
    Emory University, Department of Internal Medicine and the Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 100:2153-7. 1997
  6. ncbi request reprint Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
    David G Harrison
    Division of Caridology, Emory University, Atlanta, Georgia 30322, USA
    J Renin Angiotensin Aldosterone Syst 4:51-61. 2003
  7. ncbi request reprint Role of oxidative stress in atherosclerosis
    David Harrison
    Department of Medicine, Division of Cardioogy, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Am J Cardiol 91:7A-11A. 2003
  8. doi request reprint Enhanced hype
    David G Harrison
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Cardiol 102:368-9. 2008
  9. ncbi request reprint Endothelial control of vasomotion and nitric oxide production
    David G Harrison
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Room 319 WMRB, Atlanta, GA 30322, USA
    Cardiol Clin 21:289-302. 2003
  10. ncbi request reprint Is hypertension an immunologic disease?
    David G Harrison
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Room 319 WMRB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Curr Cardiol Rep 10:464-9. 2008

Research Grants

Collaborators

Detail Information

Publications71

  1. ncbi request reprint Endothelial mechanotransduction, nitric oxide and vascular inflammation
    D G Harrison
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Intern Med 259:351-63. 2006
    ..We will also review data that exercise training in vivo has a similar effect as laminar shear on endothelial function and discuss the clinical relevance of these basic findings...
  2. pmc Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension
    Antony Vinh
    Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circulation 122:2529-37. 2010
    ..The latter often involves interaction between B7 ligands (CD80 and CD86) on antigen-presenting cells with the T-cell coreceptor CD28. This study was therefore performed to examine the role of this pathway in hypertension...
  3. pmc Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription
    Wei Chen
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30022, USA
    J Biol Chem 283:16293-8. 2008
    ..This was associated with opening of chromatin at the SSRE. In conclusion, these studies reveal a previously unknown role of p300/HAT activation as a very early response to shear that is essential for increasing eNOS mRNA levels...
  4. pmc Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
    Tomasz J Guzik
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30033, USA
    J Exp Med 204:2449-60. 2007
    ..T cells might represent a novel therapeutic target for the treatment of high blood pressure...
  5. pmc Cellular and molecular mechanisms of endothelial cell dysfunction
    D G Harrison
    Emory University, Department of Internal Medicine and the Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 100:2153-7. 1997
  6. ncbi request reprint Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
    David G Harrison
    Division of Caridology, Emory University, Atlanta, Georgia 30322, USA
    J Renin Angiotensin Aldosterone Syst 4:51-61. 2003
    ..Furthermore, increasing evidence suggest that the NAD(P)H oxidase contributes to human disease, suggesting that it is a potential target for future therapeutic intervention...
  7. ncbi request reprint Role of oxidative stress in atherosclerosis
    David Harrison
    Department of Medicine, Division of Cardioogy, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Am J Cardiol 91:7A-11A. 2003
    ..Oxidative stress in humans with coronary artery disease is also exacerbated by a reduction of vascular extracellular superoxide dismutase, normally an important protective enzyme against the superoxide anion...
  8. doi request reprint Enhanced hype
    David G Harrison
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Cardiol 102:368-9. 2008
    ..In conclusion, the public fury over this study, with physicians making unsupported statements to the press and on the Web, is unfortunate and should be discouraged in the future...
  9. ncbi request reprint Endothelial control of vasomotion and nitric oxide production
    David G Harrison
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Room 319 WMRB, Atlanta, GA 30322, USA
    Cardiol Clin 21:289-302. 2003
    ..Because of the complexity of abnormalities that underlie endothelial dysfunction, there are various therapeutic targets that may have to be addressed to improve endothelial function and ultimately improve prognosis in these individuals...
  10. ncbi request reprint Is hypertension an immunologic disease?
    David G Harrison
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Room 319 WMRB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Curr Cardiol Rep 10:464-9. 2008
    ..These findings provide some insight into the relationship between inflammation and hypertension and suggest that efforts to reduce T-cell activation may be useful in preventing or treating this disease...
  11. doi request reprint Oxidative stress and hypertension
    David G Harrison
    Department of Medicine, Division of Cardiology, Emory University School of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Med Clin North Am 93:621-35. 2009
    ..Future studies are needed to understand the interaction of T cells with the CNS, the kidney, and the vasculature and how this might be interrupted to provide therapeutic benefit...
  12. ncbi request reprint Oxidative stress and coronary artery disease
    D Harrison
    Emory University School of Medicine, Department of Internal Medicine, Atlanta, GA 30322, USA
    Can J Cardiol 14:30D-32D. 1998
    ..This update focuses on data implicating oxidative inactivation of nitric oxide in atherosclerosis and hypercholesterolemia...
  13. pmc Role of the adaptive immune system in hypertension
    David G Harrison
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30345, USA
    Curr Opin Pharmacol 10:203-7. 2010
    ..Identification of these neoantigens and understanding how they form might prove useful in the prevention and treatment of this widespread and devastating disease...
  14. pmc Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis
    Douglas Nam
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA
    Am J Physiol Heart Circ Physiol 297:H1535-43. 2009
    ..It also allows for easy and rapid intimal RNA isolation. This novel model and method could be used for genome-wide studies to determine molecular mechanisms underlying flow-dependent regulation of vascular biology and diseases...
  15. pmc Induction of hypertension and peripheral inflammation by reduction of extracellular superoxide dismutase in the central nervous system
    Heinrich E Lob
    Division of Cardiology, Lowance Center of Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 55:277-83, 6p following 283. 2010
    ..These findings provide insight into how central signals produce vascular inflammation in response to hypertensive stimuli, such as angiotensin II...
  16. pmc Interleukin 17 promotes angiotensin II-induced hypertension and vascular dysfunction
    Meena S Madhur
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Hypertension 55:500-7. 2010
    ..We conclude that IL-17 is critical for the maintenance of angiotensin II-induced hypertension and vascular dysfunction and might be a therapeutic target for this widespread disease...
  17. pmc GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide
    Li Li
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Dr WMBR 319, Atlanta, GA 30322, USA
    Circ Res 106:328-36. 2010
    ....
  18. ncbi request reprint Vascular NADPH oxidases as drug targets for novel antioxidant strategies
    Tomasz J Guzik
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
    Drug Discov Today 11:524-33. 2006
    ..Here, we discuss novel possibilities where drugs that directly inhibit Nox activation could successfully inhibit oxidative stress...
  19. ncbi request reprint Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation
    Sumitra Miriyala
    Division of Cardiology, Emory University, Emory University, Atlanta, GA 30322, USA
    Circulation 113:2818-25. 2006
    ....
  20. ncbi request reprint The relationship between plasma levels of oxidized and reduced thiols and early atherosclerosis in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, Kansas, USA
    J Am Coll Cardiol 47:1005-11. 2006
    ..The study investigated the relationship between biomarkers of oxidative stress and early atherosclerosis...
  21. ncbi request reprint RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response
    Paul Modlinger
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
    Hypertension 47:238-44. 2006
    ..005). An increase in p22phox is required for increased renal NADPH oxidase activity, expression of Nox proteins and oxidative stress, and contributes < or =50% to hypertension during an Ang II slow-pressor response...
  22. ncbi request reprint Coronary artery superoxide production and nox isoform expression in human coronary artery disease
    Tomasz J Guzik
    Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, United Kingdom
    Arterioscler Thromb Vasc Biol 26:333-9. 2006
    ..Oxidative stress plays important role in the pathogenesis of atherosclerosis and coronary artery disease (CAD). We aimed to determine the sources and selected molecular mechanisms of oxidative stress in CAD...
  23. ncbi request reprint Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases
    Samuel C Dudley
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 112:1266-73. 2005
    ..We hypothesized that reduced LAA NO* levels observed in AF may be associated with increased superoxide (O2*-) production...
  24. ncbi request reprint The role of the multidrug resistance protein-1 in modulation of endothelial cell oxidative stress
    Cornelius F H Mueller
    Emory University Division of Cardiology, Department of Medicine, and the Atlanta Veterans Administration Hospital, Georgia 30322, USA
    Circ Res 97:637-44. 2005
    ..GSSG export by MRP1 leads to a perturbation of endothelial redox state and ultimately endothelial cell apoptosis. Endothelial MRP1 may provide a novel therapeutic target for prevention of vascular disease...
  25. ncbi request reprint A negative feedback mechanism involving nitric oxide and nuclear factor kappa-B modulates endothelial nitric oxide synthase transcription
    Isabella M Grumbach
    Division of Cardiology, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Mol Cell Cardiol 39:595-603. 2005
    ..Under these conditions, decreased NO availability may result in sustained activation of NFkappaB in response to shear and unrestrained endothelial inflammation...
  26. ncbi request reprint Role of extracellular superoxide dismutase in hypertension
    Maria Carolina Gongora
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 48:473-81. 2006
    ..These compensatory mechanisms preserve large vessel function when ecSOD is absent in hypertension...
  27. pmc Early determinants of H2O2-induced endothelial dysfunction
    Beth M Boulden
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 41:810-7. 2006
    ..Dysfunction required O(2)(*-), ONOO(-), or a functional NADPH oxidase. Repeated activation of the NADPH oxidase by ROS may act as a feed forward system to promote endothelial dysfunction...
  28. ncbi request reprint Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
    ..This can promotes thiol loss during states of increased glutathione oxidation. We investigated how MRP1 modulates blood pressure and vascular function during angiotensin II-induced hypertension...
  29. ncbi request reprint Sad heart from no SOD
    Maria Carolina Gongora
    Hypertension 51:28-30. 2008
  30. pmc Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome
    Maria Carolina Gongora
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 173:915-26. 2008
    ..Strategies either to prevent SOD3 inactivation or to augment its levels might prove useful in the treatment of acute lung injury...
  31. pmc Role of Menkes ATPase in angiotensin II-induced hypertension: a key modulator for extracellular superoxide dismutase function
    Zhenyu Qin
    Department of Medicine, Division of Cardiology, Emory University, School of Medicine, Atlanta, GA, USA
    Hypertension 52:945-51. 2008
    ....
  32. pmc Endothelial function and aminothiol biomarkers of oxidative stress in healthy adults
    Salman Ashfaq
    Division of Cardiology, University of Kansas School of Medicine, Wichita, USA
    Hypertension 52:80-5. 2008
    ....
  33. ncbi request reprint Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity
    Hua Cai
    Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, USA
    Methods Mol Med 139:293-311. 2007
    ....
  34. ncbi request reprint Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction
    Abdulrahman K Doughan
    Division of Cardiology and Department of Medicine, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circ Res 102:488-96. 2008
    ..Furthermore, mitochondrial dysfunction in response to Ang II modulates endothelial NO. and generation, which in turn has ramifications for development of endothelial dysfunction...
  35. ncbi request reprint David G. Harrison
    J Willis Hurst
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cardiol 30:629-30. 2007
  36. ncbi request reprint Regulation of tetrahydrobiopterin biosynthesis by shear stress
    Julian D Widder
    Division of Cardiology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Circ Res 101:830-8. 2007
    ..These findings illustrate a new function of casein kinase 2 in the endothelium and provide insight into regulation of GTPCH-1 activity...
  37. ncbi request reprint Endothelial NF-kappaB as a mediator of kidney damage: the missing link between systemic vascular and renal disease?
    Tomasz J Guzik
    Circ Res 101:227-9. 2007
  38. ncbi request reprint Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase
    Nermin Kuzkaya
    Department of Internal Medicine, Justus Liebig University School of Medicine, Giessen, Germany
    Biochem Pharmacol 70:343-54. 2005
    ..We conclude that the reducing and acidic properties of urate are important in effective scavenging of peroxynitrite and that cysteine and ascorbate markedly augment urate's antioxidant effect by reducing urate-derived radicals...
  39. ncbi request reprint Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium
    J Scott McNally
    Division of Cardiology, Emory University, 101 Woodruff Cir, WMB 319, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:1623-8. 2005
    ..We postulated that H2O2 may modulate the irreversible conversion of xanthine dehydrogenase (XDH) to XO and sought to examine mechanisms involved...
  40. ncbi request reprint Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress
    J Scott McNally
    Division of Cardiology and Molecular and Systems Pharmacology Program, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 285:H2290-7. 2003
    ..These data suggest that the NAD(P)H oxidase maintains endothelial cell XO levels and that XO is responsible for increased reactive oxygen species production in response to oscillatory shear stress...
  41. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease...
  42. ncbi request reprint Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    Nermin Kuzkaya
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:22546-54. 2003
    ..We confirmed that ONOO- uncouples eNOS by oxidation of tetrahydrobiopterin and that ascorbate does not fully protect BH4 from oxidation but recycles BH3. radical back to BH4...
  43. ncbi request reprint Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation
    Stephan Spiekermann
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA, USA
    Circulation 107:1383-9. 2003
    ..We therefore characterized the vascular activities of xanthine oxidase and NAD(P)H oxidase, 2 major O2*--producing enzyme systems, and their relationship with flow-dependent, endothelium-mediated vasodilation (FDD) in patients with CAD...
  44. ncbi request reprint Role of c-Src in regulation of endothelial nitric oxide synthase expression during exercise training
    Michael E Davis
    Division of Cardiology and Molecular and Systems Pharmacology Program, Emory University, and Veterans Hospital Medical Center, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 284:H1449-53. 2003
    ..These data indicate that c-Src has an important role in modulating vascular adaptations to exercise training, in particular increasing eNOS and extracellular superoxide dismutase protein expression...
  45. ncbi request reprint Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase 1/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide
    Hua Cai
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Pharmacol 63:325-31. 2003
    ..This may represent an acute cellular adaptation to an increase in oxidant stress...
  46. ncbi request reprint Vascular oxidative stress and endothelial dysfunction in patients with chronic heart failure: role of xanthine-oxidase and extracellular superoxide dismutase
    Ulf Landmesser
    Abteilung Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany
    Circulation 106:3073-8. 2002
    ....
  47. ncbi request reprint Downregulation of endocardial nitric oxide synthase expression and nitric oxide production in atrial fibrillation: potential mechanisms for atrial thrombosis and stroke
    Hua Cai
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 106:2854-8. 2002
    ..We hypothesized that atrial fibrillation (AF) causes a downregulation of atrial endocardial NOS expression and NO* production. Because NO* has antithrombotic properties, this may contribute to thromboembolism in AF...
  48. ncbi request reprint NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II
    Hua Cai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:48311-7. 2002
    ..Because angiotensin II also stimulates O(2)() production from the NAD(P)H oxidase, the H(2)O(2) stimulation of NO(.) may facilitate peroxynitrite formation in response to this octapeptide...
  49. ncbi request reprint Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Hypertension 40:511-5. 2002
    ..These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo...
  50. ncbi request reprint Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity
    H Ulrich Hink
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 22:1402-8. 2002
    ..We examined peroxidase properties of the extracellular form of SOD (SOD3), a major isoform of SOD in the vessel wall, by using recombinant SOD3 and an in vivo model of atherosclerosis...
  51. ncbi request reprint Extracellular superoxide dismutase and cardiovascular disease
    Tohru Fukai
    Department of Medicine, Division of Cardiology, Emory University, 1639 Pierce Drive, WMB 319, Atlanta, GA 30322, USA
    Cardiovasc Res 55:239-49. 2002
    ..Particularly, a major form of SOD in the vessel wall is the extracellular SOD (ecSOD). This review will discuss the characteristics of ecSOD and the role of ecSOD in cardiovascular diseases...
  52. ncbi request reprint Free radicals in heart failure: therapeutic targets for old and new drugs
    A Maziar Zafari
    Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Congest Heart Fail 8:129-30. 2002
  53. ncbi request reprint Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Georgia 30322, USA
    J Biol Chem 277:25480-5. 2002
    ..In light of these findings, the studies using geldanamycin as an inhibitor of Hsp90 should be interpreted with caution...
  54. ncbi request reprint Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion
    Jinah Hwang
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    J Biol Chem 278:47291-8. 2003
    ....
  55. ncbi request reprint The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
    Hua Cai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Pharmacol Sci 24:471-8. 2003
    ..Recently, efforts have been devoted to developing inhibitors of NAD(P)H oxidases that will provide useful experimental tools and might have therapeutic potential in the treatment of human diseases...
  56. ncbi request reprint Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor kappaB binding
    Michael E Davis
    Division of Cardiology, Molecular and Systems Pharmacology Program, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:163-8. 2004
    ....
  57. ncbi request reprint Laminar shear stress and 3' polyadenylation of eNOS mRNA
    Martina Weber
    Division of Cardiology, Department of Medicine, Emory University School of Medicine and Atlanta Veterans Adminitration Medical Center, Atlanta, GA, USA
    Circ Res 96:1161-8. 2005
    ..We suggest that mRNA 3' polyadenylation is a posttranscriptional mechanism used by endothelial cells to regulate gene expression...
  58. ncbi request reprint The shear stress of keeping arteries clear
    David G Harrison
    Nat Med 11:375-6. 2005
  59. ncbi request reprint Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase
    Nadine Lauer
    Institut fur Pharmakologie und Klinische Pharmakologie, Heinrich Heine Universitat, Dusseldorf, Germany
    Cardiovasc Res 65:254-62. 2005
    ..In vivo, exercise training, known to increase both endothelial shear stress and oxidative stress, also increases eNOS expression. It is unclear if H(2)O(2) contributes to an increase in eNOS expression in response to exercise training...
  60. ncbi request reprint Association between novel oxidative stress markers and C-reactive protein among adults without clinical coronary heart disease
    Jerome L Abramson
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Briarcliff Complex, Atlanta, GA 30322, USA
    Atherosclerosis 178:115-21. 2005
    ..The causes of increased CRP, however, are not completely understood. Studies suggest that oxidative stress may have pro-inflammatory effects, but data on the relationship between oxidative stress and CRP in healthy persons is sparse...
  61. ncbi request reprint ATVB in focus: redox mechanisms in blood vessels
    Cornelius F H Mueller
    Emory University Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:274-8. 2005
    ..Upcoming series of articles in Arteriosclerosis, Thrombosis, and Vascular Biology help elucidate how reactive oxygen species are produced by vascular cells and their role in vascular homeostasis...
  62. ncbi request reprint Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice
    Karine Laude
    Division of Cardiology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 288:H7-12. 2005
    ..NO in turn increases ecSOD protein expression and counterbalances increased ROS production leading to the maintenance of normal vascular function and hemodynamics...
  63. ncbi request reprint Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle
    David S Weber
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 288:H37-42. 2005
    ....
  64. ncbi request reprint Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
    Bruno Fink
    FRIMCORE, Division of Cardiology, Emory Univ School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 287:C895-902. 2004
    ..Detection of oxyethidium using HPLC represents a new, convenient, quantitative method for the detection of superoxide in intact cells and tissues...
  65. ncbi request reprint Oscillatory shear stress upregulation of endothelial nitric oxide synthase requires intracellular hydrogen peroxide and CaMKII
    Hua Cai
    Department of Medicine, Section of Cardiology, The University of Chicago, 5841 South Maryland Avenue, MC 6088, Chicago, IL 60637, USA
    J Mol Cell Cardiol 37:121-5. 2004
    ..Both OSS and LSS upregulate eNOS expression but via different signaling mechanisms...
  66. ncbi request reprint Established and emerging plasma biomarkers in the prediction of first atherothrombotic events
    Paul M Ridker
    Center for Cardiovascular Disease Prevention and the Department of Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, Mass 02115, USA
    Circulation 109:IV6-19. 2004
  67. ncbi request reprint C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils
    Keith E Wyche
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 43:1246-51. 2004
    ..Because p22phox exists in both the neutrophil and vessel wall, vascular oxidative stress is likely diminished in individuals with this polymorphism...
  68. ncbi request reprint Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma
    Jaikirshan J Khatri
    Division of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circulation 109:520-5. 2004
    ..Although multiple pathological processes have been associated with oxidative stress, the causative relation between oxidative stress and arterial lesion progression remains unclear...
  69. ncbi request reprint Endothelial NO synthase phosphorylated at SER635 produces NO without requiring intracellular calcium increase
    Yong Chool Boo
    Wallace H Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 35:729-41. 2003
    ..PKA-dependent phosphorylation of eNOS S635 and subsequent basal NO production in a Ca2+-independent manner may play an important role in regulating vascular biology and pathophysiology...
  70. ncbi request reprint The AT(1)-type angiotensin receptor in oxidative stress and atherogenesis: part I: oxidative stress and atherogenesis
    Georg Nickenig
    Klinik und Poliklinik Innere Medizin III, Universitat des Saarlandes, Homburg Saar, Germany
    Circulation 105:393-6. 2002
  71. ncbi request reprint Role of antioxidant-1 in extracellular superoxide dismutase function and expression
    Viktoria Jeney
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 96:723-9. 2005
    ..In summary, Atox1 functions not only as a copper chaperone for SOD3 but also as a positive regulator for SOD3 transcription and may have an important role in modulating oxidative stress in the cardiovascular system...

Research Grants27

  1. Roles of oxidation and inflammation in aortic stiffening
    David G Harrison; Fiscal Year: 2010
    ..These studies promise to provide new information regarding hypertension, vascular disease and how alterations in arterial compliance predispose to inflammation. ..
  2. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David G Harrison; Fiscal Year: 2010
    ..Our planned studies promise to provide new understanding of the mechanisms underlying this disease, and may provide new treatment targets for high blood pressure. ..
  3. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2007
    ..Our planned studies promise to provide new understanding of the mechanisms underlying this disease, and may provide new treatment targets for high blood pressure. ..
  4. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2003
    ..Aim 4 is to define the enzymatic source involved in oscillatory shear-induced superoxide production by cultured endothelial cells using electron spin resonance. ..
  5. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2002
    ..Aim 4 is to define the enzymatic source involved in oscillatory shear-induced superoxide production by cultured endothelial cells using electron spin resonance. ..
  6. EXTRACELLULAR SUPEROXIDE DISMUTASE AND ATHEROSCLEROSIS
    David Harrison; Fiscal Year: 2001
    ....
  7. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2001
    ..Overall, these studies should provide new insights into mechanisms regulating vascular superoxide production and reactivity. ..
  8. EXTRACELLULAR SUPEROXIDE DISMUTASE AND ATHEROSCLEROSIS
    David Harrison; Fiscal Year: 1999
    ....
  9. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 1993
    ..Because of our past experience in this field and a variety of unique experimental preparations and technology available in our laboratories, we are in a unique position to accomplish these goals...
  10. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2009
    ..Our planned studies promise to provide new understanding of the mechanisms underlying this disease, and may provide new treatment targets for high blood pressure. ..
  11. RESEARCH TRAINING IN ACADEMIC CARDIOLOGY
    David Harrison; Fiscal Year: 2007
    ..Successful trainees will be well-equipped to initiate a research career in academic cardiology. ..
  12. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2006
    ..Aim 4 is to define the enzymatic source involved in oscillatory shear-induced superoxide production by cultured endothelial cells using electron spin resonance. ..
  13. Post-transcriptional Regulation of NO Synthase
    David Harrison; Fiscal Year: 2005
    ..Overall, these studies promise to provide very novel information regarding how mechanical forces and other stimuli modulate gene expression via regulation of mRNA 3' poly(A) tail length. ..
  14. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2005
    ..Aim 4 is to define the enzymatic source involved in oscillatory shear-induced superoxide production by cultured endothelial cells using electron spin resonance. ..
  15. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2004
    ..Aim 4 is to define the enzymatic source involved in oscillatory shear-induced superoxide production by cultured endothelial cells using electron spin resonance. ..
  16. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 1999
    ..Overall, these studies should provide new insights into mechanisms regulating vascular superoxide production and reactivity. ..
  17. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 1991
    ..Because of our past experience in this field and a variety of unique experimental preparations and technology available in our laboratories, we are in a unique position to accomplish these goals...
  18. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 1992
    ..Because of our past experience in this field and a variety of unique experimental preparations and technology available in our laboratories, we are in a unique position to accomplish these goals...
  19. EXTRACELLULAR SUPEROXIDE DISMUTASE AND ATHEROSCLEROSIS
    David Harrison; Fiscal Year: 2000
    ....
  20. REGULATION OF VASCULAR FUNCTION BY THE ENDOTHELIUM
    David Harrison; Fiscal Year: 2000
    ..Overall, these studies should provide new insights into mechanisms regulating vascular superoxide production and reactivity. ..