Jason M Hansen

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Oxidative stress as a mechanism of teratogenesis
    Jason M Hansen
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Birth Defects Res C Embryo Today 78:293-307. 2006
  2. pmc Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species
    Amrita Kumar
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    EMBO J 26:4457-66. 2007
  3. pmc Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion
    Young Mi Go
    Department of Medicine Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 171:1670-81. 2007
  4. ncbi request reprint Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes
    William R Hunt
    2015 Uppergate Dr, Suite 350, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 306:L43-9. 2014
  5. doi request reprint Redox control of teratogenesis
    Jason M Hansen
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, GA 30322, United States
    Reprod Toxicol 35:165-79. 2013
  6. doi request reprint Thioredoxin redox status assessment during embryonic development: the redox Western
    Jason M Hansen
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    Methods Mol Biol 889:305-13. 2012
  7. doi request reprint In vivo models of developmental toxicology
    Jason M Hansen
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    Methods Mol Biol 889:7-13. 2012
  8. pmc Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities
    Jason M Hansen
    Department of Pediatrics, Emory School of Medicine, Emory University, 2015 Uppergate Drive 350, Atlanta, GA 30322, USA
    Free Radic Biol Med 43:282-8. 2007
  9. ncbi request reprint Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis
    Jason M Hansen
    Division of Pulmonary, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 91:643-50. 2006
  10. ncbi request reprint Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
    Jason M Hansen
    Department of Medicine and Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:215-34. 2006

Research Grants

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Oxidative stress as a mechanism of teratogenesis
    Jason M Hansen
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Birth Defects Res C Embryo Today 78:293-307. 2006
    ..Due to the ability of many known and suspected teratogens to induce oxidative stress and the many signaling pathways that have redox-sensitive components, further research is warranted to fully understand these mechanisms...
  2. pmc Commensal bacteria modulate cullin-dependent signaling via generation of reactive oxygen species
    Amrita Kumar
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    EMBO J 26:4457-66. 2007
    ....
  3. pmc Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion
    Young Mi Go
    Department of Medicine Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 171:1670-81. 2007
    ..Chemical modification of Trx1 by common environmental and endogenously generated reactive aldehydes can contribute to atherosclerosis development by interfering with antioxidant and redox signaling functions of Trx1...
  4. ncbi request reprint Hyperglycemia impedes lung bacterial clearance in a murine model of cystic fibrosis-related diabetes
    William R Hunt
    2015 Uppergate Dr, Suite 350, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 306:L43-9. 2014
    ....
  5. doi request reprint Redox control of teratogenesis
    Jason M Hansen
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, GA 30322, United States
    Reprod Toxicol 35:165-79. 2013
    ....
  6. doi request reprint Thioredoxin redox status assessment during embryonic development: the redox Western
    Jason M Hansen
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    Methods Mol Biol 889:305-13. 2012
    ..These approaches provide a means to evaluate this unique redox couple during development and allow for the measurement of compartmentalized (mitochondrial vs. cytosolic) oxidation during chemical insult...
  7. doi request reprint In vivo models of developmental toxicology
    Jason M Hansen
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    Methods Mol Biol 889:7-13. 2012
    ..This chapter is dedicated to reviewing the advantages of specific animal models and how these animal models may be used to assess toxicity in the embryo, both descriptively and mechanistically...
  8. pmc Nuclear and cytoplasmic peroxiredoxin-1 differentially regulate NF-kappaB activities
    Jason M Hansen
    Department of Pediatrics, Emory School of Medicine, Emory University, 2015 Uppergate Drive 350, Atlanta, GA 30322, USA
    Free Radic Biol Med 43:282-8. 2007
    ..Such spatial resolution and protein-specific redox differences imply that the balance of peroxide generation/metabolism in microcompartments provides an important specific component of redox signaling...
  9. ncbi request reprint Mitochondrial thioredoxin-2 has a key role in determining tumor necrosis factor-alpha-induced reactive oxygen species generation, NF-kappaB activation, and apoptosis
    Jason M Hansen
    Division of Pulmonary, Asthma, Cystic Fibrosis and Sleep, Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 91:643-50. 2006
    ..These findings support the interpretation that mitochondrial-generated ROS is a principal component in TNF-alpha-induced effects and that Trx2 blocks TNF-alpha-induced ROS generation and downstream NF-kappaB activation and apoptosis...
  10. ncbi request reprint Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
    Jason M Hansen
    Department of Medicine and Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:215-34. 2006
    ..The new methods are applicable to a broad range of experimental systems and their use will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants...
  11. ncbi request reprint Differential oxidation of thioredoxin-1, thioredoxin-2, and glutathione by metal ions
    Jason M Hansen
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, School of Medicine, 615 Michael Street, 225 Whitehead Biomedical Research Building, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 40:138-45. 2006
    ....
  12. ncbi request reprint Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase
    Patrick J Halvey
    Division of Pulmonary, Allergy, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Antioxid Redox Signal 9:807-16. 2007
    ..Furthermore, the attenuation of NF-kappaB reporter activity in the absence of nuclear Trx1 oxidation suggests that critical nuclear redox proteins are subject to control by S-glutathionylation during oxidative stress in the nucleus...
  13. pmc Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:363-70. 2007
    ..These results further suggest that energy and/or substrate supply may contribute to sensitivity of mitochondrial and cytoplasmic systems to oxidative damage...
  14. pmc Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
    ..Results showed that only cytosolic Trx1 undergoes significant oxidation. Thus EGF signalling involves subcellular compartmental oxidation of Trx1 in the absence of a generalized cellular oxidation...
  15. pmc Lactobacillus rhamnosus blocks inflammatory signaling in vivo via reactive oxygen species generation
    Patricia W Lin
    Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 47:1205-11. 2009
    ....
  16. doi request reprint Extracellular redox status regulates Nrf2 activation through mitochondrial reactive oxygen species
    Barry R Imhoff
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochem J 424:491-500. 2009
    ....
  17. doi request reprint Extracellular redox environments regulate adipocyte differentiation
    Barry R Imhoff
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Emory Department of Pediatrics, Emory University, Atlanta, GA 30322, USA
    Differentiation 80:31-9. 2010
    ..Data presented here show that adipocytes/excessive adipose preferentially alter extracellular E(h) to a more oxidized state in vivo and in vitro and may promote further adipogenesis...
  18. pmc Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice
    Arianne L Theiss
    Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:199-208, 208.e1-6. 2009
    ....
  19. pmc Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system
    JAMES R ROEDE
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 121:368-75. 2011
    ....
  20. doi request reprint Tert-butylhydroquinone induces mitochondrial oxidative stress causing Nrf2 activation
    Barry R Imhoff
    Division of Pulmonary, Allergy and Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory School of Medicine, Emory University, 2015 Uppergate Drive 350, Atlanta, GA 30322, USA
    Cell Biol Toxicol 26:541-51. 2010
    ..These data show a compartment-specific effect where tBHQ-induced Nrf2 signaling is mediated by Trx2 and suggest that antioxidant status in various compartments would provide different levels of control of redox signaling...
  21. doi request reprint Differential redox potential profiles during adipogenesis and osteogenesis
    Barry R Imhoff
    Division of Pulmonary, Allergy Immunology, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory School of Medicine, Emory University Atlanta, 2015 Uppergate Drive Suite 350, Altanta, GA 30322, USA
    Cell Mol Biol Lett 16:149-61. 2011
    ....
  22. pmc A reducing redox environment promotes C2C12 myogenesis: implications for regeneration in aged muscle
    Jason M Hansen
    Department of Anesthesiology, School of Medicine, Emory University, 1462 Clifton Road NE, Suite 420, Atlanta, GA 30322, USA
    Cell Biol Int 31:546-53. 2007
    ..Thus, oxidative intracellular environments impair myoblast differentiation, while reducing environments favor myogenesis...
  23. ncbi request reprint Compartmentation of Nrf-2 redox control: regulation of cytoplasmic activation by glutathione and DNA binding by thioredoxin-1
    Jason M Hansen
    Department of Medicine and Biochemistry, Emory University School of Medicine, Atlanta, GA 30322, USA
    Toxicol Sci 82:308-17. 2004
    ..In contrast, the ARE reporter was principally controlled by nuclear-targeted Trx-1 and not by GSH. The data show that the GSH and TRX systems have unique, compartmented functions in the control of transcriptional regulation by Nrf-2/ARE...
  24. pmc Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition
    Min He
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Toxicol Sci 105:44-50. 2008
    ..Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT...
  25. pmc Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery
    Nana Gletsu-Miller
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Obesity (Silver Spring) 17:439-46. 2009
    ..38 and -0.42). This study found longitudinal associations between general, and more specifically intra-abdominal adiposity, and systemic lipid peroxides, suggesting that adipose tissue mass contributes to oxidative stress...
  26. ncbi request reprint Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation
    Sampath Ramachandiran
    Center for Neurodegenerative Disease, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 95:163-71. 2007
    ..In addition, intracellular dopamine does not seem to exacerbate the toxicity of these dopaminergic neurotoxicants in this model...
  27. ncbi request reprint Spatial activities and induction of glutamate-cysteine ligase (GCL) in the postimplantation rat embryo and visceral yolk sac
    Jason M Hansen
    Department of Biochemistry, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 81:371-8. 2004
    ..Following treatments, a marked increase was induced in embryonic GCL(C) content with both DEM (85%) and diamide (19%), but in the VYS, only DEM caused an increase in GCL(C) protein (38%)...
  28. ncbi request reprint Methanol, formaldehyde, and sodium formate exposure in rat and mouse conceptuses: a potential role of the visceral yolk sac in embryotoxicity
    Jason M Hansen
    Department of Biochemistry, School of Medicine, Emory University, Atlanta, Georgia, USA
    Birth Defects Res A Clin Mol Teratol 73:72-82. 2005
    ..Methanol (CH3OH) is believed to be teratogenic based on rodent studies. The mouse is more sensitive than the rat, but mechanisms of toxicity and identification of teratogenic metabolites are uncertain...
  29. pmc Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production
    Jennifer M Kleinhenz
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 297:H1647-54. 2009
    ..These findings demonstrate that endothelial PPARgamma regulates vascular nitric oxide production and that the disruption of endothelial PPARgamma contributes to endothelial dysfunction in vivo...
  30. pmc Retinoic acid stimulation of VEGF secretion from human endometrial stromal cells is mediated by production of reactive oxygen species
    Juanjuan Wu
    Department of Gynecology and Obstetrics, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Physiol 589:863-75. 2011
    ..Together, these findings predict a redox-mediated mechanism for retinoid regulation of localized VEGF secretion in the human endometrium that may be necessary for the successful establishment of pregnancy...
  31. pmc The role of mitochondrial oxidation in endotoxin-induced liver-dependent swine pulmonary edema
    Amsel M Siore
    Center for Translational Research in the Lungs, McKelvey Center for Lung Transplantation, Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine and Predictive Health Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Pulm Pharmacol Ther 25:407-12. 2012
    ..Procysteine reduced thioredoxin-2 oxidation, attenuated hemodynamic, gas exchange, hepatocellular dysfunction, and cytokine responses and prevented lung edema. n-acetylcysteine had more modest effects and did not prevent lung edema...
  32. pmc SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain 134:196-209. 2011
    ..These results suggest that SOD1 in the mitochondrial intermembrane space is fundamental for motor axon maintenance, and implicate oxidative damage initiated at mitochondrial sites in the pathogenesis of motor axon degeneration...
  33. ncbi request reprint Misregulation of gene expression in the redox-sensitive NF-kappab-dependent limb outgrowth pathway by thalidomide
    Jason M Hansen
    Toxicology Program, Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109, USA
    Dev Dyn 225:186-94. 2002
    ..These findings show that NF-kappaB binding is diminished due to selective thalidomide-induced redox changes in the rabbit, resulting in the significant attenuation of expression of genes necessary for limb outgrowth...
  34. ncbi request reprint A novel hypothesis for thalidomide-induced limb teratogenesis: redox misregulation of the NF-kappaB pathway
    Jason M Hansen
    Antioxid Redox Signal 6:1-14. 2004
    ..We hypothesize that species-selective alterations in redox microenvironment caused by free radical production from thalidomide results in attenuation of the NF-kappaB-mediated gene expression that is responsible for limb outgrowth...
  35. ncbi request reprint Thalidomide modulates nuclear redox status and preferentially depletes glutathione in rabbit limb versus rat limb
    Jason M Hansen
    University of Michigan, Department of Environmental Health Sciences Toxicology Program, Ann Arbor, Michigan, USA
    J Pharmacol Exp Ther 300:768-76. 2002
    ..Redox shifts in the nucleus may result in the misregulation of transcription factor/DNA interactions and cause defective growth and development...
  36. ncbi request reprint Effect of mercury(II) on Nrf2, thioredoxin reductase-1 and thioredoxin-1 in human monocytes
    John C Wataha
    University of Washington, Seattle, WA 98195 7456, USA
    Dent Mater 24:765-72. 2008
    ..In the current study, we tested a hypothesis that concentrations of mercury <100nM altered levels and activities of key proteins that maintain monocytic redox balance...

Research Grants1

  1. Redox control of Nrf2/ARE by thioredoxin and GSH
    Jason Hansen; Fiscal Year: 2005
    ..The roles of GSH and cytosolic and nuclear TRX during NRF2 activation and binding will provide an essential foundation for future developmental toxicology. ..