S W Han

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:4627-35. 2003
  2. pmc Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells
    Shou Wei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, 615 Michael Street Suite 205, Atlanta, GA 30322, USA
    PPAR Res 2008:254108. 2008
  3. pmc Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    PPAR Res 2007:29632. 2007
  4. ncbi Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Mol Cancer Ther 5:430-7. 2006
  5. ncbi COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Lung Cancer 51:283-96. 2006
  6. ncbi Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:315-23. 2006
  7. ncbi Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B
    S W Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 25:4341-9. 2006
  8. ncbi Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:29614-24. 2006
  9. ncbi Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:7961-72. 2007
  10. ncbi Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics?
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Anticancer Drugs 18:237-44. 2007

Detail Information

Publications33

  1. ncbi Control of COX-2 gene expression through peroxisome proliferator-activated receptor gamma in human cervical cancer cells
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:4627-35. 2003
    ..In this study we explored the possible mechanism(s) of control of COX-2 gene expression through PPARgamma signaling in human cervical cancer...
  2. pmc Activated PPARgamma Targets Surface and Intracellular Signals That Inhibit the Proliferation of Lung Carcinoma Cells
    Shou Wei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, 615 Michael Street Suite 205, Atlanta, GA 30322, USA
    PPAR Res 2008:254108. 2008
    ..This review summarizes the research being conducted in this area, and focuses on the mechanisms by which a member of this family (PPARgamma) is believed to affect lung tumor cell biology...
  3. pmc Rosiglitazone, an Agonist of PPARgamma, Inhibits Non-Small Cell Carcinoma Cell Proliferation In Part through Activation of Tumor Sclerosis Complex-2
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    PPAR Res 2007:29632. 2007
    ..These observations suggest that rosiglitazone inhibits NSCLC growth partially through phosphorylation of TSC2 via PPARgamma-independent pathways...
  4. ncbi Rosiglitazone suppresses human lung carcinoma cell growth through PPARgamma-dependent and PPARgamma-independent signal pathways
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Mol Cancer Ther 5:430-7. 2006
    ....
  5. ncbi COX-2 inhibitors suppress lung cancer cell growth by inducing p21 via COX-2 independent signals
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Lung Cancer 51:283-96. 2006
    ..These observations unveil a mechanism for p21 gene regulation by COX-2 inhibitors in lung carcinoma cell growth and this pathway represents a potential target for therapy...
  6. ncbi Fibronectin stimulates non-small cell lung carcinoma cell growth through activation of Akt/mammalian target of rapamycin/S6 kinase and inactivation of LKB1/AMP-activated protein kinase signal pathways
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:315-23. 2006
    ..Taken together, these observations suggest that fibronectin-induced stimulation of NSCLC cell proliferation requires activation of the Akt/mTOR/p70S6K pathway and is associated with inhibition of LKB1/AMPK signaling...
  7. ncbi Fibronectin induces cell proliferation and inhibits apoptosis in human bronchial epithelial cells: pro-oncogenic effects mediated by PI3-kinase and NF-kappa B
    S W Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Oncogene 25:4341-9. 2006
    ..Therefore, alternations in the extracellular matrix composition of the lung, with increased fibronectin, might promote epithelial cell growth and thereby contribute to oncogenesis in certain settings...
  8. ncbi Fibronectin increases matrix metalloproteinase 9 expression through activation of c-Fos via extracellular-regulated kinase and phosphatidylinositol 3-kinase pathways in human lung carcinoma cells
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:29614-24. 2006
    ..The data unveils a novel mechanism by which FN could promote NSCLC cell invasion and metastasis...
  9. ncbi Extracellular matrix fibronectin increases prostaglandin E2 receptor subtype EP4 in lung carcinoma cells through multiple signaling pathways: the role of AP-2
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:7961-72. 2007
    ..These events lead to activation of the transcription factor AP-2alpha, which interacts with specific regions in the EP4 gene promoter, leading to transcription of the EP4 gene...
  10. ncbi Peroxisome proliferator-activated receptor gamma: a novel target for cancer therapeutics?
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Anticancer Drugs 18:237-44. 2007
    ..Together, these studies, coupled with a few clinical trials, suggest that peroxisome proliferator-activated receptor gamma is a novel target for the development of new and effective anticancer therapies...
  11. doi PPARbeta/delta agonist stimulates human lung carcinoma cell growth through inhibition of PTEN expression: the involvement of PI3K and NF-kappaB signals
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Bldg, 615 Michael St, Suite 205 M, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 294:L1238-49. 2008
    ..Overexpression of PTEN overcomes this effect and unveils PPARbeta/delta and PTEN as potential therapeutic targets in NSCLC...
  12. pmc Activation of peroxisome proliferator-activated receptor beta/delta induces lung cancer growth via peroxisome proliferator-activated receptor coactivator gamma-1alpha
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 40:325-31. 2009
    ..This study unveils a novel mechanism by which GW501516 and activation of PPARbeta/delta stimulate human lung carcinoma cell proliferation, and suggests that activation of AMPKalpha may oppose this effect...
  13. pmc Fish oil inhibits human lung carcinoma cell growth by suppressing integrin-linked kinase
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Mol Cancer Res 7:108-17. 2009
    ..In turn, this leads to inhibition of NSCLC cell proliferation. This study unveils a novel mechanism by which fish oil inhibits human lung cancer cell growth...
  14. ncbi Activation of peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) increases the expression of prostaglandin E2 receptor subtype EP4. The roles of phosphatidylinositol 3-kinase and CCAAT/enhancer-binding protein beta
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:33240-9. 2005
    ....
  15. ncbi Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1
    ShouWei Han
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 289:L419-28. 2005
    ..In summary, our results demonstrate that PPARgamma ligands inhibit Fn gene expression in NSCLC cells through PPARgamma-dependent and -independent pathways that affect both CREB and Sp1...
  16. ncbi Suppression of prostaglandin E2 receptor subtype EP2 by PPARgamma ligands inhibits human lung carcinoma cell growth
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Biophys Res Commun 314:1093-9. 2004
    ..PPARgamma ligands inhibit human lung carcinoma cell growth by decreasing the expression of EP2 receptors through Erk signaling and PPARgamma-dependent and -independent pathways...
  17. ncbi Up-regulation of p21 gene expression by peroxisome proliferator-activated receptor gamma in human lung carcinoma cells
    ShouWei Han
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:1911-9. 2004
    ..In this study, we explored the role of PPARgamma signaling on the control of gene expression of the cycle-dependent kinase inhibitor p21 in human lung carcinoma cells...
  18. ncbi Ligands of peroxisome proliferator-activated receptor gamma inhibit lung cancer cell growth and induce apoptosis by stimulation of P21 expression
    ShouWei Han
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Chest 125:134S. 2004
  19. ncbi Fibronectin stimulates human lung carcinoma cell growth by inducing cyclooxygenase-2 (COX-2) expression
    ShouWei Han
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 111:322-31. 2004
    ..This work demonstrates that signaling through specific matrix-binding beta1 integrins (i.e., alpha5beta1) resulting from exaggerated deposition in lung of the matrix glycoprotein fibronectin might promote lung carcinoma cell growth...
  20. ncbi Peroxisome proliferator-activated receptor-gamma ligands inhibit alpha5 integrin gene transcription in non-small cell lung carcinoma cells
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Am J Respir Cell Mol Biol 32:350-9. 2005
    ..These results suggest that PPARgamma ligands inhibit alpha5 expression in NSCLC through Erk-related signals...
  21. ncbi Fibronectin stimulates human lung carcinoma cell proliferation by suppressing p21 gene expression via signals involving Erk and Rho kinase
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Lett 219:71-81. 2005
    ..These observations unveil a novel mechanism for p21 gene regulation by fibronectin in lung carcinoma cell growth that represents a potential target for therapy...
  22. ncbi COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites
    ShouWei Han
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 116:536-46. 2005
    ..e., fibronectin) by tumor cells. (c) 2005 Wiley-Liss, Inc...
  23. pmc Nicotine stimulates PPARbeta/delta expression in human lung carcinoma cells through activation of PI3K/mTOR and suppression of AP-2alpha
    Xiaojuan Sun
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 69:6445-53. 2009
    ..Sp1 seems to modulate this process. This study unveils a novel mechanism by which nicotine promotes human lung carcinoma cell growth...
  24. ncbi Nicotine stimulates human lung cancer cell growth by inducing fibronectin expression
    Ying Zheng
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Respir Cell Mol Biol 37:681-90. 2007
    ..This work highlights the role of fibronectin and alpha5beta1 integrins as potential targets for anti-lung cancer therapies...
  25. doi PPARbeta/delta agonist increases the expression of PGE2 receptor subtype EP4 in human lung carcinoma cells
    Jeffrey D Ritzenthaler
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Methods Mol Biol 512:309-23. 2009
    ..Therefore, PPARbeta/delta activation represents a novel molecular mechanism for regulating human cancer cell growth...
  26. ncbi Cytokine regulation by peroxisome proliferator-activated receptor gamma in human endometrial cells
    Thitikorn Wanichkul
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Fertil Steril 79:763-9. 2003
    ..To determine whether peroxisome proliferator-activated receptor (PPAR)-gamma ligands can affect the expression of interleukin-6 (IL-6) and cytokines related to the pathogenesis of endometriosis...
  27. doi Prostaglandin E2 stimulates human lung carcinoma cell growth through induction of integrin-linked kinase: the involvement of EP4 and Sp1
    Ying Zheng
    Department of Medicine, Division of Pulmonary, Emory University School of Medicine, Atlanta, USA
    Cancer Res 69:896-904. 2009
    ..These studies suggest a novel molecular mechanism by which PGE(2) stimulates NSCLC cell growth and unveils a new molecular target for the development of therapies against NSCLC...
  28. pmc Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals
    Xiaojuan Sun
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Whitehead Bioresearch Building, 615 Michael Street, Suite 205 M, Atlanta, GA 30322, USA
    Mol Cancer Ther 8:110-8. 2009
    ..Finally, like others, we found that nicotine stimulated the expression of alpha4 nAChR. This process was also inhibited by rosiglitazone through similar pathways...
  29. pmc Peroxisome-proliferator-activated-receptor gamma (PPARgamma) independent induction of CD36 in THP-1 monocytes by retinoic acid
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Immunology 106:53-9. 2002
    ..This study suggests a possible role for RA in physiological processes involving the scavenger receptor function in cells of the monocyte/macrophage lineage...
  30. ncbi Novel expression and function of peroxisome proliferator-activated receptor gamma (PPARgamma) in human neuroblastoma cells
    S W Han
    Department of Obstetrics and Gynecology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 7:98-104. 2001
    ..Taken together, these studies have implicated a role for PPARgamma in peripheral nerve cell biology and suggest that the PPARgamma signaling pathway is involved in the regulation of nb cell growth and differentiation...
  31. doi Stimulation of lung carcinoma cell growth by fibronectin-integrin signalling
    Jeffrey D Ritzenthaler
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Whitehead Biomedical Research Building, 615 Michael Street, Rm 205 M, Atlanta, Georgia 3032, USA
    Mol Biosyst 4:1160-9. 2008
    ..Thus, integrin-mediated signals triggered by fibronectin in tumor cells represent promising targets for the development of novel anti-cancer strategies...
  32. ncbi Targeting apoptotic signaling pathways in human lung cancer
    S W Han
    Division of Pulmonary, Critical Care and Sleep Disorders Medicine, Louisville School of Medicine, Louisville, KY 40202, USA
    Curr Cancer Drug Targets 10:566-74. 2010
    ..This mini review summaries the molecular events that contribute to drug-induced apoptosis and how lung tumors evade apoptotic death followed by an analysis of the implications for treatment...
  33. ncbi RU486-induced growth inhibition of human endometrial cells involves the nuclear factor-kappa B signaling pathway
    ShouWei Han
    Division of Research, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 88:713-9. 2003
    ..This study demonstrates that the inhibition of growth and apoptosis of human endometrial cells by RU486 involves stimulation of NF-kappa B binding with subsequent modulation of apoptosis regulatory genes bax and bcl-2...