Research Topics
| M Elizabeth HalloranSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Community interventions and the epidemic prevention potentialM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Vaccine 20:3254-62. 2002..The concepts are general and could be applied to other interventions, such as antivirals and quarantine...- Using validation sets for outcomes and exposure to infection in vaccine field studiesM E Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 154:391-8. 2001.... - Containing bioterrorist smallpoxM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Science 298:1428-32. 2002..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox... - Containing pandemic influenza at the sourceIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Science 309:1083-7. 2005..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4... - Containing pandemic influenza with antiviral agentsIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
Am J Epidemiol 159:623-33. 2004..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available... 
On estimation of vaccine efficacy using validation samples with selection biasDaniel O Scharfstein
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Biostatistics 7:615-29. 2006..Our approach is generally applicable to studies with missing binary outcomes with categorical covariates...- Finding optimal vaccination strategies for pandemic influenza using genetic algorithmsRajan Patel
Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
J Theor Biol 234:201-12. 2005..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures... - Bayesian estimation of vaccine efficacyHaitao Chu
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
Clin Trials 1:306-14. 2004..We illustrate the methods using the data from two pertussis vaccine studies and the H. influenza Type B preventive trial... - Estimating vaccine efficacy using auxiliary outcome data and a small validation sampleHaitao Chu
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Stat Med 23:2697-711. 2004..Comparing the performance of these approaches using data from a field study of influenza vaccine and simulations, we recommend to use the Bayesian method in this situation... - Model-based estimation of vaccine effects from community vaccine trialsIra M Longini
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
Stat Med 21:481-95. 2002..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions... - Effects of pertussis vaccination on disease: vaccine efficacy in reducing clinical severityMarie Pierre Preziosi
Niakhar Project, Institut de Recherche pour le Developpement, Dakar, Senegal
Clin Infect Dis 37:772-9. 2003..Primary cases were more severe than secondary cases in residential compounds. Pertussis vaccination is effective in reducing the severity of illness... - Effects of pertussis vaccination on transmission: vaccine efficacy for infectiousnessMarie Pierre Preziosi
Niakhar Project, Institut de Recherche pour le Developpement, Dakar, Senegal
Vaccine 21:1853-61. 2003..It was high for all case definitions. Partial vaccination reduced infectiousness. Pertussis vaccination is highly effective in reducing transmission from vaccinated breakthrough cases... - Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance culturesM Elizabeth Halloran
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 158:305-11. 2003..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies... - Strategy for distribution of influenza vaccine to high-risk groups and childrenIra M Longini
Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Am J Epidemiol 161:303-6. 2005..The effectiveness of the alternative plan could be assessed through nationwide community studies... - Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, ThailandMichael G Hudgens
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
Am J Epidemiol 155:159-68. 2002..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype... - Estimating heterogeneous transmission with multiple infectives using MCMC methodsHaitao Chu
Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Stat Med 23:35-49. 2004..Parameters are estimated using Markov chain Monte Carlo methods... - Containing a large bioterrorist smallpox attack: a computer simulation approachIra M Longini
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
Int J Infect Dis 11:98-108. 2007..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries... - Population-wide benefits of routine vaccination of children against influenzaDerek Weycker
Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
Vaccine 23:1284-93. 2005..Similar reductions were estimated to occur in influenza-related mortality and economic costs... - Safety of cold-adapted live influenza vaccineW Paul Glezen
Pediatr Infect Dis J 23:593-4; author reply 594. 2004 - Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy childrenManjusha J Gaglani
Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
Arch Pediatr Adolesc Med 158:65-73. 2004.... - Detecting human-to-human transmission of avian influenza A (H5N1)Yang Yang
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
Emerg Infect Dis 13:1348-53. 2007..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains... - Accounting for variability in sample size estimation with applications to nonadherence and estimation of variance and effect sizeMichael P Fay
National Institute of Allergy and Infectious Diseases, 6700 B Rockledge Drive, Bethesda, Maryland 20892 7609, USA
Biometrics 63:465-74. 2007..This latter situation, as well as several of the previous ones, is motivated by sample size calculations for a Phase II trial of a malaria vaccine candidate... - Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004M Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Vaccine 25:4038-45. 2007..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza... - Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trialsM Elizabeth Halloran
Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Epidemiol 165:212-21. 2007..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies... - Invited commentary: Challenges of using contact data to understand acute respiratory disease transmissionM Elizabeth Halloran
Public Health Sciences Division, Fred Hutchinson Cancer Research Center, MS LE-400, Seattle, WA 98109, USA
Am J Epidemiol 164:945-6. 2006 - Public health. Community studies for vaccinating schoolchildren against influenzaM Elizabeth Halloran
Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Science 311:615-6. 2006 - Modeling targeted layered containment of an influenza pandemic in the United StatesM Elizabeth Halloran
Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
Proc Natl Acad Sci U S A 105:4639-44. 2008....
Research Grants
- METHODS FOR EVALUATING VACCINE EFFICACYM Halloran; Fiscal Year: 2006..The methods will be motivated by the design and analysis of studies of vaccines against influenza, pertussis, pneumococcus, HIV, meningitis, as well as other acute and childhood diseases and influenza antiviral prophylaxis. ..