M Elizabeth Halloran

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Community interventions and the epidemic prevention potential
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 20:3254-62. 2002
  2. ncbi request reprint Using validation sets for outcomes and exposure to infection in vaccine field studies
    M E Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 154:391-8. 2001
  3. ncbi request reprint Containing bioterrorist smallpox
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Science 298:1428-32. 2002
  4. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
  5. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
  6. pmc On estimation of vaccine efficacy using validation samples with selection bias
    Daniel O Scharfstein
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biostatistics 7:615-29. 2006
  7. ncbi request reprint Finding optimal vaccination strategies for pandemic influenza using genetic algorithms
    Rajan Patel
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    J Theor Biol 234:201-12. 2005
  8. ncbi request reprint Bayesian estimation of vaccine efficacy
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Clin Trials 1:306-14. 2004
  9. ncbi request reprint Estimating vaccine efficacy using auxiliary outcome data and a small validation sample
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:2697-711. 2004
  10. ncbi request reprint Model-based estimation of vaccine effects from community vaccine trials
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Stat Med 21:481-95. 2002

Research Grants

  1. METHODS FOR EVALUATING VACCINE EFFICACY
    M Halloran; Fiscal Year: 2006

Detail Information

Publications27

  1. ncbi request reprint Community interventions and the epidemic prevention potential
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Vaccine 20:3254-62. 2002
    ..The concepts are general and could be applied to other interventions, such as antivirals and quarantine...
  2. ncbi request reprint Using validation sets for outcomes and exposure to infection in vaccine field studies
    M E Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 154:391-8. 2001
    ....
  3. ncbi request reprint Containing bioterrorist smallpox
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Science 298:1428-32. 2002
    ..It could also help targeted vaccination be more competitive with mass vaccination at both preventing and containing a deliberate introduction of smallpox...
  4. ncbi request reprint Containing pandemic influenza at the source
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Science 309:1083-7. 2005
    ..1. Combinations of targeted antiviral prophylaxis, pre-vaccination, and quarantine could contain strains with an R(0) as high as 2.4...
  5. ncbi request reprint Containing pandemic influenza with antiviral agents
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Am J Epidemiol 159:623-33. 2004
    ..Targeted antiviral prophylaxis has potential as an effective measure for containing influenza until adequate quantities of vaccine are available...
  6. pmc On estimation of vaccine efficacy using validation samples with selection bias
    Daniel O Scharfstein
    Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Biostatistics 7:615-29. 2006
    ..Our approach is generally applicable to studies with missing binary outcomes with categorical covariates...
  7. ncbi request reprint Finding optimal vaccination strategies for pandemic influenza using genetic algorithms
    Rajan Patel
    Department of Biostatistics, The Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA
    J Theor Biol 234:201-12. 2005
    ..GA is generalizable to the optimization of stochastic model parameters for other infectious diseases and population structures...
  8. ncbi request reprint Bayesian estimation of vaccine efficacy
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA, USA
    Clin Trials 1:306-14. 2004
    ..We illustrate the methods using the data from two pertussis vaccine studies and the H. influenza Type B preventive trial...
  9. ncbi request reprint Estimating vaccine efficacy using auxiliary outcome data and a small validation sample
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:2697-711. 2004
    ..Comparing the performance of these approaches using data from a field study of influenza vaccine and simulations, we recommend to use the Bayesian method in this situation...
  10. ncbi request reprint Model-based estimation of vaccine effects from community vaccine trials
    Ira M Longini
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road, N E, Atlanta, GA 30322, USA
    Stat Med 21:481-95. 2002
    ..Thus, it can be used as a public health policy tool for predicting the community level effects of vaccination. We demonstrate such use by predicting total vaccine effectiveness for the whole range of vaccination fractions...
  11. ncbi request reprint Effects of pertussis vaccination on disease: vaccine efficacy in reducing clinical severity
    Marie Pierre Preziosi
    Niakhar Project, Institut de Recherche pour le Developpement, Dakar, Senegal
    Clin Infect Dis 37:772-9. 2003
    ..Primary cases were more severe than secondary cases in residential compounds. Pertussis vaccination is effective in reducing the severity of illness...
  12. ncbi request reprint Effects of pertussis vaccination on transmission: vaccine efficacy for infectiousness
    Marie Pierre Preziosi
    Niakhar Project, Institut de Recherche pour le Developpement, Dakar, Senegal
    Vaccine 21:1853-61. 2003
    ..It was high for all case definitions. Partial vaccination reduced infectiousness. Pertussis vaccination is highly effective in reducing transmission from vaccinated breakthrough cases...
  13. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  14. ncbi request reprint Strategy for distribution of influenza vaccine to high-risk groups and children
    Ira M Longini
    Department of Biostatistics, The Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Am J Epidemiol 161:303-6. 2005
    ..The effectiveness of the alternative plan could be assessed through nationwide community studies...
  15. ncbi request reprint Subtype-specific transmission probabilities for human immunodeficiency virus type 1 among injecting drug users in Bangkok, Thailand
    Michael G Hudgens
    Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 98109, USA
    Am J Epidemiol 155:159-68. 2002
    ..Since many epidemiologic, virologic, and host factors can influence HIV transmission, it was difficult to conclude whether these differences in transmission probabilities were due to biologic properties associated with subtype...
  16. ncbi request reprint Estimating heterogeneous transmission with multiple infectives using MCMC methods
    Haitao Chu
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Stat Med 23:35-49. 2004
    ..Parameters are estimated using Markov chain Monte Carlo methods...
  17. ncbi request reprint Containing a large bioterrorist smallpox attack: a computer simulation approach
    Ira M Longini
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, LE 400, PO Box 19024, Seattle, WA 98109 1024, USA
    Int J Infect Dis 11:98-108. 2007
    ..A bioterrorist release of smallpox is a constant threat to the population of the USA and other countries...
  18. ncbi request reprint Population-wide benefits of routine vaccination of children against influenza
    Derek Weycker
    Policy Analysis Inc, Four Davis Court, Brookline, MA 02445, USA
    Vaccine 23:1284-93. 2005
    ..Similar reductions were estimated to occur in influenza-related mortality and economic costs...
  19. ncbi request reprint Safety of cold-adapted live influenza vaccine
    W Paul Glezen
    Pediatr Infect Dis J 23:593-4; author reply 594. 2004
  20. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  21. pmc Detecting human-to-human transmission of avian influenza A (H5N1)
    Yang Yang
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109 1024, USA
    Emerg Infect Dis 13:1348-53. 2007
    ..The estimated lower limit on the local R0 was 1.14 (95% CI 0.61-2.14). Effective HPAI (H5N1) surveillance, containment response, and field evaluation are essential to monitor and contain potential pandemic strains...
  22. ncbi request reprint Accounting for variability in sample size estimation with applications to nonadherence and estimation of variance and effect size
    Michael P Fay
    National Institute of Allergy and Infectious Diseases, 6700 B Rockledge Drive, Bethesda, Maryland 20892 7609, USA
    Biometrics 63:465-74. 2007
    ..This latter situation, as well as several of the previous ones, is motivated by sample size calculations for a Phase II trial of a malaria vaccine candidate...
  23. pmc Efficacy of trivalent, cold-adapted, influenza virus vaccine against influenza A (Fujian), a drift variant, during 2003-2004
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Vaccine 25:4038-45. 2007
    ..LAIV-T was cross-protective with a drift variant strain in 2003-2004, evidence that such vaccines could be important for preparing for a pandemic and for annual influenza...
  24. ncbi request reprint Antiviral effects on influenza viral transmission and pathogenicity: observations from household-based trials
    M Elizabeth Halloran
    Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    Am J Epidemiol 165:212-21. 2007
    ..Studies of influenza antivirals in transmission units would be improved if randomization schemes were used that allow estimation of the antiviral effect on infectiousness from individual studies...
  25. ncbi request reprint Invited commentary: Challenges of using contact data to understand acute respiratory disease transmission
    M Elizabeth Halloran
    Public Health Sciences Division, Fred Hutchinson Cancer Research Center, MS LE 400, Seattle, WA 98109, USA
    Am J Epidemiol 164:945-6. 2006
  26. ncbi request reprint Public health. Community studies for vaccinating schoolchildren against influenza
    M Elizabeth Halloran
    Program of Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 311:615-6. 2006
  27. pmc Modeling targeted layered containment of an influenza pandemic in the United States
    M Elizabeth Halloran
    Virginia Bioinformatics Institute, Virginia Polytechnical Institute and State University, Blacksburg, VA 24061, USA
    Proc Natl Acad Sci U S A 105:4639-44. 2008
    ....

Research Grants1

  1. METHODS FOR EVALUATING VACCINE EFFICACY
    M Halloran; Fiscal Year: 2006
    ..The methods will be motivated by the design and analysis of studies of vaccines against influenza, pertussis, pneumococcus, HIV, meningitis, as well as other acute and childhood diseases and influenza antiviral prophylaxis. ..