David A Gutman

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set
    David A Gutman
    Department of Biomedical Informatics, 36 Eagle Row, Room 572 PAIS, Emory University Hospital, Atlanta, GA 30322, USA
    Radiology 267:560-9. 2013
  2. pmc Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in rats
    David A Gutman
    Center for Comprehensive Informatics, Emory University, 36 Eagle Row, Room 572, Suite 4000, Atlanta, GA 30322, USA
    Neuropharmacology 60:1135-41. 2011
  3. doi request reprint A tractography analysis of two deep brain stimulation white matter targets for depression
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:276-82. 2009
  4. pmc Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes
    Jun Kong
    Center for Comprehensive Informatics, Emory University, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 58:3469-74. 2011
  5. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
  6. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007
  7. pmc The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma
    Lee A D Cooper
    Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 180:2108-19. 2012
  8. pmc Integrated morphologic analysis for the identification and characterization of disease subtypes
    Lee A D Cooper
    Center for Comprehensive Informatics, Emory University, Atlanta, Georgia 30322, USA
    J Am Med Inform Assoc 19:317-23. 2012
  9. pmc Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data
    David A Gutman
    Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA
    J Am Med Inform Assoc 20:1091-8. 2013
  10. doi request reprint PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus
    Jennifer Strafford Stevens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 111:3158-63. 2014

Detail Information

Publications23

  1. pmc MR imaging predictors of molecular profile and survival: multi-institutional study of the TCGA glioblastoma data set
    David A Gutman
    Department of Biomedical Informatics, 36 Eagle Row, Room 572 PAIS, Emory University Hospital, Atlanta, GA 30322, USA
    Radiology 267:560-9. 2013
    ....
  2. pmc Persistent anxiolytic affects after chronic administration of the CRF₁ receptor antagonist R121919 in rats
    David A Gutman
    Center for Comprehensive Informatics, Emory University, 36 Eagle Row, Room 572, Suite 4000, Atlanta, GA 30322, USA
    Neuropharmacology 60:1135-41. 2011
    ..This article is part of a Special Issue entitled 'Trends in neuropharmacology: in memory of Erminio Costa'...
  3. doi request reprint A tractography analysis of two deep brain stimulation white matter targets for depression
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 65:276-82. 2009
    ..Connectivity patterns of these regions may inform on mechanisms of action for DBS of these targets...
  4. pmc Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes
    Jun Kong
    Center for Comprehensive Informatics, Emory University, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 58:3469-74. 2011
    ..Our preliminary results demonstrate numerous clinically and biologically significant correlations across multiple data types, revealing the power of in silico multimodal data integration for cancer research...
  5. ncbi request reprint The CRF1 receptor antagonist, R121919, attenuates the severity of precipitated morphine withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Eur J Pharmacol 571:17-24. 2007
    ....
  6. ncbi request reprint The CRF1 receptor antagonist R121919 attenuates the neuroendocrine and behavioral effects of precipitated lorazepam withdrawal
    Kelly H Skelton
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 192:385-96. 2007
    ....
  7. pmc The tumor microenvironment strongly impacts master transcriptional regulators and gene expression class of glioblastoma
    Lee A D Cooper
    Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 180:2108-19. 2012
    ..Strong, specific expression of C/EBP-β and C/EBP-δ by hypoxic, perinecrotic cells in GBM likely account for their tight association with necrosis and may be related to their poor prognosis...
  8. pmc Integrated morphologic analysis for the identification and characterization of disease subtypes
    Lee A D Cooper
    Center for Comprehensive Informatics, Emory University, Atlanta, Georgia 30322, USA
    J Am Med Inform Assoc 19:317-23. 2012
    ....
  9. pmc Cancer Digital Slide Archive: an informatics resource to support integrated in silico analysis of TCGA pathology data
    David A Gutman
    Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA
    J Am Med Inform Assoc 20:1091-8. 2013
    ..However, better tools are needed to integrate the vast and disparate data types...
  10. doi request reprint PACAP receptor gene polymorphism impacts fear responses in the amygdala and hippocampus
    Jennifer Strafford Stevens
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322
    Proc Natl Acad Sci U S A 111:3158-63. 2014
    ..Individual differences in ADCYAP1R1 genotype may contribute to dysregulated fear circuitry known to play a central role in PTSD and other anxiety disorders. ..
  11. pmc Tumor-infiltrating lymphocytes in glioblastoma are associated with specific genomic alterations and related to transcriptional class
    W Caleb Rutledge
    Authors Affiliations Emory University School of Medicine, Departments of Biomedical Informatics and Pathology and Laboratory Medicine, Center for Comprehensive Informatics, Winship Cancer Institute, Emory University Department of Pathology, Children s Healthcare of Atlanta, Atlanta, Georgia Department of Neurosurgery, Henry Ford Hospital, Detroit, Michigan Department of Pathology, Case Western Reserve University, Cleveland, Ohio Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas Department of Pathology, Duke University Medical Center, Durham, North Carolina Department of Pathology, Ohio State University, Columbus, Ohio Department of Pathology, University of North Carolina, Chapel Hill, North Carolina and Department of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York
    Clin Cancer Res 19:4951-60. 2013
    ..We hypothesized that TILs in glioblastoma are associated with molecular alterations, histologies, and survival...
  12. pmc Mapping of the mouse olfactory system with manganese-enhanced magnetic resonance imaging and diffusion tensor imaging
    David A Gutman
    Department of Biomedical Informatics, School of Medicine, Emory University, Atlanta, GA 30329, USA
    Brain Struct Funct 218:527-37. 2013
    ..These data demonstrate that MEMRI and DTI are complementary, high-resolution neuroimaging tools that can be applied to mouse genetic models of olfactory and limbic system connectivity...
  13. doi request reprint Behavioral effects of the CRF1 receptor antagonist R121919 in rats selectively bred for high and low activity in the swim test
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000 WMRB, Atlanta, GA 30322, United States
    Psychoneuroendocrinology 33:1093-101. 2008
    ..This effect was observed in both male and female rats. No differences between strains or the effects of R121919 were observed for spontaneous ambulation or in the elevated plus maze test...
  14. pmc The proneural molecular signature is enriched in oligodendrogliomas and predicts improved survival among diffuse gliomas
    Lee A D Cooper
    Center for Comprehensive Informatics, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e12548. 2010
    ....
  15. pmc White matter integrity in highly traumatized adults with and without post-traumatic stress disorder
    Negar Fani
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 37:2740-6. 2012
    ..The role of this pathway in problems that characterize PTSD, such as inadequate extinction of learned fear, as well as attention and explicit memory functions, are discussed...
  16. ncbi request reprint The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress
    David A Gutman
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University of School of Medicine, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 304:874-80. 2003
    ..These data confirm that R121919 acts as a CRF(1) receptor antagonist in vivo, attenuates HPA axis responsivity, and possesses anxiolytic properties...
  17. pmc An integrative approach for in silico glioma research
    Lee A D Cooper
    Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 57:2617-21. 2010
    ..The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research...
  18. doi request reprint Subcallosal cingulate deep brain stimulation for treatment-resistant unipolar and bipolar depression
    Paul E Holtzheimer
    Department of Psychiatry, Dartmouth Medical School, One Medical Center Dr, Lebanon, NH 03756, USA
    Arch Gen Psychiatry 69:150-8. 2012
    ..Deep brain stimulation (DBS) may be an effective intervention for treatment-resistant depression (TRD), but available data are limited...
  19. ncbi request reprint Persistent central nervous system effects of an adverse early environment: clinical and preclinical studies
    David A Gutman
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000 WMRB, Atlanta, GA 30322, USA
    Physiol Behav 79:471-8. 2003
    ..The discussion will be framed in regards to a stress-diathesis model in which early adverse events result in a sensitized stress axis that predisposes individuals to develop mood disorders...
  20. ncbi request reprint Microembolism induces anhedonia but no detectable changes in white matter integrity in aged rats
    Christina L Nemeth
    Department of Psychiatry and Behavioral Science, Emory University, Atlanta, Georgia, United States of America Department of Physiology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 9:e96624. 2014
    ..Together, data suggest that behavioral deficits are not the result of damage to brain regions or white matter tracts, rather the activity of other systems may underlie functional disruption and recovery. ..
  21. pmc Differences in neural activation for object-directed grasping in chimpanzees and humans
    Erin E Hecht
    Department of Anthropology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:14117-34. 2013
    ..This indicates a more "bottom-up" representation of observed action in the human brain and suggests that the evolution of tool use, social learning, and cumulative culture may have involved modifications of frontoparietal interactions. ..
  22. pmc A DTI tractography analysis of infralimbic and prelimbic connectivity in the mouse using high-throughput MRI
    David A Gutman
    Department of Biomedical Informatics, Emory University, USA
    Neuroimage 63:800-11. 2012
    ..Combining such tractography techniques with small animal models will allow more rapid integration of systems neuroscience with molecular genetic, behavioral, and cellular approaches...
  23. ncbi request reprint Serotonin and norepinephrine transporter binding profile of SSRIs
    David A Gutman
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Essent Psychopharmacol 7:35-41. 2006
    ..The rationale for the use of drugs that affect multiple transports is based on the suggestion that antidepressants that block both the SERT and the NET may provide better efficacy. This can only be determined through empirical studies...