Christina Gross

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110β-selective inhibitor
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Med 18:336-45. 2012
  2. pmc Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation
    Vijayalaxmi C Nalavadi
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci 32:2582-7. 2012
  3. pmc Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling
    Ravi S Muddashetty
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 42:673-88. 2011
  4. pmc Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:10624-38. 2010
  5. pmc Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2
    Christina Gross
    Departments of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:5693-8. 2011
  6. pmc Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model
    Sharon A Swanger
    Department of Cell Biology, Emory University, 615 Michael St, NE, Atlanta, GA 30322, USA
    Mol Brain 4:38. 2011
  7. doi request reprint High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo
    Sharon A Swanger
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Methods Mol Biol 714:103-23. 2011
  8. ncbi request reprint Identification of axon-enriched microRNAs localized to growth cones of cortical neurons
    Yukio Sasaki
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322 Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, 236 0004, Japan
    Dev Neurobiol 74:397-406. 2014
  9. pmc Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 37:178-95. 2012
  10. pmc Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans
    Changhui Pak
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 108:12390-5. 2011

Collaborators

Detail Information

Publications12

  1. pmc Excess protein synthesis in FXS patient lymphoblastoid cells can be rescued with a p110β-selective inhibitor
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Med 18:336-45. 2012
    ..Moreover, we provide rationale to pursue p110β-targeting treatments as potential therapy in FXS, and possibly other autism spectrum disorders...
  2. pmc Dephosphorylation-induced ubiquitination and degradation of FMRP in dendrites: a role in immediate early mGluR-stimulated translation
    Vijayalaxmi C Nalavadi
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurosci 32:2582-7. 2012
    ..Thus, control of FMRP levels at the synapse by dephosphorylation-induced and UPS-mediated degradation provides a mode to regulate protein synthesis...
  3. pmc Reversible inhibition of PSD-95 mRNA translation by miR-125a, FMRP phosphorylation, and mGluR signaling
    Ravi S Muddashetty
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 42:673-88. 2011
    ..These findings reveal a mechanism whereby FMRP phosphorylation provides a reversible switch for AGO2 and microRNA to selectively regulate mRNA translation at synapses in response to receptor activation...
  4. pmc Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:10624-38. 2010
    ..Targeting excessive PI3K activity might thus be a potent therapeutic strategy for FXS...
  5. pmc Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2
    Christina Gross
    Departments of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:5693-8. 2011
    ..2 mRNA translation, protein expression, and plasma membrane levels might contribute to excess neuronal excitability in Fmr1 KO mice, and thus imply a potential mechanism underlying FXS-associated epilepsy...
  6. pmc Automated 4D analysis of dendritic spine morphology: applications to stimulus-induced spine remodeling and pharmacological rescue in a disease model
    Sharon A Swanger
    Department of Cell Biology, Emory University, 615 Michael St, NE, Atlanta, GA 30322, USA
    Mol Brain 4:38. 2011
    ..We anticipate that this approach will advance studies of synapse structure and function in brain development, plasticity, and disease...
  7. doi request reprint High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo
    Sharon A Swanger
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA
    Methods Mol Biol 714:103-23. 2011
    ..It enables the quantitative analyses of developmental and cell type-specific patterns of gene expression, and how these are modified by physiological signals or during disease states...
  8. ncbi request reprint Identification of axon-enriched microRNAs localized to growth cones of cortical neurons
    Yukio Sasaki
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia, 30322 Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama, 236 0004, Japan
    Dev Neurobiol 74:397-406. 2014
    ..These findings provide new insight into the presence of axonal miRNAs and motivate further analysis of their function in local protein synthesis underlying axon guidance...
  9. pmc Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 37:178-95. 2012
    ....
  10. pmc Mutation of the conserved polyadenosine RNA binding protein, ZC3H14/dNab2, impairs neural function in Drosophila and humans
    Changhui Pak
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 108:12390-5. 2011
    ..These studies reveal a conserved requirement for ZC3H14/dNab2 in the metazoan nervous system and identify a poly(A) RNA binding protein associated with a human brain disorder...
  11. ncbi request reprint Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
    Ravi S Muddashetty
    Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:5338-48. 2007
    ....