Kathy Griendling

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint NAD(P)H oxidase: role in cardiovascular biology and disease
    K K Griendling
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Res 86:494-501. 2000
  2. pmc Novel NAD(P)H oxidases in the cardiovascular system
    K K Griendling
    Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Heart 90:491-3. 2004
  3. pmc Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation
    Abel Martin-Garrido
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e79657. 2013
  4. pmc Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells
    Holly C Williams
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Circ Res 111:56-65. 2012
  5. pmc Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
    BERNARD LASSEGUE
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Circ Res 110:1364-90. 2012
  6. ncbi request reprint Reactive oxygen species as mediators of angiotensin II signaling
    K K Griendling
    Division of Cardiology, School of Medicine, Emory University, 319 WMB, 1639 Pierce Drive, 30322, Atlanta, GA 30322, USA
    Regul Pept 91:21-7. 2000
  7. ncbi request reprint Angiotensin II signaling in vascular smooth muscle. New concepts
    K K Griendling
    Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Hypertension 29:366-73. 1997
  8. pmc Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK
    Hirofumi Hitomi
    Department of Medicine, Division of Cardiology, Emory University, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 301:C1415-22. 2011
  9. ncbi request reprint Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology
    K K Griendling
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 20:2175-83. 2000
  10. ncbi request reprint ATVB in focus: redox mechanisms in blood vessels
    Kathy K Griendling
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:272-3. 2005

Research Grants

  1. Second International Conference on NADPH Oxidases
    Kathy Griendling; Fiscal Year: 2004
  2. Vascular Oxidases in Atherosclerosis
    Kathy Griendling; Fiscal Year: 2004
  3. Vascular NADPH / NADH Oxidases and Hypertrophy
    Kathy Griendling; Fiscal Year: 2005
  4. Vascular Oxidases in Migration
    Kathy Griendling; Fiscal Year: 2007
  5. Nox4 and Vascular Smooth Muscle Differentiation
    Kathy Griendling; Fiscal Year: 2007
  6. Vascular Oxidases in Migration
    Kathy Griendling; Fiscal Year: 2009
  7. VASCULAR SMOOTH MUSCLE PHOSPHOLIPASE D
    Kathy Griendling; Fiscal Year: 1993
  8. NADH OXIDASE ACTIVATION BY CYTOKINES IN VASCULAR CELLS
    Kathy Griendling; Fiscal Year: 1999
  9. VASCULAR NADPH/NADH OXIDASES AND HYPERTROPHY
    Kathy Griendling; Fiscal Year: 2000
  10. NoxR1, a regulator of Nox4-dependent cytoskeletal remodeling in vascular cells
    Kathy K Griendling; Fiscal Year: 2010

Detail Information

Publications93

  1. ncbi request reprint NAD(P)H oxidase: role in cardiovascular biology and disease
    K K Griendling
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Res 86:494-501. 2000
    ..They have also been linked to hypertension and to pathological states associated with uncontrolled growth and inflammation, such as atherosclerosis...
  2. pmc Novel NAD(P)H oxidases in the cardiovascular system
    K K Griendling
    Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Heart 90:491-3. 2004
  3. pmc Transforming growth factor β inhibits platelet derived growth factor-induced vascular smooth muscle cell proliferation via Akt-independent, Smad-mediated cyclin D1 downregulation
    Abel Martin-Garrido
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e79657. 2013
    ..Taken together, our results demonstrate that KLF5 is required for PDGF-induced Cyclin D1 expression, which is inhibited by TGFβ via a Smad dependent mechanism, resulting in arrest of VSMCs in the G1 phase of the cell cycle. ..
  4. pmc Role of coronin 1B in PDGF-induced migration of vascular smooth muscle cells
    Holly C Williams
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
    Circ Res 111:56-65. 2012
    ..However, the existence and role of coronins in vascular smooth muscle cell (VSMC) migration has yet to be determined...
  5. pmc Biochemistry, physiology, and pathophysiology of NADPH oxidases in the cardiovascular system
    BERNARD LASSEGUE
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Circ Res 110:1364-90. 2012
    ..In this review, we discuss in detail the biochemistry of Nox enzymes expressed in the cardiovascular system (Nox1, 2, 4, and 5), their roles in cardiovascular cell biology, and their contributions to disease development...
  6. ncbi request reprint Reactive oxygen species as mediators of angiotensin II signaling
    K K Griendling
    Division of Cardiology, School of Medicine, Emory University, 319 WMB, 1639 Pierce Drive, 30322, Atlanta, GA 30322, USA
    Regul Pept 91:21-7. 2000
    ..Future work will be directed towards identifying other important redox-sensitive signaling pathways and their relationship to the physiology and pathophysiology of the renin-angiotensin system...
  7. ncbi request reprint Angiotensin II signaling in vascular smooth muscle. New concepts
    K K Griendling
    Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Hypertension 29:366-73. 1997
    ..Elucidation of these pathways is important to our understanding of AT1 receptor function as a final effector of the renin-angiotensin system...
  8. pmc Vascular smooth muscle insulin resistance, but not hypertrophic signaling, is independent of angiotensin II-induced IRS-1 phosphorylation by JNK
    Hirofumi Hitomi
    Department of Medicine, Division of Cardiology, Emory University, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 301:C1415-22. 2011
    ....
  9. ncbi request reprint Modulation of protein kinase activity and gene expression by reactive oxygen species and their role in vascular physiology and pathophysiology
    K K Griendling
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 20:2175-83. 2000
    ....
  10. ncbi request reprint ATVB in focus: redox mechanisms in blood vessels
    Kathy K Griendling
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:272-3. 2005
  11. ncbi request reprint p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin II-induced hypertrophy in vascular smooth muscle cells
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 271:23317-21. 1996
    ..We provide the first evidence that p22(phox) is a critical component of superoxide-generating vascular NADH/NADPH oxidase and suggest a central role for this oxidase system in vascular hypertrophy...
  12. ncbi request reprint Novel gp91(phox) homologues in vascular smooth muscle cells : nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways
    B Lassegue
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA, USA
    Circ Res 88:888-94. 2001
    ..These data support a role for nox1 in redox signaling in VSMCs and provide insight into the molecular identity of the VSMC NAD(P)H oxidase and its potentially critical role in vascular disease...
  13. ncbi request reprint NAD(P)H oxidases and their relevance to atherosclerosis
    D Sorescu
    Department of Medicine, Emory University, Division of Cardiology, 319 WMB, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Trends Cardiovasc Med 11:124-31. 2001
    ..Evidence from experimental animal and human studies implicate the nonphagocytic NAD(P)H oxidases in multiple aspects of atherogenesis, suggesting that these enzymes may be important determinants of the course of vascular disease...
  14. ncbi request reprint Electron spin resonance characterization of the NAD(P)H oxidase in vascular smooth muscle cells
    D Sorescu
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 30:603-12. 2001
    ....
  15. ncbi request reprint Vascular thrombin receptor regulation in hypertensive rats
    Q Capers
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 80:838-44. 1997
    ..Thus, increased TR expression via a redox-sensitive mechanism in the aortic smooth muscle of rats treated with Ang II represents a novel in vivo mechanism through which the hypertensive effects of Ang II are mediated...
  16. ncbi request reprint Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:48269-75. 2001
    ....
  17. ncbi request reprint Epidermal growth factor receptor transactivation by angiotensin II requires reactive oxygen species in vascular smooth muscle cells
    M Ushio-Fukai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 21:489-95. 2001
    ..These findings emphasize the importance of ROS in specific Ang II-stimulated growth-related signaling pathways and suggest that redox-sensitive EGF-R transactivation may be a potential target for antioxidant therapy in vascular disease...
  18. ncbi request reprint Temporal dispersion of activation of phospholipase C-beta1 and -gamma isoforms by angiotensin II in vascular smooth muscle cells. Role of alphaq/11, alpha12, and beta gamma G protein subunits
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 273:19772-7. 1998
    ....
  19. doi request reprint Hydrogen peroxide down-regulates inositol 1,4,5-trisphosphate receptor content through proteasome activation
    A Martin-Garrido
    Departamento Fisiologia, Universidad de Alcala, Alcala de Henares, 28871 Madrid, Spain
    Free Radic Biol Med 47:1362-70. 2009
    ..Altogether, these results suggest that H(2)O(2) mediates IP(3)R down-regulation via proteasome activity...
  20. ncbi request reprint Specific regulation of RGS2 messenger RNA by angiotensin II in cultured vascular smooth muscle cells
    S L Grant
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, USA
    Mol Pharmacol 57:460-7. 2000
    ..Regulation of this protein may be of critical importance in modulating the role of Ang II in vascular disease...
  21. ncbi request reprint p38 Mitogen-activated protein kinase is a critical component of the redox-sensitive signaling pathways activated by angiotensin II. Role in vascular smooth muscle cell hypertrophy
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 273:15022-9. 1998
    ....
  22. ncbi request reprint Heme oxygenase-1 is regulated by angiotensin II in rat vascular smooth muscle cells
    N Ishizaka
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 29:790-5. 1997
    ..In conclusion, Ang II decreases HO-1 mRNA in a calcium-dependent manner in vascular smooth muscle cells, which may provide a novel mechanism for the modulation of vascular tone and oxidative stress...
  23. ncbi request reprint G protein-coupled receptor kinase 5 in cultured vascular smooth muscle cells and rat aorta. Regulation by angiotensin II and hypertension
    N Ishizaka
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 272:32482-8. 1997
    ..Hormone- and hemodynamic stress-induced GRK5 regulation may provide a novel molecular basis for long-term regulation of agonist sensitivity of vascular cells...
  24. ncbi request reprint Angiotensin II receptor coupling to phospholipase D is mediated by the betagamma subunits of heterotrimeric G proteins in vascular smooth muscle cells
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, USA
    Mol Pharmacol 55:142-9. 1999
    ..These results may provide insight into the molecular mechanisms underlying the highly organized, complex, chronic signaling programs associated with vascular smooth muscle growth and remodeling in response to Ang II...
  25. ncbi request reprint Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells
    M Ushio-Fukai
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 274:22699-704. 1999
    ....
  26. ncbi request reprint Cell transformation by the superoxide-generating oxidase Mox1
    Y A Suh
    Department of Biochemistry, Emory University Medical School, Atlanta, Georgia 30322, USA
    Nature 401:79-82. 1999
    ..Cells expressing mox1 have a transformed appearance, show anchorage-independent growth and produce tumours in athymic mice. These data link ROS production by Mox1 to growth control in non-phagocytic cells...
  27. ncbi request reprint Angiotensin II stimulation of vascular smooth muscle cells. Secondary signalling mechanisms
    K K Griendling
    Department of Medicine, Emory University, Atlanta, GA 30322
    Am J Hypertens 2:659-65. 1989
    ....
  28. pmc Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells
    Chan Woo Kim
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 33:1350-9. 2013
    ..BMP actions are mediated by 2 different types of BMP receptors (BMPRI and BMPRII). Here, we show a surprising finding that loss of BMPRII expression causes endothelial inflammation and atherosclerosis...
  29. ncbi request reprint Endothelial control of the cardiovascular system: recent advances
    K K Griendling
    Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    FASEB J 10:283-92. 1996
    ....
  30. ncbi request reprint Endothelin A and B receptors are down-regulated in the hearts of hypertensive rats
    D J Hayzer
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322
    Am J Med Sci 307:222-7. 1994
    ..Conversely, in the brain of spontaneously hypertensive rats, mRNAs for both ET-R(A) and ET-R(B) mRNA were present.(ABSTRACT TRUNCATED AT 250 WORDS)..
  31. ncbi request reprint Isolation of a cDNA encoding the vascular type-1 angiotensin II receptor
    T J Murphy
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322
    Nature 351:233-6. 1991
    ..Knowledge of the AT1 receptor primary sequence should now permit structural analysis, definition of the angiotensin II receptor gene family and delineation of the contribution of AT receptors to the genetic component of hypertension...
  32. pmc Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 117:719-29. 2007
    ..Akt thus serves as a molecular switch that increases angiogenesis and the generation of superoxide, fostering more aggressive tumor behavior. Targeting Akt and ROS may be of therapeutic importance in treatment of advanced melanoma...
  33. ncbi request reprint Cytochrome b-558 alpha-subunit cloning and expression in rat aortic smooth muscle cells
    T Fukui
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1231:215-9. 1995
    ..Our results provide a tool with which to explore the mechanism of superoxide anion generation in rat VSMCs and other non-phagocytic cells...
  34. ncbi request reprint Inhibition of vascular cell growth by X-ray irradiation: comparison with gamma radiation and mechanism of action
    N A Scott
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Int J Radiat Oncol Biol Phys 50:485-93. 2001
    ..This inhibition is apparently due to a delay in progression through the cell cycle, which is mediated by increases in the levels of cell cycle inhibitors...
  35. ncbi request reprint RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response
    Paul Modlinger
    Division of Nephrology and Hypertension, Georgetown University, Washington, DC, USA
    Hypertension 47:238-44. 2006
    ..005). An increase in p22phox is required for increased renal NADPH oxidase activity, expression of Nox proteins and oxidative stress, and contributes < or =50% to hypertension during an Ang II slow-pressor response...
  36. ncbi request reprint Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
    Anna Dikalova
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circulation 112:2668-76. 2005
    ..Nox1 upregulation has been implicated in cardiovascular pathologies such as hypertension and restenosis...
  37. ncbi request reprint Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
    Maria C Wendt
    The University Clinics Eppendorf, Division of Cardiology, Hamburg, Germany
    Free Radic Biol Med 39:381-91. 2005
    ..We conclude that in addition to phagocytic NADPH oxidase, also nonphagocytic, vascular NADPH oxidase subunit nox1, uncoupled NOSIII, and plasma xanthine oxidase contribute to endothelial dysfunction in the setting of diabetes mellitus...
  38. ncbi request reprint Mechanisms of reactive oxygen species-dependent downregulation of insulin receptor substrate-1 by angiotensin II
    Yoshihiro Taniyama
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:1142-7. 2005
    ..Therefore, we examined the effects of chronic angiotensin II treatment on IRS-1 phosphorylation and protein expression in vascular smooth muscle cells (VSMCs)...
  39. pmc Nox5 mediates PDGF-induced proliferation in human aortic smooth muscle cells
    DESMOND B JAY
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 45:329-35. 2008
    ..Additionally, siRNA to Nox5 inhibited PDGF-stimulated JAK2 and STAT3 phosphorylation. ROS produced by Nox5 play an important role in PDGF-induced JAK/STAT activation and HASMC proliferation...
  40. ncbi request reprint Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production
    Jinah Hwang
    Division of Pulmonary and Critical Care Medicine, Pulmonary Section, Atlanta Veterans Affairs and Emory University Medical Centers 151 P 1670 Clairmont Road, Decatur, GA 30033, USA
    Am J Physiol Cell Physiol 288:C899-905. 2005
    ..metabolism through suppression of NADPH oxidase and induction of Cu/Zn-SOD. These findings further elucidate the molecular mechanisms by which PPAR-gamma ligands directly alter vascular endothelial function...
  41. ncbi request reprint Functional association of nox1 with p22phox in vascular smooth muscle cells
    Ibrahim R Hanna
    Division of Cardiology, Department of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Free Radic Biol Med 37:1542-9. 2004
    ....
  42. ncbi request reprint Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase
    George P Sorescu
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Circ Res 95:773-9. 2004
    ..Together, these results suggest that BMP4 produced in ECs by OS stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step...
  43. ncbi request reprint Oxidative stress and diabetic cardiovascular complications
    Desmond Jay
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 40:183-92. 2006
    ..The elucidation of the mechanisms of oxidative stress in diabetes and their relationship with atherosclerosis could potentially identify molecular targets of therapy for this condition and its cardiovascular consequences...
  44. pmc Reactive oxygen species signaling in vascular smooth muscle cells
    Roza E Clempus
    Department of Medicine, Division of Cardiology, Emory University, 319 WMB, 1639 Pierce Dr Atlanta, GA 30322, USA
    Cardiovasc Res 71:216-25. 2006
    ..Therefore, it becomes critical to understand the different roles ROS play in the physiology and pathophysiology of VSMCs...
  45. pmc Redox signaling, vascular function, and hypertension
    Moo Yeol Lee
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 10:1045-59. 2008
    ..Thus, there are diverse roles of the vascular redox system in hypertension, suggesting that the complexity of redox signaling in distinct spatial spectrums should be considered for a better understanding of hypertension...
  46. ncbi request reprint Detection of reactive oxygen species and nitric oxide in vascular cells and tissues: comparison of sensitivity and specificity
    Hua Cai
    Division of Molecular Medicine, Department of Anesthesiology, Cardiovascular Research Laboratories, David Geffen School of Medicine, University of California, Los Angeles, USA
    Methods Mol Med 139:293-311. 2007
    ....
  47. ncbi request reprint Nox1-based NADPH oxidase-derived superoxide is required for VSMC activation by advanced glycation end-products
    Alejandra San Martin
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:1671-9. 2007
    ..This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase...
  48. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
    ..These data shed light on molecular processes underlying the oxidative signaling cascade engaged by Ang II and identify potential targets for intervention to prevent renal hypertrophy and fibrosis...
  49. pmc Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury
    Christopher A Papaharalambus
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Trends Cardiovasc Med 17:48-54. 2007
    ....
  50. ncbi request reprint Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
    ..This can promotes thiol loss during states of increased glutathione oxidation. We investigated how MRP1 modulates blood pressure and vascular function during angiotensin II-induced hypertension...
  51. pmc Nox4 is required for maintenance of the differentiated vascular smooth muscle cell phenotype
    Roza E Clempus
    Emory University, Division of Cardiology, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:42-8. 2007
    ..Reactive oxygen species (ROS) have been implicated in VSMC differentiation, but the responsible sources are unknown. In this study, we investigated the role of Nox1 and Nox4-derived ROS in this process...
  52. ncbi request reprint Angiotensin II cell signaling: physiological and pathological effects in the cardiovascular system
    Puja K Mehta
    Division of Cardiology, 319 WMB, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 292:C82-97. 2007
    ..This review focuses on the structure and function of AT(1) receptors and the major signaling mechanisms by which angiotensin influences cardiovascular physiology and pathology...
  53. ncbi request reprint Modulation of vascular smooth muscle signaling by reactive oxygen species
    Alicia N Lyle
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia, USA
    Physiology (Bethesda) 21:269-80. 2006
    ..Identifying the precise intracellular targets of ROS enhances understanding of their role in cardiovascular physiology and pathophysiology...
  54. ncbi request reprint Angiotensin II-induced hypertrophy is potentiated in mice overexpressing p22phox in vascular smooth muscle
    David S Weber
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 288:H37-42. 2005
    ....
  55. ncbi request reprint Direct interaction of the novel Nox proteins with p22phox is required for the formation of a functionally active NADPH oxidase
    Rashmi K Ambasta
    Institut für Kardiovaskuläre Physiologie, Klinikum der J W Goethe Universitat, D 60596 Frankfurt am Main, Germany
    J Biol Chem 279:45935-41. 2004
    ....
  56. ncbi request reprint Oscillatory shear stress stimulates endothelial production of O2- from p47phox-dependent NAD(P)H oxidases, leading to monocyte adhesion
    Jinah Hwang
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    J Biol Chem 278:47291-8. 2003
    ....
  57. ncbi request reprint Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury
    Katalin Szocs
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 22:21-7. 2002
    ..This dynamic regulation of oxidase components may be critical to smooth muscle phenotypic modulation in restenosis and atherosclerosis...
  58. ncbi request reprint Reactive oxygen species sensitivity of angiotensin II-dependent translation initiation in vascular smooth muscle cells
    Petra Rocic
    Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 278:36973-9. 2003
    ....
  59. ncbi request reprint Interactions of angiotensin II with NAD(P)H oxidase, oxidant stress and cardiovascular disease
    David G Harrison
    Division of Caridology, Emory University, Atlanta, Georgia 30322, USA
    J Renin Angiotensin Aldosterone Syst 4:51-61. 2003
    ..Furthermore, increasing evidence suggest that the NAD(P)H oxidase contributes to human disease, suggesting that it is a potential target for future therapeutic intervention...
  60. ncbi request reprint Role of oxidative stress in atherosclerosis
    David Harrison
    Department of Medicine, Division of Cardioogy, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Am J Cardiol 91:7A-11A. 2003
    ..Oxidative stress in humans with coronary artery disease is also exacerbated by a reduction of vascular extracellular superoxide dismutase, normally an important protective enzyme against the superoxide anion...
  61. ncbi request reprint NAD(P)H oxidase-derived reactive oxygen species as mediators of angiotensin II signaling
    Ibrahim R Hanna
    Emory University, Division of Cardiology, Atlanta, GA 30322, USA
    Antioxid Redox Signal 4:899-914. 2002
    ..As such, we provide a framework linking angiotensin II to crucial vascular pathologies, such as hypertension, atherosclerosis, and restenosis after angioplasty, by means of the NAD(P)H-dependent oxidases and their effector molecules...
  62. ncbi request reprint The A640G and C242T p22(phox) polymorphisms in patients with coronary artery disease
    A Maziar Zafari
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Antioxid Redox Signal 4:675-80. 2002
    ..Our study does not support a functional role for the A640G or C242T polymorphisms either in the severity of CAD or in determining endothelial function in older men...
  63. ncbi request reprint Angiotensin II stimulation of NAD(P)H oxidase activity: upstream mediators
    Puvi N Seshiah
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Res 91:406-13. 2002
    ....
  64. ncbi request reprint Functional evaluation of nonphagocytic NAD(P)H oxidases
    Francis J Miller
    Department of Internal Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    Methods Enzymol 353:220-33. 2002
  65. ncbi request reprint Reactive oxygen species, mitochondria, and NAD(P)H oxidases in the development and progression of heart failure
    Dan Sorescu
    Emory University School of Medicine, Department of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Congest Heart Fail 8:132-40. 2002
    ..Future studies are necessary to identify the sources, mechanisms of activation of NAD(P)H oxidases, and downstream signaling targets implicated in the progression of chronic heart failure...
  66. ncbi request reprint Superoxide production and expression of nox family proteins in human atherosclerosis
    Dan Sorescu
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Circulation 105:1429-35. 2002
    ....
  67. ncbi request reprint Out phoxing the endothelium: what's left without p47?
    BERNARD LASSEGUE
    Circ Res 90:123-4. 2002
  68. ncbi request reprint The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
    Hua Cai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Trends Pharmacol Sci 24:471-8. 2003
    ..Recently, efforts have been devoted to developing inhibitors of NAD(P)H oxidases that will provide useful experimental tools and might have therapeutic potential in the treatment of human diseases...
  69. ncbi request reprint Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS
    Kathy K Griendling
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Circulation 108:1912-6. 2003
  70. ncbi request reprint Reactive oxygen species in the vasculature: molecular and cellular mechanisms
    Yoshihiro Taniyama
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 42:1075-81. 2003
    ..ROS, by regulating vascular cell function, can play a central role in normal vascular physiology, and can contribute substantially to the development of vascular disease...
  71. ncbi request reprint Oxidative stress and cardiovascular injury: Part II: animal and human studies
    Kathy K Griendling
    Division of Cardiology, Emory University, Atlanta, GA, USA
    Circulation 108:2034-40. 2003
  72. ncbi request reprint Distinct subcellular localizations of Nox1 and Nox4 in vascular smooth muscle cells
    Lula L Hilenski
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 24:677-83. 2004
    ..We hypothesize that the opposing functions of Nox1 and Nox4 are reflected in their differential subcellular locations...
  73. pmc Pyk2- and Src-dependent tyrosine phosphorylation of PDK1 regulates focal adhesions
    Yoshihiro Taniyama
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Mol Cell Biol 23:8019-29. 2003
    ..These observations identify a novel interaction between PDK1 and Pyk2 that regulates the integrity of focal adhesions, which are major compartments for integrating signals for cell growth, apoptosis, and migration...
  74. ncbi request reprint Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice
    Karine Laude
    Division of Cardiology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 288:H7-12. 2005
    ..NO in turn increases ecSOD protein expression and counterbalances increased ROS production leading to the maintenance of normal vascular function and hemodynamics...
  75. ncbi request reprint C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils
    Keith E Wyche
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 43:1246-51. 2004
    ..Because p22phox exists in both the neutrophil and vessel wall, vascular oxidative stress is likely diminished in individuals with this polymorphism...
  76. ncbi request reprint Nox is playing with a full deck in vascular smooth muscle, a commentary on "Noxa1 is a central component of the smooth muscle NADPH oxidase in mice"
    BERNARD LASSEGUE
    Emory University School of Medicine, Division of Cardiology, Atlanta, GA 30322, USA
    Free Radic Biol Med 41:185-7. 2006
  77. ncbi request reprint Resveratrol suppresses angiotensin II-induced Akt/protein kinase B and p70 S6 kinase phosphorylation and subsequent hypertrophy in rat aortic smooth muscle cells
    Ursula G B Haider
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Mol Pharmacol 62:772-7. 2002
    ..Thus, this study delivers important new insight in the molecular pathways that may contribute to the proposed beneficial effects of RV in cardiovascular disease...
  78. ncbi request reprint Phosphoinositide-dependent kinase 1 and p21-activated protein kinase mediate reactive oxygen species-dependent regulation of platelet-derived growth factor-induced smooth muscle cell migration
    David S Weber
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circ Res 94:1219-26. 2004
    ..Such information is critical to understanding the role of ROS in vascular diseases in which migration of VSMCs is an important component...
  79. ncbi request reprint Role of p38 MAPK and MAPKAPK-2 in angiotensin II-induced Akt activation in vascular smooth muscle cells
    Yoshihiro Taniyama
    Division of Cardiology, Department of Medicine, Emory University, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 287:C494-9. 2004
    ..These results provide evidence for a novel signaling complex that may help to spatially organize hypertrophy-related, ROS-sensitive signaling in VSMCs...
  80. ncbi request reprint Redox control of growth factor signaling in heart, lung, and circulation
    Yuichiro J Suzuki
    Antioxid Redox Signal 5:689-90. 2003
  81. ncbi request reprint Oxidative stress and diabetic vascular complications
    Seok Man Son
    Emory University School of Medicine, Division of Cardiology, 319 WMB, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Curr Diab Rep 4:247-52. 2004
    ....
  82. ncbi request reprint Reactive oxygen species in hypertension; An update
    BERNARD LASSEGUE
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Hypertens 17:852-60. 2004
    ..Progress in our understanding of the mechanisms of ROS formation and their plethora of pathophysiologic effects is expected to lead from simple antioxidant therapy to specific antihypertensive treatments...
  83. ncbi request reprint Resveratrol increases serine15-phosphorylated but transcriptionally impaired p53 and induces a reversible DNA replication block in serum-activated vascular smooth muscle cells
    Ursula G B Haider
    Department of Pharmacy, Center of Drug Research, University of Munich, Munich, Germany
    Mol Pharmacol 63:925-32. 2003
    ..This is the first study elucidating the molecular pathways mediating the antiproliferative properties of RV in VSMCs...
  84. ncbi request reprint NADPH oxidase inhibitors: new antihypertensive agents?
    Holly C Williams
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    J Cardiovasc Pharmacol 50:9-16. 2007
    ..Targeting NADPH homologues may have a distinct advantage over current therapies because it would specifically prevent the pathophysiological formation of reactive oxygen species that contributes to hypertension...
  85. pmc NADPH oxidases: new regulators of old functions
    Kathy K Griendling
    Antioxid Redox Signal 8:1443-5. 2006
  86. ncbi request reprint Mycophenolic acid is a new Nox2 inhibitor
    BERNARD LASSEGUE
    Hypertension 49:25-6. 2007
  87. pmc Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species
    Derek E Doran
    Division of Cardiology, Department of Medicine, Emory University School of Medicine and the Atlanta VA Medical Center, Atlanta, GA, United States
    Atherosclerosis 195:39-47. 2007
    ..These data demonstrate that angiotensin II receptor blockade inhibits atherosclerosis by reducing vascular oxidative stress and inflammatory gene production independent of blood pressure reduction...
  88. ncbi request reprint Reactive oxygen species-selective regulation of aortic inflammatory gene expression in Type 2 diabetes
    Alejandra San Martin
    Division of Cardiology, Department of Medicine, Emory University, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 292:H2073-82. 2007
    ..The ability of Tempol to reverse ROS production as well as OPN and BMP-4, but not CTGF, induction suggests that DM-induced vascular inflammation involves both ROS-sensitive and -insensitive pathways...
  89. ncbi request reprint Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2
    Yong Zhang
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 46:732-7. 2005
    ..4+/-2.0 versus 43.2+/-7.6 microm; P<0.001). These results demonstrate that vascular SMC-derived hydrogen peroxide plays an important role in angiotensin II-induced hypertrophy of the arterial wall...
  90. pmc Measurement of reactive oxygen species in cardiovascular studies
    Sergey Dikalov
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Hypertension 49:717-27. 2007
  91. ncbi request reprint Expression of inducible nitric-oxide synthase and intracellular protein tyrosine nitration in vascular smooth muscle cells: role of reactive oxygen species
    Diana M Fries
    Stokes Research Institute, Children s Hospital of Pennsylvania and University of Pennsylvania, Philadelphia, Pennsylvania 19140, USA
    J Biol Chem 278:22901-7. 2003
    ....
  92. ncbi request reprint Resveratrol inhibits angiotensin II- and epidermal growth factor-mediated Akt activation: role of Gab1 and Shp2
    Ursula G B Haider
    Department of Pharmacy, Center of Drug Research, Butenandtstrasse 5 13, D 81377 Munich, Germany
    Mol Pharmacol 68:41-8. 2005
    ..We therefore propose that RV blocks Akt activation in Ang II- and EGF-stimulated VSMCs by activating Shp2, thus preventing interaction between Gab1 and PI3K that is necessary for further signal transduction...
  93. pmc The yin/yang of superoxide dismutase mimetics: potential cardiovascular therapies?
    David S Weber
    Division of Cardiology, Emory University, WMB 319, 1639 Pierce Dr, Atlanta, GA 30322, U S A
    Br J Pharmacol 139:1059-60. 2003

Research Grants30

  1. Second International Conference on NADPH Oxidases
    Kathy Griendling; Fiscal Year: 2004
    ..b>Kathy Griendling and J. David Lambeth, both of whom are leaders in the field...
  2. Vascular Oxidases in Atherosclerosis
    Kathy Griendling; Fiscal Year: 2004
    ..Understanding the role of this new potent oxidase in vascular disease may suggest new therapeutic interventions targeted to nox-1. ..
  3. Vascular NADPH / NADH Oxidases and Hypertrophy
    Kathy Griendling; Fiscal Year: 2005
    ....
  4. Vascular Oxidases in Migration
    Kathy Griendling; Fiscal Year: 2007
    ..Such information may lead to the development of new therapeutic strategies that can be carefully and specifically targeted to the critically important events in disease initiation. ..
  5. Nox4 and Vascular Smooth Muscle Differentiation
    Kathy Griendling; Fiscal Year: 2007
    ..Delineating the functional consequences of Nox4 activation will lead to a better understanding of the mechanisms controlling vascular smooth muscle function in health and disease. ..
  6. Vascular Oxidases in Migration
    Kathy Griendling; Fiscal Year: 2009
    ..Such information may lead to the development of new therapeutic strategies that can be carefully and specifically targeted to the critically important events in disease initiation. ..
  7. VASCULAR SMOOTH MUSCLE PHOSPHOLIPASE D
    Kathy Griendling; Fiscal Year: 1993
    ....
  8. NADH OXIDASE ACTIVATION BY CYTOKINES IN VASCULAR CELLS
    Kathy Griendling; Fiscal Year: 1999
    ....
  9. VASCULAR NADPH/NADH OXIDASES AND HYPERTROPHY
    Kathy Griendling; Fiscal Year: 2000
    ..Understanding the cellular events involved in controlling the oxidative environment of VSMC may thus lead to the development of specific therapeutic strategies. ..
  10. NoxR1, a regulator of Nox4-dependent cytoskeletal remodeling in vascular cells
    Kathy K Griendling; Fiscal Year: 2010
    ..Virtually nothing is known about the mechaases. ..