James G Greene

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism
    James G Greene
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 18:19-31. 2005
  2. pmc Current status and future directions of gene expression profiling in Parkinson's disease
    James G Greene
    Department of Neurology and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 45:76-82. 2012
  3. pmc Neuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents
    James G Greene
    Departments of Neurology and Pharmacology, and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA
    Neurobiol Dis 38:476-81. 2010
  4. pmc Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
  5. pmc Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss
    Dana M Annerino
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Acta Neuropathol 124:665-80. 2012
  6. pmc Quantitative transcriptional neuroanatomy of the rat hippocampus: evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers
    James G Greene
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Hippocampus 19:253-64. 2009
  7. pmc Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity
    Tonya N Taylor
    Center for Neurodegenerative Disease and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 29:8103-13. 2009
  8. doi request reprint Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system
    Ali Reza Noorian
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 48:9-19. 2012
  9. pmc BMP2 promotes differentiation of nitrergic and catecholaminergic enteric neurons through a Smad1-dependent pathway
    Mallappa Anitha
    Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 298:G375-83. 2010
  10. ncbi request reprint Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1
    Cecily E Hamill
    Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Pharmacol 72:653-64. 2007

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Gene expression profiling of rat midbrain dopamine neurons: implications for selective vulnerability in parkinsonism
    James G Greene
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 18:19-31. 2005
    ..These results provide the first large scale description of gene expression profiles of dopamine neurons and suggest several avenues for investigation into dopaminergic neuroprotective therapy for PD...
  2. pmc Current status and future directions of gene expression profiling in Parkinson's disease
    James G Greene
    Department of Neurology and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 45:76-82. 2012
    ..It will focus on the use of microarray experiments to stimulate hypotheses concerning mechanisms of neurodegeneration in PD, since the majority of studies thus far have addressed that complicated issue...
  3. pmc Neuron-selective changes in RNA transcripts related to energy metabolism in toxic models of parkinsonism in rodents
    James G Greene
    Departments of Neurology and Pharmacology, and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA, USA
    Neurobiol Dis 38:476-81. 2010
    ....
  4. pmc Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease
    James G Greene
    Department of Neurology, Emory University School of Medicine, 505H Whitehead Biomedical Research Bldg, 615 Michael St, Atlanta, GA 30322, USA
    Exp Neurol 218:154-61. 2009
    ....
  5. pmc Parkinson's disease is not associated with gastrointestinal myenteric ganglion neuron loss
    Dana M Annerino
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Acta Neuropathol 124:665-80. 2012
    ....
  6. pmc Quantitative transcriptional neuroanatomy of the rat hippocampus: evidence for wide-ranging, pathway-specific heterogeneity among three principal cell layers
    James G Greene
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Hippocampus 19:253-64. 2009
    ....
  7. pmc Nonmotor symptoms of Parkinson's disease revealed in an animal model with reduced monoamine storage capacity
    Tonya N Taylor
    Center for Neurodegenerative Disease and Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 29:8103-13. 2009
    ..Furthermore, monoamine dysfunction may contribute to many of the nonmotor symptoms of PD, and interventions aimed at restoring monoamine function may be beneficial in treating the disease...
  8. doi request reprint Alpha-synuclein transgenic mice display age-related slowing of gastrointestinal motility associated with transgene expression in the vagal system
    Ali Reza Noorian
    Department of Neurology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 48:9-19. 2012
    ..These behavioral and neuropathological patterns parallel those seen in PD patients and suggest the DMV as a target for further investigation into causes for GI neuropathology and symptomatology in parkinsonism...
  9. pmc BMP2 promotes differentiation of nitrergic and catecholaminergic enteric neurons through a Smad1-dependent pathway
    Mallappa Anitha
    Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 298:G375-83. 2010
    ..The effects of BMP2 on catecholaminergic neurons may have therapeutic implications in gastrointestinal motility disturbances...
  10. ncbi request reprint Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1
    Cecily E Hamill
    Department of Pharmacology, Emory University School of Medicine, 5025 Rollins Research Center, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Pharmacol 72:653-64. 2007
    ..Together, these data suggest that PAR1 might be a target for therapeutic intervention in Parkinson's disease...
  11. pmc Behavioral phenotyping of mouse models of Parkinson's disease
    Tonya N Taylor
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, United States
    Behav Brain Res 211:1-10. 2010
    ..Here, we suggest an extensive, yet feasible, battery of behavioral tests for mouse models of PD aimed to better assess both non-motor and motor deficits associated with the disease...
  12. pmc Neurochemical phenotypes of myenteric neurons in the rhesus monkey
    Ali Reza Noorian
    Department of Neurology and the Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Comp Neurol 519:3387-401. 2011
    ....
  13. pmc Gene expression profiles of brain dopamine neurons and relevance to neuropsychiatric disease
    James G Greene
    Emory University School of Medicine, 505 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    J Physiol 575:411-6. 2006
    ..As new functions of dopaminergic neurotransmission become clearer, continued exploration of the transcriptional neuroanatomy of these unique neurons will be vital for producing targeted, selective, and effective therapeutic agents...
  14. pmc Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease
    Grant Anderson
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 207:4-12. 2007
    ..They provide insight into the impact of dopaminergic dysfunction on gastrointestinal motility and a benchmark for assessment of other PD model systems...
  15. ncbi request reprint Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
    ..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect...
  16. ncbi request reprint Animal models of gastrointestinal problems in Parkinson's disease
    James G Greene
    Department of Neurology, Emory University, Whitehead Biomedical Research Bldg, Atlanta, GA 30322, USA
    J Parkinsons Dis 1:137-49. 2011
    ....
  17. doi request reprint Gastrointestinal features of Parkinson's disease
    Leslie J Cloud
    Emory University, Atlanta, GA, 30329, USA
    Curr Neurol Neurosci Rep 11:379-84. 2011
    ..A brief discussion about the impacts of commonly used medical and surgical PD therapies on GI symptom manifestation is also included...

Research Grants2

  1. Molecular mechanism of selective neuronal vulnerability
    James Greene; Fiscal Year: 2007
    ..The proposal includes active mentoring by experienced scientists, access to diverse resources, and an environment uniquely suited to help the PI develop as an independent physician scientist. ..