Shannon L Gourley

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
    Shannon L Gourley
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:3107-12. 2013
  2. ncbi Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
    Shannon L Gourley
    Department of Pediatrics, Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory School of Medicine, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 109:20714-9. 2012
  3. ncbi Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 219:805-14. 2012
  4. ncbi Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 32:2314-23. 2012
  5. ncbi Corticosterone regulates pERK1/2 map kinase in a chronic depression model
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1148:509-14. 2008
  6. ncbi Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior
    M Sloan Warren
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
    J Neurosci 32:2824-34. 2012
  7. ncbi Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
    Shannon L Gourley
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Learn Mem 16:756-60. 2009
  8. ncbi Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 63:353-9. 2008
  9. ncbi A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 34:707-16. 2009
  10. ncbi Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:884-90. 2008

Collaborators

  • Peter Olausson
  • Anne Williamson
  • Maribel Rios
  • Yu Chih Lin
  • Jane R Taylor
  • Anthony J Koleske
  • M Sloan Warren
  • Douglas J Guarnieri
  • Brian A Couch
  • William D Bradley
  • Charles A Greer
  • Mindan K Sfakianos
  • Mounira Banasr
  • Catherine E Brayton
  • Louis F Reichardt
  • Joseph R Trinko
  • Sarah M Richards
  • Ralph J DiLeone
  • Jaime Maldonado-Aviles
  • Mark A Simpson
  • Jessica Nelson
  • George J Demarco
  • Xiao-Yuan Li
  • Jeffrey Settleman
  • Gerald W Valentine
  • Ronald S Duman
  • Xiao Yuan Li
  • Aaron Eisman
  • Alfred J Scheetz

Detail Information

Publications18

  1. ncbi Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
    Shannon L Gourley
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:3107-12. 2013
    ....
  2. ncbi Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
    Shannon L Gourley
    Department of Pediatrics, Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory School of Medicine, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 109:20714-9. 2012
    ....
  3. ncbi Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 219:805-14. 2012
    ..Despite the increasing utility of transgenic and knockout mice in addressing such issues, previous studies aimed at characterizing biochemical mechanisms have been conducted in rats...
  4. ncbi Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 32:2314-23. 2012
    ....
  5. ncbi Corticosterone regulates pERK1/2 map kinase in a chronic depression model
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1148:509-14. 2008
    ..Notably, prefrontal cortical targets were also regulated. Our data suggest ADTs restore hippocampal pERK1/2 after stress-related insult, and potentially reveal a novel role for prefrontal neurotrophins in depressive-like symptomology...
  6. ncbi Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior
    M Sloan Warren
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
    J Neurosci 32:2824-34. 2012
    ....
  7. ncbi Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
    Shannon L Gourley
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Learn Mem 16:756-60. 2009
    ....
  8. ncbi Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 63:353-9. 2008
    ..The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate...
  9. ncbi A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 34:707-16. 2009
    ....
  10. ncbi Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:884-90. 2008
    ....
  11. ncbi Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 106:16859-64. 2009
    ..These findings provide evidence that stabilization of dendritic structure beginning in adolescence is critical for the development of adaptive and flexible behavior after cocaine exposure...
  12. ncbi Recapitulation and reversal of a persistent depression-like syndrome in rodents
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Curr Protoc Neurosci . 2009
    ....
  13. ncbi Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction
    Douglas J Guarnieri
    Division of Molecular Psychiatry, Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Biol Psychiatry 71:358-65. 2012
    ..Food restriction is known to enhance learning and motivation. The neural mechanisms underlying these responses likely involve alterations in gene expression in brain regions mediating the motivation to feed...
  14. ncbi Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration
    Brian A Couch
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Alzheimers Dis 20:1003-8. 2010
    ..We report that increased dendrite branching occurs in AbetaPP/PS1 mice and that fasudil promotes lengthening of the dendrite arbors of CA1 pyramidal neurons...
  15. ncbi Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior
    Mindan K Sfakianos
    Department of Molecular Biophysics and Biochemistry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:10982-92. 2007
    ..Together, these data indicate that signaling through Arg and p190RhoGAP acts late during synaptic refinement to promote dendritic spine maturation and synapse/dendrite stability by attenuating synaptic Rho activity...
  16. ncbi Dissociable regulation of instrumental action within mouse prefrontal cortex
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06508, USA
    Eur J Neurosci 32:1726-34. 2010
    ..Our findings thus selectively implicate the rodent mOFC in braking reinforced goal-directed action when reinforcement requires the acquisition of novel response contingencies...
  17. ncbi Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, CMHC, 34 Park St, New Haven, CT, 06508, USA
    Psychopharmacology (Berl) 225:569-77. 2013
    ..We have previously reported that prior chronic corticosterone exposure to mice produces a lasting depressive-like state that can be reversed by chronic antidepressant treatment...
  18. ncbi Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 62:496-504. 2007
    ..However, little is known about the mechanisms that contribute to this decrease in cell number...