Shannon L Gourley

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum
    Shannon L Gourley
    Department of Pediatrics, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive NE, Atlanta, GA 30322, USA
    Eur J Neurosci 38:2382-8. 2013
  2. pmc Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
    Shannon L Gourley
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:3107-12. 2013
  3. pmc Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
    Shannon L Gourley
    Department of Pediatrics, Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory School of Medicine, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 109:20714-9. 2012
  4. pmc Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 219:805-14. 2012
  5. pmc Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 32:2314-23. 2012
  6. pmc Corticosterone regulates pERK1/2 map kinase in a chronic depression model
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1148:509-14. 2008
  7. pmc Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior
    M Sloan Warren
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
    J Neurosci 32:2824-34. 2012
  8. pmc Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, 34 Park St, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 225:569-77. 2013
  9. pmc Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
    Shannon L Gourley
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Learn Mem 16:756-60. 2009
  10. pmc Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 63:353-9. 2008

Collaborators

  • Peter Olausson
  • Anne Williamson
  • Maribel Rios
  • Yu Chih Lin
  • Ralph J DiLeone
  • Jane R Taylor
  • Anthony J Koleske
  • Lauren M Depoy
  • M Sloan Warren
  • Douglas J Guarnieri
  • Brian A Couch
  • Charles A Greer
  • William D Bradley
  • Mindan K Sfakianos
  • Mounira Banasr
  • Amanda G Allen
  • Benjamin Noble
  • Mark A Simpson
  • Jessica Nelson
  • Jaime Maldonado-Aviles
  • Joseph R Trinko
  • Sarah M Richards
  • Louis F Reichardt
  • Catherine E Brayton
  • George J Demarco
  • Alfred J Scheetz
  • Aaron Eisman
  • Ronald S Duman
  • Jeffrey Settleman
  • Gerald W Valentine
  • Xiao Yuan Li

Detail Information

Publications21

  1. pmc The orbitofrontal cortex regulates outcome-based decision-making via the lateral striatum
    Shannon L Gourley
    Department of Pediatrics, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive NE, Atlanta, GA 30322, USA
    Eur J Neurosci 38:2382-8. 2013
    ..This compartmentalisation may apply to both 'natural', as in the case of food-reinforced behavior, and 'pathological', as in the case of cocaine-seeking, contexts. ..
  2. pmc Corticosteroid-induced neural remodeling predicts behavioral vulnerability and resilience
    Shannon L Gourley
    Department of Pediatrics, Emory School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 33:3107-12. 2013
    ....
  3. pmc Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding
    Shannon L Gourley
    Department of Pediatrics, Graduate Program in Neuroscience, Yerkes National Primate Research Center, Emory School of Medicine, Atlanta, GA 30329, USA
    Proc Natl Acad Sci U S A 109:20714-9. 2012
    ....
  4. pmc Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 219:805-14. 2012
    ..Despite the increasing utility of transgenic and knockout mice in addressing such issues, previous studies aimed at characterizing biochemical mechanisms have been conducted in rats...
  5. pmc Arg kinase regulates prefrontal dendritic spine refinement and cocaine-induced plasticity
    Shannon L Gourley
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 32:2314-23. 2012
    ....
  6. pmc Corticosterone regulates pERK1/2 map kinase in a chronic depression model
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1148:509-14. 2008
    ..Notably, prefrontal cortical targets were also regulated. Our data suggest ADTs restore hippocampal pERK1/2 after stress-related insult, and potentially reveal a novel role for prefrontal neurotrophins in depressive-like symptomology...
  7. pmc Integrin β1 signals through Arg to regulate postnatal dendritic arborization, synapse density, and behavior
    M Sloan Warren
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06510, USA
    J Neurosci 32:2824-34. 2012
    ....
  8. pmc Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, 34 Park St, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 225:569-77. 2013
    ..We have previously reported that prior chronic corticosterone exposure to mice produces a lasting depressive-like state that can be reversed by chronic antidepressant treatment...
  9. pmc Prelimbic cortex bdnf knock-down reduces instrumental responding in extinction
    Shannon L Gourley
    Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Learn Mem 16:756-60. 2009
    ....
  10. pmc Regionally specific regulation of ERK MAP kinase in a model of antidepressant-sensitive chronic depression
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 63:353-9. 2008
    ..The intracellular factors by which ADTs and glucocorticoids, causal factors in depression, regulate depression-like behavior remain unclear, but extracellular signal-regulated kinase 1/2 (ERK1/2), upstream of CREB, is a likely candidate...
  11. pmc A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 34:707-16. 2009
    ....
  12. pmc Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:884-90. 2008
    ....
  13. pmc Cytoskeletal determinants of stimulus-response habits
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Division of Molecular Psychiatry, Department of Psychiatry, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 33:11811-6. 2013
    ..These findings provide a structural mechanism by which even acute exposure to drugs of abuse can reorganize behavioral response strategies and promote outcome-insensitive stimulus-response habits. ..
  14. pmc Developmentally divergent effects of Rho-kinase inhibition on cocaine- and BDNF-induced behavioral plasticity
    Lauren M Depoy
    Department of Pediatrics, Emory School of Medicine, Atlanta, GA, United States
    Behav Brain Res 243:171-5. 2013
    ..Thus, early-life Rho-kinase inhibition confers cocaine vulnerability, but may actually protect against pathological reward-seeking - particularly in cases of diminished neurotrophic support - in adulthood...
  15. pmc Loss of dendrite stabilization by the Abl-related gene (Arg) kinase regulates behavioral flexibility and sensitivity to cocaine
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Department of Psychiatry, Yale University, New Haven, CT 06511, USA
    Proc Natl Acad Sci U S A 106:16859-64. 2009
    ..These findings provide evidence that stabilization of dendritic structure beginning in adolescence is critical for the development of adaptive and flexible behavior after cocaine exposure...
  16. pmc Recapitulation and reversal of a persistent depression-like syndrome in rodents
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut, USA
    Curr Protoc Neurosci . 2009
    ....
  17. pmc Gene profiling reveals a role for stress hormones in the molecular and behavioral response to food restriction
    Douglas J Guarnieri
    Division of Molecular Psychiatry, Ribicoff Research Facilities, Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Biol Psychiatry 71:358-65. 2012
    ..Food restriction is known to enhance learning and motivation. The neural mechanisms underlying these responses likely involve alterations in gene expression in brain regions mediating the motivation to feed...
  18. ncbi request reprint Inhibition of Rho via Arg and p190RhoGAP in the postnatal mouse hippocampus regulates dendritic spine maturation, synapse and dendrite stability, and behavior
    Mindan K Sfakianos
    Department of Molecular Biophysics and Biochemistry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:10982-92. 2007
    ..Together, these data indicate that signaling through Arg and p190RhoGAP acts late during synaptic refinement to promote dendritic spine maturation and synapse/dendrite stability by attenuating synaptic Rho activity...
  19. pmc Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration
    Brian A Couch
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Alzheimers Dis 20:1003-8. 2010
    ..We report that increased dendrite branching occurs in AbetaPP/PS1 mice and that fasudil promotes lengthening of the dendrite arbors of CA1 pyramidal neurons...
  20. pmc Dissociable regulation of instrumental action within mouse prefrontal cortex
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT 06508, USA
    Eur J Neurosci 32:1726-34. 2010
    ..Our findings thus selectively implicate the rodent mOFC in braking reinforced goal-directed action when reinforcement requires the acquisition of novel response contingencies...
  21. ncbi request reprint Chronic unpredictable stress decreases cell proliferation in the cerebral cortex of the adult rat
    Mounira Banasr
    Laboratory of Molecular Psychiatry, Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 62:496-504. 2007
    ..However, little is known about the mechanisms that contribute to this decrease in cell number...