Jorg J Goronzy

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study
    Kenneth J Warrington
    Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
    Arthritis Res Ther 7:R984-91. 2005
  2. pmc The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis
    Carl Turesson
    Department of Rheumatology, Malmo University Hospital, Södra Förstadsgatan 101, 205 02 Malmo, Sweden
    Arthritis Res Ther 7:R1386-93. 2005
  3. ncbi request reprint Rheumatoid arthritis
    Jorg J Goronzy
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, GA 30322, USA
    Immunol Rev 204:55-73. 2005
  4. pmc T-cell co-stimulatory pathways in autoimmunity
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Woodruff Circle, Atlanta, Georgia 30322, USA
    Arthritis Res Ther 10:S3. 2008
  5. ncbi request reprint T cell development and receptor diversity during aging
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Opin Immunol 17:468-75. 2005
  6. pmc Aging and T-cell diversity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle 1003, Atlanta, GA 30322, USA
    Exp Gerontol 42:400-6. 2007
  7. ncbi request reprint Telomeres, immune aging and autoimmunity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Cricle, Atlanta, GA 30322, USA
    Exp Gerontol 41:246-51. 2006
  8. ncbi request reprint Costimulatory pathways in rheumatoid synovitis and T-cell senescence
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1062:182-94. 2005
  9. pmc Developments in the scientific understanding of rheumatoid arthritis
    Jorg J Goronzy
    Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arthritis Res Ther 11:249. 2009
  10. ncbi request reprint T-cell regulation in rheumatoid arthritis
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Curr Opin Rheumatol 16:212-7. 2004

Collaborators

Detail Information

Publications83

  1. pmc Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study
    Kenneth J Warrington
    Division of Rheumatology, Mayo Clinic, Rochester, MN, USA
    Arthritis Res Ther 7:R984-91. 2005
    ..Expansion of CD4+CD28null T cells in these patients may contribute to the progression of atherosclerosis...
  2. pmc The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis
    Carl Turesson
    Department of Rheumatology, Malmo University Hospital, Södra Förstadsgatan 101, 205 02 Malmo, Sweden
    Arthritis Res Ther 7:R1386-93. 2005
    ..This confirms that SE genes contribute to RA disease severity and ExRA. Other genetic and environmental factors may have a more specific impact on individual ExRA manifestations...
  3. ncbi request reprint Rheumatoid arthritis
    Jorg J Goronzy
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, GA 30322, USA
    Immunol Rev 204:55-73. 2005
    ....
  4. pmc T-cell co-stimulatory pathways in autoimmunity
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Woodruff Circle, Atlanta, Georgia 30322, USA
    Arthritis Res Ther 10:S3. 2008
    ..By intercepting these signals, we may be able to influence disease-relevant T-cell responses in autoimmune diseases while potentially minimizing broad immunosuppression...
  5. ncbi request reprint T cell development and receptor diversity during aging
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Opin Immunol 17:468-75. 2005
    ..Elucidation of the underlying mechanisms will allow for extending this turning point to later in life; ultimately, interventions have to aim at restoring thymic function and complementary modes of T cell reconstitution...
  6. pmc Aging and T-cell diversity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle 1003, Atlanta, GA 30322, USA
    Exp Gerontol 42:400-6. 2007
    ..Research efforts need to aim at understanding T-cell homeostatic control mechanisms to ultimately expand the time period of repertoire stability...
  7. ncbi request reprint Telomeres, immune aging and autoimmunity
    Jorg J Goronzy
    Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Cricle, Atlanta, GA 30322, USA
    Exp Gerontol 41:246-51. 2006
    ..Equally interestingly, accelerated T-cell aging combined with telomeric shortening may predispose for autoimmune responses and thereby explain the increased susceptibility for chronic inflammatory diseases in the elderly...
  8. ncbi request reprint Costimulatory pathways in rheumatoid synovitis and T-cell senescence
    Jorg J Goronzy
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1062:182-94. 2005
    ..By acquiring a new set of regulatory receptors, senescent CD4 T cells become responsive to novel environmental cues and find ideal stimulatory conditions in the synovial microenvironment...
  9. pmc Developments in the scientific understanding of rheumatoid arthritis
    Jorg J Goronzy
    Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arthritis Res Ther 11:249. 2009
    ..Targeting mediators involved in this process has greatly improved the management of this chronic inflammatory syndrome...
  10. ncbi request reprint T-cell regulation in rheumatoid arthritis
    Jorg J Goronzy
    Lowance Center for Human Immunology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Curr Opin Rheumatol 16:212-7. 2004
    ..This review summarizes recent insights in pathways that are functional in RA and that favor continuous and pathogenic T-cell activation...
  11. ncbi request reprint Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis
    Eduardo Davila
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:7292-301. 2005
    ..We propose that rheumatoid synovitis can be suppressed by cell-based immunotherapy with immunoregulatory CD8(+) T cells...
  12. pmc Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis
    Yong Wook Park
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 165:2087-98. 2004
    ..We propose that TSP2 is an endogenous regulator of angiogenesis and autoimmune inflammation in the synovium and represents a protective mechanism preventing ectopic lympho-organogenesis and persistent inflammation in this tissue site...
  13. ncbi request reprint T-cell-mediated lysis of endothelial cells in acute coronary syndromes
    Takako Nakajima
    Department of Medicine, Division of Cardiology, Mayo Clinic, Rochester, Minnesota, USA
    Circulation 105:570-5. 2002
    ..CD4 T lymphocytes accumulate in unstable plaque. The direct and indirect involvement of these T cells in tissue injury and plaque instability is not understood...
  14. pmc Inhibitory CD8+ T cells in autoimmune disease
    Masakatsu Suzuki
    The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Hum Immunol 69:781-9. 2008
    ..In essence, disease-specific approaches may be necessary to identify CD8(+) Ts optimally suited to treat immune dysfunctions in different autoimmune syndromes...
  15. doi request reprint Rejuvenating the immune system in rheumatoid arthritis
    Cornelia M Weyand
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA 30322, USA
    Nat Rev Rheumatol 5:583-8. 2009
    ..Therapeutic attempts to reset the immune systems of patients with RA and prevent premature immunosenescence should include restoration of DNA repair capability...
  16. pmc Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages
    David L Lamar
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Blood 115:3278-86. 2010
    ..These cell-specific mechanisms allow tailoring of CD85j levels to the distinct roles it plays in different hematopoietic lineages...
  17. ncbi request reprint The influence of age on T cell generation and TCR diversity
    Keith Naylor
    Department of Medicine, Mayo Clinic and Graduate School, Rochester, MN 55905, USA
    J Immunol 174:7446-52. 2005
    ..The collapse in CD4 T cell diversity during the seventh and eighth decades indicates substantial T cell loss and implies that therapeutic measures to improve vaccine responses will have to include strategies for T cell replenishment...
  18. pmc CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis
    Young Mo Kang
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 195:1325-36. 2002
    ..We propose that CD8+ T cells regulate the structural integrity and functional activity of GCs in ectopic lymphoid follicles...
  19. pmc TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque
    Kayoko Sato
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 203:239-50. 2006
    ..These data identify that the death pathway is triggered by TRAIL-producing CD4 T cells as a direct mechanism of VSMC apoptosis, a process which may lead to plaque destabilization...
  20. pmc T cell subset-specific susceptibility to aging
    Marta Czesnikiewicz-Guzik
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA30322, USA
    Clin Immunol 127:107-18. 2008
    ..The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules...
  21. pmc Dampened ERK signaling in hematopoietic progenitor cells in rheumatoid arthritis
    Ines Colmegna
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, USA
    Clin Immunol 143:73-82. 2012
    ..Thus, hyporesponsiveness of RA HPC to growth factors results from dampening of the ERK signaling pathways; with a defect localized in the very early steps of the ERK signaling cascade...
  22. pmc Telomerase insufficiency in rheumatoid arthritis
    Hiroshi Fujii
    Department of Medicine, Lowance Center for Human Immunology and Rheumatology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 106:4360-5. 2009
    ..Restoring defective telomerase activity emerges as a therapeutic target in resetting immune abnormalities in RA...
  23. pmc Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis
    Wei Ma-Krupa
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Exp Med 199:173-83. 2004
    ..Activation of adventitial DCs initiates and maintains T cell responses in the artery and breaks tissue tolerance in the perivascular space...
  24. pmc Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis
    Wei Ma Krupa
    Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Pathol 161:1815-23. 2002
    ....
  25. ncbi request reprint T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis
    Hirokazu Sawai
    Emory University School of Medicine, Atlanta, Georgia, USA
    Arthritis Rheum 52:1392-401. 2005
    ..This study explored whether interactions between CX(3)CR1 and FKN are relevant for T cell functions in rheumatoid synovitis...
  26. pmc Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity
    Guangjin Li
    Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Nat Med 18:1518-24. 2012
    ..DUSP6 is a potential intervention target for restoring T cell responses in the elderly, which may augment the effectiveness of vaccination...
  27. pmc Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age
    Mingcan Yu
    Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 109:E879-88. 2012
    ..004) was restored. Our data suggest that increased DUSP4 expression in activated T cells in the elderly in part accounts for defective adaptive immune responses...
  28. pmc Regulation of T cell receptor signaling by activation-induced zinc influx
    Mingcan Yu
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Exp Med 208:775-85. 2011
    ..By calibrating TCR activation thresholds, increased extracellular zinc bioavailability facilitated the induction of T cell proliferative responses to suboptimal stimuli...
  29. ncbi request reprint Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis
    Karnail Singh
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 180:1971-8. 2008
    ..These findings identify ICAM-2 as a potential therapeutic target to inhibit FLS activation in RA, allowing for a more selective intervention than broad LFA-1 inhibition...
  30. ncbi request reprint T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome
    Sergey Pryshchep
    Department of Medicine, Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
    Circ Res 98:1168-76. 2006
    ..Lowered setting of the T cell activation threshold, attributable to excessive amplification of proximal CD3-mediated signals, may contribute to CD4 T cell-mediated killing of VSMCs and promote plaque instability...
  31. pmc Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors
    Gabriella Henel
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 107:4449-57. 2006
    ..We propose that KIRs on memory T cells operate to uncouple effector functions by modifying the transcriptional profile while leaving granule exocytosis unabated...
  32. pmc Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis
    Won Woo Lee
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University, Atlanta, GA 30322, USA
    J Immunol 179:2609-15. 2007
    ..The data support a model in which CD70 expressed on T cells causes degeneracy in T cell responses and undermines tolerance mechanisms that normally control T cell autoreactivity...
  33. pmc IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens
    Pratima Deshpande
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 190:1416-23. 2013
    ..We propose that HCs, possibly induced by lymphopenia, decrease the signaling threshold for TCR activation and are thereby partly responsible for autoimmunity in RA...
  34. pmc Toll-like receptors 4 and 5 induce distinct types of vasculitis
    Jiusheng Deng
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 104:488-95. 2009
    ..Thus, depending on the original danger signal, vascular DCs edit the emerging immune response by differentially recruiting specialized T effector cells and direct the disease process toward distinct types of vasculitis...
  35. pmc Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells
    Guangjin Li
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University School of Medicine, 101 Woodruff Circle, 1003, Atlanta, GA 30322, USA
    J Leukoc Biol 84:824-34. 2008
    ..The partially accessible promoter is sensitive to DNMT inhibition, which is sufficient to induce full transcription without further histone acetylation and methylation...
  36. ncbi request reprint Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis
    Hirokazu Sawai
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Arthritis Rheum 56:3215-25. 2007
    ..The aim of this study was to examine the mechanisms through which CD4 T cells, the dominant lymphocyte population in patients with rheumatoid synovitis, regulate synoviocyte proliferation...
  37. pmc TLR-mediated induction of negative regulatory ligands on dendritic cells
    Stefan Gröschel
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Room 1003 Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Mol Med (Berl) 86:443-55. 2008
    ..Conversely, TLR3 ligands may have therapeutic value in silencing pathogenic immune responses...
  38. pmc ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis
    Karnail Singh
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory UniversitySchool of Medicine, Atlanta, GA 30322, USA
    J Immunol 183:8258-67. 2009
    ..Treatment with subtherapeutic doses of a MEK-1/2 inhibitor delayed arthritis onset and reduced severity, suggesting that increased ERK phosphorylation predisposes for autoimmunity and can be targeted to prevent disease...
  39. pmc Telomeres and immunological diseases of aging
    Nicolas P Andrews
    Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gerontology 56:390-403. 2010
    ....
  40. pmc Insufficient deactivation of the protein tyrosine kinase lck amplifies T-cell responsiveness in acute coronary syndrome
    Sergey Pryshchep
    Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Circ Res 106:769-78. 2010
    ..The balance between protein phosphorylation and dephosphorylation defines the signal transduction threshold and determines appropriate T-cell responses...
  41. ncbi request reprint Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque
    Xiaoyu Zhang
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA, USA
    Circ Res 98:524-31. 2006
    ....
  42. ncbi request reprint Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells
    Jing Xu
    Department of Medicine, Lowance Center for Human Immunology, Emory School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:24277-85. 2005
    ..We suggest that the regulated expression of KIRs in T cells profoundly influences peripheral tolerance and antigen-specific immune responses...
  43. ncbi request reprint Homeostatic control of T-cell generation in neonates
    Stefan O Schonland
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 102:1428-34. 2003
    ..Maintaining optimal clonal size instead of filling the space in a lymphopenic host appears to regulate homeostatic T-cell proliferation during fetal development...
  44. pmc K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis
    Karnail Singh
    Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 109:E1629-37. 2012
    ..We propose that increased expression of B-RAF and K-RAS lowers T-cell activation thresholds in RA T cells, enabling responses to autoantigens...
  45. pmc CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells
    Masakatsu Suzuki
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Immunol 189:2118-30. 2012
    ..Loss of CD8+CCR7+ Tregs in the elderly host may be of relevance in the aging immune system as immunosenescence is associated with a state of chronic smoldering inflammation...
  46. doi request reprint Immune aging and autoimmunity
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 269 Campus Drive West, Stanford, CA, 94305 5166, USA
    Cell Mol Life Sci 69:1615-23. 2012
    ....
  47. pmc Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis
    Lan Shao
    The Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Exp Med 206:1435-49. 2009
    ..Restoration of DNA repair mechanisms emerges as an important therapeutic target in RA...
  48. pmc Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells
    Guangjin Li
    Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA 30322, USA
    Blood 114:3422-30. 2009
    ..The ensuing partial demethylation lowers the threshold for transcriptional activation and renders CD8 T cells more susceptible to express KIR, thereby contributing to the immune defect in the elderly...
  49. pmc Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis
    Ines Colmegna
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Arthritis Rheum 58:990-1000. 2008
    ..The purpose of this study was to examine the functional competence (proliferative capacity, maintenance of telomeric reserve) of CD34+ HPCs in RA...
  50. pmc Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling
    Won Woo Lee
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Rejuvenation Res 11:1001-11. 2008
    ....
  51. ncbi request reprint Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction
    Abbe N Vallejo
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Immunol 171:1732-40. 2003
    ..Because TSP1 is abundantly expressed in the rheumatoid synovium, CD47-TSP1 interaction is proposed to be a key component of an FLS/T cell regulatory circuit that perpetuates the inflammatory process in the rheumatoid joint...
  52. ncbi request reprint Toll-like receptors in giant cell arteritis
    Wei Ma-Krupa
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Clin Immunol 115:38-46. 2005
    ..These data identify tissue-residing DCs as gatekeepers in vasculitis and support the model that TLR ligands function as instigators of vessel wall inflammation...
  53. ncbi request reprint B cells as a therapeutic target in autoimmune diseases
    Yong Wook Park
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Woodruff Memorial Research Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Expert Opin Ther Targets 9:431-45. 2005
    ..As a general rule, clinical effects of B cell-directed therapeutics have often been unanticipated and unpredicted by experimental models, emphasis-ing the need to explore and verify disease principles in the patient...
  54. pmc Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis
    Kisha Piggott
    Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, GA, USA
    Circulation 123:309-18. 2011
    ....
  55. ncbi request reprint Stem cell aging and autoimmunity in rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology, Emory School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Trends Mol Med 10:426-33. 2004
  56. ncbi request reprint Premature immunosenescence in rheumatoid arthritis
    Cornelia M Weyand
    Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    J Rheumatol 29:1141-6. 2002
  57. doi request reprint Vascular damage in giant cell arteritis
    Kisha Piggott
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Autoimmunity 42:596-604. 2009
    ..Differences in vascular damage pattern encountered in different patients may relate to distinct instigators of vasculitis...
  58. pmc Immune aging and rheumatoid arthritis
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University, 269 West Campus Drive, Stanford, CA 94305 5166, USA
    Rheum Dis Clin North Am 36:297-310. 2010
    ....
  59. ncbi request reprint Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque
    Alexander Niessner
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circulation 116:2043-52. 2007
    ..In rupture-prone atherosclerotic plaques, plasmacytoid dendritic cells produce IFN-alpha. In the present study we explored the contribution of IFN-alpha to inflammation and tissue injury in the plaque microenvironment...
  60. doi request reprint Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation
    Ji W Han
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 102:546-53. 2008
    ..DCs are superior in sensing pathogen-derived motifs and are highly efficient in breaking T-cell tolerance, guiding T cells toward proinflammatory and tissue-invasive behavior...
  61. pmc Treatment of chronic inflammatory diseases with biologic agents: opportunities and risks for the elderly
    Alejandro Diaz-Borjon
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Exp Gerontol 41:1250-5. 2006
    ....
  62. doi request reprint The immunopathology of giant cell arteritis: diagnostic and therapeutic implications
    Cornelia M Weyand
    Department of Medicine, and the Byers Eye Institute at Stanford, Stanford University, Stanford, CA, USA
    J Neuroophthalmol 32:259-65. 2012
    ..Expansion of the therapeutic armamentarium for GCA needs to focus on approaches that mitigate the impact of the aging artery and adapt to the needs of the immunosenescent host...
  63. ncbi request reprint Cytokines in giant-cell arteritis
    Jorg J Goronzy
    Department of Medicine, Mayo Medical and Graduate Schools, Mayo Clinic, Rochester, MN 55905, USA
    Cleve Clin J Med 69:SII91-4. 2002
    ..IFN-gamma appears to be critically involved in modulating the process of intimal hyperplasia, the most destructive consequence of vasculitis, and, as such, emerges as a prime target for novel therapeutic approaches...
  64. pmc Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension
    Antony Vinh
    Cardiology Division, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circulation 122:2529-37. 2010
    ..The latter often involves interaction between B7 ligands (CD80 and CD86) on antigen-presenting cells with the T-cell coreceptor CD28. This study was therefore performed to examine the role of this pathway in hypertension...
  65. pmc DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis
    Lan Shao
    Department of Medicine, Immunology and Rheumatology, Stanford University, Stanford, CA, USA
    EMBO Mol Med 2:415-27. 2010
    ..Therapeutic blockade of the DNA-PK-dependent cell-death machinery may rejuvenate the immune system in RA...
  66. pmc Vessel-specific Toll-like receptor profiles in human medium and large arteries
    Olga Pryshchep
    Lowance Center for Human Immunology and Rheumatology, Emory University, School of Medicine, Atlanta, GA 30322, USA
    Circulation 118:1276-84. 2008
    ....
  67. ncbi request reprint T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection
    Abbe N Vallejo
    Division of Rheumatology, Department of Medicine, Mayo Clinic and Foundation, Rochester, MN 55905, USA
    Trends Mol Med 10:119-24. 2004
    ..Indeed, studies on the molecular basis for the loss of CD28 are already providing information on methods to functionally rescue senescent T cells...
  68. pmc B cells in rheumatoid synovitis
    Cornelia M Weyand
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia, USA
    Arthritis Res Ther 7:S9-12. 2005
    ..Furthermore, studies of rheumatoid lesions implanted in immunodeficient mice suggest that T cell activation in synovitis is B cell dependent, indicating the role played by B cells in presenting antigens and providing survival signals...
  69. pmc BLyS and APRIL in rheumatoid arthritis
    Thorsten M Seyler
    Department of Medicine, Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 115:3083-92. 2005
    ..We propose that BLyS and APRIL regulate B cell as well as T cell function and have pro- and antiinflammatory activities in RA...
  70. doi request reprint Mechanisms of immunosenescence: lessons from models of accelerated immune aging
    Sabine Le Saux
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, California, USA
    Ann N Y Acad Sci 1247:69-82. 2012
    ..Studies of accelerated immune aging in autoimmune diseases have identified an unexpected link to chronic DNA damage responses that are known to be important in aging, but so far had not been implicated in immune aging...
  71. pmc Giant cell arteritis: immune and vascular aging as disease risk factors
    Shalini V Mohan
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 5166, USA
    Arthritis Res Ther 13:231. 2011
    ..Thus, the aging process impacts the two major biologic systems that liaise to promote giant cell arteritis; the immune system and the vessel wall niche...
  72. pmc Pathomechanisms in rheumatoid arthritis--time for a string theory?
    Cornelia M Weyand
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Invest 116:869-71. 2006
    ..We may want to seek guidance from our colleagues in physics and mathematics who have successfully integrated their knowledge of elementary particles and the complexity of their interacting forces by formulating the string theory...
  73. ncbi request reprint Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha
    Alexander Niessner
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Circulation 114:2482-9. 2006
    ..We therefore explored whether plasmacytoid dendritic cells (pDCs) that specialize in sensing bacterial and viral products can regulate effector functions of plaque-residing T cells and thus connect host infection and plaque instability...
  74. pmc T cells in arteritis and atherosclerosis
    Cornelia M Weyand
    Kathleen B and Mason Lowance Center for Human Immunology and Rheumatology, Emory University, Atlanta, Georgia 30322, USA
    Curr Opin Lipidol 19:469-77. 2008
    ..Pro-inflammatory and anti-inflammatory T cells regulate master pathogenic pathways, providing a framework for novel immunotherapeutic strategies...
  75. doi request reprint Systems biology of vaccination in the elderly
    Sai S Duraisingham
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA, 30329, USA
    Curr Top Microbiol Immunol 363:117-42. 2013
    ..Moreover, the identification of specific defects may be used to target novel vaccination strategies that improve efficacy in elderly populations...
  76. pmc Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age
    Philip L F Johnson
    Department of Biology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 109:21432-7. 2012
    ..g., by an increased division rate or decreased death rate), with the person as a whole incurring the long-term cost of a decreased ability to fight infections...
  77. ncbi request reprint CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation
    Kenneth J Warrington
    Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Blood 101:3543-9. 2003
    ..The re-expressed CD28 was functional and restored the ability of CD4(+)CD28(null) T cells to express CD25 and CD40 ligand. Our data suggest that IL-12 may, in part, functionally rescue senescent CD4(+) T cells...
  78. pmc Treating autoimmune disease by targeting CD8(+) T suppressor cells
    Christine Konya
    Emory University School of Medicine, Kathleen B and Mason I Lowance Center for Human Immunology and Rheumatology, Atlanta, GA 30322, USA
    Expert Opin Biol Ther 9:951-65. 2009
    ....
  79. ncbi request reprint T-cell-targeted therapies in rheumatoid arthritis
    Cornelia M Weyand
    Kathleen B and Mason I Lowance Center for Human Immunology, Department of Medicine, Emory School of Medicine, Atlanta, GA 30322, USA
    Nat Clin Pract Rheumatol 2:201-10. 2006
    ....
  80. pmc The janus head of T cell aging - autoimmunity and immunodeficiency
    Jorg J Goronzy
    Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA Department of Medicine, Palo Alto Veteran Administration Health Care System, Palo Alto, CA, USA
    Front Immunol 4:131. 2013
    ..In this review, we will discuss age-associated deviations in the immune repertoire and the regulation of signaling pathways that may shed light on this conundrum...
  81. pmc IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritis
    Cornelia M Weyand
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305 5166, USA
    Curr Opin Rheumatol 23:43-9. 2011
    ..Recent data demonstrate that at least two separate lineages of CD4 T cells participate in vascular inflammation, providing an important clue that multiple disease instigators may initiate pathogenic immunity...
  82. ncbi request reprint Vascular dendritic cells in giant cell arteritis
    Cornelia M Weyand
    Kathleen B and Mason I Lowance Center for Human Immunology, Emory University School of Medicine, Rm 1003, Woodruff Memorial Research Bldg, 101 Woodruff Cir, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1062:195-208. 2005
    ..A switch of adventitial DCs from being nonstimulatory to T-cell activating emerges as a critical event in the initiation of vasculitis...
  83. ncbi request reprint Pathogenic mechanisms in giant cell arteritis
    Cornelia M Weyand
    Department of Medicine, Mayo Medical and Graduate Schools, Rochester, MN, USA
    Cleve Clin J Med 69:SII28-32. 2002
    ....