Young Mi Go

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
  2. pmc Cysteine/cystine redox signaling in cardiovascular disease
    Young Mi Go
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 50:495-509. 2011
  3. doi request reprint Mapping the cysteine proteome: analysis of redox-sensing thiols
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Curr Opin Chem Biol 15:103-12. 2011
  4. pmc A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 48:275-83. 2010
  5. pmc Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
  6. pmc Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:363-70. 2007
  7. ncbi request reprint Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling
    Yvonne S Nkabyo
    Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 289:G70-8. 2005
  8. ncbi request reprint Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
    Dean P Jones
    Department of Medicine, 4131 Rollins Research Center, Emory University, Atlanta, GA 30322, USA
    FASEB J 18:1246-8. 2004
  9. ncbi request reprint Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state
    Young Mi Go
    Department of Medicine, Divisions of Cardiology and Pulmonary, Emory University, Atlanta, GA 30322, USA
    Circulation 111:2973-80. 2005
  10. pmc Actin cytoskeleton redox proteome oxidation by cadmium
    Young Mi Go
    Emory Univ, 205 Whitehead Research Center, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 305:L831-43. 2013

Detail Information

Publications32

  1. ncbi request reprint H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1
    Young Mi Go
    Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:5837-45. 2004
    ..Thus, "redox signaling" resulting in kinase signaling pathways is distinct from "oxidative stress," and is mediated by discrete, localized redox circuitry...
  2. pmc Cysteine/cystine redox signaling in cardiovascular disease
    Young Mi Go
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 50:495-509. 2011
    ..Plasma redox-state-based pharmacologic interventions to control or improve E(h)CySS may be effective in preventing CVD onset or progression...
  3. doi request reprint Mapping the cysteine proteome: analysis of redox-sensing thiols
    Dean P Jones
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Curr Opin Chem Biol 15:103-12. 2011
    ..Complementary databases and Cys proteome maps are needed to describe thiol redox circuits and connect these to functional redox-dependent pathways. This article summarizes progress in quantitative redox proteomics to develop such maps...
  4. pmc A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potential
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 48:275-83. 2010
    ..Together, the data show that the proinflammatory effects of oxidized plasma E(h)CySS are due to a mitochondrial signaling pathway that is mediated through redox control of downstream effector proteins...
  5. pmc Compartmental oxidation of thiol-disulphide redox couples during epidermal growth factor signalling
    Patrick J Halvey
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, Room 225, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Biochem J 386:215-9. 2005
    ..Results showed that only cytosolic Trx1 undergoes significant oxidation. Thus EGF signalling involves subcellular compartmental oxidation of Trx1 in the absence of a generalized cellular oxidation...
  6. pmc Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cells
    Young Mi Go
    Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 42:363-70. 2007
    ..These results further suggest that energy and/or substrate supply may contribute to sensitivity of mitochondrial and cytoplasmic systems to oxidative damage...
  7. ncbi request reprint Extracellular cysteine/cystine redox regulates the p44/p42 MAPK pathway by metalloproteinase-dependent epidermal growth factor receptor signaling
    Yvonne S Nkabyo
    Graduate Program in Molecular and Systems Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 289:G70-8. 2005
    ....
  8. ncbi request reprint Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and control
    Dean P Jones
    Department of Medicine, 4131 Rollins Research Center, Emory University, Atlanta, GA 30322, USA
    FASEB J 18:1246-8. 2004
    ..Moreover, inclusion of cysteine/cystine as a signaling node distinct from GSH and Trx1 significantly expands the redox range over which protein thiol/disulfide couples may operate to control physiologically relevant processes...
  9. ncbi request reprint Intracellular proatherogenic events and cell adhesion modulated by extracellular thiol/disulfide redox state
    Young Mi Go
    Department of Medicine, Divisions of Cardiology and Pulmonary, Emory University, Atlanta, GA 30322, USA
    Circulation 111:2973-80. 2005
    ..We examined the function of extracellular Cys/CySS redox potential (E(h)) in the regulation of early events of atherosclerosis using cultured aortic endothelial cells and monocytes as a vascular model system...
  10. pmc Actin cytoskeleton redox proteome oxidation by cadmium
    Young Mi Go
    Emory Univ, 205 Whitehead Research Center, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 305:L831-43. 2013
    ..Taken together, the results show that redox states of peptidyl Cys in proteins associated with actin cytoskeleton pathways are selectively oxidized in lung by Cd at levels thought to occur from environmental exposure. ..
  11. doi request reprint Thiol/disulfide redox states in signaling and sensing
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Crit Rev Biochem Mol Biol 48:173-81. 2013
    ..Biological responses to cadmium, a widespread environmental agent, are used to illustrate the utility of these advances to the understanding of complex pleiotropic toxicities...
  12. pmc Increased nuclear thioredoxin-1 potentiates cadmium-induced cytotoxicity
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 131:84-94. 2013
    ..Taken together, the results show that nuclear translocation and accumulation of redox-active Trx1 in nuclei play an important role in Cd-induced inflammation and cell death...
  13. ncbi request reprint Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidase
    Patrick J Halvey
    Division of Pulmonary, Allergy, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    Antioxid Redox Signal 9:807-16. 2007
    ..Furthermore, the attenuation of NF-kappaB reporter activity in the absence of nuclear Trx1 oxidation suggests that critical nuclear redox proteins are subject to control by S-glutathionylation during oxidative stress in the nucleus...
  14. pmc Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesion
    Young Mi Go
    Department of Medicine Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 171:1670-81. 2007
    ..Chemical modification of Trx1 by common environmental and endogenously generated reactive aldehydes can contribute to atherosclerosis development by interfering with antioxidant and redox signaling functions of Trx1...
  15. pmc Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 6:e18918. 2011
    ..Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses...
  16. pmc Gene and protein responses of human monocytes to extracellular cysteine redox potential
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 112:354-62. 2009
    ..Therefore, plasma E(h)Cys provides a control over monocyte phenotype, which could contribute to cardiovascular disease risk and provide a novel therapeutic target for disease prevention...
  17. pmc The redox proteome
    Young Mi Go
    From the Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322
    J Biol Chem 288:26512-20. 2013
    ....
  18. ncbi request reprint Nuclear and mitochondrial compartmentation of oxidative stress and redox signaling
    Jason M Hansen
    Department of Medicine and Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
    Annu Rev Pharmacol Toxicol 46:215-34. 2006
    ..The new methods are applicable to a broad range of experimental systems and their use will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants...
  19. pmc Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiency
    Sachin S Kunde
    Division of Gastroenterology, Hepatology and Nutrition, Emory Children s Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nutrients 3:987-1002. 2011
    ....
  20. doi request reprint Redox equivalents and mitochondrial bioenergetics
    JAMES R ROEDE
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 201 Dowman Drive, Atlanta, GA 30322, USA
    Methods Mol Biol 810:249-80. 2012
    ..Together, the approaches provide the opportunity to develop integrated systems biology descriptions of mitochondrial redox signaling and control mechanisms...
  21. pmc Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system
    JAMES R ROEDE
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
    Toxicol Sci 121:368-75. 2011
    ....
  22. ncbi request reprint Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stress
    Hong Zhang
    Department of Medicine, Emory University School of Medicine, Whitehead Biomedical Research Center, 615 Michael Street, Suite 205P, Atlanta, GA 30322, USA
    Arch Biochem Biophys 465:119-26. 2007
    ..The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions...
  23. doi request reprint Thioredoxin redox western analysis
    Young Mi Go
    Emory University, Atlanta, Georgia, USA
    Curr Protoc Toxicol . 2009
    ..Consequently, the redox western analysis of Trx provides a convenient tool to estimate the redox state of different compartments and improve the understanding of redox signaling...
  24. pmc Integrated redox proteomics and metabolomics of mitochondria to identify mechanisms of cd toxicity
    Young Mi Go
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322
    Toxicol Sci 139:59-73. 2014
    ..The results further indicate that redox proteomics and metabolomics can be used in an integrated systems approach to investigate complex disease mechanisms. ..
  25. pmc H(2)S inhibits oscillatory shear stress-induced monocyte binding to endothelial cells via nitric oxide production
    Young Mi Go
    Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, GA, USA
    Mol Cells 34:449-55. 2012
    ....
  26. pmc Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgery
    Nana Gletsu-Miller
    Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Obesity (Silver Spring) 17:439-46. 2009
    ..38 and -0.42). This study found longitudinal associations between general, and more specifically intra-abdominal adiposity, and systemic lipid peroxides, suggesting that adipose tissue mass contributes to oxidative stress...
  27. pmc Redox clamp model for study of extracellular thiols and disulfides in redox signaling
    Young Mi Go
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia, USA
    Methods Enzymol 474:165-79. 2010
    ..Application of the redox clamp to studies of different signaling pathways could enhance the understanding of redox transitions in many aspects of normal physiology and disease...
  28. pmc Redox control systems in the nucleus: mechanisms and functions
    Young Mi Go
    Department of Medicine, Emory University, Atlanta, GA, USA
    Antioxid Redox Signal 13:489-509. 2010
    ....
  29. doi request reprint Quantification of redox conditions in the nucleus
    Young Mi Go
    Department of Medicine, Emory University, Atlanta, GA, USA
    Methods Mol Biol 464:303-17. 2009
    ....
  30. pmc Redox compartmentalization in eukaryotic cells
    Young Mi Go
    Emory Clinical Biomarkers Laboratory and Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta GA 30322, USA
    Biochim Biophys Acta 1780:1273-90. 2008
    ..Further elucidation of the redox control networks within compartments will improve the mechanistic understanding of cell functions and their disruption in disease...
  31. pmc Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biology
    Melissa Kemp
    The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
    Free Radic Biol Med 44:921-37. 2008
    ....
  32. pmc Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition
    Min He
    Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Toxicol Sci 105:44-50. 2008
    ..Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT...