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Genomes and Genes | Young Mi GoSummaryAffiliation: Emory University Country: USA Publications
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Publications
H2O2-dependent activation of GCLC-ARE4 reporter occurs by mitogen-activated protein kinase pathways without oxidation of cellular glutathione or thioredoxin-1Young Mi Go
Department of Medicine, Division of Cardiology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 279:5837-45. 2004..Thus, "redox signaling" resulting in kinase signaling pathways is distinct from "oxidative stress," and is mediated by discrete, localized redox circuitry...
Cysteine/cystine redox signaling in cardiovascular diseaseYoung Mi Go
Department of Medicine, Emory University, Atlanta, GA 30322, USA
Free Radic Biol Med 50:495-509. 2011..Plasma redox-state-based pharmacologic interventions to control or improve E(h)CySS may be effective in preventing CVD onset or progression...
Mapping the cysteine proteome: analysis of redox-sensing thiolsDean P Jones
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Curr Opin Chem Biol 15:103-12. 2011..Complementary databases and Cys proteome maps are needed to describe thiol redox circuits and connect these to functional redox-dependent pathways. This article summarizes progress in quantitative redox proteomics to develop such maps...- A key role for mitochondria in endothelial signaling by plasma cysteine/cystine redox potentialYoung Mi Go
Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
Free Radic Biol Med 48:275-83. 2010..Together, the data show that the proinflammatory effects of oxidized plasma E(h)CySS are due to a mitochondrial signaling pathway that is mediated through redox control of downstream effector proteins... - Selective protection of nuclear thioredoxin-1 and glutathione redox systems against oxidation during glucose and glutamine deficiency in human colonic epithelial cellsYoung Mi Go
Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
Free Radic Biol Med 42:363-70. 2007..These results further suggest that energy and/or substrate supply may contribute to sensitivity of mitochondrial and cytoplasmic systems to oxidative damage... - Cysteine/cystine couple is a newly recognized node in the circuitry for biologic redox signaling and controlDean P Jones
Department of Medicine, 4131 Rollins Research Center, Emory University, Atlanta, GA 30322, USA
FASEB J 18:1246-8. 2004..Moreover, inclusion of cysteine/cystine as a signaling node distinct from GSH and Trx1 significantly expands the redox range over which protein thiol/disulfide couples may operate to control physiologically relevant processes... - Selective oxidative stress in cell nuclei by nuclear-targeted D-amino acid oxidasePatrick J Halvey
Division of Pulmonary, Allergy, Cystic Fibrosis and Sleep, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
Antioxid Redox Signal 9:807-16. 2007..Furthermore, the attenuation of NF-kappaB reporter activity in the absence of nuclear Trx1 oxidation suggests that critical nuclear redox proteins are subject to control by S-glutathionylation during oxidative stress in the nucleus... - Reactive aldehyde modification of thioredoxin-1 activates early steps of inflammation and cell adhesionYoung Mi Go
Department of Medicine Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
Am J Pathol 171:1670-81. 2007..Chemical modification of Trx1 by common environmental and endogenously generated reactive aldehydes can contribute to atherosclerosis development by interfering with antioxidant and redox signaling functions of Trx1... - Increased inflammatory signaling and lethality of influenza H1N1 by nuclear thioredoxin-1Young Mi Go
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
PLoS ONE 6:e18918. 2011..Excessive proinflammatory signaling in vivo contributes to immune hyper-responsiveness and disease severity, but no studies have addressed whether nuclear Trx1 mediates such responses... - Gene and protein responses of human monocytes to extracellular cysteine redox potentialYoung Mi Go
Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
Toxicol Sci 112:354-62. 2009..Therefore, plasma E(h)Cys provides a control over monocyte phenotype, which could contribute to cardiovascular disease risk and provide a novel therapeutic target for disease prevention... - Nuclear and mitochondrial compartmentation of oxidative stress and redox signalingJason M Hansen
Department of Medicine and Clinical Biomarkers Laboratory, Division of Pulmonary Medicine, Emory University, Atlanta, GA 30322, USA
Annu Rev Pharmacol Toxicol 46:215-34. 2006..The new methods are applicable to a broad range of experimental systems and their use will provide improved understanding of the pharmacologic and toxicologic actions of drugs and toxicants... - Hepatic oxidative stress in fructose-induced fatty liver is not caused by sulfur amino acid insufficiencySachin S Kunde
Division of Gastroenterology, Hepatology and Nutrition, Emory Children s Center, Emory University School of Medicine, Atlanta, GA 30322, USA
Nutrients 3:987-1002. 2011.... - Redox equivalents and mitochondrial bioenergeticsJAMES R ROEDE
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, 201 Dowman Drive, Atlanta, GA 30322, USA
Methods Mol Biol 810:249-80. 2012..Together, the approaches provide the opportunity to develop integrated systems biology descriptions of mitochondrial redox signaling and control mechanisms... - Mitochondrial thioredoxin-2/peroxiredoxin-3 system functions in parallel with mitochondrial GSH system in protection against oxidative stressHong Zhang
Department of Medicine, Emory University School of Medicine, Whitehead Biomedical Research Center, 615 Michael Street, Suite 205P, Atlanta, GA 30322, USA
Arch Biochem Biophys 465:119-26. 2007..The additive protection by Trx2 and GSH shows that Trx2 and GSH systems are both functionally important at low oxidative stress conditions... - Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin systemJAMES R ROEDE
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia 30322, USA
Toxicol Sci 121:368-75. 2011.... - Thioredoxin redox western analysisYoung Mi Go
Emory University, Atlanta, Georgia, USA
Curr Protoc Toxicol . 2009..Consequently, the redox western analysis of Trx provides a convenient tool to estimate the redox state of different compartments and improve the understanding of redox signaling... - Redox clamp model for study of extracellular thiols and disulfides in redox signalingYoung Mi Go
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University, Atlanta, Georgia, USA
Methods Enzymol 474:165-79. 2010..Application of the redox clamp to studies of different signaling pathways could enhance the understanding of redox transitions in many aspects of normal physiology and disease... - Redox control systems in the nucleus: mechanisms and functionsYoung Mi Go
Department of Medicine, Emory University, Atlanta, GA, USA
Antioxid Redox Signal 13:489-509. 2010.... - Loss of total and visceral adipose tissue mass predicts decreases in oxidative stress after weight-loss surgeryNana Gletsu-Miller
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
Obesity (Silver Spring) 17:439-46. 2009..38 and -0.42). This study found longitudinal associations between general, and more specifically intra-abdominal adiposity, and systemic lipid peroxides, suggesting that adipose tissue mass contributes to oxidative stress... - Nonequilibrium thermodynamics of thiol/disulfide redox systems: a perspective on redox systems biologyMelissa Kemp
The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA
Free Radic Biol Med 44:921-37. 2008.... - Redox compartmentalization in eukaryotic cellsYoung Mi Go
Emory Clinical Biomarkers Laboratory and Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta GA 30322, USA
Biochim Biophys Acta 1780:1273-90. 2008..Further elucidation of the redox control networks within compartments will improve the mechanistic understanding of cell functions and their disruption in disease... - Quantification of redox conditions in the nucleusYoung Mi Go
Department of Medicine, Emory University, Atlanta, GA, USA
Methods Mol Biol 464:303-17. 2009.... - Increased nuclear thioredoxin-1 potentiates cadmium-induced cytotoxicityYoung Mi Go
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
Toxicol Sci 131:84-94. 2013..Taken together, the results show that nuclear translocation and accumulation of redox-active Trx1 in nuclei play an important role in Cd-induced inflammation and cell death... - Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transitionMin He
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA 30322, USA
Toxicol Sci 105:44-50. 2008..Unexpectedly, Trx2 also protected against the MPT induced by Ca(2+) in the absence of added peroxide. The results indicate that in addition to protecting against oxidative stress, Trx2 is an endogenous regulator of the MPT... - Thiol/disulfide redox states in signaling and sensingYoung Mi Go
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, GA, USA
Crit Rev Biochem Mol Biol 48:173-81. 2013..Biological responses to cadmium, a widespread environmental agent, are used to illustrate the utility of these advances to the understanding of complex pleiotropic toxicities... - H(2)S inhibits oscillatory shear stress-induced monocyte binding to endothelial cells via nitric oxide productionYoung Mi Go
Division of Pulmonary Medicine, Department of Medicine, Emory University, Atlanta, GA, USA
Mol Cells 34:449-55. 2012....