JONATHAN DAVID GLASS

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Stem Cells 30:1144-51. 2012
  2. doi request reprint The ultimate question: why do axons degenerate? A tribute to the work and mentorship of John W. Griffin, MD
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Peripher Nerv Syst 17:24-9. 2012
  3. pmc Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
    Yair M Gozal
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 6:82. 2011
  4. ncbi request reprint Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant
    J D Glass
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci Res 52:653-60. 1998
  5. ncbi request reprint Wallerian degeneration as a window to peripheral neuropathy
    Jonathan D Glass
    Neurology and Pathology, Emory Center for Neurodegenerative Disease, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    J Neurol Sci 220:123-4. 2004
  6. ncbi request reprint Microglia in HIV-associated neurological diseases
    J D Glass
    Departments of Neurology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Microsc Res Tech 54:95-105. 2001
  7. ncbi request reprint Very early activation of m-calpain in peripheral nerve during Wallerian degeneration
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, 1639 Pierce Drive, Suite 6000, Atlanta, GA 30322, USA
    J Neurol Sci 196:9-20. 2002
  8. ncbi request reprint Calpain inhibition protects against Taxol-induced sensory neuropathy
    Min Sheng Wang
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Brain 127:671-9. 2004
  9. ncbi request reprint WldS mice are resistant to paclitaxel (taxol) neuropathy
    Min Sheng Wang
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Ann Neurol 52:442-7. 2002
  10. ncbi request reprint Evidence for direct axonal toxicity in vincristine neuropathy
    Angelica Silva
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Peripher Nerv Syst 11:211-6. 2006

Research Grants

  1. Axonal Protection for Multiple Sclerosis
    Jonathan Glass; Fiscal Year: 2007
  2. Proteomic Markers for ALS
    Jonathan Glass; Fiscal Year: 2007
  3. Discovering Calpain Inhibitors for Neurological Diseases
    Jonathan Glass; Fiscal Year: 2007

Collaborators

  • Surendra K Ravula
  • S L Wesselingh
  • Jason Richardson
  • Ritu Aneja
  • Jun Zhou
  • Michael Coleman
  • STEVEN SIMON SCHERER
  • Lindsey R Fischer
  • Deborah G Culver
  • Albert A Davis
  • Min Sheng Wang
  • Minsheng Wang
  • Yair M Gozal
  • Asli Ovat
  • Seneshaw A Asress
  • Thomas S Guillot
  • James C Powers
  • Angelica Silva
  • Grace S Lin Liang
  • Philip Tennant
  • Howard D Rees
  • Jordi Magrane
  • Craig J Heilman
  • Anissa Igoudjil
  • Giovanni Manfredi
  • Marla Gearing
  • Deborah S Cooper
  • Qiangwei Xia
  • Dongmei Cheng
  • Nicholas T Seyfried
  • Yingjie Li
  • Joanne Wuu
  • James J Lah
  • Junmin Peng
  • Jason M Hansen
  • Jason J Fritz
  • Duc M Duong
  • Allan I Levey
  • Facundo M Fernandez
  • Zhao Zhao Li
  • Christina Y Hampton
  • Gary W Miller
  • Qingbo Wang
  • Mark Mintz
  • Juan M Gómez-Hernández
  • Kenneth H Fischbeck
  • Marta de Miguel
  • Robert Adalbert
  • Seneshaw Asress
  • Luis C Barrio
  • Guillermo M Alexander
  • Meraida A Polak
  • Qinbo Wang
  • Jaffar Khan
  • Amilcar Castellano-Sanchez

Detail Information

Publications21

  1. doi request reprint Lumbar intraspinal injection of neural stem cells in patients with amyotrophic lateral sclerosis: results of a phase I trial in 12 patients
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia, USA
    Stem Cells 30:1144-51. 2012
    ....
  2. doi request reprint The ultimate question: why do axons degenerate? A tribute to the work and mentorship of John W. Griffin, MD
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Peripher Nerv Syst 17:24-9. 2012
    ..Griffin. The importance of axonal degeneration in the pathogenesis of neurodegenerative disorders of the central and peripheral nervous systems is emphasized...
  3. pmc Aberrant septin 11 is associated with sporadic frontotemporal lobar degeneration
    Yair M Gozal
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Neurodegener 6:82. 2011
    ....
  4. ncbi request reprint Cloning of m-calpain 80 kD subunit from the axonal degeneration-resistant WLD(S) mouse mutant
    J D Glass
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci Res 52:653-60. 1998
    ..These data suggest that a defect in m-calpain 80 kD subunit does not likely underlie the WLD(S) phenotype, but raise questions about other subunits of calpain and possibly other proteases...
  5. ncbi request reprint Wallerian degeneration as a window to peripheral neuropathy
    Jonathan D Glass
    Neurology and Pathology, Emory Center for Neurodegenerative Disease, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    J Neurol Sci 220:123-4. 2004
  6. ncbi request reprint Microglia in HIV-associated neurological diseases
    J D Glass
    Departments of Neurology and Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Microsc Res Tech 54:95-105. 2001
    ..Interaction of these infected cells with astrocytes may accelerate neurotoxic mechanisms. A hypothetical scenario for how HIV-1 infection leads to neurologic disease is presented...
  7. ncbi request reprint Very early activation of m-calpain in peripheral nerve during Wallerian degeneration
    Jonathan D Glass
    Department of Neurology, Emory University School of Medicine, 1639 Pierce Drive, Suite 6000, Atlanta, GA 30322, USA
    J Neurol Sci 196:9-20. 2002
    ..Calpain activation may be an early event in a proteolytic cascade that is initiated by axonal injury and culminates with axonal degeneration...
  8. ncbi request reprint Calpain inhibition protects against Taxol-induced sensory neuropathy
    Min Sheng Wang
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Brain 127:671-9. 2004
    ....
  9. ncbi request reprint WldS mice are resistant to paclitaxel (taxol) neuropathy
    Min Sheng Wang
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Ann Neurol 52:442-7. 2002
    ..Understanding how this mutant gene confers protection against axonal degeneration will provide important clues toward prevention of axonal degeneration in several human neurological disorders...
  10. ncbi request reprint Evidence for direct axonal toxicity in vincristine neuropathy
    Angelica Silva
    Department of Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Peripher Nerv Syst 11:211-6. 2006
    ..Toxicity was seen only with exposure of the growing axonal tips. These data support localized axonal toxicity as a cause of distal axonal degeneration due to vincristine...
  11. ncbi request reprint Axonal degeneration in motor neuron disease
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA
    Neurodegener Dis 4:431-42. 2007
    ..We contend that axonal degeneration may be a primary feature in the pathogenesis of motor neuron disease, and that preventing axonal degeneration represents an important therapeutic target that deserves increased attention...
  12. ncbi request reprint The WldS gene modestly prolongs survival in the SOD1G93A fALS mouse
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 19:293-300. 2005
    ..We also report that SOD1G93A mice show significant degeneration of sensory axons during the course of disease, supporting previous data from humans demonstrating that ALS is not purely a motor disorder...
  13. ncbi request reprint A compartmented neuronal culture system in microdevice format
    Surendra K Ravula
    Georgia Institute of Technology, Atlanta, GA, USA
    J Neurosci Methods 159:78-85. 2007
    ..Vincristine was applied to the axonal compartment to show that the interaction of drugs with DRG neurons progresses in a way similar to neurons cultured/exposed using conventional techniques...
  14. pmc Galectin-3 is a candidate biomarker for amyotrophic lateral sclerosis: discovery by a proteomics approach
    Jian Ying Zhou
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Proteome Res 9:5133-41. 2010
    ..The challenge is to validate our biomarker candidate proteins as true biomarkers for ALS that will be useful for diagnosis and/or monitoring disease activity in future clinical trials...
  15. pmc Peptidyl alpha-ketoamides with nucleobases, methylpiperazine, and dimethylaminoalkyl substituents as calpain inhibitors
    Asli Ovat
    School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA
    J Med Chem 53:6326-36. 2010
    ..These inhibitors have good potential to be used in the treatment of neurodegenerative diseases...
  16. doi request reprint Oxidative stress induced by loss of Cu,Zn-superoxide dismutase (SOD1) or superoxide-generating herbicides causes axonal degeneration in mouse DRG cultures
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Acta Neuropathol 119:249-59. 2010
    ..These in vitro models provide a novel means of investigating oxidative stress-mediated injury to axons, to improve our understanding of axonal redox control and dysfunction in peripheral neuropathy...
  17. doi request reprint Treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease or amyotrophic lateral sclerosis
    Thomas S Guillot
    Center for Neurodegenerative Disease, Emory University, Atlanta, GA, USA
    J Mot Behav 40:568-77. 2008
    ..On the basis of the authors' findings, they inferred that computerized gait analysis on a motorized treadmill is not suited to measuring motor deficits in either the MPTP mouse model of PD or the SOD1 G93A mouse model of ALS...
  18. pmc Non-toxic melanoma therapy by a novel tubulin-binding agent
    Ritu Aneja
    Department of Biology, Georgia State University, Atlanta, GA 30303, USA
    Int J Cancer 126:256-65. 2010
    ..Unlike currently available chemotherapeutics, EM011 is non-toxic to normal tissues and most importantly, does not cause any immunosuppression and neurotoxicity. Our data thus warrant a clinical evaluation of EM011 for melanoma therapy...
  19. pmc SOD1 targeted to the mitochondrial intermembrane space prevents motor neuropathy in the Sod1 knockout mouse
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain 134:196-209. 2011
    ..These results suggest that SOD1 in the mitochondrial intermembrane space is fundamental for motor axon maintenance, and implicate oxidative damage initiated at mitochondrial sites in the pathogenesis of motor axon degeneration...
  20. ncbi request reprint Severe neuropathy with leaky connexin32 hemichannels
    Grace S Lin Liang
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, University of Pennsylvania Medical Center, Philadelphia, PA 19107, USA
    Ann Neurol 57:749-54. 2005
    ..Abnormal leakiness of connexin hemichannels is likely a mechanism of cellular toxicity in this and perhaps other diseases caused by connexin mutations...
  21. ncbi request reprint Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man
    Lindsey R Fischer
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Exp Neurol 185:232-40. 2004
    ..We conclude that in this widely studied animal model of human ALS, and in this single human case, motor neuron pathology begins at the distal axon and proceeds in a "dying back" pattern...

Research Grants4

  1. Axonal Protection for Multiple Sclerosis
    Jonathan Glass; Fiscal Year: 2007
    ..Combined with immunomodulatory therapy, axonal protection by calpain inhibition may significantly change the course of disease for people with MS. ..
  2. Proteomic Markers for ALS
    Jonathan Glass; Fiscal Year: 2007
    ..These candidate biomarkers will be tested for their sensitivity and specificity for disease in plasma and spinal fluid samples from mice and people with ALS. ..
  3. Discovering Calpain Inhibitors for Neurological Diseases
    Jonathan Glass; Fiscal Year: 2007
    ..The target of our small molecule screen is the calcium-activated protease calpain. Inhibitors of calpain will be developed as novel treatments of neurological diseases. ..