S Nassir Ghaemi

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants
    S Nassir Ghaemi
    Department of Psychiatry at Emory University in Atlanta, Georgia 30322, USA
    Psychiatr Serv 57:660-5. 2006
  2. doi Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
  3. ncbi Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
  4. ncbi Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    J Clin Psychiatry 68:1840-4. 2007
  5. ncbi Is adjunctive open-label zonisamide effective for bipolar disorder?
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, United States
    J Affect Disord 105:311-4. 2008
  6. ncbi Paradigms of psychiatry: eclecticism and its discontents
    Seyyed Nassir Ghaemi
    Department of Psychiatry and Public Health, Emory University, Atlanta, Georgia 30322, USA
    Curr Opin Psychiatry 19:619-24. 2006
  7. ncbi An open prospective study of zonisamide in acute bipolar depression
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
    J Clin Psychopharmacol 26:385-8. 2006
  8. pmc Feeling and time: the phenomenology of mood disorders, depressive realism, and existential psychotherapy
    S Nassir Ghaemi
    Emory Clinic, 1365 Clifton Road, Atlanta, GA 30322, USA
    Schizophr Bull 33:122-30. 2007
  9. ncbi Existence and pluralism: the rediscovery of Karl Jaspers
    S Nassir Ghaemi
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Psychopathology 40:75-82. 2007
  10. ncbi Long-term lamotrigine plus lithium for bipolar disorder: One year outcome
    S Nassir Ghaemi
    Department of Psychiatry, School of Medicine, Emory University, GA, USA
    J Psychiatr Pract 12:300-5. 2006

Detail Information

Publications43

  1. ncbi Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD Participants
    S Nassir Ghaemi
    Department of Psychiatry at Emory University in Atlanta, Georgia 30322, USA
    Psychiatr Serv 57:660-5. 2006
    ..This study assessed patterns of psychopharmacological treatment for bipolar disorder...
  2. doi Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
    Bipolar Disord 10:117-28. 2008
    ....
  3. ncbi Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BD
    Joseph F Goldberg
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 70:155-62. 2009
    ..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established...
  4. ncbi Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    J Clin Psychiatry 68:1840-4. 2007
    ..To determine the efficacy of divalproex (extended release) in the treatment of acute nonrefractory bipolar depression...
  5. ncbi Is adjunctive open-label zonisamide effective for bipolar disorder?
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, United States
    J Affect Disord 105:311-4. 2008
    ..To assess the effectiveness and safety of zonisamide in bipolar disorder...
  6. ncbi Paradigms of psychiatry: eclecticism and its discontents
    Seyyed Nassir Ghaemi
    Department of Psychiatry and Public Health, Emory University, Atlanta, Georgia 30322, USA
    Curr Opin Psychiatry 19:619-24. 2006
    ..To assess paradigms of psychiatry, assessing their strengths and limitations...
  7. ncbi An open prospective study of zonisamide in acute bipolar depression
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
    J Clin Psychopharmacol 26:385-8. 2006
    ..To examine the effectiveness and safety of zonisamide in the treatment of acute bipolar depression...
  8. pmc Feeling and time: the phenomenology of mood disorders, depressive realism, and existential psychotherapy
    S Nassir Ghaemi
    Emory Clinic, 1365 Clifton Road, Atlanta, GA 30322, USA
    Schizophr Bull 33:122-30. 2007
    ....
  9. ncbi Existence and pluralism: the rediscovery of Karl Jaspers
    S Nassir Ghaemi
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Psychopathology 40:75-82. 2007
    ..Contemporary psychiatry has only a limited appreciation of Jaspers' work. In this paper, I attempt to describe these important concepts that can help us understand what we do in psychiatry, what we should be doing and why...
  10. ncbi Long-term lamotrigine plus lithium for bipolar disorder: One year outcome
    S Nassir Ghaemi
    Department of Psychiatry, School of Medicine, Emory University, GA, USA
    J Psychiatr Pract 12:300-5. 2006
    ..To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer...
  11. ncbi Toward a Hippocratic psychopharmacology
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Emory University, Atlanta, Georgia, USA
    Can J Psychiatry 53:189-96. 2008
    ..To provide a conceptual basis for psychopharmacology...
  12. pmc The ethics of clinical innovation in psychopharmacology: Challenging traditional bioethics
    S Nassir Ghaemi
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA
    Philos Ethics Humanit Med 2:26. 2007
    ..To assess the scientific and ethical basis for clinical innovation in psychopharmacology...
  13. doi Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safety
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
    J Clin Psychiatry 71:372-80. 2010
    ..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression...
  14. ncbi Strategies for preventing the recurrence of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Mass 02139, USA
    J Clin Psychiatry 65:16-23. 2004
    ..Some psychotherapies also may possess adjunctive maintenance efficacy...
  15. doi Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patients
    Rif S El-Mallakh
    Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 501 East Broadway, Medcenter One, Suite 340, Louisville, Kentucky 40202, United States
    J Affect Disord 111:372-7. 2008
    ..This phenomenon has only been described in case series format, and has not been prospectively validated...
  16. doi A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
    S Nassir Ghaemi
    Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
    J Clin Psychopharmacol 29:291-5. 2009
    ..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed...
  17. ncbi Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart review
    Sumita G Manwani
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    J Clin Psychiatry 67:1341-5. 2006
    ..To determine if substance use disorder (SUD) is a predictor of antidepressant-induced mania (ADM) in bipolar disorder, correcting for confounding factors in a regression model...
  18. ncbi Oxcarbazepine treatment of bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, Mass, USA
    J Clin Psychiatry 64:943-5. 2003
    ..To assess the effectiveness and safety of oxcarbazepine in bipolar disorder...
  19. ncbi Long-term observational comparison of risperidone and olanzapine in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
    Ann Clin Psychiatry 16:69-73. 2004
    ..EPS was similar, and tardive dyskinesia did not occur. Risperidone and olanzapine appeared to have similar real-world maintenance effectiveness for bipolar disorder, but differed somewhat in side effects...
  20. doi Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depression
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, 1007, Boston, MA 02111, USA
    Bipolar Disord 10:957-68. 2008
    ..Diagnostic criteria for a revival of the concept of neurotic depression are proposed...
  21. ncbi Antidepressants in bipolar disorder: the case for caution
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
    Bipolar Disord 5:421-33. 2003
    ....
  22. ncbi Extrapyramidal side effects with atypical neuroleptics in bipolar disorder
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Emory University, 1365 Clifton Road, Building B, Suite 6100, Atlanta, GA 30322, USA
    Prog Neuropsychopharmacol Biol Psychiatry 30:209-13. 2006
    ..To examine, in a real-world clinical setting, the risk of extrapyramidal symptoms (EPS) with atypical neuroleptics in bipolar patients...
  23. ncbi Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safety
    Gary S Sachs
    Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
    Am J Psychiatry 159:1146-54. 2002
    ..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania...
  24. ncbi Bipolar spectrum disorder: a pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA 02139, USA
    Psychopathology 37:222-6. 2004
    ..To assess depressive features of a proposed definition of bipolar spectrum disorder (BSD)...
  25. ncbi Misdiagnosis of bipolar disorder in children and adolescents: a comparison with ADHD and major depressive disorder
    Jagan K Chilakamarri
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Ann Clin Psychiatry 23:25-9. 2011
    ..Controversy surrounds the frequency of underdiagnosis vs overdiagnosis of bipolar disorder (BD) in children and adolescents compared with diagnoses of attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD)...
  26. ncbi The prescription of psychotropic medications for patients discharged from a psychiatric emergency service
    Carrie L Ernst
    Department of Psychiatry, Massachusetts General Hospital, Boston, USA
    J Clin Psychiatry 67:720-6. 2006
    ..We evaluated the nature and prevalence of medication prescriptions for patients discharged from an urban psychiatric emergency service and the extent to which pharmacotherapy initiation was predictive of follow-through with aftercare...
  27. ncbi Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  28. ncbi Long-term outcome with divalproex in children and adolescents with bipolar disorder
    Charles A Henry
    Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts, USA
    J Child Adolesc Psychopharmacol 13:523-9. 2003
    ..To assess the outcome and safety of divalproex treatment in children and adolescents with bipolar disorder...
  29. doi Mixed depression: a study of its phenomenology and relation to treatment response
    Chi Un Pae
    Department of Psychiatry, Duke University Medical Center, Durham, NC, United States
    J Affect Disord 136:1059-61. 2012
    ..In this report, we examine the specific manic symptoms that are most present in mixed depression, especially as they correlate with prospectively assessed treatment response...
  30. doi The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disorders
    Mauricio Tohen
    Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
    Bipolar Disord 11:453-73. 2009
    ....
  31. ncbi Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder
    Christopher J Miller
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
    J Affect Disord 81:167-71. 2004
    ..Unlike prior telephone-based validation, this is the first clinical study to assess the validity of the MDQ...
  32. ncbi Antidepressant treatment in bipolar versus unipolar depression
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, MA 02139, USA
    Am J Psychiatry 161:163-5. 2004
    ..Antidepressant responses were compared in DSM-IV bipolar and unipolar depression...
  33. ncbi Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart review
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
    Bipolar Disord 4:70-4. 2002
    ..To determine if oxcarbazepine is effective as treatment for refractory bipolar illness in a naturalistic setting...
  34. ncbi Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorder
    Mark H Pollack
    Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
    J Clin Psychiatry 67:394-9. 2006
    ....
  35. doi The varieties of depressive experience: diagnosing mood disorders
    S Nassir Ghaemi
    Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street 1007, Boston, MA 02111, USA
    Psychiatr Clin North Am 35:73-86. 2012
    ..The authors propose a return to careful psychopathology as the basis of all nosology, which has led to identifying four main types of depressive illness, and a method-based, existential approach to understanding depression...
  36. ncbi Evidence-based pharmacotherapy of bipolar disorder
    S Nassir Ghaemi
    Cambridge Health Alliance, Department of Psychiatry, Cambridge, MA 02139, USA
    Int J Neuropsychopharmacol 6:303-8. 2003
    ..Further, RCTs only establish a categorical response to a research question, i.e. whether or not something happens. The frequency of an event (treatment response, side-effects) is often more accurately assessed with observational studies...
  37. pmc Nosologomania: DSM & Karl Jaspers' critique of Kraepelin
    S Nassir Ghaemi
    Mood Disorders Program, Mood Disorders Clinic, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, Box 1007, Boston, MA 02111, USA
    Philos Ethics Humanit Med 4:10. 2009
    ..Jaspers' critique of Kraepelin may help us reformulate our current neo-Kraepelinian nosology for the better...
  38. ncbi "Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorder
    S Nassir Ghaemi
    Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
    Can J Psychiatry 47:125-34. 2002
    ..The role of antidepressants is also controversial. Our review of the evidence leads us to conclude that there should be less emphasis on using antidepressants to treat persons with this illness...
  39. ncbi Is insight in mania state-dependent?: A meta-analysis
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Massachusetts 02139, USA
    J Nerv Ment Dis 192:771-5. 2004
    ..We suggest that impaired insight be considered as part of the diagnostic picture of acute mania...
  40. ncbi A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorder
    Aliza P Wingo
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
    J Clin Psychiatry 68:1776-84. 2007
    ..Concurrent diagnosis of adult ADHD and bipolar disorder remains controversial. In this study, we conducted a systematic review to examine the rates and diagnostic validity of the concept of comorbid adult ADHD and bipolar disorder...
  41. ncbi Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patients
    Aliza P Wingo
    Department of Psychiatry, Emory University, Atlanta, GA, USA
    Psychopharmacol Bull 41:37-47. 2008
    ..However, the effects of stimulant treatment in BD patients have been insufficiently studied. To date, this is the largest study on amphetamine/ methylphenidate treatment and associated mania/hypomania in BD patients...
  42. ncbi Insight in psychosis: a systematic review of treatment interventions
    Charles Henry
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA, USA
    Psychopathology 37:194-9. 2004
    ..We conclude that this literature suggests potentially useful options for clinicians, but further research is needed with better validated insight scales...
  43. ncbi Galantamine treatment of cognitive impairment in bipolar disorder: four cases
    Eric Schrauwen
    Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
    Bipolar Disord 8:196-9. 2006
    ..To determine if galantamine is effective in the treatment of chronic cognitive impairment in bipolar disorder...

Research Grants3

  1. Long-term antidepressant outcome in bipolar depression
    NASSIR GHAEMI; Fiscal Year: 2005
    ..In this process, the applicant will develop competence to lead independent studies of the long-term treatment of bipolar disorder as a principal investigator. ..
  2. Treatment for Bipolar Depression: Acute & Prophylactic Efficacy with Citalopram
    NASSIR GHAEMI; Fiscal Year: 2007
    ..Especially given suggestions that some patients may markedly worsen with antidepressants, better understanding of when to use, and when not to use, antidepressants in bipolar disorder is a major public health concern. ..