Research Topics
| S Nassir GhaemiSummaryAffiliation: Emory University Country: USA Publications
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Publications
Pharmacological Treatment Patterns at Study Entry for the First 500 STEP-BD ParticipantsS Nassir Ghaemi
Department of Psychiatry at Emory University in Atlanta, Georgia 30322, USA
Psychiatr Serv 57:660-5. 2006..This study assessed patterns of psychopharmacological treatment for bipolar disorder...
Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force ReportS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, USA
Bipolar Disord 10:117-28. 2008....- Depressive illness burden associated with complex polypharmacy in patients with bipolar disorder: findings from the STEP-BDJoseph F Goldberg
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
J Clin Psychiatry 70:155-62. 2009..Many patients with bipolar disorder receive multi-drug treatment regimens, but the distinguishing profiles of patients who receive complex pharmacologies have not been established... - Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot studyS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
J Clin Psychiatry 68:1840-4. 2007..To determine the efficacy of divalproex (extended release) in the treatment of acute nonrefractory bipolar depression... - Is adjunctive open-label zonisamide effective for bipolar disorder?S Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, Atlanta, GA 30322, United States
J Affect Disord 105:311-4. 2008..To assess the effectiveness and safety of zonisamide in bipolar disorder... - Paradigms of psychiatry: eclecticism and its discontentsSeyyed Nassir Ghaemi
Department of Psychiatry and Public Health, Emory University, Atlanta, Georgia 30322, USA
Curr Opin Psychiatry 19:619-24. 2006..To assess paradigms of psychiatry, assessing their strengths and limitations... - An open prospective study of zonisamide in acute bipolar depressionS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
J Clin Psychopharmacol 26:385-8. 2006..To examine the effectiveness and safety of zonisamide in the treatment of acute bipolar depression... 
Feeling and time: the phenomenology of mood disorders, depressive realism, and existential psychotherapyS Nassir Ghaemi
Emory Clinic, 1365 Clifton Road, Atlanta, GA 30322, USA
Schizophr Bull 33:122-30. 2007....- Existence and pluralism: the rediscovery of Karl JaspersS Nassir Ghaemi
Department of Psychiatry, Emory University, Atlanta, GA, USA
Psychopathology 40:75-82. 2007..Contemporary psychiatry has only a limited appreciation of Jaspers' work. In this paper, I attempt to describe these important concepts that can help us understand what we do in psychiatry, what we should be doing and why... - Long-term lamotrigine plus lithium for bipolar disorder: One year outcomeS Nassir Ghaemi
Department of Psychiatry, School of Medicine, Emory University, GA, USA
J Psychiatr Pract 12:300-5. 2006..To obtain pilot data in an observational setting on the use of lamotrigine plus lithium in the long-term treatment of patients with bipolar disorder, 87% of whom had failed to respond to at least one previous mood stabilizer... - Toward a Hippocratic psychopharmacologyS Nassir Ghaemi
Bipolar Disorder Research Program, Emory University, Atlanta, Georgia, USA
Can J Psychiatry 53:189-96. 2008..To provide a conceptual basis for psychopharmacology... - The ethics of clinical innovation in psychopharmacology: Challenging traditional bioethicsS Nassir Ghaemi
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA USA
Philos Ethics Humanit Med 2:26. 2007..To assess the scientific and ethical basis for clinical innovation in psychopharmacology... - Antidepressant discontinuation in bipolar depression: a Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) randomized clinical trial of long-term effectiveness and safetyS Nassir Ghaemi
Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington St, Box 1007, Boston, MA 02111, USA
J Clin Psychiatry 71:372-80. 2010..To assess long-term effectiveness and safety of randomized antidepressant discontinuation after acute recovery from bipolar depression... - Strategies for preventing the recurrence of bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Mass 02139, USA
J Clin Psychiatry 65:16-23. 2004..Some psychotherapies also may possess adjunctive maintenance efficacy... - Antidepressant-associated chronic irritable dysphoria (ACID) in STEP-BD patientsRif S El-Mallakh
Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, 501 East Broadway, Medcenter One, Suite 340, Louisville, Kentucky 40202, United States
J Affect Disord 111:372-7. 2008..This phenomenon has only been described in case series format, and has not been prospectively validated... - A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorderS Nassir Ghaemi
Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
J Clin Psychopharmacol 29:291-5. 2009..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed... - Substance use disorder and other predictors of antidepressant-induced mania: a retrospective chart reviewSumita G Manwani
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
J Clin Psychiatry 67:1341-5. 2006..Type II illness, female gender, and TCA use also appeared to be predictors of ADM, while bupropion use appeared to predict lower likelihood of ADM... - Oxcarbazepine treatment of bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, Mass, USA
J Clin Psychiatry 64:943-5. 2003..To assess the effectiveness and safety of oxcarbazepine in bipolar disorder... - Long-term observational comparison of risperidone and olanzapine in bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Health Alliance, Cambridge, Massachusetts, USA
Ann Clin Psychiatry 16:69-73. 2004..EPS was similar, and tardive dyskinesia did not occur. Risperidone and olanzapine appeared to have similar real-world maintenance effectiveness for bipolar disorder, but differed somewhat in side effects... - Why antidepressants are not antidepressants: STEP-BD, STAR*D, and the return of neurotic depressionS Nassir Ghaemi
Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, 1007, Boston, MA 02111, USA
Bipolar Disord 10:957-68. 2008..Diagnostic criteria for a revival of the concept of neurotic depression are proposed... - Antidepressants in bipolar disorder: the case for cautionS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
Bipolar Disord 5:421-33. 2003.... - Extrapyramidal side effects with atypical neuroleptics in bipolar disorderS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Emory University, 1365 Clifton Road, Building B, Suite 6100, Atlanta, GA 30322, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:209-13. 2006..This rate is much higher than the 5-15% range reported in clinical trials, suggesting potential problems with clinical trial generalizability... - Combination of a mood stabilizer with risperidone or haloperidol for treatment of acute mania: a double-blind, placebo-controlled comparison of efficacy and safetyGary S Sachs
Bipolar Research Program, Department of Psychiatry, Massachusetts General Hospital, 50 Staniford Street, Suite 580, Boston, MA 02114, USA
Am J Psychiatry 159:1146-54. 2002..The study assessed the efficacy and safety of risperidone as an adjunctive agent to mood stabilizers in the treatment of acute mania... - Bipolar spectrum disorder: a pilot studyS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA 02139, USA
Psychopathology 37:222-6. 2004..Further prospective study needs to be conducted comparing BSD with unipolar depression... - Misdiagnosis of bipolar disorder in children and adolescents: a comparison with ADHD and major depressive disorderJagan K Chilakamarri
Department of Psychiatry, Emory University, Atlanta, GA, USA
Ann Clin Psychiatry 23:25-9. 2011..Controversy surrounds the frequency of underdiagnosis vs overdiagnosis of bipolar disorder (BD) in children and adolescents compared with diagnoses of attention-deficit/hyperactivity disorder (ADHD) and major depressive disorder (MDD)... - The prescription of psychotropic medications for patients discharged from a psychiatric emergency serviceCarrie L Ernst
Department of Psychiatry, Massachusetts General Hospital, Boston, USA
J Clin Psychiatry 67:720-6. 2006.... - Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participantsClaudia F Baldassano
Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
Bipolar Disord 7:465-70. 2005..To examine gender differences in a large sample of patients with bipolar illness... - Long-term outcome with divalproex in children and adolescents with bipolar disorderCharles A Henry
Department of Psychiatry, Harvard Medical School, Cambridge, Massachusetts, USA
J Child Adolesc Psychopharmacol 13:523-9. 2003..One third of the patients discontinued treatment secondary to side effects, including a case of reversible liver enzyme elevation... - Mixed depression: a study of its phenomenology and relation to treatment responseChi Un Pae
Department of Psychiatry, Duke University Medical Center, Durham, NC, United States
J Affect Disord 136:1059-61. 2012..In this report, we examine the specific manic symptoms that are most present in mixed depression, especially as they correlate with prospectively assessed treatment response... - The International Society for Bipolar Disorders (ISBD) Task Force report on the nomenclature of course and outcome in bipolar disordersMauricio Tohen
Department of Psychiatry, Division of Mood and Anxiety Disorders, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 7792, San Antonio, TX 78229, USA
Bipolar Disord 11:453-73. 2009.... - Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorderChristopher J Miller
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
J Affect Disord 81:167-71. 2004..Specificity was 0.67. CONCLUSIONS: The MDQ demonstrates good sensitivity in insightful patients with bipolar I disorder, but may be less useful in patients with impaired insight or milder bipolar spectrum conditions... - Antidepressant treatment in bipolar versus unipolar depressionS Nassir Ghaemi
Department of Psychiatry, Cambridge Hospital, MA 02139, USA
Am J Psychiatry 161:163-5. 2004..Antidepressant responses were compared in DSM-IV bipolar and unipolar depression... - Oxcarbazepine treatment of refractory bipolar disorder: a retrospective chart reviewS Nassir Ghaemi
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA 02139, USA
Bipolar Disord 4:70-4. 2002..To determine if oxcarbazepine is effective as treatment for refractory bipolar illness in a naturalistic setting... - Persistent posttraumatic stress disorder following September 11 in patients with bipolar disorderMark H Pollack
Department of Psychiatry, Massachusetts General Hospital, Boston, Mass, USA
J Clin Psychiatry 67:394-9. 2006.... - The varieties of depressive experience: diagnosing mood disordersS Nassir Ghaemi
Mood Disorders Program, Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, 800 Washington Street 1007, Boston, MA 02111, USA
Psychiatr Clin North Am 35:73-86. 2012..The authors propose a return to careful psychopathology as the basis of all nosology, which has led to identifying four main types of depressive illness, and a method-based, existential approach to understanding depression... - Evidence-based pharmacotherapy of bipolar disorderS Nassir Ghaemi
Cambridge Health Alliance, Department of Psychiatry, Cambridge, MA 02139, USA
Int J Neuropsychopharmacol 6:303-8. 2003..Further, RCTs only establish a categorical response to a research question, i.e. whether or not something happens. The frequency of an event (treatment response, side-effects) is often more accurately assessed with observational studies... - Nosologomania: DSM & Karl Jaspers' critique of KraepelinS Nassir Ghaemi
Mood Disorders Program, Mood Disorders Clinic, Department of Psychiatry, Tufts Medical Center, 800 Washington Street, Box 1007, Boston, MA 02111, USA
Philos Ethics Humanit Med 4:10. 2009..Jaspers' critique of Kraepelin may help us reformulate our current neo-Kraepelinian nosology for the better... - "Cade's disease" and beyond: misdiagnosis, antidepressant use, and a proposed definition for bipolar spectrum disorderS Nassir Ghaemi
Department of Psychiatry, Cambridge Hospital, 1493 Cambridge Street, Cambridge, MA 02139, USA
Can J Psychiatry 47:125-34. 2002..The role of antidepressants is also controversial. Our review of the evidence leads us to conclude that there should be less emphasis on using antidepressants to treat persons with this illness... - Is insight in mania state-dependent?: A meta-analysisS Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, Massachusetts 02139, USA
J Nerv Ment Dis 192:771-5. 2004..We suggest that impaired insight be considered as part of the diagnostic picture of acute mania... - A systematic review of rates and diagnostic validity of comorbid adult attention-deficit/hyperactivity disorder and bipolar disorderAliza P Wingo
Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA 30322, USA
J Clin Psychiatry 68:1776-84. 2007..Concurrent diagnosis of adult ADHD and bipolar disorder remains controversial. In this study, we conducted a systematic review to examine the rates and diagnostic validity of the concept of comorbid adult ADHD and bipolar disorder... - Frequency of stimulant treatment and of stimulant-associated mania/hypomania in bipolar disorder patientsAliza P Wingo
Department of Psychiatry, Emory University, Atlanta, GA, USA
Psychopharmacol Bull 41:37-47. 2008..However, the effects of stimulant treatment in BD patients have been insufficiently studied. To date, this is the largest study on amphetamine/ methylphenidate treatment and associated mania/hypomania in BD patients... - Insight in psychosis: a systematic review of treatment interventionsCharles Henry
Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA, USA
Psychopathology 37:194-9. 2004..We conclude that this literature suggests potentially useful options for clinicians, but further research is needed with better validated insight scales... - Galantamine treatment of cognitive impairment in bipolar disorder: four casesEric Schrauwen
Bipolar Disorder Research Program, Department of Psychiatry, Cambridge Health Alliance, Cambridge, MA, USA
Bipolar Disord 8:196-9. 2006..CONCLUSIONS: This pilot case series suggests that galantamine may have some utility in improving chronic cognitive impairment in bipolar disorder. Larger studies are required to clarify these initial pilot data...
Research Grants
- Long-term antidepressant outcome in bipolar depressionNASSIR GHAEMI; Fiscal Year: 2005..In this process, the applicant will develop competence to lead independent studies of the long-term treatment of bipolar disorder as a principal investigator. ..
- Treatment for Bipolar Depression: Acute & Prophylactic Efficacy with CitalopramNASSIR GHAEMI; Fiscal Year: 2007..Especially given suggestions that some patients may markedly worsen with antidepressants, better understanding of when to use, and when not to use, antidepressants in bipolar disorder is a major public health concern. ..