Andrew Gewirtz

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components
    A H Frias
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Mucosal Immunol 3:622-32. 2010
  2. doi request reprint Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
    Frederic A Carvalho
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gut 61:373-84. 2012
  3. pmc Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice
    Matam Vijay-Kumar
    Division of Nutrition, School of Health Professions, College of Health and Human Sciences, Georgia State University, Atlanta, GA 30302, USA
    J Inflamm (Lond) 8:2. 2011
  4. pmc Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs
    A T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 101:1860-9. 1998
  5. ncbi request reprint Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1157-63. 2006
  6. ncbi request reprint Flag in the crossroads: flagellin modulates innate and adaptive immunity
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Gastroenterol 22:8-12. 2006
  7. ncbi request reprint Lipoxin analogs: novel anti-inflammatory mediators
    Andrew Gewirtz
    Pathology WBRB 105H, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 6:1112-5. 2005
  8. ncbi request reprint Intestinal epithelial toll-like receptors: to protect. And serve?
    Andrew T Gewirtz
    Epithelial Pathobiology Division, Department of Pathology and Laboratory Medicine, Emory University, Atlanta GA 30322, USA
    Curr Pharm Des 9:1-5. 2003
  9. ncbi request reprint Tacrolimus Fujisawa
    Andrew T Gewirtz
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 3:1307-11. 2002
  10. ncbi request reprint Technology evaluation: alicaforsen (Isis)
    Andrew T Gewirtz
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, GA 30322, USA
    Curr Opin Mol Ther 7:273-81. 2005

Research Grants

  1. Pathophysiology of TLR5KO Colitis
    Andrew T Gewirtz; Fiscal Year: 2010
  2. Flagellin-induced gut epithelial chemokine secretion
    Andrew T Gewirtz; Fiscal Year: 2010
  3. REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETION
    Andrew Gewirtz; Fiscal Year: 2002
  4. Flagellin-induced gut epithelial chemokine secretion
    Andrew T Gewirtz; Fiscal Year: 2010
  5. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2009
  6. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2009
  7. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2007
  8. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2006
  9. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2005
  10. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2004

Detail Information

Publications74

  1. pmc Intestinal epithelia activate anti-viral signaling via intracellular sensing of rotavirus structural components
    A H Frias
    Department of Pathology, Emory University, Atlanta, Georgia, USA
    Mucosal Immunol 3:622-32. 2010
    ..Together, these results suggest that RV proteins mediate viral entry into epithelial cells leading to intracellular detection of RV RNA that generates an anti-viral response...
  2. doi request reprint Interleukin-1β (IL-1β) promotes susceptibility of Toll-like receptor 5 (TLR5) deficient mice to colitis
    Frederic A Carvalho
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gut 61:373-84. 2012
    ....
  3. pmc Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice
    Matam Vijay-Kumar
    Division of Nutrition, School of Health Professions, College of Health and Human Sciences, Georgia State University, Atlanta, GA 30302, USA
    J Inflamm (Lond) 8:2. 2011
    ..abstract:..
  4. pmc Pathogen-induced chemokine secretion from model intestinal epithelium is inhibited by lipoxin A4 analogs
    A T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 101:1860-9. 1998
    ..These data suggest that LXA4 and its stable analogs may be useful in downregulating active inflammation at mucosal surfaces...
  5. ncbi request reprint Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn's disease
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G1157-63. 2006
    ..These results demonstrate that natural acquisition of immune responses to flagellin are regulated by TLR5 and suggest that immune responses to flagellin are not merely associated with CD but rather promote the pathogenic response...
  6. ncbi request reprint Flag in the crossroads: flagellin modulates innate and adaptive immunity
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Opin Gastroenterol 22:8-12. 2006
    ....
  7. ncbi request reprint Lipoxin analogs: novel anti-inflammatory mediators
    Andrew Gewirtz
    Pathology WBRB 105H, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 6:1112-5. 2005
    ..Lipoxin analogs could be potentially useful for a wide array of disease states that have an inflammatory component, and look particularly promising for treatment of inflammatory bowel disease...
  8. ncbi request reprint Intestinal epithelial toll-like receptors: to protect. And serve?
    Andrew T Gewirtz
    Epithelial Pathobiology Division, Department of Pathology and Laboratory Medicine, Emory University, Atlanta GA 30322, USA
    Curr Pharm Des 9:1-5. 2003
    ..This minireview considers the current findings regarding TLR expression in the intestinal epithelium and the role these receptors might serve in host defense...
  9. ncbi request reprint Tacrolimus Fujisawa
    Andrew T Gewirtz
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 3:1307-11. 2002
    ..By March 2002, tacrolimus had entered phase III trials for inflammatory bowel disease (IBD) in Japan [442503]. This evaluation will focus on the development of tacrolimus for this indication...
  10. ncbi request reprint Technology evaluation: alicaforsen (Isis)
    Andrew T Gewirtz
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, GA 30322, USA
    Curr Opin Mol Ther 7:273-81. 2005
    ..Isis is developing alicaforsen, an RNase H-dependent antisense inhibitor of intercellular adhesion molecule-1, for the potential treatment of ulcerative colitis. The therapy is currently undergoing phase II clinical trials...
  11. pmc A most important annexation
    Brian A Babbin
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University, Woodruff Memorial Bldg, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Pathol 166:1581-3. 2005
  12. ncbi request reprint Lipoxin a4 analogs attenuate induction of intestinal epithelial proinflammatory gene expression and reduce the severity of dextran sodium sulfate-induced colitis
    Andrew T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University, WRB 10SH, 6125 Michael Street, Atlanta, GA 30322, USA
    J Immunol 168:5260-7. 2002
    ..Thus, LXA(4) analog-mediated down-regulation of proinflammatory gene expression via inhibition of the NF-kappaB pathway can be therapeutic for diseases characterized by mucosal inflammation...
  13. ncbi request reprint Alicaforsen. Isis Pharmaceuticals
    A T Gewirtz
    Emory University School of Medicine, Department of Pathology and Laboratory Medicine, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 2:1401-6. 2001
    ..US-05514788, and other patents, cover antisense cell adhesion molecule inhibitors [212289], [234792]...
  14. pmc Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response
    A T Gewirtz
    Epithelial Pathobiology Division, Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Invest 107:99-109. 2001
    ..These findings indicate that translocation of flagellin across epithelia, subsequent to apical epithelial-S. typhimurium interaction, is likely a major means of activating a mucosal inflammatory response...
  15. ncbi request reprint LXA4, aspirin-triggered 15-epi-LXA4, and their analogs selectively downregulate PMN azurophilic degranulation
    A T Gewirtz
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Physiol 276:C988-94. 1999
    ..Thus the cellular basis of action of these natural off-switches to inflammation appears to involve downregulation of neutrophil azurophilic granule release...
  16. ncbi request reprint TLRs in the Gut. III. Immune responses to flagellin in Crohn's disease: good, bad, or irrelevant?
    Andrew T Gewirtz
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 292:G706-10. 2007
    ..This article discusses the evidence that supports a role for flagellin in Crohn's disease and considers the potential roles of these responses in the pathophysiology of this disorder...
  17. pmc A2B adenosine receptor gene deletion attenuates murine colitis
    Vasantha L Kolachala
    Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Gastroenterology 135:861-70. 2008
    ..We have previously shown that A(2B)AR mRNA and protein levels are up-regulated during colitis. In this study, we addressed the role of the A(2B)AR in the development of murine colitis and the potential mechanism underlying its effects...
  18. pmc Toll-like receptor 5-deficient mice have dysregulated intestinal gene expression and nonspecific resistance to Salmonella-induced typhoid-like disease
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Infect Immun 76:1276-81. 2008
    ..All together, these results indicate that the resistance of TLR5KO mice to Salmonella-induced typhoid-like illness resulted from alterations in their basal phenotype rather than from the lack of TLR5 ligation during the infection per se...
  19. ncbi request reprint TLR5-mediated activation of p38 MAPK regulates epithelial IL-8 expression via posttranscriptional mechanism
    Yimin Yu
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Gastrointest Liver Physiol 285:G282-90. 2003
    ..Together, these results indicate that epithelial TLR5 mediates p38 activation and subsequently regulates flagellin-induced IL-8 expression independently of NF-kappaB, probably by influencing IL-8 mRNA translation...
  20. pmc Deletion of TLR5 results in spontaneous colitis in mice
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 117:3909-21. 2007
    ..That an engineered innate immune deficiency ultimately results in spontaneous intestinal inflammation supports the notion that an innate immune deficiency might underlie some instances of inflammatory bowel disease...
  21. ncbi request reprint Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium
    Torsten Kucharzik
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Cell Physiol 284:C888-96. 2003
    ..Thus LXA(4) generated in or near the paracellular space via neutrophil-epithelial interactions can rapidly act on epithelial LXA(4)R to downregulate epithelial promotion of intestinal inflammation...
  22. ncbi request reprint Colonic leptin: source of a novel proinflammatory cytokine involved in IBD
    Shanthi Sitaraman
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, GA 30322, USA
    FASEB J 18:696-8. 2004
    ..These observations provide evidence for an intraluminal biological signaling of leptin and a new pathophysiological role for intraluminal leptin during states of intestinal inflammation such as inflammatory bowel disease...
  23. pmc Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis
    Pallavi Garg
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 296:G175-84. 2009
    ..Thus inhibition of MMP-9 may be beneficial in treatment of colitis even if resulting in inhibition of MMP-2...
  24. ncbi request reprint Flagellin/TLR5 responses in epithelia reveal intertwined activation of inflammatory and apoptotic pathways
    Hui Zeng
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 105 F Whitehead Bldg, 615 Michaels St, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 290:G96-G108. 2006
    ..Such intertwining of proinflammatory and apoptotic signaling mediated by bacterial products suggests roles for host programmed cell death in the pathogenesis of enteric infections...
  25. ncbi request reprint Flagellin treatment protects against chemicals, bacteria, viruses, and radiation
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol 180:8280-5. 2008
    ..Thus, systemic administration of flagellin may be a relatively safe means of providing temporary non-specific protection against a variety of challenges...
  26. ncbi request reprint Intestinal epithelial cell regulation of mucosal inflammation
    Yimin Yu
    Epithelial Pathobiology Division, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Immunol Res 29:55-68. 2004
    ....
  27. ncbi request reprint Epithelial-derived fibronectin expression, signaling, and function in intestinal inflammation
    Vasantha L Kolachala
    Division of Digestive Diseases, Department of Medicine, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    J Biol Chem 282:32965-73. 2007
    ....
  28. ncbi request reprint Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP
    Florencia E Castaneda
    Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 129:1991-2008. 2005
    ....
  29. ncbi request reprint Protein kinase R mediates intestinal epithelial gene remodeling in response to double-stranded RNA and live rotavirus
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 174:6322-31. 2005
    ....
  30. pmc Interferon-gamma increases hPepT1-mediated uptake of di-tripeptides including the bacterial tripeptide fMLP in polarized intestinal epithelia
    Marion Buyse
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Am J Pathol 163:1969-77. 2003
    ..The intracellular accumulation of such di-tripeptides may be important in enterocytes becoming immune accessory cells...
  31. ncbi request reprint Salmonella typhimurium transcytoses flagellin via an SPI2-mediated vesicular transport pathway
    Sean Lyons
    Epithelial Pathobiology Division, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Cell Sci 117:5771-80. 2004
    ....
  32. pmc Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis
    Bindu Chandrasekharan
    Division of Digestive Diseases, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 3:e3304. 2008
    ..Neurogenic inflammation plays a major role in the pathogenesis of inflammatory bowel disease (IBD). We examined the role of neuropeptide Y (NPY) and neuronal nitric oxide synthase (nNOS) in modulating colitis...
  33. ncbi request reprint IL-6 induces NF-kappa B activation in the intestinal epithelia
    Lixin Wang
    Department of Medicine, Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    J Immunol 171:3194-201. 2003
    ..These data may have mechanistic and therapeutic implications in diseases such as IBD and rheumatoid arthritis in which IL-6 plays an important role in the pathogenesis...
  34. ncbi request reprint Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis
    Pallavi Garg
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    J Immunol 177:4103-12. 2006
    ..Together, our data suggest that a critical balance between the two gelatinases determines the outcome of inflammatory response during acute colitis...
  35. pmc Dietary glutamine and oral antibiotics each improve indexes of gut barrier function in rat short bowel syndrome
    Junqiang Tian
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Am J Physiol Gastrointest Liver Physiol 296:G348-55. 2009
    ..These indexes of gut barrier dysfunction are ameliorated or blunted by administration of dietary GLN or oral ABX, respectively. Dietary GLN upregulates small bowel sIgA in this model...
  36. ncbi request reprint Humoral immune response to flagellin requires T cells and activation of innate immunity
    Catherine J Sanders
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol 177:2810-8. 2006
    ..Thus, acquisition of a humoral immune response to flagellin requires activation of innate immunity, is T cell dependent, and can originate from flagellin in the intestinal tract in inflammatory conditions in the intestine...
  37. ncbi request reprint Elevated flagellin-specific immunoglobulins in Crohn's disease
    Shanthi V Sitaraman
    Department of Medicine, Emory University, Atlanta, Georgia, USA
    Am J Physiol Gastrointest Liver Physiol 288:G403-6. 2005
    ....
  38. ncbi request reprint The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells
    Katharine A Reed
    Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, Whitehead Research Building, Atlanta, GA 30322, USA
    J Biol Chem 277:13346-53. 2002
    ..typhimurium-induced proinflammatory responses through basolateral TLR5 and is consistent with the emerging model of S. typhimurium flagellin-induced inflammation...
  39. ncbi request reprint Helicobacter pylori flagellin evades toll-like receptor 5-mediated innate immunity
    Andrew T Gewirtz
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Infect Dis 189:1914-20. 2004
    ..pylori flagellin plays no role in activating epithelial orchestration of inflammation. We conclude that H. pylori evades TLR5-mediated detection, which may contribute to its long-term persistence in individual hosts...
  40. pmc Flagellin suppresses epithelial apoptosis and limits disease during enteric infection
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Pathol 169:1686-700. 2006
    ..This notion is consistent with the emerging paradigm that specific TLR ligands may have a fundamental cytoprotective effect during inflammatory stress...
  41. pmc Matrix metalloproteinase-9 functions as a tumor suppressor in colitis-associated cancer
    Pallavi Garg
    Division of Digestive Diseases and Department of Pathology, Emory University, Atlanta, Georgia 30322, USA
    Cancer Res 70:792-801. 2010
    ....
  42. ncbi request reprint Toll like receptor-5: protecting the gut from enteric microbes
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA, USA
    Semin Immunopathol 30:11-21. 2008
    ..This article reviews studies performed in vitro, in mice, and in humans that indicate an important role for the flagellin-TLR5 interaction in regulating both the innate and adaptive immune responses in the intestine...
  43. pmc Toll-like receptor 5-dependent regulation of inflammation in systemic Salmonella enterica Serovar typhimurium infection
    Benedicte Fournier
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Infect Immun 77:4121-9. 2009
    ..Thus, the characteristic inflammatory pathology of Salmonella infection occurs only in PPs and to a lesser extent in MLN during the initial phases of infection and these early responses are dependent on TLR5...
  44. ncbi request reprint Secretion of IL-2 and IFN-gamma, but not IL-4, by antigen-specific T cells requires extracellular ATP
    Heather P Langston
    Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 170:2962-70. 2003
    ..These results suggest that extracellular ATP plays an essential role in the TCR-mediated signal transduction cascade for expression of certain cytokine genes...
  45. pmc Adenosine 2B receptor expression is post-transcriptionally regulated by microRNA
    Vasantha L Kolachala
    Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:18184-90. 2010
    ..Collectively, these data demonstrate that TNF-alpha-induced A(2B)AR expression in colonic epithelial cells is post-transcriptionally regulated by miR27b and miR128a and show that miR27b influences A(2B)AR expression in murine colitis...
  46. pmc The rate of bloodstream infection is high in infants with short bowel syndrome: relationship with small bowel bacterial overgrowth, enteral feeding, and inflammatory and immune responses
    Conrad R Cole
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pediatr 156:941-7, 947.e1. 2010
    ....
  47. pmc Prohibitin is a novel regulator of antioxidant response that attenuates colonic inflammation in mice
    Arianne L Theiss
    Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 137:199-208, 208.e1-6. 2009
    ....
  48. ncbi request reprint ADAM-15/metargidin mediates homotypic aggregation of human T lymphocytes and heterotypic interactions of T lymphocytes with intestinal epithelial cells
    Laetitia Charrier
    Department of Medicine, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 282:16948-58. 2007
    ..Altogether these findings point to ADAM-15 as a possible therapeutic target for prevention of inappropriate T cell activation involved in some pathologies...
  49. pmc Detectable serum flagellin and lipopolysaccharide and upregulated anti-flagellin and lipopolysaccharide immunoglobulins in human short bowel syndrome
    Thomas R Ziegler
    General Clinical Research Center, Emory University Hospital, 1364 Clifton Road, Atlanta, GA 30322, USA
    Am J Physiol Regul Integr Comp Physiol 294:R402-10. 2008
    ..We conclude that adults with PN-dependent SBS are systemically exposed to flagellin and LPS, presumably from the gut lumen. This likely regulates innate and adaptive immune responses to these specific bacterial products...
  50. ncbi request reprint Semapimod. Cytokine
    Shanthi V Sitaraman
    Division of Digestive Diseases, Emory University School of Medicine, 615 Michael Street, Whitehead Research Bldg, Rm 205F, Atlanta, GA 30322, USA
    Curr Opin Investig Drugs 4:1363-8. 2003
    ..In April 2003, preclinical and early clinical studies were underway for a variety of indications, including congestive heart failure and pancreatitis...
  51. ncbi request reprint TLR5-mediated phosphoinositide 3-kinase activation negatively regulates flagellin-induced proinflammatory gene expression
    Yimin Yu
    Epithelial Pathobiology Division, Department of Pathology, Emory University School of Medicine, 6156 Michael Street, Atlanta, GA 30322, USA
    J Immunol 176:6194-201. 2006
    ..Thus, TLR5's rapid activation of PI3K serves to limit MAPK signaling, thus limiting proinflammatory gene expression and reducing the potential negative consequences of proinflammatory gene expression...
  52. ncbi request reprint Cutting edge: impaired Toll-like receptor expression and function in aging
    Mary Renshaw
    Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    J Immunol 169:4697-701. 2002
    ..These results support the concept that increased susceptibility to infections and poor adaptive immune responses in aging may be due to the decline in TLR expression and function...
  53. ncbi request reprint Flagellin is the major proinflammatory determinant of enteropathogenic Salmonella
    Hui Zeng
    Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 171:3668-74. 2003
    ..Thus, S. typhimurium flagellin is the major molecular trigger by which this pathogen activates gut epithelial proinflammatory gene expression...
  54. ncbi request reprint STAT signaling underlies difference between flagellin-induced and tumor necrosis factor-alpha-induced epithelial gene expression
    Yimin Yu
    Department of Pathology, Division of Digestive Diseases, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 279:35210-8. 2004
    ..Together, these results indicate that epithelial cell induction of flagellin-specific gene expression is mediated, in part, by STAT activation that results from autocrine activation via IL-6...
  55. pmc Polarized fibronectin secretion induced by adenosine regulates bacterial-epithelial interaction in human intestinal epithelial cells
    Baljit Walia
    Division of Digestive Diseases, Emory University, Atlanta, GA 30322, USA
    Biochem J 382:589-96. 2004
    ..FN may be a critical host factor that modulates adherence and invasion of bacteria, thus playing a key role in mucosal immune responses during inflammation...
  56. ncbi request reprint Matrix metalloproteinase-9 regulates MUC-2 expression through its effect on goblet cell differentiation
    Pallavi Garg
    Division of Digestive Diseases, Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Gastroenterology 132:1877-89. 2007
    ..In this study, we sought to address the role and mechanism by which MMP-9 influences barrier protective function...
  57. pmc Latent cytomegalovirus infection exacerbates experimental colitis
    Chukwuma Onyeagocha
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Am J Pathol 175:2034-42. 2009
    ..Thus, underlying CMV infection can alter mucosal immunity, potentially increasing the tendency of CMV-infected hosts to develop colitis...
  58. pmc Induction of adaptive immunity by flagellin does not require robust activation of innate immunity
    Catherine J Sanders
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Eur J Immunol 39:359-71. 2009
    ..Thus, it should be possible to design innate immune activators that are highly effective vaccine adjuvants yet avoid the adverse events associated with systemic TLR activation...
  59. ncbi request reprint Activation of toll-like receptor 3 protects against DSS-induced acute colitis
    Matam Vijay-Kumar
    Department of Pathology and Laboratory Medicine, Epithelial Pathobiology Unit, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 13:856-64. 2007
    ....
  60. ncbi request reprint CD98 and intracellular adhesion molecule I regulate the activity of amino acid transporter LAT-2 in polarized intestinal epithelia
    Xia Liu
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:23672-7. 2003
    ..Our data provide a novel mechanism by which events such as adhesion may be integrated by amino acid transport activity resulting from the direct interaction of cell surface molecules such as CD98 and ICAM-1...
  61. pmc Dysregulation of inflammatory responses by chronic circadian disruption
    Oscar Castanon-Cervantes
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    J Immunol 185:5796-805. 2010
    ..Such immune changes might be a common mechanism for the myriad negative health effects of shift work...
  62. ncbi request reprint Mechanisms of active intestinal inflammation and potential down-regulation via lipoxins
    Andrew T Gewirtz
    Epithelial Pathobiology Research Unit, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 507:229-36. 2002
    ....
  63. ncbi request reprint Both radioresistant and hemopoietic cells promote innate and adaptive immune responses to flagellin
    Catherine J Sanders
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    J Immunol 180:7184-92. 2008
    ..Thus, in vivo both radioresistant and hemopoietic cells play key nonredundant roles in mediating innate and adaptive immune responses to flagellin...
  64. ncbi request reprint Intestinal epithelial pathobiology: past, present and future
    Andrew T Gewirtz
    Epithelial Pathobiology Division, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA
    Best Pract Res Clin Gastroenterol 16:851-67. 2002
    ....
  65. ncbi request reprint Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5
    Matam Vijay-Kumar
    Department of Pathology, Emory University, Atlanta, GA 30322, USA
    Science 328:228-31. 2010
    ..These results support the emerging view that the gut microbiota contributes to metabolic disease and suggest that malfunction of the innate immune system may promote the development of metabolic syndrome...
  66. doi request reprint Role of flagellin in Crohn's disease: emblematic of the progress and enigmas in understanding inflammatory bowel disease
    Matam Vijay-Kumar
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Inflamm Bowel Dis 15:789-95. 2009
    ..This article reviews such progress and discusses these challenges in the context of focusing on 1 particular protein, bacterial flagellin...
  67. pmc Toll-like receptors 4 and 5 induce distinct types of vasculitis
    Jiusheng Deng
    Lowance Center for Human Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 104:488-95. 2009
    ..Thus, depending on the original danger signal, vascular DCs edit the emerging immune response by differentially recruiting specialized T effector cells and direct the disease process toward distinct types of vasculitis...
  68. pmc Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia
    Randall J Mrsny
    School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff, Wales CF10 3XF, United Kingdom
    Proc Natl Acad Sci U S A 101:7421-6. 2004
    ....
  69. ncbi request reprint Paneth cell cryptdins act in vitro as apical paracrine regulators of the innate inflammatory response
    Patricia W Lin
    Gastrointestinal Cell Biology Department, Combined Program in Pediatric Gastroenterology and Nutrition, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    J Biol Chem 279:19902-7. 2004
    ..These results show that selective cryptdins may amplify their roles in innate immunity by acting as novel paracrine agonists to coordinate an inflammatory response with the antimicrobial secretions of Paneth cells...
  70. ncbi request reprint Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice
    Isabelle Angers
    Department of Human Genetics, McGill University, Montreal, Quebec, Canada H3G 1A4
    Mamm Genome 17:385-97. 2006
    ..MOLF-Ity mice, they exhibit a different phenotype with respect to Tlr5 expression and Tlr5 signaling, supporting the prediction that Tlr5 is not primarily involved in the disease phenotype underlying the Ity3 locus in MOLF/Ei mice...
  71. ncbi request reprint Identification of proinflammatory flagellin proteins in supernatants of Vibrio cholerae O1 by proteomics analysis
    Juan Xicohtencatl-Cortes
    Department of Immunobiology, University of Arizona, Tucson, Arizona 85724, USA
    Mol Cell Proteomics 5:2374-83. 2006
    ..This observation may explain, in part, the observed reactogenicity of cholera vaccine strains in humans...
  72. ncbi request reprint Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo
    Stephen J McSorley
    Department of Microbiology, Center for Immunology, University of Minnesota Medical School, Minneapolis MN 55455, USA
    J Immunol 169:3914-9. 2002
    ..Such an adjuvant effect for flagellin has important implications for vaccine development and the generation of CD4 T cell responses to enteric bacteria...
  73. doi request reprint Guardians of the gut: newly appreciated role of epithelial toll-like receptors in protecting the intestine
    Matam Vijay-Kumar
    Gastroenterology 135:351-4. 2008
  74. ncbi request reprint Cutting edge: enhanced pulmonary clearance of Pseudomonas aeruginosa by Muc1 knockout mice
    Wenju Lu
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, 21201, USA
    J Immunol 176:3890-4. 2006
    ..We conclude that MUC1/Muc1 suppresses pulmonary innate immunity and speculate its anti-inflammatory activity may play an important modulatory role during microbial infection...

Research Grants13

  1. Pathophysiology of TLR5KO Colitis
    Andrew T Gewirtz; Fiscal Year: 2010
    ..We expect this information will prove insightful toward understanding the pathogenesis of Crohn's disease and ulcerative colitis, collectively referred to as inflammatory bowel disease. ..
  2. Flagellin-induced gut epithelial chemokine secretion
    Andrew T Gewirtz; Fiscal Year: 2010
    ..Thus, we propose to understand the role of the interaction in mouse models of disease. ..
  3. REGULATION OF INTESTINAL EPITHELIAL CHEMOKINE SECRETION
    Andrew Gewirtz; Fiscal Year: 2002
    ..In addition to containing an extensive array of basic research equipment, this lab space contains a new thermostatted spectrofluorimeter to be used primarily by Dr. Gewirtz. ..
  4. Flagellin-induced gut epithelial chemokine secretion
    Andrew T Gewirtz; Fiscal Year: 2010
    ..Thus, we propose to understand the role of the interaction in mouse models of disease. ..
  5. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The overall goal of this application is to leverage our ongoing studies on flagellin-induced gut epithelial chemokine secretion to begin to develop a new paradigm of protection against pandemic infection. ..
  6. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2009
    ..Thus, we propose to understand the role of the interaction in mouse models of disease. ..
  7. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2007
    ..In vitro and in vivo models will be utilized. ..
  8. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2006
    ..In vitro and in vivo models will be utilized. ..
  9. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2005
    ..In vitro and in vivo models will be utilized. ..
  10. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2004
    ..In vitro and in vivo models will be utilized. ..
  11. Flagellin-induced gut epithelial chemokine secretion
    Andrew Gewirtz; Fiscal Year: 2003
    ..In vitro and in vivo models will be utilized. ..