THERESA WANZOR GAUTHIER

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency
    T W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Matern Fetal Med 9:252-4. 2000
  2. ncbi Maternal alcohol use during pregnancy causes systemic oxidation of the glutathione redox system
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 34:123-30. 2010
  3. ncbi Delayed neonatal lung macrophage differentiation in a mouse model of in utero ethanol exposure
    Theresa W Gauthier
    Emory Univ Dept of Pediatrics, Division of Neonatal Perinatal Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 299:L8-16. 2010
  4. ncbi Maternal alcohol abuse and neonatal infection
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Alcohol Clin Exp Res 29:1035-43. 2005
  5. ncbi Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Atlanta, GA 30322, USA
    Pediatr Res 57:76-81. 2005
  6. ncbi Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns?
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Alcohol 33:139-45. 2004
  7. ncbi In vivo dysfunction of the term alveolar macrophage after in utero ethanol exposure
    Xiao Du Ping
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 31:308-16. 2007
  8. ncbi In utero ethanol exposure impairs defenses against experimental group B streptococcus in the term Guinea pig lung
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 33:300-6. 2009
  9. ncbi Impaired terminal differentiation of pulmonary macrophages in a Guinea pig model of chronic ethanol ingestion
    Sheena D Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 33:1782-93. 2009
  10. ncbi Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?
    Lou Ann S Brown
    Department of Pediatrics, Emory University, 2015 Uppergate Drive, NE, Atlanta, GA 30322, USA
    Alcohol 33:191-7. 2004

Research Grants

  1. MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2002
  2. ALCOHOL'S EFFECTS ON THE DEVELOPING ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2006
  3. In Utero Alcohol and Alveolar Macrophage Maturation-A Risk For The Newborn
    THERESA GAUTHIER; Fiscal Year: 2009
  4. In Utero Alcohol and Alveolar Macrophage Maturation-A Risk For The Newborn
    THERESA WANZOR GAUTHIER; Fiscal Year: 2010

Collaborators

Detail Information

Publications13

  1. ncbi Methylene blue-induced hyperbilirubinemia in neonatal glucose-6-phosphate dehydrogenase (G6PD) deficiency
    T W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Matern Fetal Med 9:252-4. 2000
    ..Two neonates were subsequently diagnosed with G6PD deficiency. Continued caution is warranted prior to the use of methylene blue in the gravid female...
  2. ncbi Maternal alcohol use during pregnancy causes systemic oxidation of the glutathione redox system
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 34:123-30. 2010
    ..We hypothesized that maternal alcohol use would increase systemic oxidant stress in the pregnant female, evidenced by an oxidized systemic GSH redox potential...
  3. ncbi Delayed neonatal lung macrophage differentiation in a mouse model of in utero ethanol exposure
    Theresa W Gauthier
    Emory Univ Dept of Pediatrics, Division of Neonatal Perinatal Medicine, 2015 Uppergate Dr NE, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 299:L8-16. 2010
    ..Increased oxidant stress and elevated TGF-beta(1) contributed to the impaired differentiation of both interstitial and alveolar macrophage...
  4. ncbi Maternal alcohol abuse and neonatal infection
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Alcohol Clin Exp Res 29:1035-43. 2005
    ..Since chronic alcohol use suppresses the adult immune system, we tested the hypothesis that maternal alcohol ingestion increases the risk of infection in term newborns...
  5. ncbi Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Atlanta, GA 30322, USA
    Pediatr Res 57:76-81. 2005
    ..These results add a new dimension to the detrimental effects of fetal alcohol exposure on the developing alveolar macrophage, raising the possibility of GSH therapy to augment premature alveolar macrophage function...
  6. ncbi Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns?
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Alcohol 33:139-45. 2004
    ..The effects of maternal alcohol abuse during pregnancy on the risk of infection in the VLBW newborn require further analysis...
  7. ncbi In vivo dysfunction of the term alveolar macrophage after in utero ethanol exposure
    Xiao Du Ping
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 31:308-16. 2007
    ..We hypothesized that dysfunction of the neonatal alveolar macrophage exposed to ETOH in utero would persist at term gestation...
  8. ncbi In utero ethanol exposure impairs defenses against experimental group B streptococcus in the term Guinea pig lung
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 33:300-6. 2009
    ..In utero ethanol (ETOH) exposure deranges the function of both premature and term guinea pig AM. We hypothesized that fetal ETOH exposure would increase the risk of pulmonary infection in vivo...
  9. ncbi Impaired terminal differentiation of pulmonary macrophages in a Guinea pig model of chronic ethanol ingestion
    Sheena D Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 33:1782-93. 2009
    ..In this study, we demonstrated in a guinea pig model that chronic ethanol ingestion significantly impaired alveolar macrophage differentiation and function...
  10. ncbi Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?
    Lou Ann S Brown
    Department of Pediatrics, Emory University, 2015 Uppergate Drive, NE, Atlanta, GA 30322, USA
    Alcohol 33:191-7. 2004
    ..Because chronic oxidative stress alters cellular functions and viability, the lung becomes more susceptible when a second hit such as sepsis occurs...
  11. ncbi Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat
    Lou Ann S Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 292:L824-32. 2007
    ..These results suggested that decreased glutathione availability in the alcoholic lung contribute to alveolar macrophage dysfunction via oxidative stress, resulting in not only decreased function but decreased viability...
  12. ncbi N-acetylcysteine improves group B streptococcus clearance in a rat model of chronic ethanol ingestion
    SONJA M TANG
    Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 33:1197-201. 2009
    ....
  13. ncbi Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia
    Martha H Manar
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Perinatol 24:30-5. 2004
    ..We hypothesized that polymorphisms encoding for less efficient enzymes were associated with bronchopulmonary dysphasia (BPD)...

Research Grants9

  1. MATERNAL ALCOHOL IMPAIRS FETAL ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2002
    ..Understanding the modulatory role of GSH availability in AM function will broaden our understanding of GSH supplements not only as a possible therapy for infants exposed to ETOH in utero but premature infants in general. ..
  2. ALCOHOL'S EFFECTS ON THE DEVELOPING ALVEOLAR MACROPHAGE
    THERESA GAUTHIER; Fiscal Year: 2006
    ..abstract_text> ..
  3. In Utero Alcohol and Alveolar Macrophage Maturation-A Risk For The Newborn
    THERESA GAUTHIER; Fiscal Year: 2009
    ..This pre-clinical application is the first to investigate potential therapeutic interventions for the at-risk neonate exposed to increased oxidative stress, such as occurs with in utero alcohol exposure. ..
  4. In Utero Alcohol and Alveolar Macrophage Maturation-A Risk For The Newborn
    THERESA WANZOR GAUTHIER; Fiscal Year: 2010
    ..This pre-clinical application is the first to investigate potential therapeutic interventions for the at-risk neonate exposed to increased oxidative stress, such as occurs with in utero alcohol exposure. ..