Mary Galinski

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Plasmodium vivax merozoite surface protein-3 (PvMSP3): expression of an 11 member multigene family in blood-stage parasites
    Jianlin Jiang
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e63888. 2013
  2. doi request reprint Plasmodium vivax: modern strategies to study a persistent parasite's life cycle
    Mary R Galinski
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA
    Adv Parasitol 81:1-26. 2013
  3. pmc Two functional reticulocyte binding-like (RBL) invasion ligands of zoonotic Plasmodium knowlesi exhibit differential adhesion to monkey and human erythrocytes
    Amma A Semenya
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Malar J 11:228. 2012
  4. pmc Redefining the expressed prototype SICAvar gene involved in Plasmodium knowlesi antigenic variation
    Stacey A Lapp
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Malar J 8:181. 2009
  5. doi request reprint Monkey malaria kills four humans
    Mary R Galinski
    Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Trends Parasitol 25:200-4. 2009
  6. pmc Plasmodium vivax: who cares?
    Mary R Galinski
    Emory Vaccine Center and Yerkes National Primate Research Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA
    Malar J 7:S9. 2008
  7. ncbi request reprint Merozoite surface protein-9 of Plasmodium vivax and related simian malaria parasites is orthologous to p101/ABRA of P. falciparum
    Esmeralda Vargas-Serrato
    Department of Medicine, Emory Vaccine Research Center, Yerkes Primate Research Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
    Mol Biochem Parasitol 120:41-52. 2002
  8. ncbi request reprint Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population
    Tuan M Tran
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 73:244-55. 2005
  9. ncbi request reprint Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi
    Esmeralda Vargas-Serrato
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, N E, Atlanta, GA 30329, USA
    Infect Genet Evol 3:67-73. 2003
  10. ncbi request reprint Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria
    Ivette Caro-Aguilar
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 7:1324-37. 2005

Collaborators

Detail Information

Publications22

  1. pmc Plasmodium vivax merozoite surface protein-3 (PvMSP3): expression of an 11 member multigene family in blood-stage parasites
    Jianlin Jiang
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 8:e63888. 2013
    ..PvMSP3-α and PvMSP3-β have become genetic markers in epidemiological studies, and are being evaluated as vaccine candidates. This research investigates the gene and protein expression of the entire family and pertinent implications...
  2. doi request reprint Plasmodium vivax: modern strategies to study a persistent parasite's life cycle
    Mary R Galinski
    Department of Medicine, Division of Infectious Diseases, Emory University School of Medicine, Emory University, Atlanta, Georgia, USA
    Adv Parasitol 81:1-26. 2013
    ..Opportunities for research on vivax malaria are increasing with the use of existing and new methodological strategies in combination with modern technologies...
  3. pmc Two functional reticulocyte binding-like (RBL) invasion ligands of zoonotic Plasmodium knowlesi exhibit differential adhesion to monkey and human erythrocytes
    Amma A Semenya
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA
    Malar J 11:228. 2012
    ..One step involves the adhesion of Plasmodium reticulocyte binding-like (RBL) proteins. Plasmodium knowlesi merozoites express only two RBL invasion ligands, known as Normocyte Binding Proteins (PkNBPXa and PkNBPXb)...
  4. pmc Redefining the expressed prototype SICAvar gene involved in Plasmodium knowlesi antigenic variation
    Stacey A Lapp
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA
    Malar J 8:181. 2009
    ..However, in the published P. knowlesi database this gene remains disjointed in five fragments. This study addresses a number of structural and functional questions that are critical for understanding SICAvar gene expression...
  5. doi request reprint Monkey malaria kills four humans
    Mary R Galinski
    Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Trends Parasitol 25:200-4. 2009
    ....
  6. pmc Plasmodium vivax: who cares?
    Mary R Galinski
    Emory Vaccine Center and Yerkes National Primate Research Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Atlanta, GA, USA
    Malar J 7:S9. 2008
    ....
  7. ncbi request reprint Merozoite surface protein-9 of Plasmodium vivax and related simian malaria parasites is orthologous to p101/ABRA of P. falciparum
    Esmeralda Vargas-Serrato
    Department of Medicine, Emory Vaccine Research Center, Yerkes Primate Research Center, Emory University, 954 Gatewood Rd, Atlanta, GA 30329, USA
    Mol Biochem Parasitol 120:41-52. 2002
    ..Comparative interspecies investigations of the potential role(s) of Plasmodium MSP-9 in merozoite invasion of erythrocytes and as a malaria vaccine candidate can now be pursued...
  8. ncbi request reprint Comparison of IgG reactivities to Plasmodium vivax merozoite invasion antigens in a Brazilian Amazon population
    Tuan M Tran
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 73:244-55. 2005
    ....
  9. ncbi request reprint Phylogenetic analysis of CSP and MSP-9 gene sequences demonstrates the close relationship of Plasmodium coatneyi to Plasmodium knowlesi
    Esmeralda Vargas-Serrato
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, N E, Atlanta, GA 30329, USA
    Infect Genet Evol 3:67-73. 2003
    ..vivax. P. coatneyi forms a monophyletic group with P. knowlesi, demonstrating their close relationship despite some very distinctive biological characteristics...
  10. ncbi request reprint Chimeric epitopes delivered by polymeric synthetic linear peptides induce protective immunity to malaria
    Ivette Caro-Aguilar
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Microbes Infect 7:1324-37. 2005
    ..berghei or P. yoelii sporozoites. Collectively, these results suggest that polymeric polypeptide chimeras can be used as a platform to deliver subunit vaccines...
  11. ncbi request reprint Rapid evolution of an erythrocyte invasion gene family: the Plasmodium reichenowi Reticulocyte Binding Like (RBL) genes
    Julian C Rayner
    Division of Parasitic Diseases, Centers for Disease Control and Prevention, National Center for Infectious Diseases, Atlanta, GA 30341, USA
    Mol Biochem Parasitol 133:287-96. 2004
    ..The RBL super-family, therefore, appears to be surprisingly dynamic and divergent, implying that it is involved in species-specific aspects of erythrocyte recognition and invasion...
  12. ncbi request reprint Immunogenicity of Plasmodium vivax merozoite surface protein-9 recombinant proteins expressed in E. coli
    Joseli Oliveira-Ferreira
    Department of Immunology, Institute Oswaldo Cruz, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
    Vaccine 22:2023-30. 2004
    ..We have also used the two PvMSP-9 recombinant constructs to show that individuals exposed to P. vivax infections in an endemic area of Brazil had IgG antibodies reactive with the recombinant proteins...
  13. ncbi request reprint Detection of a Plasmodium vivax erythrocyte binding protein by flow cytometry
    Tuan M Tran
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Cytometry A 63:59-66. 2005
    ..vivax Duffy binding protein region II (PvDBP-RII) recombinant protein as a model. This protein binds to all erythrocytes that express the Duffy receptor (Fy) and discriminates binding between normocytes and reticulocytes...
  14. ncbi request reprint A SICAvar switching event in Plasmodium knowlesi is associated with the DNA rearrangement of conserved 3' non-coding sequences
    Vladimir Corredor
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Mol Biochem Parasitol 138:37-49. 2004
    ..falciparum var genes, function in the stage-specific and developmentally regulated post-transcriptional gene silencing (PTGS) of variant antigen transcripts...
  15. ncbi request reprint Disseminated intravascular coagulation complicated by peripheral gangrene in a rhesus macaque (Macaca mulatta) experimentally infected with Plasmodium coatneyi
    Alberto Moreno
    Emory Vaccine Center and Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 76:648-54. 2007
    ..DIC with peripheral gangrene is very rare in Plasmodium-infected individuals. Our results indicate that the experimental model of P. coatneyi infection of rhesus monkeys is important for studies of malarial anemia and coagulopathy...
  16. ncbi request reprint Variant antigen expression in malaria infections: posttranscriptional gene silencing, virulence and severe pathology
    Mary R Galinski
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Mol Biochem Parasitol 134:17-25. 2004
  17. pmc Genetic linkage of autologous T cell epitopes in a chimeric recombinant construct improves anti-parasite and anti-disease protective effect of a malaria vaccine candidate
    Balwan Singh
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, United States
    Vaccine 28:2580-92. 2010
    ..These studies show that protective efficacy can be significantly improved by inclusion of an array of autologous promiscuous T cell epitopes in vaccine constructs...
  18. pmc The reticulocyte binding-like proteins of P. knowlesi locate to the micronemes of merozoites and define two new members of this invasion ligand family
    Esmeralda V S Meyer
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Mol Biochem Parasitol 165:111-21. 2009
    ..Importantly, PkNBPXa and PkNBPXb are shown here to bind to host erythrocytes, and discussion is centered on the importance of these proteins in host cell invasion...
  19. ncbi request reprint Dramatic difference in diversity between Plasmodium falciparum and Plasmodium vivax reticulocyte binding-like genes
    Julian C Rayner
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30329, USA
    Am J Trop Med Hyg 72:666-74. 2005
    ..Polymorphisms were frequently clustered, suggesting that different RBL domains may be evolving under different selection and functional pressures...
  20. ncbi request reprint Plasmodium vivax merozoite surface protein PvMSP-3 beta is radically polymorphic through mutation and large insertions and deletions
    Julian C Rayner
    Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, MS F 36, 4770 Buford Highway, Atlanta, GA 30341, USA
    Infect Genet Evol 4:309-19. 2004
    ..The implications for PvMSP-3 beta function and vaccine development are discussed...
  21. ncbi request reprint Proteomic studies of Plasmodium knowlesi SICA variant antigens demonstrate their relationship with P. falciparum EMP1
    Cindy C Korir
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30329, USA
    Infect Genet Evol 6:75-9. 2006
    ..These findings provide further validation of the classical in vivo P. knowlesi-rhesus monkey model system for advancing our understanding of the immunobiology of antigenic variation and variant antigen gene expression in Plasmodium...
  22. ncbi request reprint Phylogenetic and structural information on glyceraldehyde-3-phosphate dehydrogenase (G3PDH) in Plasmodium provides functional insights
    Sheila Akinyi
    Emory Vaccine Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Infect Genet Evol 8:205-12. 2008
    ..These sites may prove to be of functional importance and provide insights for drug-targeting studies, as have other regions examined in Leishmania and Toxoplasma G3PDH research...

Research Grants18

  1. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 1999
    ....
  2. Molecular Mechanisms of Antigenic Variation in Malaria
    Mary R Galinski; Fiscal Year: 2010
    ....
  3. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2009
    ....
  4. Molecular Mechanisms of Antigenic Variation in Malaria
    Mary Galinski; Fiscal Year: 2009
    ....
  5. Molecular Mechanisms of Antigenic Variation in Malaria
    Mary Galinski; Fiscal Year: 2007
    ....
  6. PLASMODIUM VIVAX MSP-3 AND MSP-9 AS VACCINE IMMUNOGENES
    Mary Galinski; Fiscal Year: 2007
    ..vivax vaccine candidates based on these antigens and also serve to establish reliable procedures to test and evaluate antigens in non-human primate models for safety, immunogenicity and efficacy. ..
  7. Molecular Mechanisms of Antigenic Variation in Malaria
    Mary Galinski; Fiscal Year: 2006
    ....
  8. PLASMODIUM VIVAX MSP-3 AND MSP-9 AS VACCINE IMMUNOGENES
    Mary Galinski; Fiscal Year: 2006
    ..vivax vaccine candidates based on these antigens and also serve to establish reliable procedures to test and evaluate antigens in non-human primate models for safety, immunogenicity and efficacy. ..
  9. PLASMODIUM VIVAX MSP-3 AND MSP-9 AS VACCINE IMMUNOGENES
    Mary Galinski; Fiscal Year: 2005
    ..vivax vaccine candidates based on these antigens and also serve to establish reliable procedures to test and evaluate antigens in non-human primate models for safety, immunogenicity and efficacy. ..
  10. PLASMODIUM VIVAX MSP-3 AND MSP-9 AS VACCINE IMMUNOGENES
    Mary Galinski; Fiscal Year: 2004
    ..vivax vaccine candidates based on these antigens and also serve to establish reliable procedures to test and evaluate antigens in non-human primate models for safety, immunogenicity and efficacy. ..
  11. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2004
    ..Selected proteins will also be tested for their safety, immunogenicity and efficacy as immunogens in Saimiri monkeys. ..
  12. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2003
    ..Selected proteins will also be tested for their safety, immunogenicity and efficacy as immunogens in Saimiri monkeys. ..
  13. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2002
    ..Selected proteins will also be tested for their safety, immunogenicity and efficacy as immunogens in Saimiri monkeys. ..
  14. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2001
    ..Selected proteins will also be tested for their safety, immunogenicity and efficacy as immunogens in Saimiri monkeys. ..
  15. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary Galinski; Fiscal Year: 2000
    ....
  16. MOLECULAR ANALYSIS OF PLASMODIUM VIVAX SURFACE ANTIGENS
    Mary R Galinski; Fiscal Year: 2010
    ....