Research Topics
Species | Harold FranchSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Molecular signaling pathways regulating muscle proteolysis during atrophyHarold A Franch
Renal Division, Emory University, Atlanta, GA 30322, USA
Curr Opin Clin Nutr Metab Care 8:271-5. 2005..When levels of insulin or insulin-like growth factor-1 are insufficient or inflammatory cytokine production is increased, muscle atrophy ensues...- Modification of the epidermal growth factor response by ammonia in renal cell hypertrophyH A Franch
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Am Soc Nephrol 11:1631-8. 2000.... 
Nutrition and muscle catabolism in maintenance hemodialysis: does feeding make muscle cells selective self-eaters?Harold A Franch
Research Service, Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA
J Ren Nutr 19:86-90. 2009..Replacement of oxidized and other damaged proteins may be a benefit of protein feeding in hemodialysis, but alternative strategies, including exercise, will be required to build muscle...- Kidney growth during catabolic illness: what it does not destroy makes it grow strongerHarold A Franch
Research Service, Atlanta Department of Veterans Affairs Medical Center, Decatur, Georgia
J Ren Nutr 17:167-72. 2007..Diabetes mellitus activates signaling through this pathway in the kidney while down-regulating it in skeletal muscle. We conclude that similar signaling pathways may regulate distinct proteolytic pathways in different tissues... - Navigating between the Scylla and Charybdis of prescribing dietary protein for chronic kidney diseasesHarold A Franch
Research Service, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
Annu Rev Nutr 29:341-64. 2009..We have examined how dietary protein influences the mechanisms causing protein wasting, and we propose a framework for approaching the variable dietary protein requirements in patients with CKD or end-stage kidney disease... - Acidosis impairs insulin receptor substrate-1-associated phosphoinositide 3-kinase signaling in muscle cells: consequences on proteolysisHarold A Franch
Renal Divisioin, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Physiol Renal Physiol 287:F700-6. 2004..We conclude that acidosis accelerates protein degradation by impairing insulin signaling through PI3K in muscle cells... - Pathways of proteolysis affecting renal cell growthHarold A Franch
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA and Atlanta Veterans Affairs Medical Center, Decatur, Georgia, USA
Curr Opin Nephrol Hypertens 11:445-50. 2002.... - Phosphatidylinositol 3-kinase activity is required for epidermal growth factor to suppress proteolysisHarold A Franch
Renal Division, Department of Medicine, Emory University School of Medicine, W M B, Room 338, 1639 Pierce Drive NE, Atlanta, GA 30322, USA
J Am Soc Nephrol 13:903-9. 2002..It was concluded that EGF suppresses proteolysis by a mechanism that involves Ras and class 1 PI 3-kinase... - Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cellsWen Shen
Address correspondence to Dr Harold A Franch, Renal Division, Emory University School of Medicine, W M B, Room 338, 1639 Pierce Drive, N E, Atlanta, GA 30322, USA
J Am Soc Nephrol 17:2414-23. 2006..Rapamycin has a novel effect of regulating proteasomal proteolysis in cells that are stimulated with EGF... - Getting to the meat of the matter: beyond protein supplementation in maintenance dialysisJames L Bailey
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Semin Dial 22:512-8. 2009..A supplementary exercise program would allow recovery of lean body mass. Given the multiple co-morbidities that exist in this population, therapy would have to be individualized... - Suppression of chaperone-mediated autophagy in the renal cortex during acute diabetes mellitusSira Sooparb
Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, and Atlanta Veterans Afffairs Medical Center, Decatur, Georgia, USA
Kidney Int 65:2135-44. 2004..Because the lysosomal proteolytic pathway of chaperone-mediated autophagy is suppressed by growth factors in cultured cells, we investigated whether the abundance of substrates of this pathway increase in diabetic hypertrophy... - Family members of patients treated for ESRD have high rates of undetected kidney diseaseClaudine Jurkovitz
Emory Center for Outcomes Research, Division of Cardiology, Emory University School of Medicine, Emory University, Atlanta, GA 30306, USA
Am J Kidney Dis 40:1173-8. 2002..Several studies have reported that relatives of patients with ESRD are at risk for kidney disease (KD), but little is known about the prevalence and awareness of CKD in this population, which is the object of this report...
Research Grants
- MECHANISMS OF PROTEIN ACCUMULATION IN RENAL HYPERTROPHYHarold Franch; Fiscal Year: 2002..It should also lay the ground work for further investigations into the mechanisms behind renal hypertrophy. ..
- Is Tissue ACE Required for Diabetic Renal Damage?Harold Franch; Fiscal Year: 2005..We believe that this approach will not only critically test our hypothesis, but will also lay the ground work for future studies into the role of ACE in the diabetic kidney. ..
- Mechanism of Protein Accumulation in Renal HypertrophyHarold A Franch; Fiscal Year: 2010..This proposal studies how this same process may be important for destroying proteins damaged by diabetes that contribute to kidney disease. ..