ANNE MENTRO FITZPATRICK

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 17:375-408. 2012
  2. pmc Severe asthma in childhood: recent advances in phenotyping and pathogenesis
    Anne M Fitzpatrick
    Emory University Department of Pediatrics, Atlanta, Georgia, USA
    Curr Opin Allergy Clin Immunol 12:193-201. 2012
  3. pmc Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    J Allergy Clin Immunol 127:1604-11. 2011
  4. pmc Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 127:382-389.e1-13. 2011
  5. pmc Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 69:154-9. 2011
  6. pmc The molecular phenotype of severe asthma in children
    Anne M Fitzpatrick
    Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 125:851-857.e18. 2010
  7. pmc Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 124:990-6.e1-9. 2009
  8. doi request reprint Tablet and inhaled controller medication refill frequencies in children with asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pediatr Nurs 24:81-9. 2009
  9. pmc Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 123:146-152.e8. 2009
  10. pmc Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 121:1372-8, 1378.e1-3. 2008

Collaborators

Detail Information

Publications15

  1. pmc Glutathione redox control of asthma: from molecular mechanisms to therapeutic opportunities
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 17:375-408. 2012
    ..We then review the literature related to GSH redox balance in health and asthma, with an emphasis on human studies. Finally, therapeutic opportunities to restore the GSH redox balance in subjects with asthma are discussed...
  2. pmc Severe asthma in childhood: recent advances in phenotyping and pathogenesis
    Anne M Fitzpatrick
    Emory University Department of Pediatrics, Atlanta, Georgia, USA
    Curr Opin Allergy Clin Immunol 12:193-201. 2012
    ..This review will discuss phenotypic and pathogenic aspects of severe asthma in childhood, as well as remaining knowledge gaps...
  3. pmc Thiol redox disturbances in children with severe asthma are associated with posttranslational modification of the transcription factor nuclear factor (erythroid-derived 2)-like 2
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University, Atlanta, GA, USA
    J Allergy Clin Immunol 127:1604-11. 2011
    ..Airway thiol redox disturbances, including depletion of the antioxidant, glutathione, are differentiating features of severe asthma in children...
  4. pmc Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 127:382-389.e1-13. 2011
    ..Although unsupervised cluster analysis is a useful tool for identifying phenotypes, it has not been applied to school-age children with persistent asthma across a wide range of severities...
  5. pmc Glutathione oxidation is associated with airway macrophage functional impairment in children with severe asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Res 69:154-9. 2011
    ..Severe asthma in children is characterized by altered airway and intracellular AM GSH homeostasis that translates to impaired AM function. Interventions to restore airway GSH homeostasis may be warranted in children with severe asthma...
  6. pmc The molecular phenotype of severe asthma in children
    Anne M Fitzpatrick
    Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 125:851-857.e18. 2010
    ..Although the clinical attributes of severe asthma in children have been well described, the differentiating features of the lower airway inflammatory response are less understood...
  7. pmc Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 124:990-6.e1-9. 2009
    ..Children with severe allergic asthma have persistent airway inflammation and oxidant stress...
  8. doi request reprint Tablet and inhaled controller medication refill frequencies in children with asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Pediatr Nurs 24:81-9. 2009
    ..41%, p = .03). Refills peaked at the first month and incrementally declined (p < .05). Expanded asthma education did not increase refill frequency. Other methods of improving medication adherence may be warranted in this population...
  9. pmc Airway glutathione homeostasis is altered in children with severe asthma: evidence for oxidant stress
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 123:146-152.e8. 2009
    ..Severe asthma is characterized by persistent airway inflammation and increased formation of reactive oxygen species...
  10. pmc Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 121:1372-8, 1378.e1-3. 2008
    ..Lower respiratory tract infection is a differentiating feature of children with poorly controlled asthma...
  11. pmc Features of severe asthma in school-age children: Atopy and increased exhaled nitric oxide
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Allergy Clin Immunol 118:1218-25. 2006
    ..Children with severe asthma have persistent symptoms despite treatment with inhaled corticosteroids (ICSs). The differentiating features of severe asthma in children are poorly defined...
  12. pmc Breath formate is a marker of airway S-nitrosothiol depletion in severe asthma
    Roby Greenwald
    Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
    PLoS ONE 5:e11919. 2010
    ..We therefore hypothesize that depletion of airway SNOs is related to asthma pathology, and breath formate concentration may be a proxy measure of SNO catabolism...
  13. pmc Alterations of the arginine metabolome in asthma
    Abigail Lara
    Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    Am J Respir Crit Care Med 178:673-81. 2008
    ..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation...
  14. ncbi request reprint Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation
    Ronald L Sorkness
    Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
    J Appl Physiol (1985) 104:394-403. 2008
    ..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component...
  15. pmc Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program
    Wendy C Moore
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 119:405-13. 2007
    ..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important...

Research Grants4

  1. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2007
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  2. Pediatric Severe Asthma: Role of Oxidant Stress and Alveolar Macrophage Function
    Anne Fitzpatrick; Fiscal Year: 2009
    ..This proposal will lay the foundation for further studies, and the mechanisms identified may ultimately be targeted in future interventional trials. ..
  3. Redox disturbances and corticosteroid responses in children with severe asthma
    ANNE MENTRO FITZPATRICK; Fiscal Year: 2010
    ..The purpose of this study is to understand whether corticosteroid insensitivity is a feature of severe asthma in children and whether oxidant stress regulates the response to corticosteroids in these children. ..