Research Topics


YUE contact FENG


Affiliation: Emory University
Country: USA


  1. Mandler M, Ku L, Feng Y. A cytoplasmic quaking I isoform regulates the hnRNP F/H-dependent alternative splicing pathway in myelinating glia. Nucleic Acids Res. 2014;42:7319-29 pubmed publisher
    ..Together, our studies provide the first evidence that cytoplasmic QKI-6 acts upstream of hnRNP F/H, which forms a novel pathway to control AS in myelinating glia. ..
  2. Tan X, Chen Y, Li J, Li X, Miao Z, Xin N, et al. The inhibition of Cdk5 activity after hypoxia/ischemia injury reduces infarct size and promotes functional recovery in neonatal rats. Neuroscience. 2015;290:552-60 pubmed publisher
    ..Therefore, Cdk5 inhibition by the small peptide p5-TAT or its derivatives is a promising therapeutic strategy for the treatment of ischemic brain injury including hypoxic-ischemic encephalopathy and stroke. ..
  3. Feng Y. Convergence and divergence in the etiology of myelin impairment in psychiatric disorders and drug addiction. Neurochem Res. 2008;33:1940-9 pubmed publisher
    ..Importantly, OL defect is not only a pathological consequence but also a causative factor for dopaminergic dysfunction. Hence, myelin impairment is a key factor in the pathogenic loop of psychiatric diseases and drug addiction. ..
  4. Li W, Allen M, Rui Y, Ku L, Liu G, Bankston A, et al. p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses. J Neurosci. 2016;36:11283-11294 pubmed
  5. Chen X, Ku L, Mei R, Liu G, Xu C, Wen Z, et al. Novel schizophrenia risk factor pathways regulate FEZ1 to advance oligodendroglia development. Transl Psychiatry. 2017;7:1293 pubmed publisher
    ..These observations have uncovered novel pathways that involve multifaceted genetic lesions and/or epigenetic dysregulations in schizophrenia, which converge on FEZ1 regulation and cause OL impairment in neuropsychiatric disorders. ..