William E Fantegrossi

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
    W E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 83:122-9. 2006
  2. ncbi Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 88:358-65. 2008
  3. ncbi The behavioral pharmacology of hallucinogens
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Biochem Pharmacol 75:17-33. 2008
  4. ncbi Reinforcing effects of methylenedioxy amphetamine congeners in rhesus monkeys: are intravenous self-administration experiments relevant to MDMA neurotoxicity?
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 189:471-82. 2007
  5. ncbi Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    Behav Pharmacol 16:627-33. 2005
  6. ncbi Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 181:529-36. 2005
  7. ncbi Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 181:496-503. 2005
  8. ncbi Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice
    James E Goeders
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 93:67-74. 2009
  9. ncbi MDMA-like behavioral effects of N-substituted piperazines in the mouse
    H L Yarosh
    Neuroscience and Behavioral Biology Program, Emory University, Atlanta, GA, United States
    Pharmacol Biochem Behav 88:18-27. 2007
  10. ncbi A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse
    W E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Neuroscience 151:533-43. 2008

Research Grants

  1. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007

Detail Information

Publications19

  1. ncbi Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats
    W E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 83:122-9. 2006
    ....
  2. ncbi Hallucinogen-like effects of N,N-dipropyltryptamine (DPT): possible mediation by serotonin 5-HT1A and 5-HT2A receptors in rodents
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 88:358-65. 2008
    ....
  3. ncbi The behavioral pharmacology of hallucinogens
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Biochem Pharmacol 75:17-33. 2008
    ..As clinical interest in the therapeutic potential of these compounds is once again beginning to emerge, it is important to recognize the wealth of data derived from controlled preclinical studies on these compounds...
  4. ncbi Reinforcing effects of methylenedioxy amphetamine congeners in rhesus monkeys: are intravenous self-administration experiments relevant to MDMA neurotoxicity?
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 189:471-82. 2007
    ....
  5. ncbi Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA
    Behav Pharmacol 16:627-33. 2005
    ..Such pharmacological differences among these kappa-opioids raise the possibility that the development of other diterpene-based opioids may yield important therapeutic compounds...
  6. ncbi Serotonin synthesis inhibition reveals distinct mechanisms of action for MDMA and its enantiomers in the mouse
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 181:529-36. 2005
    ..Drug challenges in "intact" and p-chlorophenylalanine (p-CPA)-treated animals can be used to distinguish agents that act as direct serotonin (5-HT) agonists from agents that function as 5-HT releasers...
  7. ncbi Hallucinogen-like actions of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in mice and rats
    William E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Psychopharmacology (Berl) 181:496-503. 2005
    ..Few studies have examined the effects of 2,5-dimethoxy-4-(n)-propylthiophenethylamine (2C-T-7) in vivo...
  8. ncbi Escalation of food-maintained responding and sensitivity to the locomotor stimulant effects of cocaine in mice
    James E Goeders
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road, Atlanta, GA 30322, USA
    Pharmacol Biochem Behav 93:67-74. 2009
    ....
  9. ncbi MDMA-like behavioral effects of N-substituted piperazines in the mouse
    H L Yarosh
    Neuroscience and Behavioral Biology Program, Emory University, Atlanta, GA, United States
    Pharmacol Biochem Behav 88:18-27. 2007
    ..Their structural analogues, however, do not share these behavioral profiles. Further studies into the relationships between the N-substituted piperazines and MDMA are warranted...
  10. ncbi A comparison of the physiological, behavioral, neurochemical and microglial effects of methamphetamine and 3,4-methylenedioxymethamphetamine in the mouse
    W E Fantegrossi
    Division of Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Drive, Atlanta, GA 30322, USA
    Neuroscience 151:533-43. 2008
    ..The finding that METH, but not MDMA, induces microglial effects in the striatum consistent with neurotoxicity might imply different mechanisms of toxic action for these two psychostimulants...
  11. ncbi Discriminative stimulus effects of psychostimulants and hallucinogens in S(+)-3,4-methylenedioxymethamphetamine (MDMA) and R(-)-MDMA trained mice
    K S Murnane
    Emory University, Neuroscience Graduate Program, Atlanta, Georgia, USA
    J Pharmacol Exp Ther 331:717-23. 2009
    ..These data suggest that qualitative differences in the discriminative stimulus effects of each stereoisomer of MDMA exist in mice and further our understanding of the complex nature of the interoceptive effects of MDMA...
  12. ncbi Endocrine and neurochemical effects of 3,4-methylenedioxymethamphetamine and its stereoisomers in rhesus monkeys
    K S Murnane
    Division of Neuroscience, Yerkes National Primate Research Center, Atlanta, Georgia 30322, USA
    J Pharmacol Exp Ther 334:642-50. 2010
    ....
  13. ncbi In vivo pharmacology of MDMA and its enantiomers in rhesus monkeys
    William E Fantegrossi
    Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205 7199, USA
    Exp Clin Psychopharmacol 16:1-12. 2008
    ..The non-human primate studies reviewed herein caution that any results obtained in vivo with the MDMA enantiomers may not be particularly informative with regards to the racemate and vice versa...
  14. ncbi 3,4-Methylenedioxymethamphetamine (MDMA, "ecstasy") and its stereoisomers as reinforcers in rhesus monkeys: serotonergic involvement
    William E Fantegrossi
    Department of Psychology (Biopsychology Program, University of Michigan, Ann Arbor, MI 48109-1109, USA
    Psychopharmacology (Berl) 161:356-64. 2002
    ..CONCLUSIONS: MDMA and its stereoisomers serve as reinforcers in rhesus monkeys. We suggest that stimulation of 5-HT(2A) receptors is integral to the reinforcing effects of MDMA...
  15. ncbi Behavioral and neurochemical consequences of long-term intravenous self-administration of MDMA and its enantiomers by rhesus monkeys
    William E Fantegrossi
    Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48101 0632, USA
    Neuropsychopharmacology 29:1270-81. 2004
    ..The reinforcing effects of MDMA are selectively attenuated by chronic MDMA self-administration, although this behavioral change appears to occur in the absence of any frank neurochemical correlates of toxicity...
  16. ncbi Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice
    William E Fantegrossi
    Department of Pharmacology, Medical School, University of Michigan, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
    Psychopharmacology (Berl) 173:270-7. 2004
    ..No selective antagonists for the effects of MDMA have yet been identified. The structurally-similar, naturally-occurring plant alkaloid nantenine (9,10-methylenedioxy-1,2 dimethoxyaporphine) may represent such a compound...
  17. ncbi Pharmacological characterization of the effects of 3,4-methylenedioxymethamphetamine ("ecstasy") and its enantiomers on lethality, core temperature, and locomotor activity in singly housed and crowded mice
    William E Fantegrossi
    Department of Pharmacology, University of Michigan, Medical School, 1301 MSRB III, Ann Arbor, MI 48109 0632, USA
    Psychopharmacology (Berl) 166:202-11. 2003
    ..Few studies have directly compared the effects of methylenedioxymethamphetamine (MDMA, "ecstasy") and its enantiomers across measures...
  18. ncbi The value of nonhuman primates in drug abuse research
    Elise M Weerts
    Division of Behavioral Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    Exp Clin Psychopharmacol 15:309-27. 2007
    ..This review focuses on important species differences between rodents and NHP and on the value of NHP in bridging the gap between rodents and humans to enhance the ability to generalize preclinical findings to human drug abuse...
  19. ncbi MDMA use and neurocognition: a meta-analytic review
    Ari D Kalechstein
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at the University of California, Los Angeles, CA 90024, USA
    Psychopharmacology (Berl) 189:531-7. 2007
    ..To determine the association between MDMA misuse and neurocognition using meta-analysis...

Research Grants1

  1. Effects of self-administered MDMA on brain and behavior in rhesus monkeys
    William Fantegrossi; Fiscal Year: 2007
    ..Thus, these studies are likely to be more relevant to the potential human condition of MDMA-induced lasting neurochemical alterations and behavioral changes ..