Xian Fan

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats
    Xian Fan
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, 615 Michael St, Ste 205, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 305:L267-77. 2013
  2. ncbi request reprint Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells
    X Fan
    Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    Am J Physiol Endocrinol Metab 280:E103-11. 2001
  3. pmc Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats
    Xian Fan
    Pulmonary Section, Atlanta VAMC, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 35:1866-75. 2011
  4. ncbi request reprint Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion
    Xian Fan
    Department of Medicine, Emory University Medical School and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Biol Chem 278:10232-8. 2003
  5. ncbi request reprint Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells
    Xian Fan
    Department of Medicine, Veterans Affairs Medical Center, VAMC 151, 1670 Clairmont Road, Decatur, GA 30033, USA
    Endocrinology 145:751-9. 2004
  6. ncbi request reprint Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells
    Xian Fan
    Department of Medicine, VA Medical Center Emory University Medical School, Atlanta, Georgia 30033, USA
    J Cell Biochem 93:807-18. 2004
  7. ncbi request reprint Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2
    Xian Fan
    Department of Medicine, Emory University School of Medicine and the Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Cell Physiol 207:454-60. 2006
  8. ncbi request reprint Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK
    Janet Rubin
    Department of Medicine, Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia 30033, USA
    J Biol Chem 278:34018-25. 2003
  9. pmc Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats
    Pratibha C Joshi
    Atlanta Veterans Affairs Medical Center VAMC 151 P, 1670 Clairmont Road, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 41:207-16. 2009
  10. ncbi request reprint Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase
    Janet Rubin
    Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Biol Chem 281:1412-8. 2006

Detail Information

Publications21

  1. pmc Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats
    Xian Fan
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, 615 Michael St, Ste 205, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 305:L267-77. 2013
    ..Furthermore, this study suggests that activating the Nrf2/ARE pathway with the dietary supplement sulforaphane could augment antioxidant defenses and lung health in HIV-1-infected individuals. ..
  2. ncbi request reprint Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells
    X Fan
    Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    Am J Physiol Endocrinol Metab 280:E103-11. 2001
    ..Increasing mMCSF above basal levels does not further enhance osteoclast formation from BMMs, indicating that mMCSF does not play a dominant regulatory role in the bone marrow...
  3. pmc Chronic alcohol ingestion exacerbates lung epithelial barrier dysfunction in HIV-1 transgenic rats
    Xian Fan
    Pulmonary Section, Atlanta VAMC, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 35:1866-75. 2011
    ..Although alcohol ingestion and HIV-1 transgene expression have been shown to independently cause oxidative stress and disrupt alveolar epithelial barrier function in experimental models, their interactive effects have not been examined...
  4. ncbi request reprint Nitric oxide donors inhibit luciferase expression in a promoter-independent fashion
    Xian Fan
    Department of Medicine, Emory University Medical School and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Biol Chem 278:10232-8. 2003
    ..Thus, the use of luciferase reporter systems to study transcriptional regulation by NO should be attempted with caution...
  5. ncbi request reprint Nitric oxide regulates receptor activator of nuclear factor-kappaB ligand and osteoprotegerin expression in bone marrow stromal cells
    Xian Fan
    Department of Medicine, Veterans Affairs Medical Center, VAMC 151, 1670 Clairmont Road, Decatur, GA 30033, USA
    Endocrinology 145:751-9. 2004
    ..Thus, drugs and conditions that cause local increase in NO formation in bone may have positive effects on bone remodeling...
  6. ncbi request reprint Regulation of RANKL promoter activity is associated with histone remodeling in murine bone stromal cells
    Xian Fan
    Department of Medicine, VA Medical Center Emory University Medical School, Atlanta, Georgia 30033, USA
    J Cell Biochem 93:807-18. 2004
    ..Preventing deacetylation, however, blocks 1,25(OH)2D3 action on this gene. Chromatin remodeling is therefore involved in RANKL expression...
  7. ncbi request reprint Response to mechanical strain in an immortalized pre-osteoblast cell is dependent on ERK1/2
    Xian Fan
    Department of Medicine, Emory University School of Medicine and the Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Cell Physiol 207:454-60. 2006
    ....
  8. ncbi request reprint Mechanical strain differentially regulates endothelial nitric-oxide synthase and receptor activator of nuclear kappa B ligand expression via ERK1/2 MAPK
    Janet Rubin
    Department of Medicine, Veterans Affairs Medical Center and Emory University School of Medicine, Atlanta, Georgia 30033, USA
    J Biol Chem 278:34018-25. 2003
    ..Our data suggest that physiologic levels of mechanical strain utilize ERK1/2 kinase to coordinately regulate eNOS and RANKL in a manner leading to positive bone remodeling...
  9. pmc Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats
    Pratibha C Joshi
    Atlanta Veterans Affairs Medical Center VAMC 151 P, 1670 Clairmont Road, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 41:207-16. 2009
    ....
  10. ncbi request reprint Mechanical inhibition of RANKL expression is regulated by H-Ras-GTPase
    Janet Rubin
    Department of Medicine, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    J Biol Chem 281:1412-8. 2006
    ..By partitioning signals this way, cells may be able to generate different downstream responses through seemingly similar signaling cascades...
  11. ncbi request reprint Alcohol causes alveolar epithelial oxidative stress by inhibiting the nuclear factor (erythroid-derived 2)-like 2-antioxidant response element signaling pathway
    J Spencer Jensen
    Atlanta Veterans Affairs Medical Center, Decatur, GA, USA
    Am J Respir Cell Mol Biol 48:511-7. 2013
    ....
  12. ncbi request reprint Activation of extracellular signal-regulated kinase is involved in mechanical strain inhibition of RANKL expression in bone stromal cells
    Janet Rubin
    Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    J Bone Miner Res 17:1452-60. 2002
    ..This suggests that JNK may represent an accessory pathway for mechanical transduction in bone cells. Our data indicate that strain modulation of RANKL expression involves activation of MAPK pathways...
  13. pmc Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats
    Alberto L Fernandez
    Atlanta VA Medical Center, Atlanta, GA 30033, USA
    Alcohol 41:371-9. 2007
    ..Therefore, these findings suggest that changes in claudin expression in the alveolar epithelium produce a "leakier" phenotype that renders the alcoholic lung susceptible to alveolar flooding during acute inflammatory stresses...
  14. pmc Zinc supplementation restores PU.1 and Nrf2 nuclear binding in alveolar macrophages and improves redox balance and bacterial clearance in the lungs of alcohol-fed rats
    Ashish J Mehta
    Atlanta VAMC, Emory University School of Medicine, Atlanta, GA 30033, USA
    Alcohol Clin Exp Res 35:1519-28. 2011
    ..1. In parallel, the antioxidant response element signals via the transcription factor Nrf2. However, the role of zinc bioavailability on these signaling pathways within the alveolar space is unknown...
  15. ncbi request reprint Caveolin-1 knockout mice have increased bone size and stiffness
    Janet Rubin
    Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Bone Miner Res 22:1408-18. 2007
    ..Cell studies showed that cav-1 deficiency leads to increased osteoblast differentiation. These results suggest that cav-1 helps to maintain osteoblast progenitors in a less differentiated state...
  16. ncbi request reprint IGF-I secretion by prostate carcinoma cells does not alter tumor-bone cell interactions in vitro or in vivo
    Janet Rubin
    Department of Medicine, Emory University and VAMC, Decatur, Georgia
    Prostate 66:789-800. 2006
    ..IGF-I is an important growth and differentiative factor for osteoblasts and may have a role in defining prostate cancer risk and skeletal metastases...
  17. ncbi request reprint Detection of endothelial nitric oxide release with the 2,3-diaminonapthalene assay
    Dean J Kleinhenz
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, GA, USA
    Free Radic Biol Med 34:856-61. 2003
    ..Our findings emphasize that NO3-reduction may be required to enable the DAN assay to detect small amounts of NO produced by cultured endothelial cells...
  18. pmc Alterations in the immuno-skeletal interface drive bone destruction in HIV-1 transgenic rats
    Tatyana Vikulina
    Division of Endocrinology and Metabolism and Lipids, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 107:13848-53. 2010
    ..Understanding the mechanisms driving bone loss in HIV-infected individuals will be critical to developing effective therapeutic strategies...
  19. pmc HIV-1-transgene expression in rats decreases alveolar macrophage zinc levels and phagocytosis
    Pratibha C Joshi
    Department of Medicine, Atlanta Veterans Affairs Medical Center, and Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Am J Respir Cell Mol Biol 39:218-26. 2008
    ....
  20. pmc Chronic alcohol ingestion primes the lung for bleomycin-induced fibrosis in mice
    Viranuj Sueblinvong
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, Georgia
    Alcohol Clin Exp Res 38:336-43. 2014
    ..Therefore, we hypothesized that alcohol ingestion could promote aberrant fibrosis following experimental ALI and that treatment with the glutathione precursor s-adenosylmethionine (SAMe) could mitigate these effects...
  21. pmc The role of nitric oxide in the mechanical repression of RANKL in bone stromal cells
    Jill Rahnert
    Applied Physiology, Georgia Institute of Technology College of Sciences, Atlanta GA 30332, USA
    Bone 43:48-54. 2008
    ..While our results confirm the importance of NO in the mechanical control of skeletal remodeling, they also suggest alternative signaling pathways by which mechanical force can produce anti-catabolic effects on the skeleton...