Research Topics
| MICHAEL PHILIP EPSTEINSummaryAffiliation: Emory University Country: USA Publications
Research Grants
| Collaborators
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Detail Information
Publications
A simple and improved correction for population stratification in case-control studiesMichael P Epstein
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Hum Genet 80:921-30. 2007..and find no association between the LCT locus and tall/short status. Using simulated data, we show that our approach yields a more appropriate correction for stratification than does principal components or genomic control...
Improved association analyses of disease subtypes in case-parent triadsMichael P Epstein
Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
Genet Epidemiol 30:209-19. 2006....- A tobit variance-component method for linkage analysis of censored trait dataMichael P Epstein
Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
Am J Hum Genet 72:611-20. 2003.... - Genetic association analysis using data from triads and unrelated subjectsMichael P Epstein
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Hum Genet 76:592-608. 2005..Our approach also allows for flexible modeling and estimation of allele effects, as well as for missing parental data. We illustrate the usefulness of our approach using SNP data from a candidate-gene study of psoriasis... - Inference on haplotype effects in case-control studies using unphased genotype dataMichael P Epstein
Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA
Am J Hum Genet 73:1316-29. 2003..We also assess the accuracy of asymptotic confidence intervals for relative-risk parameters for haplotype effects, by a simulation study based on the FUSION data... - Comparison of prospective and retrospective methods for haplotype inference in case-control studiesGlen A Satten
Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Genet Epidemiol 27:192-201. 2004.... - Gender differences in 542 Chinese inpatients with schizophreniaYi lang Tang
Beijing Anding Hospital, Capital Medical University, Beijing, PR China
Schizophr Res 97:88-96. 2007..To investigate gender differences in the onset and other clinical features of Han Chinese inpatients with schizophrenia... - Comment on "Ascertainment adjustment in complex diseases"Michael P Epstein
Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109-2029, USA
Genet Epidemiol 23:209-13. 2002 - A powerful and flexible multilocus association test for quantitative traitsLydia Coulter Kwee
Department of Biostatistics, Emory University, Atlanta, GA 30322, USA
Am J Hum Genet 82:386-97. 2008..Our approach is also flexible, because it allows easy modeling of covariates and, if interest exists, high-dimensional interactions among tagSNPs and environmental predictors... - A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10Satoko Shimizu
Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
Am J Med Genet A 130:372-7. 2004.... - Powerful SNP-set analysis for case-control genome-wide association studiesMichael C Wu
Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Am J Hum Genet 86:929-42. 2010..When the correlation is low, both individual-SNP analysis and the SNP-set analysis tend to have low power. We apply SNP-set analysis to analyze the Cancer Genetic Markers of Susceptibility (CGEMS) breast cancer GWAS discovery-phase data... - Fragile X-associated primary ovarian insufficiency: evidence for additional genetic contributions to severityJessica Ezzell Hunter
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Genet Epidemiol 32:553-9. 2008..This result is important for proper counseling of women who carry FMR1 premutation alleles and for guidance of future studies to identify additional genes that influence ovarian insufficiency... - Ascertainment-adjusted parameter estimates revisitedMichael P Epstein
Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109-2029, USA
Am J Hum Genet 70:886-95. 2002.... - Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adultsElisabeth B Binder
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
JAMA 299:1291-305. 2008..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability... - Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophySayoko E Moroi
Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA
Am J Ophthalmol 135:461-70. 2003..To evaluate the clinical history, histopathology, and genetics of posterior polymorphous corneal dystrophy (PPMD) in a woman with a prominent retrocorneal membrane... - Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cellsCharles M Krafchak
Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA
Am J Hum Genet 77:694-708. 2005.... - Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African AmericansYi lang Tang
Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, CT, USA
Eur J Hum Genet 15:878-83. 2007..0025 and 0.0036, respectively). The data support the validity of prior reported associations and underscore the importance of analyzing multiple SNPs across DBH in future association studies examining disease and biochemical phenotypes... - Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor geneRebekah G Bradley
Atlanta VA Medical Center, Georgia, USA
Arch Gen Psychiatry 65:190-200. 2008..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression... - A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14Kaisa Silander
Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
Diabetes 53:821-9. 2004....
Research Grants
- Novel Statistical Methods for Human Gene MappingMichael Epstein; Fiscal Year: 2007..Finally, this project will be opportunistic in identifying and addressing unforseen statistical problems arising in human gene mapping studies. ..
- Novel Statistical Methods for Human Gene MappingMICHAEL PHILIP EPSTEIN; Fiscal Year: 2010..Finally, this project will be opportunistic in identifying and addressing unforseen statistical problems arising in human gene mapping studies. ..