MICHAEL PHILIP EPSTEIN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc A simple and improved correction for population stratification in case-control studies
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 80:921-30. 2007
  2. ncbi request reprint Improved association analyses of disease subtypes in case-parent triads
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    Genet Epidemiol 30:209-19. 2006
  3. pmc A tobit variance-component method for linkage analysis of censored trait data
    Michael P Epstein
    Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 72:611-20. 2003
  4. pmc Genetic association analysis using data from triads and unrelated subjects
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 76:592-608. 2005
  5. pmc Inference on haplotype effects in case-control studies using unphased genotype data
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA
    Am J Hum Genet 73:1316-29. 2003
  6. ncbi request reprint Comparison of prospective and retrospective methods for haplotype inference in case-control studies
    Glen A Satten
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Epidemiol 27:192-201. 2004
  7. ncbi request reprint Gender differences in 542 Chinese inpatients with schizophrenia
    Yi lang Tang
    Beijing Anding Hospital, Capital Medical University, Beijing, PR China
    Schizophr Res 97:88-96. 2007
  8. ncbi request reprint Comment on "Ascertainment adjustment in complex diseases"
    Michael P Epstein
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 23:209-13. 2002
  9. pmc A powerful and flexible multilocus association test for quantitative traits
    Lydia Coulter Kwee
    Department of Biostatistics, Emory University, Atlanta, GA 30322, USA
    Am J Hum Genet 82:386-97. 2008
  10. pmc A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10
    Satoko Shimizu
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Am J Med Genet A 130:372-7. 2004

Research Grants

  1. Novel Statistical Methods for Human Gene Mapping
    Michael Epstein; Fiscal Year: 2007
  2. Novel Statistical Methods for Human Gene Mapping
    MICHAEL PHILIP EPSTEIN; Fiscal Year: 2010

Detail Information

Publications19

  1. pmc A simple and improved correction for population stratification in case-control studies
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 80:921-30. 2007
    ..and find no association between the LCT locus and tall/short status. Using simulated data, we show that our approach yields a more appropriate correction for stratification than does principal components or genomic control...
  2. ncbi request reprint Improved association analyses of disease subtypes in case-parent triads
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    Genet Epidemiol 30:209-19. 2006
    ....
  3. pmc A tobit variance-component method for linkage analysis of censored trait data
    Michael P Epstein
    Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
    Am J Hum Genet 72:611-20. 2003
    ....
  4. pmc Genetic association analysis using data from triads and unrelated subjects
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 76:592-608. 2005
    ..Our approach also allows for flexible modeling and estimation of allele effects, as well as for missing parental data. We illustrate the usefulness of our approach using SNP data from a candidate-gene study of psoriasis...
  5. pmc Inference on haplotype effects in case-control studies using unphased genotype data
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, GA, 30322, USA
    Am J Hum Genet 73:1316-29. 2003
    ..We also assess the accuracy of asymptotic confidence intervals for relative-risk parameters for haplotype effects, by a simulation study based on the FUSION data...
  6. ncbi request reprint Comparison of prospective and retrospective methods for haplotype inference in case-control studies
    Glen A Satten
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Epidemiol 27:192-201. 2004
    ....
  7. ncbi request reprint Gender differences in 542 Chinese inpatients with schizophrenia
    Yi lang Tang
    Beijing Anding Hospital, Capital Medical University, Beijing, PR China
    Schizophr Res 97:88-96. 2007
    ..To investigate gender differences in the onset and other clinical features of Han Chinese inpatients with schizophrenia...
  8. ncbi request reprint Comment on "Ascertainment adjustment in complex diseases"
    Michael P Epstein
    Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109 2029, USA
    Genet Epidemiol 23:209-13. 2002
  9. pmc A powerful and flexible multilocus association test for quantitative traits
    Lydia Coulter Kwee
    Department of Biostatistics, Emory University, Atlanta, GA 30322, USA
    Am J Hum Genet 82:386-97. 2008
    ..Our approach is also flexible, because it allows easy modeling of covariates and, if interest exists, high-dimensional interactions among tagSNPs and environmental predictors...
  10. pmc A locus for posterior polymorphous corneal dystrophy (PPCD3) maps to chromosome 10
    Satoko Shimizu
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, 1000 Wall Street, Ann Arbor, MI 48105, USA
    Am J Med Genet A 130:372-7. 2004
    ....
  11. pmc Powerful SNP-set analysis for case-control genome-wide association studies
    Michael C Wu
    Department of Biostatistics, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Hum Genet 86:929-42. 2010
    ..When the correlation is low, both individual-SNP analysis and the SNP-set analysis tend to have low power. We apply SNP-set analysis to analyze the Cancer Genetic Markers of Susceptibility (CGEMS) breast cancer GWAS discovery-phase data...
  12. pmc Fragile X-associated primary ovarian insufficiency: evidence for additional genetic contributions to severity
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Epidemiol 32:553-9. 2008
    ..This result is important for proper counseling of women who carry FMR1 premutation alleles and for guidance of future studies to identify additional genes that influence ovarian insufficiency...
  13. pmc Ascertainment-adjusted parameter estimates revisited
    Michael P Epstein
    Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Am J Hum Genet 70:886-95. 2002
    ....
  14. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  15. ncbi request reprint Clinicopathologic correlation and genetic analysis in a case of posterior polymorphous corneal dystrophy
    Sayoko E Moroi
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan 48105, USA
    Am J Ophthalmol 135:461-70. 2003
    ..To evaluate the clinical history, histopathology, and genetics of posterior polymorphous corneal dystrophy (PPMD) in a woman with a prominent retrocorneal membrane...
  16. pmc Mutations in TCF8 cause posterior polymorphous corneal dystrophy and ectopic expression of COL4A3 by corneal endothelial cells
    Charles M Krafchak
    Department of Ophthalmology and Visual Sciences, W K Kellogg Eye Center, University of Michigan, Ann Arbor, MI 48105, USA
    Am J Hum Genet 77:694-708. 2005
    ....
  17. ncbi request reprint Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, CT, USA
    Eur J Hum Genet 15:878-83. 2007
    ..0025 and 0.0036, respectively). The data support the validity of prior reported associations and underscore the importance of analyzing multiple SNPs across DBH in future association studies examining disease and biochemical phenotypes...
  18. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  19. ncbi request reprint A large set of Finnish affected sibling pair families with type 2 diabetes suggests susceptibility loci on chromosomes 6, 11, and 14
    Kaisa Silander
    Genome Technology Branch, National Human Genome Research Institute, Bethesda, Maryland, USA
    Diabetes 53:821-9. 2004
    ....

Research Grants5

  1. Novel Statistical Methods for Human Gene Mapping
    Michael Epstein; Fiscal Year: 2007
    ..Finally, this project will be opportunistic in identifying and addressing unforseen statistical problems arising in human gene mapping studies. ..
  2. Novel Statistical Methods for Human Gene Mapping
    MICHAEL PHILIP EPSTEIN; Fiscal Year: 2010
    ..Finally, this project will be opportunistic in identifying and addressing unforseen statistical problems arising in human gene mapping studies. ..