Michael P Epstein

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc A permutation procedure to correct for confounders in case-control studies, including tests of rare variation
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Am J Hum Genet 91:215-23. 2012
  2. pmc Stratification-score matching improves correction for confounding by population stratification in case-control association studies
    Michael P Epstein
    Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Genet Epidemiol 36:195-205. 2012
  3. pmc Modifiers of ovarian function in girls and women with classic galactosemia
    Jessica B Spencer
    Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 98:E1257-65. 2013
  4. pmc A simple and improved correction for population stratification in case-control studies
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 80:921-30. 2007
  5. pmc The FMR1 premutation and attention-deficit hyperactivity disorder (ADHD): evidence for a complex inheritance
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Behav Genet 42:415-22. 2012
  6. pmc Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Genet B Neuropsychiatr Genet 159:549-59. 2012
  7. pmc Genetic association analysis using data from triads and unrelated subjects
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 76:592-608. 2005
  8. pmc Ovarian function in Duarte galactosemia
    Jennifer R Badik
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
    Fertil Steril 96:469-473.e1. 2011
  9. ncbi request reprint Assessing the impact of population stratification on association studies of rare variation
    Yunxuan Jiang
    Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA
    Hum Hered 76:28-35. 2013
  10. ncbi request reprint Improved association analyses of disease subtypes in case-parent triads
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    Genet Epidemiol 30:209-19. 2006

Collaborators

Detail Information

Publications17

  1. pmc A permutation procedure to correct for confounders in case-control studies, including tests of rare variation
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, GA 30322, USA
    Am J Hum Genet 91:215-23. 2012
    ..We further illustrate the approach by using sequence data from the Dallas Heart Study of energy metabolism traits. Researchers can implement our permutation approach by using the R package BiasedUrn...
  2. pmc Stratification-score matching improves correction for confounding by population stratification in case-control association studies
    Michael P Epstein
    Department of Human Genetics, Emory University, 615 Michael Street, Atlanta, GA 30322, USA
    Genet Epidemiol 36:195-205. 2012
    ..We also use simulated data to show our novel matching approach can provide a more appropriate correction for population stratification than existing matching approaches...
  3. pmc Modifiers of ovarian function in girls and women with classic galactosemia
    Jessica B Spencer
    Division of Reproductive Endocrinology and Infertility, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Clin Endocrinol Metab 98:E1257-65. 2013
    ..More than 80% of girls and women with classic galactosemia experience primary or premature ovarian insufficiency despite neonatal diagnosis and rigorous lifelong dietary galactose restriction...
  4. pmc A simple and improved correction for population stratification in case-control studies
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 80:921-30. 2007
    ..and find no association between the LCT locus and tall/short status. Using simulated data, we show that our approach yields a more appropriate correction for stratification than does principal components or genomic control...
  5. pmc The FMR1 premutation and attention-deficit hyperactivity disorder (ADHD): evidence for a complex inheritance
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Behav Genet 42:415-22. 2012
    ..For both measures, FMR1 accounts for ~5% of the variance while polygenes account for ~50% of the residual variance, suggesting that the premutation acts in concert with additional genetic loci to influence the severity of ADHD symptoms...
  6. pmc Depression and anxiety symptoms among women who carry the FMR1 premutation: impact of raising a child with fragile X syndrome is moderated by CRHR1 polymorphisms
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Med Genet B Neuropsychiatr Genet 159:549-59. 2012
    ..0001). Our data suggest that genetic variants in CRHR1 that associate with differential cortisol activation may also modulate levels of anxiety related to the stress of raising a child with FXS among women who carry an FMR1 premutation...
  7. pmc Genetic association analysis using data from triads and unrelated subjects
    Michael P Epstein
    Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Hum Genet 76:592-608. 2005
    ..Our approach also allows for flexible modeling and estimation of allele effects, as well as for missing parental data. We illustrate the usefulness of our approach using SNP data from a candidate-gene study of psoriasis...
  8. pmc Ovarian function in Duarte galactosemia
    Jennifer R Badik
    Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA
    Fertil Steril 96:469-473.e1. 2011
    ..To determine if girls with Duarte variant galactosemia (DG) have an increased risk of developing premature ovarian insufficiency based on prepubertal anti-M├╝llerian hormone (AMH) levels...
  9. ncbi request reprint Assessing the impact of population stratification on association studies of rare variation
    Yunxuan Jiang
    Department of Biostatistics and Bioinformatics, Emory University, Atlanta, GA, USA
    Hum Hered 76:28-35. 2013
    ..Using simulations, we investigated the impact of population stratification on false-positive rates of rare-variant association tests...
  10. ncbi request reprint Improved association analyses of disease subtypes in case-parent triads
    Michael P Epstein
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    Genet Epidemiol 30:209-19. 2006
    ....
  11. pmc Cryptic residual GALT activity is a potential modifier of scholastic outcome in school age children with classic galactosemia
    Emily L Ryan
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University, Atlanta, GA, USA
    J Inherit Metab Dis 36:1049-61. 2013
    ..These data raise the intriguing possibility that cryptic GALT activity might also influence the severity of other long-term complications in classic galactosemia. ..
  12. pmc A powerful and flexible multilocus association test for quantitative traits
    Lydia Coulter Kwee
    Department of Biostatistics, Emory University, Atlanta, GA 30322, USA
    Am J Hum Genet 82:386-97. 2008
    ..Our approach is also flexible, because it allows easy modeling of covariates and, if interest exists, high-dimensional interactions among tagSNPs and environmental predictors...
  13. pmc Variation in folate pathway genes contributes to risk of congenital heart defects among individuals with Down syndrome
    Adam E Locke
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA
    Genet Epidemiol 34:613-23. 2010
    ..1298A was over-transmitted to cases with AVSD (P=0.05) and under-transmitted to controls (P=0.02). We conclude, therefore, that disruption of the folate pathway contributes to the incidence of AVSD among individuals with DS...
  14. pmc Fragile X-associated primary ovarian insufficiency: evidence for additional genetic contributions to severity
    Jessica Ezzell Hunter
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Genet Epidemiol 32:553-9. 2008
    ..This result is important for proper counseling of women who carry FMR1 premutation alleles and for guidance of future studies to identify additional genes that influence ovarian insufficiency...
  15. ncbi request reprint Comparison of prospective and retrospective methods for haplotype inference in case-control studies
    Glen A Satten
    Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
    Genet Epidemiol 27:192-201. 2004
    ....
  16. pmc Biomarkers of ovarian function in girls and women with classic galactosemia
    Rebecca D Sanders
    Graduate Program in Biochemistry, Cell, and Developmental Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Fertil Steril 92:344-51. 2009
    ..To determine whether premature ovarian insufficiency (POI) associated with classic galactosemia results from a true impairment of ovarian function or from aberrant FSH...
  17. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...