Jin Tang Dong

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Defining the region(s) of deletion at 6q16-q22 in human prostate cancer
    Eija Riitta Hyytinen
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Genes Chromosomes Cancer 34:306-12. 2002
  2. ncbi request reprint Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer
    Xiaodong Sun
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Genet 37:407-12. 2005
  3. ncbi request reprint Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
    Ceshi Chen
    Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:41553-61. 2005
  4. ncbi request reprint Prevalent mutations in prostate cancer
    Jin Tang Dong
    Department of Hematology and Oncology, Program in Genetics and Molecular Biology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    J Cell Biochem 97:433-47. 2006
  5. pmc Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors
    Jia Jie Hao
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Science, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China
    BMC Cancer 12:367. 2012
  6. ncbi request reprint Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells
    Ceshi Chen
    Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA, USA
    Oncogene 24:3319-27. 2005
  7. pmc Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification
    Peng Guo
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:6071-8. 2009
  8. ncbi request reprint KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line
    Ceshi Chen
    Winship Cancer Institute and Department of Oncology and Hematology, Emory University School of Medicine, Atlanta, GA, USA
    Int J Cancer 118:1346-55. 2006
  9. ncbi request reprint Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells
    Ceshi Chen
    Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Gene 330:133-42. 2004
  10. pmc Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells
    Peng Guo
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 126:81-9. 2010

Collaborators

Detail Information

Publications44

  1. ncbi request reprint Defining the region(s) of deletion at 6q16-q22 in human prostate cancer
    Eija Riitta Hyytinen
    Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908 0214, USA
    Genes Chromosomes Cancer 34:306-12. 2002
    ..These findings suggest that deletion of 6q16 - q22 is a frequent event in prostate cancer, and that the deletion originates from two distinct regions. These results should be useful in identifying the target gene(s) of deletion at 6q...
  2. ncbi request reprint Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer
    Xiaodong Sun
    Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Genet 37:407-12. 2005
    ..Furthermore, ATBF1 inhibited cell proliferation. Hence, loss of ATBF1 is one mechanism that defines the absence of growth control in prostate cancer...
  3. ncbi request reprint Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells
    Ceshi Chen
    Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 280:41553-61. 2005
    ..These findings not only established WWP1 as an E3 ubiquitin ligase for KLF5, they also further implicated the KLF5 pathway in human carcinogenesis...
  4. ncbi request reprint Prevalent mutations in prostate cancer
    Jin Tang Dong
    Department of Hematology and Oncology, Program in Genetics and Molecular Biology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    J Cell Biochem 97:433-47. 2006
    ..Identification and characterization of these genes will be a key step for improving the detection and treatment of prostate cancer...
  5. pmc Characterization of genetic rearrangements in esophageal squamous carcinoma cell lines by a combination of M-FISH and array-CGH: further confirmation of some split genomic regions in primary tumors
    Jia Jie Hao
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Science, 17 Panjiayuan Nanli, Chaoyang District, Beijing, 100021, China
    BMC Cancer 12:367. 2012
    ..Chromosomal and genomic aberrations are common features of human cancers. However, chromosomal numerical and structural aberrations, breakpoints and disrupted genes have yet to be identified in esophageal squamous cell carcinoma (ESCC)...
  6. ncbi request reprint Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cells
    Ceshi Chen
    Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA, USA
    Oncogene 24:3319-27. 2005
    ..These results suggest that KLF5 protein is degraded at least in part through ubiquitination-proteasome pathway, which may have become hyperactive for KLF5 in cancer cells...
  7. pmc Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modification
    Peng Guo
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:6071-8. 2009
    ..Furthermore, they establish KLF5 as an essential cofactor for TGFbeta signaling...
  8. ncbi request reprint KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell line
    Ceshi Chen
    Winship Cancer Institute and Department of Oncology and Hematology, Emory University School of Medicine, Atlanta, GA, USA
    Int J Cancer 118:1346-55. 2006
    ..These findings suggest that the KLF5 transcription factor plays an oncogenic role in the TSU-Pr1 bladder cancer cell line through the regulation of a subset of genes...
  9. ncbi request reprint Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cells
    Ceshi Chen
    Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Gene 330:133-42. 2004
    ..In addition, overexpression of Sp1 protein transactivates KLF5 promoter activity. These findings suggest that Sp1 is a key transcription factor in KLF5's dynamic transcriptional regulation...
  10. pmc Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cells
    Peng Guo
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Int J Cancer 126:81-9. 2010
    ..These results suggest that KLF5 inhibits the function of ERalpha in gene regulation and cell proliferation through protein interaction that interrupts the binding of ERalpha to target gene promoters to prevent target gene induction...
  11. ncbi request reprint FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancer
    Xue Yuan Dong
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:6998-7006. 2006
    ..As a well-established negative effector in the phosphatidylinositol 3-kinase/AKT signaling pathway, FOXO1A inactivation in cancer would impair the therapeutic effect of phosphatidylinositol 3-kinase/AKT inhibitors in cancer treatment...
  12. pmc Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor beta
    Peng Guo
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:28243-52. 2009
    ..Furthermore, different binding sites mediate different effects of KLF5 in the context of TGFbeta...
  13. pmc Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells
    Xue Yuan Dong
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:13879-90. 2011
    ....
  14. ncbi request reprint Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancer
    Xiaodong Sun
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Prostate 66:660-6. 2006
    ..Mismatch repair (MMR) and microsatellite instability (MSI) occur in prostate cancer, but their role has not been well documented...
  15. pmc Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP
    Xue Yuan Dong
    Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Biochem J 444:581-90. 2012
    ....
  16. ncbi request reprint Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomas
    Diansheng Zhong
    The Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Cancer Biol Ther 5:601-7. 2006
    ....
  17. pmc Interruption of nuclear localization of ATBF1 during the histopathologic progression of head and neck squamous cell carcinoma
    Xiaodong Sun
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
    Head Neck 35:1007-14. 2013
    ....
  18. pmc Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells
    Ke Wen Zhao
    Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA
    Biochem J 437:323-33. 2011
    ....
  19. pmc Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortality
    Xiaodong Sun
    Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
    Genesis 50:819-27. 2012
    ..Floxed Atbf1 mice will help us understand such biological processes as neuronal differentiation and tumorigenesis...
  20. ncbi request reprint Infrequent mutation of ATBF1 in human breast cancer
    Xiaodong Sun
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cancer Res Clin Oncol 133:103-5. 2007
    ..These findings suggest that ATBF1 plays a role in breast cancer through transcriptional downregulation rather than mutations...
  21. ncbi request reprint KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia
    Ningxi Zhu
    The Division of Pediatric Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    J Biol Chem 281:14711-8. 2006
    ..These findings identify a novel regulatory pathway for the expression of survivin under the control of KLF5 and p53. Deregulation of this pathway may result in overexpression of survivin in cancer, thus contributing to drug resistance...
  22. pmc SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer
    Xue Yuan Dong
    Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
    Hum Mol Genet 17:1031-42. 2008
    ..9; 95% confidence interval 1.17-7.21). These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers...
  23. pmc Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling
    Mei Li
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China
    PLoS ONE 7:e51283. 2012
    ..These findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells...
  24. ncbi request reprint PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancer
    Ruoxiang Wang
    Molecular Urology and Therapeutics, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Res 64:1589-94. 2004
    ..As the only prostate-specific gene identified in the most frequently amplified genomic region in prostate cancer, PrLZ may be the link between chromosome 8q amplification and malignant transformation of the prostate epithelia...
  25. ncbi request reprint Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseases
    Jin Tang Dong
    Department of Hematology and Medical Oncology, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Cell Mol Life Sci 66:2691-706. 2009
    ..Due to its significant functions in cell proliferation, survival, and differentiation, KLF5 could be a potential diagnostic biomarker and therapeutic target for cancer and cardiovascular diseases...
  26. pmc ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cells
    Xue Yuan Dong
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 285:32801-9. 2010
    ..These findings not only support the concept that ATBF1 plays a tumor-suppressive role in breast cancer, they also provide a mechanism for how ATBF1 functions as a tumor suppressor in breast cancer...
  27. pmc Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cells
    Peng Guo
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:18184-93. 2009
    ..Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription...
  28. pmc Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells
    Xiaodong Sun
    Winship Cancer Institute, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS ONE 9:e92746. 2014
    ....
  29. pmc Deletion, mutation, and loss of expression of KLF6 in human prostate cancer
    Ceshi Chen
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Pathol 162:1349-54. 2003
    ..These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers...
  30. pmc Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells
    Lizheng Guo
    Department of Hematology and Oncology, The Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, George, USA
    Mol Cancer Res 6:1421-30. 2008
    ..Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors...
  31. pmc Implication of snoRNA U50 in human breast cancer
    Xue Yuan Dong
    Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, Georgia 30322, USA
    J Genet Genomics 36:447-54. 2009
    ..Functionally, re-expression of U50 resulted in the inhibition of colony formation in breast cancer cell lines. These results suggest that noncoding snoRNA U50 plays a role in the development and/or progression of breast cancer...
  32. ncbi request reprint Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinoma
    Yi Ling Yang
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
    Genes Chromosomes Cancer 47:127-36. 2008
    ..004). Our results indicate that PRKCI is an attractive target in the 3q26 amplicon and that it may serve as a molecular marker for metastasis and occult advanced tumor stages in ESCC...
  33. ncbi request reprint Defining regulatory elements in the human KAI1 (CD 82) metastasis suppressor gene
    Allen C Gao
    Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, USA
    Prostate 57:256-60. 2003
    ..Additional studies of Marreiros et al. (Gene 302:155, 2003) have documented that a third regulatory element even further 5' (i.e., -922 to -846 bp) encodes an enhancer for the KAI1 gene...
  34. ncbi request reprint The amplified WWP1 gene is a potential molecular target in breast cancer
    Ceshi Chen
    The Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
    Int J Cancer 121:80-87. 2007
    ..These results suggest that genomic aberrations of WWP1 may contribute to the pathogenesis of breast cancer...
  35. ncbi request reprint A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer
    Ceshi Chen
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, VA 22908, USA
    Oncogene 21:6567-72. 2002
    ..These findings suggest that loss of function by deletion and/or loss of expression frequently occurs at KLF5, and KLF5 suppresses tumor cell growth in breast cancer...
  36. ncbi request reprint KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer
    Ceshi Chen
    Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA
    Prostate 55:81-8. 2003
    ..The target gene of deletion in prostate cancer, however, has not been identified at present...
  37. ncbi request reprint Absence of KLF6 gene mutations in human astrocytic tumors and cell lines
    Pasi A Koivisto
    Int J Cancer 111:642-3. 2004
  38. ncbi request reprint A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinoma
    Guang Ming Guo
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, PR China
    Oncol Rep 14:1639-46. 2005
    ..The present study defined a novel region of allelic loss in 13q33-q34. LOH at D13S248 and D13S152 are associated with higher tumor grade and metastasis, respectively...
  39. ncbi request reprint Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cells
    Min Liu
    Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    J Biol Chem 281:18090-7. 2006
    ..In addition, these findings suggest that a combination of Eg5 inhibitors with agents abrogating Hsp70 induction would be useful for myeloma therapy in the clinic...
  40. ncbi request reprint Identification of chromosome aberrations in esophageal cancer cell line KYSE180 by multicolor fluorescence in situ hybridization
    Yu Peng Wu
    National Laboratory of Molecular Oncology, Cancer Institute Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China
    Cancer Genet Cytogenet 170:102-7. 2006
    ..No chromosomes 9, 13, or Y were detected. These results add significant information to the existing karyotype description of KYSE180 and provide detailed cytogenetic background data for appropriate use of the cell line...
  41. ncbi request reprint Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathway
    Ceshi Chen
    The Center for Cell Biology and Cancer Research, MS355, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
    FEBS Lett 581:1124-30. 2007
    ..This mutant is efficiently degraded by the proteasome without ubiquitination in vitro and in vivo. These findings suggest that KLF5 protein degradation by the proteasome could be regulated in a ubiquitin-independent manner...
  42. ncbi request reprint Molecular analysis in combination with iodine staining may contribute to the risk prediction of esophageal squamous cell carcinoma
    Shun He
    State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, PUMC, CAMS, P O Box 2258, Beijing 100021, China
    J Cancer Res Clin Oncol 134:307-15. 2008
    ..In the present study, we conducted a molecular analysis combining the iodine staining in esophageal squamous cell carcinomas (ESCC) and different premalignant lesions of the esophagus in order to improve the early diagnosis of ESCC...
  43. doi request reprint The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migration
    Jinmin Gao
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, China
    J Biol Chem 283:8802-9. 2008
    ..Thus CYLD joins a growing list of CAP-Gly domain-containing proteins that regulate microtubule dynamics and function...
  44. doi request reprint Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cells
    Lei Sun
    Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
    Biochem Pharmacol 75:1027-34. 2008
    ..These results suggest that Aurora inhibitors might be effective in spindle checkpoint-defective cancer cells and a combination of Aurora inhibitors with the vinca alkaloids is a promising approach for cancer chemotherapy...