Research Topics
Genomes and Genes | Jin Tang DongSummaryAffiliation: Emory University Country: USA Publications
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Publications
Defining the region(s) of deletion at 6q16-q22 in human prostate cancerEija-Riitta Hyytinen
Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908-0214, USA
Genes Chromosomes Cancer 34:306-12. 2002..These findings suggest that deletion of 6q16 - q22 is a frequent event in prostate cancer, and that the deletion originates from two distinct regions. These results should be useful in identifying the target gene(s) of deletion at 6q...- Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancerXiaodong Sun
Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Nat Genet 37:407-12. 2005..Furthermore, ATBF1 inhibited cell proliferation. Hence, loss of ATBF1 is one mechanism that defines the absence of growth control in prostate cancer... - Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cellsCeshi Chen
Winship Cancer Institute and Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 280:41553-61. 2005..These findings not only established WWP1 as an E3 ubiquitin ligase for KLF5, they also further implicated the KLF5 pathway in human carcinogenesis... - Prevalent mutations in prostate cancerJin Tang Dong
Department of Hematology and Oncology, Program in Genetics and Molecular Biology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
J Cell Biochem 97:433-47. 2006..Identification and characterization of these genes will be a key step for improving the detection and treatment of prostate cancer... - Ubiquitin-proteasome degradation of KLF5 transcription factor in cancer and untransformed epithelial cellsCeshi Chen
Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA, USA
Oncogene 24:3319-27. 2005..These results suggest that KLF5 protein is degraded at least in part through ubiquitination-proteasome pathway, which may have become hyperactive for KLF5 in cancer cells... 
Estrogen-induced interaction between KLF5 and estrogen receptor (ER) suppresses the function of ER in ER-positive breast cancer cellsPeng Guo
Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Int J Cancer 126:81-9. 2010..These results suggest that KLF5 inhibits the function of ERalpha in gene regulation and cell proliferation through protein interaction that interrupts the binding of ERalpha to target gene promoters to prevent target gene induction...- Deletion, mutation, and loss of expression of KLF6 in human prostate cancerCeshi Chen
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Am J Pathol 162:1349-54. 2003..These findings indicate that significant genetic alterations of KLF6 occur in a minority of high-grade prostate cancers... - Pro-proliferative factor KLF5 becomes anti-proliferative in epithelial homeostasis upon signaling-mediated modificationPeng Guo
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 284:6071-8. 2009..Furthermore, they establish KLF5 as an essential cofactor for TGFbeta signaling... - Estrogen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cellsXue Yuan Dong
Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 286:13879-90. 2011.... - ATBF1 inhibits estrogen receptor (ER) function by selectively competing with AIB1 for binding to the ER in ER-positive breast cancer cellsXue Yuan Dong
Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 285:32801-9. 2010..These findings not only support the concept that ATBF1 plays a tumor-suppressive role in breast cancer, they also provide a mechanism for how ATBF1 functions as a tumor suppressor in breast cancer... - Opposing effects of KLF5 on the transcription of MYC in epithelial proliferation in the context of transforming growth factor betaPeng Guo
Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 284:28243-52. 2009..Furthermore, different binding sites mediate different effects of KLF5 in the context of TGFbeta... - FOXO1A is a candidate for the 13q14 tumor suppressor gene inhibiting androgen receptor signaling in prostate cancerXue Yuan Dong
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Cancer Res 66:6998-7006. 2006..As a well-established negative effector in the phosphatidylinositol 3-kinase/AKT signaling pathway, FOXO1A inactivation in cancer would impair the therapeutic effect of phosphatidylinositol 3-kinase/AKT inhibitors in cancer treatment... 
Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFPXue Yuan Dong
Department of Hematology and Medical Oncology, School of Medicine, Winship Cancer Institute, Emory University, 1365 C Clifton Road, Atlanta, GA 30322, USA
Biochem J 444:581-90. 2012....- Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cellsKe Wen Zhao
Department of Hematology and Medical Oncology, School of Medicine, Emory University, Atlanta, GA 30322, USA
Biochem J 437:323-33. 2011.... - Homozygous deletion of SMAD4 in breast cancer cell lines and invasive ductal carcinomasDiansheng Zhong
The Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Cancer Biol Ther 5:601-7. 2006.... - Infrequent mutation of ATBF1 in human breast cancerXiaodong Sun
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
J Cancer Res Clin Oncol 133:103-5. 2007..These findings suggest that ATBF1 plays a role in breast cancer through transcriptional downregulation rather than mutations... - KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemiaNingxi Zhu
The Division of Pediatric Hematology Oncology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
J Biol Chem 281:14711-8. 2006..These findings identify a novel regulatory pathway for the expression of survivin under the control of KLF5 and p53. Deregulation of this pathway may result in overexpression of survivin in cancer, thus contributing to drug resistance... - SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancerXue Yuan Dong
Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, GA 30322, USA
Hum Mol Genet 17:1031-42. 2008..9; 95% confidence interval 1.17-7.21). These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers... - Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signalingMei Li
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, Tianjin, China
PLoS ONE 7:e51283. 2012..These findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells... - PrLZ, a novel prostate-specific and androgen-responsive gene of the TPD52 family, amplified in chromosome 8q21.1 and overexpressed in human prostate cancerRuoxiang Wang
Molecular Urology and Therapeutics, Department of Urology, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Res 64:1589-94. 2004..As the only prostate-specific gene identified in the most frequently amplified genomic region in prostate cancer, PrLZ may be the link between chromosome 8q amplification and malignant transformation of the prostate epithelia... - Essential role of KLF5 transcription factor in cell proliferation and differentiation and its implications for human diseasesJin Tang Dong
Department of Hematology and Medical Oncology, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
Cell Mol Life Sci 66:2691-706. 2009..Due to its significant functions in cell proliferation, survival, and differentiation, KLF5 could be a potential diagnostic biomarker and therapeutic target for cancer and cardiovascular diseases... - Acetylation of KLF5 alters the assembly of p15 transcription factors in transforming growth factor-beta-mediated induction in epithelial cellsPeng Guo
Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 284:18184-93. 2009..Activation of TGFbeta recruits p300 to the KLF5-Smad complex to acetylate KLF5, and the complex with acetylated KLF5 binds to the Smad binding element and alters the binding of other factors to p15 promoter to induce its transcription... - Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortalityXiaodong Sun
Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
Genesis 50:819-27. 2012..Floxed Atbf1 mice will help us understand such biological processes as neuronal differentiation and tumorigenesis... - Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cellsLizheng Guo
Department of Hematology and Oncology, The Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, George, USA
Mol Cancer Res 6:1421-30. 2008..Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors... - Implication of snoRNA U50 in human breast cancerXue Yuan Dong
Department of Hematology and Medical Oncology and Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Road, Atlanta, Georgia 30322, USA
J Genet Genomics 36:447-54. 2009..Functionally, re-expression of U50 resulted in the inhibition of colony formation in breast cancer cell lines. These results suggest that noncoding snoRNA U50 plays a role in the development and/or progression of breast cancer... - Amplification of PRKCI, located in 3q26, is associated with lymph node metastasis in esophageal squamous cell carcinomaYi Ling Yang
State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
Genes Chromosomes Cancer 47:127-36. 2008..004). Our results indicate that PRKCI is an attractive target in the 3q26 amplicon and that it may serve as a molecular marker for metastasis and occult advanced tumor stages in ESCC... - Defining regulatory elements in the human KAI1 (CD 82) metastasis suppressor geneAllen C Gao
Grace Cancer Drug Center, Roswell Park Cancer Institute, Buffalo, New York, USA
Prostate 57:256-60. 2003..Additional studies of Marreiros et al. (Gene 302:155, 2003) have documented that a third regulatory element even further 5' (i.e., -922 to -846 bp) encodes an enhancer for the KAI1 gene... - The amplified WWP1 gene is a potential molecular target in breast cancerCeshi Chen
The Center for Cell Biology and Cancer Research, Albany Medical College, Albany, NY 12208, USA
Int J Cancer 121:80-87. 2007..These results suggest that genomic aberrations of WWP1 may contribute to the pathogenesis of breast cancer... - Small-molecule inhibition of Aurora kinases triggers spindle checkpoint-independent apoptosis in cancer cellsLei Sun
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
Biochem Pharmacol 75:1027-34. 2008..These results suggest that Aurora inhibitors might be effective in spindle checkpoint-defective cancer cells and a combination of Aurora inhibitors with the vinca alkaloids is a promising approach for cancer chemotherapy... - KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancerCeshi Chen
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, USA
Prostate 55:81-8. 2003..The target gene of deletion in prostate cancer, however, has not been identified at present... - Regulation of KLF5 involves the Sp1 transcription factor in human epithelial cellsCeshi Chen
Department of Oncology and Hematology, Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA 30322, USA
Gene 330:133-42. 2004..In addition, overexpression of Sp1 protein transactivates KLF5 promoter activity. These findings suggest that Sp1 is a key transcription factor in KLF5's dynamic transcriptional regulation... - Absence of KLF6 gene mutations in human astrocytic tumors and cell linesPasi A Koivisto
Int J Cancer 111:642-3. 2004 - Identification of chromosome aberrations in esophageal cancer cell line KYSE180 by multicolor fluorescence in situ hybridizationYu-Peng Wu
National Laboratory of Molecular Oncology, Cancer Institute (Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Chaoyang District, Beijing, China
Cancer Genet Cytogenet 170:102-7. 2006..No chromosomes 9, 13, or Y were detected. These results add significant information to the existing karyotype description of KYSE180 and provide detailed cytogenetic background data for appropriate use of the cell line... - KLF5 promotes cell proliferation and tumorigenesis through gene regulation and the TSU-Pr1 human bladder cancer cell lineCeshi Chen
Winship Cancer Institute and Department of Oncology and Hematology, Emory University School of Medicine, Atlanta, GA, USA
Int J Cancer 118:1346-55. 2006..These findings suggest that the KLF5 transcription factor plays an oncogenic role in the TSU-Pr1 bladder cancer cell line through the regulation of a subset of genes... - A novel region of deletion on 13q33-q34 in esophageal squamous cell carcinomaGuang-Ming Guo
State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, PR China
Oncol Rep 14:1639-46. 2005..The present study defined a novel region of allelic loss in 13q33-q34. LOH at D13S248 and D13S152 are associated with higher tumor grade and metastasis, respectively... - Microsatellite instability and mismatch repair target gene mutations in cell lines and xenografts of prostate cancerXiaodong Sun
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Prostate 66:660-6. 2006..CONCLUSIONS: MSI related to MMR deficiency is relatively frequent in high-grade tumors, and mutations in MSI target genes involved in cell death and proliferation appeared to be selected for during prostatic carcinogenesis... - Inhibition of the mitotic kinesin Eg5 up-regulates Hsp70 through the phosphatidylinositol 3-kinase/Akt pathway in multiple myeloma cellsMin Liu
Department of Genetics and Cell Biology and Key Laboratory of Bioactive Materials (Ministry of Education, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin 300071, China
J Biol Chem 281:18090-7. 2006..In addition, these findings suggest that a combination of Eg5 inhibitors with agents abrogating Hsp70 induction would be useful for myeloma therapy in the clinic... - Proteasomal degradation of the KLF5 transcription factor through a ubiquitin-independent pathwayCeshi Chen
The Center for Cell Biology and Cancer Research, MS355, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA
FEBS Lett 581:1124-30. 2007..This mutant is efficiently degraded by the proteasome without ubiquitination in vitro and in vivo. These findings suggest that KLF5 protein degradation by the proteasome could be regulated in a ubiquitin-independent manner... - The tumor suppressor CYLD regulates microtubule dynamics and plays a role in cell migrationJinmin Gao
Department of Genetics and Cell Biology, College of Life Sciences, Nankai University, 94 Weijin Road, Tianjin, China
J Biol Chem 283:8802-9. 2008..Thus CYLD joins a growing list of CAP-Gly domain-containing proteins that regulate microtubule dynamics and function... - Molecular analysis in combination with iodine staining may contribute to the risk prediction of esophageal squamous cell carcinomaShun He
State Key Laboratory of Molecular Oncology, Cancer Institute Hospital, PUMC, CAMS, P O Box 2258, Beijing 100021, China
J Cancer Res Clin Oncol 134:307-15. 2008..In the present study, we conducted a molecular analysis combining the iodine staining in esophageal squamous cell carcinomas (ESCC) and different premalignant lesions of the esophagus in order to improve the early diagnosis of ESCC... - A possible tumor suppressor role of the KLF5 transcription factor in human breast cancerCeshi Chen
Department of Pathology, University of Virginia Health System, Charlottesville, Virginia, VA 22908, USA
Oncogene 21:6567-72. 2002..These findings suggest that loss of function by deletion and/or loss of expression frequently occurs at KLF5, and KLF5 suppresses tumor cell growth in breast cancer...